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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | First-Principles Study of Phase Stability and Mechanical Property of Co_3(Al,W) Precipitates with Different Ratio of Al to W in Co Base Alloys显示文摘The energetics, electronic structure and mechanical property of Co3(Al,W) precipitates with different ratio of Al to W in Co base alloys were investigated by the method of supercell and augmented plane waves plus local orbitals within generalized gradient approximation. The calculated results show that the L12 Co3(Al,W) precipitate is the most stable when the ratio of Al to W is equal to 1. When the content of W is higher than 18.5 at%, the L12 and hexagonal structures co-exist in Co3(Al,W) precipitates at 1173 K. It is also shown that the L12 ordered Co3(Al,W) precipitates have an obvious strengthening effect in the disordered fcc cobalt matrix. | Yao Q Su X M Yan Y Zhao L W Sun J | 2009 | 稀有金属材料与工程2009，38，A03： | 3 |
| 3 | Robust H∞ control for a class of cascaded nonlinear system显示文摘 | Xie L Su W | 1997 | IEEE Trans on Automatic Control1997，42，10： | 2 |
| 4 | Reliability-based optimization model for water distribution systems显示文摘 | Mays L W Lansey K E | 1987 | Journal of Hydraulic Engineering1987，114，12： | 1 |
| 5 | Evaluation on the wear,tension and fatigue behavior of various PVD coated materials显示文摘 | SU Y L WU C T KAO W H | 1998 | Materials Letters1998，35，34： | 1 |
| 6 | Compact efficient Q-switched eye-safe laser at 1525 nm with a double-end diffusion-bonded Nd: YVO4 crystal as a self-Raman medium 显示文摘 | Chang Y T Su K W Chang H L | 2009 | Opics Express2009，17，： | 1 |
| 7 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 8 | 显示文摘 | Cai W L Mo C M | 1999 | Appl Phys Lett1999，74，20： | 1 |
| 9 | Nonviral vector-based gene transfection of primary human skeletal myoblasts显示文摘 | Ye L Haider H Kh Esa W B Law P K Zhang W Su L | 2007 | Exp Biol Med ( Maywood)2007，232，： | 1 |
| 10 | Band notched ultra-wide- band planar-monopole antenna显示文摘 | Su S W Wong K L Tang C L | 2005 | Microwave and Opti- cal Technology Letters2005，44，3： | 1 |
| 11 | Doxycycline inhibits inflammation-induced lymphangiogenesis in mouse cornea by multiple mechanisms显示文摘 | Han L Su W Huang J | 2014 | PLoS One2014，309，10： | 1 |
| 12 | Laparoseopic radical prosta- tectomy: current techniques 显示文摘 | Levinson A W Su L M | 2007 | Curr Opin Urol2007，17，2： | 1 |
| 13 | Research on blind deconvolution algorithm of multiframe turbulence-degraded images显示文摘 | ZHANG L J YANG J H SU W | 2013 | Journal of information and computational science2013，10，12： | 1 |
| 14 | Intrusion detection by backpropagation neural networks with sample-query and attributequery显示文摘 | Chang R I Lai L B Su W D | 2007 | International Journal of Computational Intelligence Research2007，3，1： | 1 |
| 15 | Sensitive nested reverse transcription polymerase chain reaction detection of prostatic hematogenous tumor cells: comparison of prostate specific antigen and prostate-specific antigenbased assays 显示文摘 | Israeli R S Miller W H Jr Su L | 1994 | Cancer Res1994，54，24： | 1 |
| 16 | Accurate determination of mode Ⅰ and Ⅱ leading coefficients of the Williams expansion by finite element analysis显示文摘 | SU R K L FENG W J | 2005 | Finite Elements in Analysis and Design2005，41，： | 1 |
| 17 | Degree 12 model of shear velocity heterogeneity in the mantle 显示文摘 | Su W Woodward R L Dziewanskie A M | 1994 | J Geophys Res1994，99，： | 1 |
| 18 | Preparation and photoluminescence of alumina membranes with ordered pore arrays 显示文摘 | Su Y Cai W L Mo C M | 1999 | Appl Phys Lett1999，74，20： | 1 |
| 19 | Evaluation study for the integration of electromagnetic transients simulator and transient stability simulator 显示文摘 | Su H T Chan K W Snider L A | 2005 | Electric Power Systems Research2005，75，1： | 1 |
| 20 | Discrete likelihood ratio test ligent signal recognition in software defined radio显示文摘 | Xu J L Zhou M C Su W | 2010 | and Optical Communications Conference2010，，： | 1 |
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