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| 1 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | Short-and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors显示文摘BACKGROUND It is widely recognized that endoscopic resection(ER) of superficial nonampullary duodenal epithelial tumors(SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and perforation.These adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short-and long-term outcomes have not been standardized yet.AIM To investigate the curability including short-and long-term outcomes of ER for SNADETs in a large case series.METHODS This retrospective study included cases that underwent ER for SNADETs at our university hospital between March 2004 and July 2017. Short-term outcomes of ER were measured based on en bloc and R0 resection rates as well as adverse events. Long-term outcomes included local recurrence detected on endoscopic surveillance and disease-specific mortality in patients followed up for ≥ 12 mo after ER.RESULTS In the study, 131 patients with 147 SNADETs were analyzed. The 147 ERs consisted of 136 endoscopic mucosal resections(EMRs)(93%) and 11 endoscopic submucosal dissections(ESDs)(7%). The median tumor diameter was 10 mm.The pathology diagnosis was adenocarcinoma(56/147, 38%), high-grade intraepithelial neoplasia(44/147, 30%), or low-grade intraepithelial neoplasia(47/147, 32%). The R0 resection rate was 68%(93/136) in the EMR group and73%(8/11) in the ESD group, respectively. Cap-assisted EMR(known as EMR-C)showed a higher rate of R0 resection compared to the conventional method of EMR using a snare(78% vs 62%, P = 0.06). No adverse event was observed in the EMR group, whereas delayed bleeding, intraoperative perforation, and delayed perforation in 3, 3, and 5 patients occurred in the ESD group, respectively. One patient with perforation required emergency surgery. In the 43 mo median follow-up period, local recurrence was found in four EMR cases and all cases were treated endoscopically. No patient died due to tumor recurrence.CONCLUSION Our findings suggest that ER provides good long-term outcomes in the patients with SNADETs. EMR is likely to become the safe and reliable treatment for small SNADETs. | Yuko Hara Kenichi Goda Akira Dobashi Tomohiko Richard Ohya Masayuki Kato Kazuki Sumiyama Takehiro Mitsuishi Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 3 | Efficacy of a novel auto-fluorescence imaging system with computer-assisted color analysis for assessment of colorectal lesions显示文摘AIM:To evaluate the efficacy of computer-assisted color analysis of colorectal lesions using a novel auto-fluorescence imaging(AFI)system to distinguish neoplastic lesions from non-neoplastic lesions and to predict the depth of invasion.METHODS:From January 2013 to April 2013,consecutive patients with known polyps greater than 5 mm in size who were scheduled to undergo endoscopic treatment at The Jikei University Hospital were prospectively recruited for this study.All lesions were evaluated using a novel AFI system,and color-tone sampling was performed in a region of interest determined from narrow band imaging or from chromoendoscopy findings without magnification.The green/red(G/R)ratio for each lesion on the AFI images was calculated automatically using a computer-assisted color analysis system that permits real-time color analysis during endoscopic procedures.RESULTS:A total of 88 patients with 163 lesions were enrolled in this study.There were significant differences in the G/R ratios of hyperplastic polyps(non-neoplastic lesions),adenoma/intramucosal cancer/submucosal(SM)superficial cancer,and SM deep cancer(P<0.0001).The