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| 1 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 2 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies显示文摘Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health worldwide.The viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral entry.Both SARS-CoV-2 and SARS-CoV share this mechanism.Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies.The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two viruses.This finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or SARS-CoV-2.It is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize SARS-CoV.Moreover,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing antibodies.Overall,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable. | Chunyan Yi Xiaoyu Sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu Yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，6： | 13 |
| 3 | Involvement of C2H2 zinc finger proteins in the regulation of epidermal cell fate determination in Arabidopsis显示文摘Cell fate determination is a basic developmental process during the growth of multicellular organisms.Trichomes and root hairs of Arabidopsis are both readily accessible structures originating from the epidermal cells of the aerial tissues and roots respectively, and they serve as excellent models for understanding the molecular mechanisms controlling cell fate determination and cell morphogenesis. The regulation of trichome and root hair formationis a complex program that consists of the integration of hormonal signals with a large number of transcriptional factors, including MYB and b HLH transcriptional factors.Studies during recent years have uncovered an important role of C2H2 type zinc finger proteins in the regulation of epidermal cell fate determination. Here in this minireview we briefly summarize the involvement of C2H2 zinc finger proteins in the control of trichome and root hair formation in Arabidopsis. | An Yan Minjie Wu Yongqin Zhao Aidong Zhang Bohan Liu John Schiefelbein Yinbo Gan | 2014 | Journal of Integrative Plant Biology2014，56，12： | 7 |
| 4 | Hierarchical MoS2 intercalated clay hybrid nanosheets with enhanced catalytic activity显示文摘新兴的层次瞬间 2/pillared-montmorillonite (瞬间 2/PMMT) 混血儿 nanosheets 成功地在 cetyltrimethylammonium 溴化物 PMMT 的夹层以内通过瞬间 2 的灵巧的在原处热水的合成被准备,并且他们的催化表演被 4-nitrophenol (4-NP ) 的减小反应作为 reductant 用 NaBH 4 评估。微观结构和形态学描述显示瞬间 2/PMMT 与 1.29 nm,和瞬间 2 nanosheets 的夹层间距展出了叠混血儿的分层的结构在 montmorillonite (MMT ) 以内被设置层,与大多数暴露于外面的边。瞬间 2/PMMT 的催化活动和稳定性被 MMT 两个都提高。与是的瞬间 2/PMMT 催化剂, 4-NP 减小的明显的反应率常数是 0.723 min 1 并且在 ~ 被维持在五反应以后的 0.679 min 1 骑车。为 4-NP 的减小反应的瞬间 2/PMMT 和可能的催化作用机制的结构的进化被调查。同样准备的瞬间 2/PMMT 混血儿 nanosheets 在水处理和生物医学的域为催化申请正在答应候选人。在这研究开发的策略能为设计混合 nanosheets 与提供卓见多样异构二维(2D ) nanomaterials。 | Kang Peng Liangjie Fu Huaming Yang Jing Ouyang Aidong Tang | 2017 | Nano Research2017，10，2： | 6 |
| 5 | Application of quantum neural networks in localization of acoustic emission显示文摘Due to defects of time-difference of arrival localization,which influences by speed differences of various model waveforms and waveform distortion in transmitting process,a neural network technique is introduced to calculate localization of the acoustic emission source.However,in back propagation(BP) neural network,the BP algorithm is a stochastic gradient algorithm virtually,the network may get into local minimum and the result of network training is dissatisfactory.It is a kind of genetic algorithms with the form of quantum chromosomes,the random observation which simulates the quantum collapse can bring diverse individuals,and the evolutionary operators characterized by a quantum mechanism are introduced to speed up convergence and avoid prematurity.Simulation results show that the modeling of neural network based on quantum genetic algorithm has fast convergent and higher localization accuracy,so it has a good application prospect and is worth researching further more. | Aidong Deng Li Zhao Wei Xin | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 5 |
