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2篇 您的检索式：作者名="Suchithra Menon"

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		题名	作者	年代	出处	被引量
	1	CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1显示文摘CSN1 is a component of the COP9 signalosome(CSN),a conserved protein complex with pleiotropic functions in many organs and cell types.CSN regulates ubiquitinproteasome dependent protein degradation via the deneddylation and the associated deubiquitination activities.In addition,CSN associates with protein kinases and modulates cell signaling,particularly the activator protein 1(AP-1)pathway.We have shown previously that CSN1 suppresses AP-1 transcription activity and inhibits ultraviolet(UV)and serum activation of c-fos expression.Here we show that CSN1 can inhibit phosphorylation of proto-oncogene c-Jun product and repress c-Jun dependent transcription.Further,CSN1 dramatically downregulates ectopic expression of c-Jun N-terminal kinase 1(JNK1)in cultured cells.The decline in JNK1 is not caused by excessive proteolysis or by 3′UTR-dependent mRNA instability,but by CSN1-dependent repression of one or multiple steps in transcriptional and posttranscriptional mechanisms.Thus,in contrast to CSN5/Jab1,which promotes AP-1 activity,CSN1 displays a negative effect on the AP-1 pathway.Finally,we discuss about the dynamic equilibrium of the CSN complexes in regulation of the AP-1 pathway.	Tomohiko Tsuge Suchithra Menon Yingchun Tong Ning Wei	2011	Protein & Cell2011，2，5：	2
	2	The COP9 Signalosome Inhibits p27 kip1 Degradation and Impedes G1-S Phase Progression via Deneddylation of SCF Cul1显示文摘	Xiaoming Yang Suchithra Menon Karin Lykke-Andersen Tomohiko Tsuge Di Xiao Xiping Wang Roberto J. Rodriguez-Suarez Hui Zhang Ning Wei	2002	Current Biology2002，，8：	1

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