mean±SD G/R ratios were 0.984±0.118in hyperplastic polyps and 0.827±0.081 in neoplastic lesions.The G/R ratios of hyperplastic polyps were significantly higher than those of neoplastic lesions(P<0.001).When a G/R ratio cut-off value of>0.89 was applied to determine non-neoplastic lesions,the sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV),and accuracy were 83.9%,82.6%,53.1%,95.6%and 82.8%,respectively.For neoplastic lesions,the mean G/R ratio was 0.834±0.080 in adenoma/intramucosal cancer/SM superficial cancer and 0.746±0.045 in SM deep cancer.The G/R ratio of adenoma/intramucosal cancer/SM superficial cancer was significantly higher than that of SM deep cancer(P<0.01).When a G/R ratio cut-off value of<0.77 was applied to distinguish SM deep cancers,the sensitivity,specificity,PPV,NPV,and accuracy were80.0%,84.4%,29.6%,98.1%and 84.1%,respectively.CONCLUSION:The novel AFI system with color analysis was effective in distinguishing non-neoplastic lesions from neoplastic lesions and might allow determination of the depth of invasion. | Hiroko Inomata Naoto Tamai Hiroyuki Aihara Kazuki Sumiyama Shoichi Saito Tomohiro Kato Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，41： | 5 |
| 4 | Recovery of the susceptibility of isolated bacterium achieved by giving long-established antibiotics as prophylaxis against postoperative infections显示文摘 | Kusachi S Sumiyama Y Arima Y | 2004 | Surg Today2004，34，9： | 1 |
| 5 | Structural evolution and magnetic - properties of nano - granular metallic alloys 显示文摘 | SUMIYAMA K SUZUKI K MAKHLOUF S A | 1995 | J Non - Cryst Solids1995，193，： | 1 |
| 6 | 显示文摘 | Peng Dong-liang Sumiyama K Suzuki K | 1997 | Journal of Alloys and Compounds1997，259，： | 1 |
| 7 | Magneticproperties of iron in nanocapsules显示文摘 | T HIHARA H ONODERA K SUMIYAMA | 1994 | Jpn J Appl Phys1994，33，1： | 1 |
| 8 | XPS Valence Band and Core Level Spectra of Sputter-Deposited Fe-Cu,Fe-Ag and Fe-Cu-Ag Alloy Films 显示文摘 | Tanaka Kazuhide Sumiyama Kenji | 1989 | J Phys Soc Jpn1989，58，： | 1 |
| 9 | Long - term prognosis of preop-erative 'bridge to surgery' expandable metallic stent insertion for ob-structive colorectal cancer: comparison with emergency operation 显示文摘 | Saida Y Sumiyama Y Nagao J | 2003 | Dis Colon Rectum2003，，： | 1 |
| 10 | Long-term prognosis of-preoperative'bridge to surgery'expandable metallic stentinser-tion for obstructive colorectal cancer:comparison with emergencyoperation显示文摘 | Saida Y Sumiyama Y Nagao J | 2003 | Dis Colon Rectum2003，46，： | 1 |
| 11 | Submucosal endoscopy with mucosal flap safety valve 显示文摘 | Sumiyama K Gostout CJ Rajan E | 2007 | Gastrointest Endos2007，65，4： | 1 |
| 12 | Prognostic significance of plasma interleukin-6/-8 in pancreatic cancer patients receiving chemoimmunotherapy显示文摘AIM: To investigate the association of plasma levels of interleukin(IL)-6 and-8 with Wilms' tumor 1(WT1)-specific immune responses and clinical outcomes in patients with pancreatic ductal adenocarcinoma(PDA) treated with dendritic cells(DCs) pulsed with three types of major histocompatibility complex classⅠand Ⅱ-restricted WT1 peptides combined with chemotherapy.METHODS: During the entire treatment period, plasma levels of IL-6 and-8 were analyzed by ELISA. The induction of WT1-specific immune responses was assessed using the WT1 peptide-specific delayed-type hypersensitivity(DTH) test.RESULTS: Three of 7 patients displayed strong WT1-DTH reactions throughout long-term vaccination with significantly decreased levels of IL-6/-8 after vaccinations compared with the levels prior to treatment. Moreover, overall survival(OS) was significantly longer in PDA patients with low plasma IL-6 levels(< 2 pg/m L) after 