| 6 | Construction and Expression of a Single Chain Antibody Mimicing Human Ovarian Cancer Antigen CA125显示文摘为癌症的有免疫力的治疗的一个概念包含抗原的正式就职模仿抗体对肿瘤房间触发有免疫力的反应。对为肿瘤抗原特定的抗体的抗原绑定地点指导的 Anti-idiotypic 抗体可以机能上地并且甚至在结构上模仿抗原并且导致 anti-anti-idiotypic 免疫者反应。Monoclonal 抗体 WJ02 是如此的 anti-idiotypic 抗体之一,它包含 CA125 的内部图象。以便改进 mAb WJ02 的 immunospecificity,我们在 Vl-linker-Vh 取向构造了 mAb WJ02 的单个链。scFv-WJ02 能在 recombinant Pichia pastoris 系统被表示并且藏匿。有 30 kD 的分子的重量的分泌 scFv 蛋白质保留了 mAb WJ02 的生物活动,它被直接有约束力的试金和抑制实验证明。我们的结果显示 scFv-WJ02 能对卵巢的癌症为 idiotypic 治疗被用作一个可能的工具,它可能提高消除 mAb WJ02 导致的 nonspecific 回答的可能性。 | Aidong Li Zheng Li Yinghong Wang Yongming Zhang Jie Ma | 2006 | Cellular & Molecular Immunology2006，3，1： | 5 |
| 7 | Corridor use by Asian elephants显示文摘There are 18 km of Kunming–Bangkok Highway passing through the Mengyang Nature Reserve of Xishuangbanna National Nature Reserve in Yunnan Province,China.From September 2005 to September 2006 the impact of this highway on movement of wild Asian elephants between the eastern and western part of the nature reserve was studied using track transecting,rural surveys and direct monitoring.Our results showed that the number of cross-road corridors used by Asian elephants diminished from 28 to 23 following the construction of the highway.In some areas,the elephant activity diminished or even disappeared,which indicated a change in their home ranges.The utilization rate of artificial corridors was 44%.We also found that elephants prefered artificial corridors that were placed along their original corridors.During the research,wild elephants revealed their adaptation to the highway.They were found walking across the highway road surface many times and for different reasons.We suggest that the highway management bureau should revise their management strategies to mitigate the potential risks caused by elephants on the road for the safety of the public and to protect this endangered species from harm.It is also very important to protect and maintain current Asian elephants corridors in this region. | Wenjing PAN Liu LIN Aidong LUO Li ZHANG | 2009 | Integrative Zoology2009，4，2： | 4 |
| 8 | 基于多视图融合的蛋白质功能模块检测方法显示文摘结合多种生物数据分析蛋白质相互作用网络(Protein-Protein Interaction Network,PPIN)中的功能模块结构,是目前蛋白质功能计算分析领域亟待解决的难题之一.本文提出了一种基于聚合非负矩阵分解(Collective Non-negative Matrix Factorization,CoNMF)的多视图一致性功能模块检测方法,该方法同时逼近多视图数据,寻找统一的最优解达到对原多数据的最优近似.根据该统一解得到功能模块关系,同时该方法能够找到可重叠性的功能模块.实验结果显示本文所提出算法通过融合基因本体、基因表达谱与PPIN数据,在模块检测准确度上有一定提高,检测出的蛋白质功能模块具有真实生物意义. | 张媛 贾克斌 ZHANG Aidong | 2014 | 电子学报2014，42，12： | 3 |
| 9 | Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study显示文摘A sensitive and specific liquid-chromatography tandem mass spectrometry(LC-MS/MS)assay has been developed and validated for the simultaneous quantification of ivabradine and its active metabolite N-desmethylivabradine in human plasma and urine.The assay employed a single liquid–liquid extraction of the analytes from plasma and urine samples,and diazepam was used as internal standard(IS).The chromatographic separation was achieved on a Diamonsil C18 column(150 mm4.6 mm,5 mm,Dikma)using a mixture of methanol and aqueous 5 mM ammonium acetate buffer containing 0.2%formic acid(80:20,v/v)as mobile phase.The assay for ivabradine and N-desmethylivabradine in plasma showed good linearity(r≥0.99)over the ranges 0.1013–101.3 ng/mL and 0.085–25.5 ng/mL,respectively.The assay for ivabradine and N-desmethylivabradine in urine showed good linearity(r≥0.99)over the ranges 10.13–6078 ng/mL and 8.5–850 ng/mL,respectively.The intra-and inter-day accuracy and precision values were found to be within the assay variability limits(RSD<15%)in accordance with FDA guidelines.The methods were successfully used for evaluating the pharmacokinetic properties of ivabradine and N-desmethylivabradine in human plasma and urine in Chinese healthy volunteers. | Chengtao Lu Yanyan Jia Jing Yang Xin Jin Ying Songa Wenxing Liu Yi Ding Xiaoli Sun Aidong Wen | 2012 | Acta Pharmaceutica Sinica B2012，2，2： | 3 |
