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| 1 | Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy显示文摘Background:The clinical efficacy of fentanyl for pain control differs greatly across individuals.The purpose of this study was to investigate the impact of CYP3A4*1G polymorphism including wild-type homozygote (CYP3A4*1/*1,GG),mutant heterozygote (CYP3A4*1/*1G,GA),and mutant homozygote (CYP3A4*1G/*1G,AA)on fentanyl analgesia in Chinese patients undergoing hysteroscopy by the assessment of analgesia nociception index (ANI). Methods:A total of 200 gynecologic patients scheduled for elective hysteroscopy under general anesthesia at Peking University People's Hospital from May to December in 2017 were enrolled in this study.Venous blood was withdrawn for genotyping of CYP3A4*1G before operation.Fentanyl 1μg/kg was administered preoperatively followed by target-controlled infusion of propofol for induction and maintenance.Intraoperative analgesic efficacy of fentanyl was assessed by ANI monitoring at T0(entering room),T1(cervical dilation), T2(start of cervical aspiration),and T3(end of cervical aspiration)time points.The duration of propofol infusion and total dosage of propofol were recorded as well. Results:The patients were divided into three groups according to CYP3A4*1G polymorphism,including 143 in GG group,47in GA group, and 10 in AA group.There was no significant difference in clinical demographics among three groups.The frequency of CYP3A4*1G variant alleles accounted for 16.8%and the distribution of variant alleles was consistent with Hardy-Weinberg equilibrium.Using a multilevel model,ANI values at T1(63.81±19.61),T2(63.63±17.82),and T3(65.68±17.79)were significantly lower than that at T0 (77.16±12.93)in the study population (F =23.50,P <0.001),suggesting that higher levels of pain at T 1,T2,and T3 than T0.Patients with GG genotype showed significantly lower ANI than those with GA or AA genotypes during hysteroscopy under the same dose of fentanyl. Conclusion:CYP3A4*1G polymorphism associated with the analgesic efficacy of intraoperative fentanyl in the patients undergoing hysteroscopy under general anesthesia. | Qi Yan Yi Su Lan Gao Nan Ding Hong-Ying Zhang Wen E Yue Wang Yi Feng Hai-Yan An | 2018 | Chinese Medical Journal2018，，22： | 8 |
| 2 | Crystal structure and nucleotide selectivity of human IFIT5/ISG58显示文摘 | Feng Feng LingminYuan Yao E Wang Christopher Crowley Zongyang Lv Jingjing Li Yingfang Liu Genhong Cheng Su Zeng Huanhuan Liang | 2013 | Cell Research2013，23，8： | 4 |
| 3 | Effect of garlic and garlic-green tea mixture on serum lipids in MNNG-induced experimental gastriccarcinoma and precancerous lesion显示文摘EfectofgarlicandgarlicgreenteamixtureonserumlipidsinMNNGinducedexperimentalgastriccarcinomaandprecancerouslesionSUQi,LUOZh... | SU Qi, LUO Zhao Yang, TENG Hua, YUN Wei Dong, Li Yi Qing and HE Xin E Institute of Oncology, Hengyang Medical College, Hengyang 421001, Hunan Province, China | 1998 | World Journal of Gastroenterology1998，4，1： | 4 |
| 4 | Response of Soil Organic Carbon and Its Aggregate Fractions to LongTerm Fertilization in Irrigated Desert Soil of China显示文摘Irrigated desert soil samples in the Hexi Corridor of China were collected over a period of 23 years from a site where different fertilization methods had been used. Changes of soil organic carbon(SOC) and its water stable aggregate(WSA) size fractions were studied. The effects of various fertilization methods on the distribution of added organic carbon(OC) in different WSA size fractions were also analyzed. The results showed that the applied fertilizations for 23 years improved SOC concentrations and OC concentrations in all WSA size fractions compared to the non-fertilized treatment(CK). In addition, fertilization obviously increased the OC stocks of <2 mm WSA size fractions compared to the CK. The average OC stock of <0.053 mm WSA fraction was 1.7, 1.6 and 3.2 times higher than those of >2 mm, 0.25-2 mm and 0.053-0.25 mm WSA fractions, respectively. A significant positive correlation was found between soil C gains and OC inputs(r=0.92, P<0.05), indicating that SOC may have not reached the saturation point yet at the site. The C sequestration rate was estimated by 14.02% at the site. The OC stocks in all of the <2 mm WSA fractions increased with the increase of OC input amounts; and the conversion rate of the input fresh OC to the OC stock of <0.053 mm WSA fraction was 1.2 and 2.6 times higher than those of the 0.25-2 mm and 0.053-0.25 mm WSA fractions, respectively. Therefore, the <0.053 mm WSA fraction was the most important component for soil C sequestration in the irrigated desert soil. | CHAI Yan-jun ZENG Xi-bai E Sheng-zhe HUANG Tao CHE Zong-xian SU Shi-ming BAI Ling-yu | 2014 | Journal of Integrative Agriculture2014，13，12： | 3 |
