|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antimicrobial activity of silver loaded MnO_2 nanomaterials with different crystal phases against Escherichia coli显示文摘Silver-loaded MnO_2 nanomaterials(Ag/MnO_2),including Ag/α-MnO_2,Ag/β-MnO_2,Ag/γ-MnO_2and Ag/δ-MnO_2 nanorods,were prepared with hydrothermal and impregnation methods.The bactericidal activities of four types of Ag/MnO_2 nanomaterials against Escherichia coli were investigated and an inactivation mechanism involving Ag^+ and reactive oxygen species(ROS)was also proposed.The bactericidal activities of Ag/MnO_2 depended on the MnO_2 crystal phase.Among these nanomaterials,Ag/β^-MnO_2 showed the highest bactericidal activity.There was a 6-log decrease in E.coli survival number after treatment with Ag/β^-MnO_2 for120 min.The results of 5,5-dimethyl-l-pyrroline-N-oxide spin-trapping measurements by electron spin resonance indicate OH and O_2^- formation with addition of Ag/β-MnO_2,Ag/γ-MnO_2 or Ag/δ-MnO_2.The strongest peak of OH appeared for Ag/β-MnO_2,while no OH or ·O_2^-signal was found over Ag/α-MnO_2.Through analysis of electron spin resonance(ESR) and Ag+elution results,it could be deduced that the toxicity of Ag^+ eluted from Ag/MnO_2 nanomaterials and ROS played the main roles during the bactericidal process.Silver showed the highest dispersion on the surface of β-MnO_2,which promoted ROS formation and the increase of bactericidal activity.Experimental results also indicated that Ag/MnO_2 induced the production of intracellular ROS and disruption of the cell wall and cell membrane. | Lian Wang Hong He Changbin Zhang Li Sun Sijin Liu Shaoxin Wang | 2016 | Journal of Environmental Sciences2016，28，3： | 6 |
| 2 | Evidence of multistage late Quaternary strong earthquakes on typical segments of Longmenshan Active Fault Zone in Sichuan, China显示文摘Investigation of offset landforms and trench excavation are important means to acquire the evidence of multistage activities of active faults. Here we present the result of fault trough investigation in Beichuan County and the Pingtong Town of Pingwu County along the Longmenshan Central Fault Belt, as well as the result from trench excavation at the platform foreslope in Hanwang Town of Mianzhu County on the Longmenshan Front Range Fault Belt. These results show that at least three fault activity events, including the Wenchuan earthquake, occurred in the Beichuan fault trough, at least two, including the Wenchuan earthquake, at Pingtong fault trough, and 2-3 paleoearthquakes in the Hanwang trench. Among these three localities, the times of the last strong earthquake prior to Wenchuan earthquake at Beichuan fault trough and Hanwang trench are close, approximately 6000 years ago, i.e., greater than 5.8 ka and smaller than 6.63 ka ago. This provides the evidence of synchronous activity of the Central Fault Belt and the Front Range Fault Belt of the Longmenshan Active Fault Zone during the previous strong earthquake activities prior to Wenchuan earthquake. | JIANG WaLi XIE XinSheng ZHANG JinFa SUN ChangBin HUANG Wei SHENG Qiang FENG XiYing | 2009 | Science China Earth Sciences2009，52，9： | 3 |
| 3 | Analysis on CBD Construction and Management Mode-China Case Study 显示文摘 | Jiqinren Changbin Liu Maolong Sun | 2004 | Business Trend2004，，1： | 1 |
| 4 | Analysis on CBD Construction and Management Mode-China Case Study显示文摘 | Jiqinren Changbin Liu Maolong Sun | 2004 | Business Trend2004，，1： | 1 |
| 5 | Investigation of Terraces along the Luoyunshan Piedmont Fault Zone and Its Tectonic Implications显示文摘Located at the west of the Linfen basin, the Luoyunshan piedmont fault zone controls the western boundary of the basin. According to the measurements of the terraces in eight gullies along the Luoyunshan fault zone, five levels of terraces, namely T1~T5 have developed in these gullies. The heights of terraces T1, T2, T3, T4 and T5 are about 3m, 8~10m, about 20m, about 30m and 40~50m, respectively. The dating data of the terraces and investigation of the faulted landforms show that the Luoyunshan fault zone has experienced much activity since the Late Quaternary. The uplift rate of the terraces was 0.41mm/a since the Middle-Late Pleistocene, and 0.75mm/a since the Holocene. The increasing trend of uplift rate of the terraces along the Luoyunshan fault zone from the Middle-Late Pleistocene to Holocene indicates the tendency of gradual tectonic uplift of the fault zone since the late Quaternary. This is in good agreement with the increasing trend of subsidence rate of the Linfen basin from the Late Pleistocene to Holocene. | Sun Changbin Xie Xinsheng Xu Jianhong | 2012 | Earthquake Research in China2012，26，2： | 0 |