5 vaccinations than in patients with high plasma IL-6 levels(≥ 2 pg/m L)(P = 0.025). After disease progression, WT1-DTH reactions decreased severely and were ultimately negative at the terminal stage of cancer. The decreased levels of IL-6/-8 observed throughout long-term vaccination were associated with WT1-specific DTH reactions and long-term OS.CONCLUSION: Prolonged low levels of plasma IL-6/-8 in PDA patients may be a prognostic marker for the clinical outcomes of chemoimmunotherapy. | Shintaro Tsukinaga Mikio Kajihara Kazuki Takakura Zensho Ito Tomoya Kanai Keisuke Saito Shinichiro Takami Hiroko Kobayashi Yoshihiro Matsumoto Shunichi Odahara Kan Uchiyama Hiroshi Arakawa Masato Okamoto Haruo Sugiyama Kazuki Sumiyama Toshifumi Ohkusa Shigeo Koido | 2015 | World Journal of Gastroenterology2015，21，39： | 1 |
| 13 | Longterm prognosis ofpreoperative'bridge to surgery'expandable metallic stent insertion for obstructive colorectal cancer:comparison with emergency operation显示文摘 | Saida Y Sumiyama Y Nagao J | 2003 | Dis Colon Rectum2003，46，10： | 1 |
| 14 | 显示文摘 | Peng D L Sumiyama K | 1999 | Appl Phys Lett1999，75，24： | 1 |
| 15 | High-frequency magnetic characteristics of Fe-Co-based nanocrystalline alloy films显示文摘Magnetically soft Fe-Co-based nanocrystalline alloy films were produced by two preparation methods:One using a new energetic cluster deposition technique and another using a conventional magnetron sputtering technique.Their structural,static magnetic properties and high-frequency magnetic characteristics were investigated.In the energetic cluster deposition method,by applying a high-bias voltage to a substrate,positively charged clusters in a cluster beam were accelerated electrically and deposited onto a negatively biased substrate together with neutral clusters from the same cluster source,to form a high-density Fe-Co alloy cluster-assembled film with good high-frequency magnetic characteristics.In the conventional magnetron sputtering method,only by rotating substrate holder and without applying a static inducing magnetic field on the substrates,we produced Fe-Co-based nanocrystalline alloy films with a remarkable in-plane uniaxial magnetic anisotropy and a good soft magnetic property.The obtained Fe-Co-O,Fe-Co-Ti-N,and Fe-Co-Cr-N films all revealed a high real permeability exceeding 500 at a frequency up to 1.2 GHz.This makes Fe-Co-based nanocrystalline alloy films potential candidates as soft magnetic thin film materials for the high-frequency applications. | HIHARA Takehiko SUMIYAMA Kenji | 2010 | Science China(Technological Sciences)2010，53，6： | 1 |
| 16 | Quantitative evaluation of reconstruction methods after gastrectomy using a new type of examination: digestion and absorption test with stable isotope 13C-labeled lipid compound显示文摘 | Makoto Takase Yoshinobu Sumiyama Jiro Nagao | 2003 | Gastric Cancer2003，，3： | 1 |
| 17 | Transesophageal mediastinoseopy by submucosal endoscopy with mucosal flap safety valve technique 显示文摘 | Sumiyama K Gostout C J Rajan E | 2007 | Gastrointest Endosc2007，65，4： | 1 |
| 18 | l_ong-term prognosis of preoperative 'bridge to surgery' expandable metallic stent insertion for obstructive colorectal cancer: comparison with emergency operation显示文摘 | Saida Y Sumiyama Y Nagao J | 2003 | Dis Colon Rectum2003，46，10： | 1 |
| 19 | Pharmacokinetic profiles and clinical efficacy of doripenem in surgical infection 显示文摘 | TANIMURA H AIKAWA N SUMIYAMA Y | 2005 | Jpn J Chemother2005，53，1： | 1 |
| 20 | Submucosal endoscopy with mucosal flap safety valve 显示文摘 | Sumiyama K Gostout C J Rajan E | 2007 | Gastrointest Endosc2007，65，4： | 1 |
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