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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | The role and significance of Magnesium in modern day research-A review显示文摘Magnesium is one of the largely available elements in the earth’s crust. It has a low structural density with high specific strength. This unique material property has forced an increase in the use of magnesium and its alloys in various applications pertaining to industrial sector,automobiles, aerospace and biomedical. Since magnesium is a highly reactive metal, it is prone to higher rate of corrosion as compared to its counterparts. Thus, it is essential to analyze the corrosion behavior of magnesium and its alloys in its applications. An appropriate process is to be followed in the design and development of magnesium alloys which overcome the limitations of magnesium and enhance the desired material properties in accordance to their applications. This review paper summarizes the importance of magnesium and its material properties. The influence of various alloying elements on the mechanical properties of magnesium is reviewed. The broad classification of Mg alloys and their behavioral trends are detailed. The corrosion behavior of magnesium and the influence of corrosion products on the material characteristics of magnesium, in aqueous medium, are discussed. The manufacturing techniques of magnesium alloys along with the secondary techniques are also covered. The various applications and the limitations of magnesium in these applications are covered. A complete section is dedicated towards detailing the recent trends of magnesium(Mg) alloys, i.e., the biodegradable nature and applications of Mg alloys. The influence of biocorrosion on Mg alloys and techniques to overcome it have been deliberated. This paper provides a thorough review on recent developments of magnesium with respect to engineering applications. | S V Satya Prasad S B Prasad Kartikey Verma Raghvendra Kumar Mishra Vikas Kumar Subhash Singh | 2022 | Journal of Magnesium and Alloys2022，10，1： | 11 |
| 3 | Ameliorative effects of standardized extract from Trigonella foenum-graecum L.seeds on painful peripheral neuropathy in rats显示文摘Objective:To evaluate the effects of the standardized extract of fenugreek(Trigonella foenumgraecum L.Family:Leguminasae) seed(IND01) in animal models of peripheral neuropathy. Methods:IND01 was prepared from fenugreek seeds and standardized by high performance liquid chromatography to a marker compound,trigonelline.The effects of daily oral administration of IND01(50,100 and 200 mg/kg) were studied in rats after partial sciatic nerve ligation(PSNL) and sciatic nerve crush injury(SNCI) during 30-days period.The measurements on thermal hyperalgesia(TH),motor function test(MFT) score and motor nerve conduction velocity (MNCV) were recorded.Results:IND01 offered sustained protection against TH and deranged MFT scores in both models from 7-day onwards.Fifteen days of daily oral administration of IND01 restored MNCV reduction in rats with SNCI but not with PSNL.Conclusions:IND01 was found to be effective in rat models of painful peripheral neuropathy. | Aashish S Morani Subhash L Bodhankar V Mohan Prasad A Thakurdesai | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，5： | 2 |
| 4 | Effect of mulch and irrigation on tuber size, canopy temperature, water use and yield of potato: Solanum tuberosum显示文摘 | Chandra Subhash Singh R D Bhatnagar V K | 2002 | Indian Journal of Agronomy2002，47，3： | 1 |
| 5 | Heat transfer in a visco-elastic fluid past a stretching sheet with viscous dissipation and internal heat generation 显示文摘 | Veena P H Subhash Abel M Rajagopal K Pravin V K | 2006 | Zeitschrifl fi~r Angewandte Mathematik und Physik (ZAMP)2006，57，3： | 1 |
| 6 | phytochemistry of the genus piper显示文摘 | Parmar V S Subhash C Jain | 1997 | Phytochemistry1997，46，4： | 1 |
| 7 | Label placement by maximum independent set in rectangles显示文摘 | PANKAJ K A MARC V K SUBHASH S | 1998 | Computational Geometry: Theory and Applications1998，11，34： | 1 |
| 8 | A lower bound for multicast key distribution显示文摘 | Snoeyink J Subhash S George V | 2005 | Computer Networks2005，47，3： | 1 |
| 9 | Temperature in- duced stress influence on biodiesel productivity during mixotrophic microalgae cuhivation with wastewater 显示文摘 | Venkata Subhash G Rohit M V Devi M P | 2014 | Bioresource Technolo- gy2014，169，： | 1 |
| 10 | Evaluation of rice germplasm for resistance to rice leaffolder,Cnaphalocrocis medinalis显示文摘 | Chalapathi Rao N B V Singh V S Subhash C | | 0，，02： | 1 |
| 11 | Horizontal buoyantjets in quiescent shallow water显示文摘 | Balasubramanian V Subhash J C | 1978 | Journal of the Envi-ronmental Engineering Division ASCE1978，104，4： | 1 |
| 12 | Stomach-specific drug delivery of 5-Fulouracil using ethylcellulose floating microspheres显示文摘 | Subhash V Vasanti S Kiran C | 2010 | Pharma- ceutical Development and Technology2010，15，2： | 1 |
| 13 | Optimal Allocation of Work in Assembly Lines for Lots with Homogenous Learning显示文摘 | Yuval C Gad V Subhash C | 2006 | European Journal of Operational Research2006，168，： | 1 |
| 14 | Molecular biology and pathogenesis of Kaposi sarcoma2associated hcrpesvirus 显示文摘 | Subhash C V Erie S R | 2003 | FEMS Microbiology Let2003，222，2： | 1 |
| 15 | Synthesis of substituted 2-hydroxyaryl aldehydes by the microwave-induced Reimer-Tiemann reaction 显示文摘 | Yeshwant B V Subhash M L Mudassar A S | 2007 | Mendeleev Commun2007，17，1： | 1 |
| 16 | Horizontal buoyant jets in quiescent shallow water显示文摘 | Balasubramanian V Subhash J C | 1978 | Journal of the Environmental Engineering Division ASCE1978，104，4： | 1 |
| 17 | In vitro antioxidant activities of Stevia rebaudiana leaves and callus显示文摘 | TADHANI M B PATEL V H SUBHASH R | 2007 | Journal of Food Composition and Analysis2007，20，34： | 1 |
| 18 | Design and performance evaluation of a microwave based low carbon yielding extraction technique for naturally occurring bioactive triterpenoid: Oleanolic acid显示文摘 | Mandal V Subhash C | 2010 | Biochemical Engineering Journal2010，50，12： | 1 |
| 19 | Synthesis of substituted 2-hydroxyaryl aldehydes by the microwave-induced Reimer-Tiemann reaction 显示文摘 | Yeshwant B V Subhash M L Mudassar A S | 2007 | MendeleevCommunications2007，17，： | 1 |
| 20 | Case of victims of modern imaging technology:Increased information noise concealing the diagnosis显示文摘We present a case of tubercular arthritis who underwent numerous unnecessary investigations what is known as 'victims of modern imaging technology' or VOMIT. Today there is an exponential rise in the volume of the medical imaging, part of which is contributed by unnecessary and unjustified indications. We discuss about the untoward effects of the uninhibited and careless use of modern imaging modalities and possible ways to avoid. Skeletal manifestation of the tuberculosis is still common in the endemic countries like India. Although the final diagnosis of the skeletal tuberculosis like tubercular arthritis is made by bacteriological and histological studies, few demographic, clinical and radiological features might help making early diagnosis. | Abhishek Mahajan G V Santhoshkumar Ameya Shirish Kawthalkar Richa Vaish Nilesh Sable Supreeta Arya Subhash Desai | 2017 | World Journal of Radiology2017，9，12： | 0 |
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