| 6 | Analysis on CBD Construction and Management Mode --China Case Study显示文摘 | Jiqin Ren Changbin Liu Maolong Sun | 2003 | Chinese Business Review2003，2，4： | 0 |
| 7 | High expression of BCL6 inhibits the differentiation and development of hematopoietic stem cells and affects the growth and development of chickens显示文摘Background:B-cell CLL/lymphoma 6(BCL6)is a transcriptional master regulator that represses more than 1200 potential target genes.Our previous study showed that a decline in blood production in runting and stunting syndrome(RSS)affected sex-linked dwarf(SLD)chickens compared to SLD chickens.However,the association between BCL6 gene and hematopoietic function remains unknown in chickens.Methods:In this study,we used RSS affected SLD(RSS-SLD)chickens,SLD chickens and normal chickens as research object and overexpression of BCL6 in hematopoietic stem cells(HSCs),to investigate the effect of the BCL6 on differentiation and development of HSCs.Results:The results showed that comparison of RSS-SLD chickens with SLD chickens,the BCL6 was highly expressed in RSS-SLD chickens bone marrow.The bone marrow of RSS-SLD chickens was exhausted and red bone marrow was largely replaced by yellow bone marrow,bone density was reduced,and the levels of immature erythrocytes in peripheral blood were increased.At the same time,the hematopoietic function of HSCs decreased in RSS-SLD chickens,which was manifested by a decrease in the hematopoietic growth factors(HGFs)EPO,SCF,TPO,and IL-3,as well as hemoglobinα1 and hemoglobinβexpression.Moreover,mitochondrial function in the HSCs of RSS-SLD chickens was damaged,including an increase in ROS production,decrease in ATP concentration,and decrease in mitochondrial membrane potential(ΔΨm).The same results were also observed in SLD chickens compared with normal chickens;however,the symptoms were more serious in RSS-SLD chickens.Additionally,after overexpression of the BCL6 in primary HSCs,the secretion of HGFs(EPO,SCF,TPO and IL-3)was inhibited and the expression of hemoglobinα1 and hemoglobinβwas decreased.However,cell proliferation was accelerated,apoptosis was inhibited,and the HSCs entered a cancerous state.The function of mitochondria was also abnormal,ROS production was decreased,and ATP concentration andΔΨm were increased,which was related to the inhibition of apoptosis of stem cells.Conclusions:Taken together,we conclude that the high expression of BCL6 inhibits the differentiation and development of HSCs by affecting mitochondrial function,resulting in impaired growth and development of chickens.Moreover,the abnormal expression of BCL6 might be a cause of the clinical manifestations of chicken comb,pale skin,stunted growth and development,and the tendency to appear RSS in SLD chickens. | Hongmei Li Bowen Hu Shang Hu Wen Luo Donglei Sun Minmin Yang Zhiying Liao Haohui Wei Changbin Zhao Dajian Li Meiqing Shi Qingbin Luo Dexiang Zhang Qinghua Nie Xiquan Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 0 |
| 8 | The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike显示文摘Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions. | Liping Shen Lili Zhang Changbin Yin Xiaowan Xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He Xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi Xuebo Zhao Daxing Xu Botao Ye Xuchang Yu Ziying Wang Danni Liu Yuanfeng Hao Fei Lu Zifeng Guo | 2024 | The Crop Journal2024，12，1： | 0 |
| 9 | DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms显示文摘Programmed DNA double-strand break(DSB)formation is a crucial step in meiotic recombination,yet techniques for highefficiency and precise mapping of the 3’ends of DSBs are still in their infancy.Here,we report a novel technique,named DNA End tailing and sequencing(DEtail-seq),which can directly and ultra-efficiently characterize the 3’ends of meiotic DSBs with near single-nucleotide resolution in a variety of species,including yeast,mouse,and human.We find that the 3’ends of meiotic DSBs are stable without significant resection in budding yeast.Meiotic DSBs are strongly enriched in de novo H3K4me3 peaks in the mouse genome at leptotene stage.We also profile meiotic DSBs in human and find DSB hotspots are enriched near the common fragile sites during human meiosis,especially at CCCTC-binding factor(CTCF)-associated enhancers.Therefore,DEtail-seq