| 10 | Thermal Behavior Investigation of LiNi1/3CO1/3Mn1/3O2-Based Li-ion Battery under Overcharged Test显示文摘它象隔板,电解质,阴极,阳极,和每个文件夹那样的部件的热行为被微分扫描热量测定和热 gravimetric (DSC/TG ) 调查在超载测试下面解释 Li 离子电池的热逃走的机制。DSC 结果显示了在阳极的层在大约 126 漠 ? 桴 ? 潢瑴敬的 SEI (稳固的电解质接口) 的分解反应温度吗? | Wang, Haiyan Tang, Aidong Huang, Kelong | 2011 | Chinese Journal of Chemistry2011，29，1： | 3 |
| 11 | Engineering a tubular mesoporous silica nanocontainer with well-preserved clay shell from natural halloysite显示文摘在里面从自然矿物质的 mesoporous nanotubes 的 situ 合成仍然是大挑战。此处,我们与一个变化报导 mesoporous 硅石 nanotubes (MNT ) 的成功的合成内部壳的厚度和保存泥土从 natural-halloysite nanotubes (HNT ) 的外部壳。在由酸的沥滤的管状的铝矽酸盐泥土的腔直径的增大以后,一致 mesopores 被一条修改 pseudomorphic 转变途径介绍,当时泥土外部壳保存得很好。用密度在沥滤的艾尔和 Si 期间的功能的理论计算,原子结构进化和 energetics -- 哦冷凝作用详细被学习。在从 HNT 艾尔离子沥滤以后,从艾尔的本地结构的变化(哦) 到在中等沥滤水平的艾尔(V) 并且到在沥滤的高度的艾尔(Td ) ,水平被证实。在沥滤酸的 HNT (在内部壳的弄歪的二维的硅石来源和在外部壳的未经触动的铝矽酸盐结构)的二种硅石部件的计算 hydroxylation 精力比体积硅石的高是更低的 0.5 eV 或 1.0 eV ,它在热水的过程澄清硅石部件的不同行为。从 HNT 的反应 MNT 的成功的合成用自然矿物质与特殊形态学为 mesoporous nanocontainers 的合成介绍新策略。特别地, MNT 与众多的反应艾尔(V) 种类和一个特定的表面区域取样直到 583 m 2/g (由 10 的一个因素增加了) 正在答应装载药的 nanocontainers 和 nanoreactors。 | Liangjie Fu Huaming Yang Aidong Tang Yuehua Hu | 2017 | Nano Research2017，10，8： | 3 |
| 12 | A novel visual attention method for target detection from SAR images显示文摘Synthetic Aperture Radar(SAR) imaging systems have been widely used in civil and military fields due to their all-weather and all-day abilities and various other advantages. However, due to image data exponentially increasing, there is a need for novel automatic target detection and recognition technologies. In recent years, the visual attention mechanism in the visual system has helped humans effectively deal with complex visual signals. In particular, biologically inspired top-down attention models have garnered much attention recently. This paper presents a visual attention model for SAR target detection, comprising a bottom-up stage and top-down process.In the bottom-up step, the Itti model is improved based on the difference between SAR and optical images. The top-down step fully utilizes prior information to further detect targets. Extensive detection experiments carried out on the benchmark Moving and Stationary Target Acquisition and Recognition(MSTAR) dataset show that, compared with typical visual models and other popular detection methods, our model has increased ability and robustness for SAR target detection, under a range of Signal to Clutter Ratio(SCR) conditions and scenes. In addition, results obtained using only the bottom-up stage are inferior to those of the proposed method, further demonstrating the effectiveness and rationality of a top-down strategy. In summary, our proposed visual attention method can be considered a potential benchmark resource for the SAR research community. | Fei GAO Aidong LIU Kai LIU Erfu YANG Amir HUSSAIN | 2019 | Chinese Journal of Aeronautics2019，32，8： | 3 |
| 13 | Clustering PPI Data Based on Ant Colony Optimization Algorithm显示文摘 | LEI Xiujuan WU Shuang GE Liang ZHANG Aidong | 2013 | Chinese Journal of Electronics2013，22，1： | 3 |