| 5 | Natural variation of H3K27me3 modification in two Arabidopsis accessions and their hybrid显示文摘Histone modifications affect gene expression, but hthe mechanism and biological consequence of natural variation igin histone modifications remain unclear. Here, we generated Hgenome-wide integrated maps of H3K27me3 modification and transcriptome for Col, C24 and their F1 hybrid. A total of 1,828 genomic regions showing variation in H3K27me3 modification between Col and C24 were identified, most of which were associated with genic regions. Natural variation of H3K27me3 modification between parents could result in allelic bias of H3K27me3 in hybrids. Furthermore, we found that H3K27me3 variation between Col and C24 was negatively correlated with gene expression differences between two accessions, especially with those arising from the cis-effect. Importantly,mutation of CLF, an Arabidopsis methyltransferase for H3K27,altered gene expression patterns between the parents.Together, these data provide insights into natural variation of histone modifications and their association with gene expression differences between Arabidopsis ecotypes. | Mei Yang Xuncheng Wang Hao Huang Diqiu Ren Yan'e Su Pan Zhu Danmeng Zhu Liumin Fan Liangbi Chen Guangming He Xing Wang Deng | 2016 | Journal of Integrative Plant Biology2016，58，5： | 2 |
| 6 | Integrated Therapy for Invasive Pulmonary Aspergillosis in a Patient with Asthma and Chronic Obstructive Pulmonary Disease Overlap Syndrome显示文摘To the Editor:We here present a case of invasive pulmonary aspergillosis (IPA) with asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS).The patient recently took a high dose of systemic corticosteroids.Additionally,pneumothorax occurred,prompting right upper lobectomy,which contained the majority of the Aspergillus lesion.Full recovery occurred utilizing a combination of surgical resection and systemic antifungal therapy.This case supports a surgical approach to clear the infection when antifungal agents are inadequate. | Ya-Qin Shi Pei Li Ting Wu Yuan Ding Yi Shi Mark E Wylam Xin Su | 2015 | Chinese Medical Journal2015，，16： | 2 |
| 7 | Wireless sensor networks: a survey显示文摘 | Akyildiz I F Su* W Sankarasubramaniam Y Cayirci E | 2002 | Computer Networks2002，38，： | 2 |
| 8 | The Role of NF mRNA and Calpain in NF Reduction of Acrylamide Neuropathy显示文摘The purpose of this study was to study the role of neurofilament(NF)mR NA and calpain in NF reduction of acrylamide(ACR)neuropathy.Male Wistar adult rats were injected i.p.every other day with | YU Su Fang WEI Xiao Min YAN Feng Feng WANG Shu E ZHANG Cui Li YANG Xi Wei | 2015 | Biomedical and Environmental Sciences2015，28，6： | 2 |
| 9 | Wireless Sensor Networks: A Survey 显示文摘 | Akyildiz Su W Sankarasubramaniam Y Cayirci E | 2002 | Computer Networks2002，38，： | 1 |
| 10 | Reliability-based optimization model for water distribution systems显示文摘 | Mays L W Lansey K E | 1987 | Journal of Hydraulic Engineering1987，114，12： | 1 |
| 11 | Standardizing catch and effort data of the Taiwanese distant-water longline fishery in the western and central Pacific Ocean for bigeye tuna, Thunnus obesus显示文摘 | Su N J Yeh S Z Sun C L Punt A E Chen Y Wang S P | | Fisheries Research0，90，13： | 1 |
| 12 | Wireless sensor networks:a survey显示文摘 | Kyildiz I Su W Sankara E | 2002 | Computer Networks2002，38，3： | 1 |
| 13 | Asurvey on sensor networks显示文摘 | Akyildiz I F Su W Sankarasubramaniam Y Cayirci E | 2002 | IEEE Communications Magazine2002，40，8： | 1 |
| 14 | Tumor microenvironment direct the recruitment and expansion of human Thl7 cells 显示文摘 | SU X YE J HSUEH E C | 2010 | J Immunol2010，184，3： | 1 |
| 15 | Variability of the Surface Properties of Sepiolite显示文摘 | Suárez M Garci R E | | 0，，： | 1 |
| 16 | Instability following total hip ar- throplasty 显示文摘 | DeWal H Su E DiCesare PE | 2003 | American journal of orthopedics2003，32，8： | 1 |
| 17 | Shuoshuohanyunanfangfangyanzhongde'V+a(啊)+L'jiegouzhongdejieci'a(啊)'说汉语南方方言中“V+啊+L”结构中的介词“啊”[Ontheprepositiona(啊)inthestructureof“V+a(啊)+L”inSouthChinesedialects]显示文摘 | Lin Su′e(林素娥) | 2005 | 中国语文研究2005，2，： | 1 |
| 18 | Fullerene-like soot from EurolV diesel engine: Consequences for catalytic automotive pollution control显示文摘 | Su D S Mtiller J O Jentoft R E | 2004 | Topics in Catolysis2004，3031，14： | 1 |
| 19 | Surfactant and pH mediated control over the molecular structure of poly ( phenylsilsesquioxane) resins显示文摘 | Harreld J H Su K Katsoulis D E | 2002 | Chem Mater2002，14，3： | 1 |
| 20 | Simultaneous removal of SOx and NOx using slaked lime at low temperature显示文摘 | SAKAI M SU C SASAOKA E | 2002 | Industrial & Engineering Chemistry Research2002，41，20： | 1 |
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