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| 1 | Clinical usefulness of transpapillary removal of common bile duct stones by frequency doubled double pulse Nd:YAG laser显示文摘AIM: To study the efficacy and the safety of laser lithotripsy without direct visual control by using a balloon catheter in patients with bile duct stones that could not be extracted by standard technique. METHODS: The seventeen patients (7 male and 10 female; mean age 67.8 years) with difficult common bile duct (CBD) stones were not amenable for conventional endoscopic maneuvers such as sphincterotomy and mechanical lithotripsy were included in this study. Laser wavelengths of 532 nm and 1064 nm as a double pulse were applied with pulse energy of 120 mJ. The laser fiber was advanced under fluoroscopic control through the ERCP balloon catheter. Laser lithotripsy was continued until the fragment size seemed to be less than 10 mm. Endoscopic extraction of the stones and fragments was performed with the use of the Dormia basket and balloon catheter. RESULTS: Bile duct clearance was achieved in 15 of 17 patients (88%). The mean number of treatment sessions was 1.7 ± 0.6. Endoscopic stone removal could not be achieved in 2 patients (7%). Adverse effects were noted in three patients (hemobilia, pancreatitis, and cholangitis). CONCLUSION: The Frequency Doubled Double Pulse Nd:YAG (FREDDY) laser may be an effective and safe technique in treatment of difficult bile duct stones. | Tae Hyeon Kim Hyo Jeong Oh Chang-Soo Choi Dong Han Yeom Suck Chei Choi | 2008 | World Journal of Gastroenterology2008，14，18： | 20 |
| 2 | Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study显示文摘AIM: Itopride is a newly developed prokinetic agent, which enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions. The importance of esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease (GERD) makes it interesting to examine the effect of itopride on esophageal acid exposure.METHODS: The effect of itopride on esophageal acid reflux variables for 24 h was studied in 26 patients with GERD symptoms, pre-entry total acid exposure time (pH<4) of more than 5% and mild esophagitis (SavaryMiller grades Ⅰ, Ⅱ) proven by endoscopy. Ambulatory 24-h pH-metry and symptom assessment were performed after treatments with 150 or 300 mg itopride thrice a day (t.i.d.) for 30 d in random order, using an open label method.For evaluating the safety of itopride, blood biochemical laboratory test was performed and the serum prolactin level was also examined before and after treatment.RESULTS: Total symptom score was significantly decreased after treatment in 150- or 300-mg group. Itopride 300mg was significantly effective than 150 mg on decreasing the total per cent time with pH<4, total time with pH<4and DeMeester score. No serious adverse effects were observed with administration of itopride in both groups.CONCLUSION: Itopride 100 mg t.i.d, is effective on decreasing pathologic reflux in patient with GERD and therefore it has the potential to be effective in the treatment of this disease. | Yong Sung Kim Tae Hyeon Kim Chang Soo Choi Young Woo Shon Sang Wook Kim Geom Seog Seo Yong Ho Nah Myung Gyu Choi Suck Chei Choi | 2005 | World Journal of Gastroenterology2005，11，27： | 15 |
| 3 | Cerebral and pulmonary embolisms after transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘A cerebral lipiodol embolism is an extremely rare complication of transcatheter arterial chemoem bolization for hepatocellular carcinoma. We present a case of cerebral lipiodol embolism that occurred afte the third arterial chemoembolization, report the clinica and radiological findings, and review the medica literature. | Chang Soo Choi Ki Hoon Kim Geom Seog Seo Eun Young Cho Hyo Jeong Oh Suck Chei Choi Tae Hyeon Kim Haak Cheoul Kim Byung Suk Roh | 2008 | World Journal of Gastroenterology2008，14，30： | 10 |
| 4 | Cat/dposid$,a evtnpound isolated from cata/pa ovata, attenuates indue- tionb of intestinal epithelial proinflammatory gene expression and reduces the severity of trinitrobenzene sulfonie Aeid -induced colitis in mice 显示文摘 | KIM SANG - WOOK CHOI SUCK - CHEI CHOI EUN - YOUNG | 2004 | Inflammatory Bowel Diseases2004，10，5： | 1 |
| 5 | Quality of life of patients with irritable bowel syndrome in Korea显示文摘 | Jae Myung Park Myung-Gyu Choi Yong Sung Kim Chang Hwan Choi Suck Chei Choi Su Jin Hong Jeong Jo Jeong Dong Ho Lee Joon Seong Lee Kwang Jae Lee Hee Jung Son In Kyung Sung | 2009 | Quality of Life Research2009，，4： | 1 |
| 6 | Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study显示文摘 | In Seok Lee Suck Chei Choi Ki Nam Shim Sam Ryong Jee Kyu Chan Huh Jun Haeng Lee Kwang Jae Lee Hyung Seok Park Yong Chan Lee Hoon Yong Jung Hyo Jin Park | 2010 | Digestive Diseases and Sciences2010，，7： | 1 |
