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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 3 | Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastases显示文摘 | Marko NF Angelov L Toms SA Suh JH Chao ST Vogelbaum MA Barnett GH Weil RJ | 2010 | 中国神经肿瘤杂志2010，8，3： | 4 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Protective effect of green tea polyphenlo ( - ) epigallocatechin - 3 - gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates显示文摘 | L EE S R M KJ SUH S I | 2003 | J Phytother Res2003，17，3： | 1 |
| 6 | Inhibitory actions of MCI-154 on guinea-pig femoral artery and vein preparations显示文摘 | Suh SH Chen G Xue L Zhang G Yamamoto Y Suzuki H | 1992 | Eur J Pharmacol1992，219，3： | 1 |
| 7 | Dynamic partitioning of shared cache memory显示文摘 | Suh G Devadas S Rudolph L | 2004 | The Journal of Supercomputing2004，28，1： | 1 |
| 8 | Compression Behavior of Stiff- ened Panel with a Clearly Visible Stiffener Impact Damage 显示文摘 | Suh S Han N L Yang J M | 2003 | Composite Structures2003，62，： | 1 |
| 9 | Insufficient cure under the condition of highirradiance and short irradiation time 显示文摘 | Feng L Carvalho R Suh B I | 2009 | Dent Mater2009，25，3： | 1 |
| 10 | Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps显示文摘 | Kato A Peters A Suh L | | 0，，06： | 1 |
| 11 | A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promy- elocytic leukemia ceils 显示文摘 | Luyengi L Suh N Fong HH | 1996 | Phytochemistry1996，43，2： | 1 |
| 12 | Changes in number of synapses and mitochondria in presynaptic terminals in the dentate gyrus following cere- bral ischemia and rehabilitation training 显示文摘 | Briones TL Suh E Jozsa L | 2005 | Brain Res2005，1003，1： | 1 |
| 13 | Changes in number of synapses and mitochondria in presynaptic terminals in the dentate gyrus following cerebral ischemia and rehabilitation training显示文摘 | Briones TL Suh E Jozsa L | | 0，，01： | 1 |
| 14 | Subjective Well Being: Three Decades of Progress 显示文摘 | Diener E Suh E M Lucas R E Smith H L | 1999 | Psychological Bulletin1999，125，2： | 1 |
| 15 | Preferences and trip expendi-tures-a conjoint analysis of visitors to Seoul,Korea显示文摘 | Suh Y K McAvoy L | 2005 | Tourism Management2005，26，： | 1 |
| 16 | Bonding of primed zirconia ceramics:evidence of chemical bonding and improved bond strengths显示文摘 | Chen L Suh BI Brown D | 2012 | Am J Dent2012，25，2： | 1 |
| 17 | Time-accurate computational fluid dynamics approach to transonic store separation trajectory prediction显示文摘 | Lijewski L E Suhs N E | 1994 | Journal of Aircraft1994，31，4： | 1 |
| 18 | Dynamic multi-objectiveoptimization based on membrane computing for controlof time-varying unstable plants显示文摘 | Huang L Suh I H Abraham A | 2011 | Information Sciences2011，181，11： | 1 |
| 19 | Behavioraily-induced ul-tra-structural plasticity in the hippocampal region after cerebralischemia 显示文摘 | Briones TL Suh E Jozsa L | 2004 | Brain Res2004，997，： | 1 |
| 20 | Useful immunohistochemical markers for dis- tinguishing Paget cells from Toker cells 显示文摘 | Park S Suh Y L | 2009 | Pathology2009，41，7： | 1 |
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