provides a powerful method to detect DSB ends in various species,and our results provide new insights into the distribution and regulation of meiotic DSB hotspots. | Wei Xu Chao Liu Zhe Zhang Changbin Sun Qin Li Kuan Li Hui Jiang Wei Li Qianwen Sun | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 10 | Study on Holocene Paleoearthquakes in Xizhang Trench on the Jiaocheng Fault Zone,Shanxi Province显示文摘Xizhang trench is located 10 km northwest of Taiyuan city,Shanxi Province,in front of a NNW-trending scarp of 4.6m height on the northern segment of the Jiaocheng fault zone.The dimensions of the trench are 108m in length,8m in width,and 10m in depth.There are 18 horizons revealed in the trench.The upper strata are sandy loam;the upper strata of the downthrown block of the fault are gravels,the lower ones are an interbed of brown loam and sandy loam.The strata on the upthrown block of the fault are sandy loam containing gravel.The trench shows 3 fault planes,and the upper offset point on the fault plane is 1.5m below the ground surface,the newest dislocated stratum is(3.74±0.06)ka BP.The trench reveals a lot of deformation traces,such as fault planes,dislocated strata,colluvial wedges and formation tilting.The relationship between strata and faults in the trench shows that 3 paleoearthquake events have occurred at the Jiaocheng fault zone since the Early Holocene,they are about(3.74±0.06)~(3.06±0.26)ka BP,(8.35±0.09)ka~(3.74±0.06)ka BP,and(10.66±0.85)~(8.35±0.09)ka BP.The average interval among the events is 2.6~3.6ka.The minimum coseismic vertical displacements of the 3 events are 3.0m,2.5m and 3.2m,respectively.The significance of Xizhang trench is that the Jiaocheng fault used to be active thousands of years ago,though there is no M≥7.0 earthquake recorded in historical documents.Evidence of new Jiaocheng fault zone activity during the Holocene is important for the earthquake safety assessment of Taiyuan city in the future. | Xie Xinsheng Zhao Jinquan Jiang Wali An Weiping Li Zihong Zhang Dawei Cheng Xinyuan Gao Shuyi Wang Chunhe Sun Changbin Yan Chengguo | 2008 | Earthquake Research in China2008，22，4： | 0 |
| 11 | Effects of intermittent cold-exposure on culprit plaque morphology in ST-segment elevation myocardial infarction patients: a retrospective study based on optical coherence tomography显示文摘Objective:Present study aimed to explore the effects of intermittent cold-exposure(ICE)on culprit plaque morphology in patients with ST-segment elevation myocardial infarction(STEMI)in frigid zone.Methods:Totally 848 STEMI patients with plaque rupture(N=637)or plaque erosion(N=211)were enrolled consecutively according to optical coherence tomography imaging.Data on the changes of outdoor air temperature corresponding to 24 solar terms were collected.Patients were divided into different groups according to 24 solar terms and the number of days with indoor central heating.Imaging data were measured and analyzed qualitatively and quantitatively.Statistical analysis was conducted to elucidate the possible association of the STEMI patients of different groups with plaque morphology of culprit vessel with alterations of ambient temperature.Results:The incidence of both plaque rupture and plaque erosion presented trough in summer.The incidence of plaque rupture reached a peak value in early winter when outdoor air temperature dropped below 0℃and declined with supply of central heating.Persistent cold exposure in early winter was positively and significantly associated with plaque rupture.The incidence of plaque erosion presented a peak in severe winter with outdoor air temperature dropping below-20℃and steady supply of central heating.ICE in severe winter was positively and significantly associated with plaque with intact intima,especially in aged male or current smoking patients.The positive correlation of cold exposure with lipid size in culprit plaque in winter weakened with central heating.Conclusion:ICE resulted from switching staying in between outdoor cold environment and indoor warm temperature with central heating in severe winter changed culprit plaque morphology in STEMI.Plaque rupture decreased whereas plaque erosion increased impacted by ICE.The effect of ICE on the transformation of plaque morphology might be explained by reduced lipid deposition. | Jinxin Liu Shaohong Fang Shanjie Wang Changbin Sun Rong Sun Hengxuan Cai Bo Yu | 2022 | Frigid Zone Medicine2022，2，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员