| 7 | Effects of ranitidine for exercise induced gastric mucosal changes and bleeding显示文摘瞄准:在胃的粘膜变化上并且在在长距离跑步者的官方补给的流血上评估 ranitidine 的效果。方法:24 个长距离跑步者(M:16, F:8,变老:18.2 +/- 1.5 年) 参予了这研究。一张症状问询表,凳子缝玄术测试,并且上面胃肠(官方补给) 内视镜检查法在学习以前在这些题目上被执行。这些题目拿了口头的 ranitidine (150 mg, b.i.d ) 为二个星期。上面的官方补给的内视镜检查法和凳子 Hemoccult 测试在治疗以后被重复。结果:24 个跑步者中的 22 个在药前有至少一上面的官方补给的粘膜损害。内视镜的改进在腐蚀胃炎的 14 个盒子中的十一个和食道炎的 5 个盒子中的四个中被看见。六个题目是在学习以前积极的血红素玄术,但是仅仅在药以后是积极的。结论:胃的粘膜损害并且在长距离跑步者的官方补给的流血似乎被联系到酸相关的因素由常规跑的高水平调停了。Ranitidine 似乎是并且阻止胃的粘膜损害并且官方补给的流血的有效预防。 | Suck Jun Choi Yong Sung Kim Jeong Ryong Chae Hong Kwan Cho Tae Hyeon Kim Young Woo Sohn Yong Leol Oh Geom Seog Seo Yong-Ho Nah Suck Chei Choi | 2006 | World Journal of Gastroenterology2006，12，16： | 1 |
| 8 | Prevalence of Barrett’s Esophagus Remains Low in the Korean Population: Nationwide Cross-Sectional Prospective Multicenter Study显示文摘 | In Seok Lee Suck Chei Choi Ki Nam Shim Sam Ryong Jee Kyu Chan Huh Jun Haeng Lee Kwang Jae Lee Hyung Seok Park Yong Chan Lee Hoon Yong Jung Hyo Jin Park | 2010 | Digestive Diseases and Sciences2010，，7： | 1 |
| 9 | Sweet food improves chronic stress-induced irritable bowel syndrome-like symptoms in rats显示文摘AIM:To investigate whether palatable sweet foods have a beneficial effect on chronic stress-induced colonic motility and inflammatory cytokines.METHODS:Adult male rats were divided into 3groups:control(CON,n=5),chronic variable stress with chow(CVS-A,n=6),and chronic variable stress with chow and sweet food(CVS-B,n=6).The rats were fed standard rodent chow as the chow food and/or AIN-76A as the sweet food.A food preference test for AIN-76A was performed in another group of normal rats(n=10)for twelve days.Fecal pellet output(FPO)was measured for 6 wk during water bedding stress in the CVS groups.The weight of the adrenal glands,adrenocorticotropic hormone(ACTH)and corticosterone levels in plasma were measured.The expression levels of transforming growth factor-β,interleukin(IL)-2,and interferon-gamma(IFN-γ)were measured in the distal part of colonic tissues and plasma using Western blot analysis.RESULTS:In sweet preference test,all rats initially preferred sweet food to chow food.However,the consumption rate of sweet food gradually decreased and reduced to below 50%of total intake eight days after sweet food feeding.Accumulated FPO was higher in the CVS-A group compared with the CVS-B group over time.All stress groups showed significant increases in the adrenal to body weight ratio(CVS-A,0.14±0.01;CVS-B,0.14±0.01)compared with the control group(0.12±0.01,P<0.05).The plasma corticosterone and ACTH levels were significantly higher in the CVS-A(537.42±32.95,44.44±6.54 pg/mL)and CVS-B(655.07±30.82,65.46±4.44 pg/mL)groups than in the control group(46.96±13.29,8.51±1.35 pg/mL,P<0.05).Notably,the ratio of corticosterone to ACTH was significantly increased in the CVS-A group only.Rats exposed to CVS displayed significantly increased expression of IL-2 and IFN-γin the plasma and distal colon compared to the control group,whereas this effect was significantly attenuated in the CVS-B group.CONCLUSION:These results suggest that concurrent sweet food ingestion during CVS might have an effect on the reduction of stress-induced colonic hyper-motility and pro-inflammatory cytokine production in rats. | Sang-Gyun Rho Yong Sung Kim Suck Chei Choi Moon Young Lee | 2014 | World Journal of Gastroenterology2014，20，9： | 0 |
| 10 | Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis显示文摘BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal cells.Fexuprazan’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent manner.AIM To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight weeks.The primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week 8.The secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life assessment.Safety profiles and serum gastrin levels were compared between the groups.RESULTS Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life assessments.Additionally,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the groups.CONCLUSION Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week 8.We suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE. | Kang Nyeong Lee Oh Young Lee Hoon Jai Chun Jin Il Kim Sung Kook Kim Sang Woo Lee Kyung Sik Park Kook Lae Lee Suck Chei Choi Jae-Young Jang Gwang Ha Kim In-kyung Sung Moo In Park Joong Goo Kwon Nayoung Kim Jae Jun Kim Soo Teik Lee Hyun Soo Kim Ki Bae Kim Yong Chan Lee Myung-Gyu Choi Joon Seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-Hyun Kim Hyunsoo Chung | 2022 | World Journal of Gastroenterology2022，28，44： | 0 |
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