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您的检索式：作者名="Sujiang Shi"
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| 1 | Universal selenium nanoadjuvant with immunopotentiating and redox-shaping activities inducing high-quality immunity for SARS-CoV-2 vaccine显示文摘Dear Editor,The COVID-19 pandemic still greatly threatens the public health worldwide and novel vaccines to highly effectively combat SARS-CoV-2 remains an unmet clinical need.However,redox imbalance in immune cells under extra stimulation by vaccine or pathogens greatly dampens the quality of the induced immunity.1 In addition,people infected with COVID-19 that characterized by immune system malfunction were also approved to be attributed by the robust oxidative stress. | Haoqiang Lai Ligeng Xu Chang Liu Sujiang Shi Yalin Jiang Yangyang Yu Bo Deng Tianfeng Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 2 | Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer显示文摘The therapeutic efficacy of radioimmunotherapy against triple negative breast cancer(TNBC)is largely limited by the complicated tumor microenvironment(TME)and its immunosuppressive state.Thus developing a strategy to reshape TME is expected to achieve highly efficient radioimmunotherapy.Therefore,we designed and synthesized a tellurium(Te)-driven maple leaf manganese carbonate nanotherapeutics(MnCO3@Te)by gas diffusion method,but also provided a chemical catalytic strategy in situ to augment ROS level and activate immune cells for improving cancer radioimmunotherapy.As expected,with the help of H2O2 in TEM,MnCO3@Te heterostructure with reversible Mn3+/Mn2+transition could catalyze the intracellular ROS overproduction to amplify radiotherapy.In addition,by virtue of the ability to scavenge H+in TME by carbonate group,MnCO3@Te directly promote the maturation of dendritic cells and macrophage M1 repolarization by stimulator of interferon genes(STING)pathway activation,resulting in remodeling immuno-microenvironment.As a result,MnCO3@Te synergized with radiotherapy and immune checkpoint blockade therapy effectively inhibited the breast cancer growth and lung metastasis in vivo.Collectively,these findings indicate that MnCO3@Te as an agonist,successfully overcome radioresistance and awaken immune systems,showing promising potential for solid tumor radioimmunotherapy. | Wei Huang Sujiang Shi Haoran Lv Zhenyu Ju Qinghua Liu Tianfeng Chen | 2023 | Bioactive Materials2023，，9： | 0 |
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