| 1 | 千根草甲醇提取物的抗高血糖及镇痛作用(英文)显示文摘目的:本研究旨在证实孟加拉国传统药用植物千根草甲醇提取物的抗高血糖及镇痛作用。方法:实验分为独立的两个部分。在研究千根草甲醇提取物抗高血糖作用的实验中,36只小鼠被分为6组,每组6只,分别给予口服不同剂量的千根草甲醇提取物、降血糖药格列本脲及10 mL/kg 1%Tween 80溶剂,1 h后,予各组小鼠口服2 g/kg葡萄糖,2 h后测取所有小鼠的血糖水平并进行比对。为观察千根草甲醇提取物的镇痛作用,另外42只小鼠被分为7组,每组6只,分别给予各组小鼠口服10 mL/kg 1%Tween 80溶剂、不同剂量千根草甲醇提取物,或200和400 mg/kg镇痛药阿司匹林1 h后,向所有小鼠腹腔内注射10 mL/kg 1%醋酸诱发扭体反应。诱发扭体反应5 min后,每只小鼠观察10 min,记录扭体次数。结果:分别口服50、100、200和400 mg/kg千根草甲醇提取物的4组小鼠与对照组相比血糖水平显著降低(P<0.05)。当小鼠口服400 mg/kg千根草甲醇提取物时,血糖水平下降最多。口服10 mg/kg格列本脲的小鼠血糖水平下降48.6%。与对照组相比,甲醇提取物同样被证实具有显著的镇痛作用(P<0.05)。当服用剂量在400 mg/kg时,小鼠扭体次数抑制率达40.9%,而口服200 mg/kg镇痛药阿司匹林时,小鼠扭体次数抑制率为49.0%。结论:孟加拉国民间草药千根草在治疗糖尿病与疼痛方面有显著作用,其甲醇提取物抗高血糖及镇痛的作用值得进一步研究,以便开发出以此植物为基础的新型化合物与有效药。 | Mohammed Rahmatullah Sumaiyah Kanij Hasan Zulfiquar Ali Shahnaz Rahman Rownak Jahan | 2012 | 中西医结合学报2012，10，2： | 9 |
| 4 | Self-management of osteoarthritis while waiting for total knee arthroplasty during the COVID-19 pandemic among older Malaysians显示文摘BACKGROUND The study sought to understand the self-management strategies used by patients during the postponement of their total knee arthroplasty(TKA)procedure,as well as the associations between the length of waiting time,pain,and physical frailty and function.The study focused on individuals aged 50 years and above,as they are known to be more vulnerable to the negative impacts of delayed elective surgery and rehabilitation.This study hypothesizes that delayed TKR due to coronavirus disease 2019(COVID-19)will bear negative effect in self-management,pain,and physical frailty and function in older adults.AIM To investigate the effects of COVID-19 pandemic on self-management,pain,and physical function in older adults awaiting TKA in Malaysia.METHODS This cross-sectional study has the data of participants,who matched the criteria and scheduled for TKA for the first time,extracted from the TKA registry in the Department of Orthopaedics and Traumatology,Hospital Canselor Tuanku Mukhriz.Data on pain status,and self-management,physical frailty,and instrumental activities daily living were also collected.Multiple linear regression analysis with a significant level of 0.05 was used to identify the association between waiting time and pain on physical frailty and functional performance.RESULTS Out of 180 had deferred TKA,50%of them aged 50 years old and above,80%were women with ethnic distribution Malay(66%),Chinese(22%),Indian(10%),and others(2%)respectively.Ninety-two percent of the participants took medication to manage their pain during the waiting time,while 10%used herbs and traditional supplements,and 68%did exercises as part of their osteoarthritis(OA)self-management.Thirty-six participants were found to have physical frailty(strength,assistance with walking,rising from a chair,climbing stairs,and falls questionnaire score>4)which accounted for 72%.Increased pain was associated with physical frailty with odds ratio,odds ratio(95%confidence interval):1.46(1.04-2.05).This association remained significant even after the adjustment according to age and self-management.CONCLUSION While deferring TKA during a pandemic is unavoidable,patient monitoring for OA treatment during the waiting period is important in reducing physical frailty,ensuring the older patients’independence. | Ahmad Nabil Khairi Mahdzir Sumaiyah Mat Shi Rui Seow Rizal Abdul Rani Muhammad Kamil Che Hasan Nor Hamdan Mohamad Yahaya | 2023 | World Journal of Clinical Cases2023，11，29： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员