| 14 | Highly stretchable and sensitive strain sensor based on silver nanowires/carbon nanotubes on hair band for human motion detection显示文摘In this work,a highly stretchable and sensitive strain sensor using silver nanowires(Ag NWs)/multi-walled carbon nanotubes(MWCNTs)on hair band is proposed.The fabrication process of such sensors enabled scalable and facile production with low cost by dipping hair band into Ag NWs/MWCNTs composites suspension.The sensing performance of the sensors was optimized by tuning the Ag NWs/MWCNTs mass ratio.The hair band based strain sensor with Ag NWs/MWCNTs mass ratio of 30 exhibited the best performance with high sensitivity of 416.0 and good stretchability up to 70%.Moreover,great repeatability and long-term stability could be achieved over 7500 cycles of stretch-release.This Ag NWs/MWCNTs-hair band sensor can be used for monitoring human motions and swallowing action. | Yanqiang Gao Tiancheng Lai Furui Teng Ghang Liu Aidong Li | 2021 | Progress in Natural Science:Materials International2021，31，3： | 2 |
| 15 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 16 | A generative model of identifying informative proteins from dynamic PPI networks显示文摘Informative proteins are the proteins that play critical functional roles inside cells.They are the fundamental knowledge of translating bioinformatics into clinical practices.Many methods of identifying informative biomarkers have been developed which are heuristic and arbitrary,without considering the dynamics characteristics of biological processes.In this paper,we present a generative model of identifying the informative proteins by systematically analyzing the topological variety of dynamic protein-protein interaction networks(PPINs).In this model,the common representation of multiple PPINs is learned using a deep feature generation model,based on which the original PPINs are rebuilt and the reconstruction errors are analyzed to locate the informative proteins.Experiments were implemented on data of yeast cell cycles and different prostate cancer stages.We analyze the effectiveness of reconstruction by comparing different methods,and the ranking results of informative proteins were also compared with the results from the baseline methods.Our method is able to reveal the critical members in the dynamic progresses which can be further studied to testify the possibilities for biomarker research. | ZHANG Yuan CHENG Yue JIA KeBin ZHANG AiDong | 2014 | Science China(Life Sciences)2014，57，11： | 2 |
| 17 | Co-regulated Protein Functional Modules with Varying Activities in Dynamic PPI Networks显示文摘Current methods for the detection of differential gene expression focus on finding individual genes that may be responsible for certain diseases or external irritants. However, for common genetic diseases, multiple genes and their interactions should be understood and treated together during the exploration of disease causes and possible drug design. The present study focuses on analyzing the dynamic patterns of co-regulated modules during biological progression and determining those having remarkably varying activities, using the yeast cell cycle as a case study. We first constructed dynamic active protein-protein interaction networks by modeling the activity of proteins and assembling the dynamic co-regulation protein network at each time point. The dynamic active modules were detected using a method based on the Bayesian graphical model and then the modules with the most varied dispersion of clustering coefficients, which could be responsible for the dynamic mechanism of the cell cycle, were identified. Comparison of results from our functional module detection with the state-of-art functional module detection methods and validation of the ranking of activities of functional modules using GO annotations demonstrate the efficacy of our method for narrowing the scope of possible essential responding modules that could provide multiple targets for biologists to further experimentally validate. | Yuan Zhang Nan Du Kang L Kebin Jia Aidong Zhang | 2013 | Tsinghua Science and Technology2013，18，5： | 2 |
