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| 1 | Effects of lateral ventricular transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene on cognition in a rat model of Alzheimer's disease显示文摘In the present study, transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene into the lateral ventricle of a rat model of Alzheimer's disease, resulted in significant attenuation of nerve cell damage in the hippocampal CA1 region. Furthermore, brain-derived neurotrophic factor and tyrosine kinase B mRNA and protein levels were significantly increased, and learning and memory were significantly improved. Results indicate that transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene can significantly improve cognitive function in a rat model of Alzheimer's disease, possibly by increasing the levels of brain-derived neurotrophic factor and tyrosine kinase B in the hippocampus. | Ping Zhang Gangyong Zhao Xianjiang Kang Likai Su | 2012 | Neural Regeneration Research2012，7，4： | 8 |
| 2 | Automatic analytical approach for the determination of 12 illicit drugs and nicotine metabolites in wastewater using on-line SPE-UHPLC-MS/MS显示文摘In this study,we developed a novel on-line solid phase extraction(SPE)-ultra-high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)-based analytical method for simultaneously quantifying 12 illicit drugs and metabolites(methamphetamine,amphetamine,morphine,codeine,6-monoacetylmorphine,benzoylecgonine,3,4-methylenedioxymethamphetamine,3,4-methylenedioxyamphetamine,cocaine,ketamine,norketamine,and methcathinone)and cotinine(COT)in wastewater samples.The analysis was performed by loading 2 m L of the sample onto an Oasis hydrophilic-lipophilic balance cartridge and using a cleanup step(5%methanol)to eliminate interference with a total run time of 13 min.The isotope-labeled internal standard method was used to quantify the target substances and correct for unavoidable losses and matrix effects during the on-line SPE process.Typical analytical characteristics used for method validation were sensitivity,linearity,precision,repeatability,recovery,and matrix effects.The limit of detection(LOD)and limit of quantification(LOQ)of each target were set at 0.20 ng/L and 0.50 ng/L,respectively.The linearity was between 0.5 ng/L and250 ng/L,except for that of COT.The intra-and inter-day precisions were<10.45%and 25.64%,respectively,and the relative recovery ranged from 83.74%to 162.26%.The method was used to analyze various wastewater samples from 33 cities in China,and the results were compared with the experimental results of identical samples analyzed using off-line SPE.The difference rate was between 19.91%and-20.44%,and the error range could be considered acceptable.These findings showed that on-line SPE is a suitable alternative to off-line SPE for the analysis of illicit drugs in samples. | Jingyuan Wang Likai Qia Chenzhi Hou Tingting Zhang Mengyi Chen Haitao Meng Mengxiang Su Hui Xu Zhendong Hua Youmei Wang Bin Di | 2021 | Journal of Pharmaceutical Analysis2021，11，6： | 5 |
| 3 | Geometrical odeling of leaf shape based on image processing and feature points detection 显示文摘 | Su Likai Wang Xiaoming | 2009 | Journel of Sorth China Normal University: Natural Science Edition2009，，4： | 1 |
| 4 | Exploration on Charge Transfer and Absorption Spectra of Spiro[fluorene-9,90-xanthene]-based Polyoxometalate Hybrids Toward High Performance Dye-sensitized Solar Cell显示文摘 | WANG Shuo GAO Yu SU Xiaofang YAN Likai | 2018 | Chemical Research in Chinese Universities2018，34，5： | 0 |
| 5 | The comparative investigation on redox property and second-order nonlinear response of Keggin-type α-[PM_(12)O_(39)NPh]^(3-) (M = W and Mo) and Mo_6NPh显示文摘Keggin-type phenylimido-polyoxometalates α-[PM12O39NPh]3- (M = W and Mo) have been systematically investigated on the electronic structures, redox as well as nonlinear optical (NLO) properties by density functional theory (DFT). The strong M≡N bond confirmed by natural bond orbital (NBO) analysis comprises one σ bond and two π bonds, the same as Mo≡N in [Mo6O18NPh]2-. Furthermore, phenylimido segment effectively modifies the electronic properties of α-[PM12O39NPh]3-. On one hand, when enlarging the inorganic cluster from {Mo6O18} to {PMo12O39}, the energy gap between HOMO and LUMO in α-[PMo12O39NPh]3- decreased, resulting in enormously