| 18 | Genetic diversity of wild barley (Hordeum vulgare ssp. spontaneum) and its utilization for barley improvement显示文摘Wild barley(Hordeum vulgare spp.spontaneum) is the undisputed progenitor of cultivated barley and offers considerable potential as a genetic resource for barley improvement.Naturally occurring populations are distributed primarily across the Fertile Crescent,but secondary areas of diversity are also found in central Asia and Tibet.The pattern of its genetic diversity is non-random,and is structured on a global,regional and local scale.On a global scale,diversity follows ecogeography,while on a regional and local scale,it is more strongly determined by ecology.Populations growing in areas where the climate is unreliable and/or the soil is heterogeneous tend to retain the most diversity.A large number of accessions are currently conserved ex situ,but a high proportion of these have originated from the Fertile Crescent.Given the likelihood of future climate change,conserving germplasm both in situ and ex situ in the various regions where the species' currently existing is a research priority.The value of H.vulgare spp.spontaneum for the improvement of cultivated barley lies largely in its potential contribution to the levels of attainable pathogen resistance and abiotic stress tolerance. | XiaoYing Ma Chao Li AiDong Wang RuiJun Duan GenLin Jiao Eviatar Nevo GuoXiong Chen | 2012 | Research in Cold and Arid Regions2012，4，6： | 2 |
| 19 | Intercalated 2D nanoclay for emerging drug delivery in cancer therapy显示文摘自然二维(2D ) kaolinite nanoclay 被合并了到一个新兴的药交货系统。kaolinite nanoclay 的基础间距通过不同的链长度的各种各样的器官的客人种类的置闰从 0.72 ~ 4.16 nm 被扩展,它能在药交货增加效率并且减少 doxorubicin (纪录影片) 的毒性。原来的 kaolinite (白陶土) 和白陶土置闰混合物向胰腺的癌症,胃的癌症,前列腺癌症,乳癌, colorectal 癌症,食道的癌症,和区分的甲状腺的房间展出了 biocompatibility 和很低的毒性的高水平癌症。然而,肺癌症和 hepatocellular 癌症房间为药交货搬运人需要更严格的组合、结构、词法的调整。纪录影片白陶土和纪录影片白陶土置闰混合物比处于中立状况在中等酸的答案显示出戏剧性地更快的药版本,并且以一种剂量依赖者方式对十种模型癌症房间文化展出了提高的治疗学的效果。为一个新奇的药交货系统的 2D nanoclay 材料的使用能 feasibly 向高效的 nanotherapeutics 铺平一条道路,与优异 antitumor 功效并且显著地减少副作用。 | Yi Zhang Mei Long Peng Huang Huaming Yang Shi Chang Yuehua Hu Aidong Tang Linfeng Mao | 2017 | Nano Research2017，10，8： | 2 |
| 20 | Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers显示文摘This paper reports the development and validation of an assay for ifenprodil based on liquid chromatography–tandem mass spectrometry(LC–MS/MS)and its application to a pharmacokinetic study involving single and multiple intravenous infusions to healthy Chinese volunteers.After sample preparation of plasma by liquid–liquid extraction with ethyl acetate,the analyte and internal standard,urapidil,were separated by reversed phase chromatography in a run time of 4 min and detected by positive ion electrospray ionization followed by multiple reaction monitoring of the precursor-to-product ion transitions at m/z 326.2-308.1 for ifenprodil and m/z 388.4-205.3 for IS.The assay was linear in the concentration range 0.2–50.0 ng/mL with recovery 476.4%.In the pharmacokinetic study of single intravenous infusions of 5,10 and 15 mg ifenprodil,peak plasma concentrations and areas under the plasma concentration–time curve were both linearly related to dose.In the pharmacokinetic study of multiple once daily intravenous infusions of 10 mg ifenprodil for 7 days,pharmacokinetic parameters were similar to those after the single dose showing that ifenprodil does not accumulate on repeated administration. | Jing Yang Chengtao Lu Wei Song Jiankang Li Yi Ding Yanrong Zhu Jinyi Cao Likun Ding Yanyan Jia Aidong Wen | 2013 | Acta Pharmaceutica Sinica B2013，3，3： | 2 |
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