anodic shift for the reduction potential, while the excitation energy is less and the total second-order polarizability β0 is up to 438.3×10?30 esu, which is nearly 10 times larger than that of [Mo6O18NPh]2-. On the other hand, when metal W in α-[PM12O39NPh]3- is substituted by Mo, the interaction between Mo and N is enhanced and the redox ability becomes stronger. The β0 value for α-[PMo12O39NPh]3- is more than 5 times higher than that of α-[PW12O39NPh]3?. It indicates that changing appropriate metal or enlarging the inorganic cluster will improve the redox properties and second-order nonlinear response. Moreover, the electron transition for three compounds mentioned above occurred mainly from organoimido segment (as the electron donor) to polyanion cluster (as the acceptor). As a result, α-[PMo12O39NPh]3- may be a promising candidate for oxidant and nonlinear optical material. | SONG Ping YAN LiKai GUAN Wei FENG JingDong LIU ChunGuang SU ZhongMin | 2009 | Chinese Science Bulletin2009，54，2： | 0 |
| 6 | Electronic properties and stabilities of methoxy-substituted Lindqvist polyoxometalates [Nb_2W_4O_(19)CH_3]^(3-) by DFT显示文摘The electronic properties and stabilities of five [Nb2W4O18OCH3]3-isomers have been investigated using a density functional theory method.The results show that the isomer with the methoxy group occupying a bridging position between two tungsten atoms(two tungsten atoms in the plane that contains two niobium atoms) in the [Nb2W4O18OCH3]3-framework is the most stable isomer in acetonitrile.The stability of the one-electron-reduced isomers changes little.The most stable one-electron-reduced isomer has the methoxy group occupying a bridging position between niobium atoms in the [Nb2W4O18OCH3]4-framework.The M-Ob(M = Nb,W;b denotes bridging) bond lengths in anions in which the metal atoms are connected by a methoxy group are longer than those in [Nb2W4O19]4-.The highest occupied molecular orbitals(HOMO) in [Nb2W4O19]4-mainly delocalize over the bridging oxygen atoms of two niobium atoms and two tungsten atoms located in the equatorial plane,and the bridging oxygen atoms on the axial surface.The lowest unoccupied molecular orbitals(LUMO) of [Nb2W4O19]4-are mainly concentrated on the tungsten atoms and antibonding oxygen atoms.Methoxy substitution modifies the electronic properties of the [Nb2W4O18OCH3]3-isomers.The HOMOs in the five isomers formally delocalize over the bridging oxygen atoms,which are distant from the surface containing the methoxy group and four metal atoms.The LUMOs delocalize over the d-shells of the four metal atoms that are close to the methoxy group,and the p-orbitals of oxygen.One-electron reduction occurred at the tungsten atoms,not the niobium atoms. | CONG Sha YAN LiKai SONG Ping GUAN Wei SU ZhongMin SUN ChiaChung | 2012 | Chinese Science Bulletin2012，57，9： | 0 |
| 7 | Density functional study of magnetic exchange of dinuclear manganese complexes with the heteropoly-molyanion:[Mn^(II)_2(X^(n+)Mo_9O_(33))_2]^(2(n-10)-) (X=P^V, As^V, Se^(VI))显示文摘The magnetic exchange interactions between the dimanganese(II)-substituted complexes and the het-eropolymolyanion, [MnII2(Xn+Mo9O33)2]2(n-10)-(X = PV(I), AsV(II) and SeVI(III)), are investigated by using density functional theory combined with broken-symmetry approach (DFT-BS) method. The calculated magnetic exchange coupling constant (J) of complex II is in reasonable agreement with the responding experimental value and the negative J values indicate that antiferromagnetic exchange interactions exist in these complexes. Furthermore, the influence of the central heteroatom on the exchange cou-pling within the dimanganese core unit is studied from standpoints of geometry, spin density and fron-tier orbitals. It demonstrates that the change of the heteroatom X via PV-AsV-SeVI elongates the dis-tances of Mn1···Mn2 and shortens the distances of Ob···Ob, and reduces the effectiveness of the super-exchange pathways, consequently, decreasing the magnitude of the antiferromagnetic coupling constant, J, of these species. | FANG Liang, GUAN Wei, YAN LiKai, YANG GuoChun, SU ZhongMin & XU Lin Faculty of Chemistry, Institute of Functional Material Chemistry, Northeast Normal University, Changchun 130024, China | 2008 | Science China Chemistry2008，51，12： | 0 |
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