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4篇 您的检索式:作者名="Sun SenYan"
    题名 作者 年代 出处 被引量
1Dynamic tubulation of mitochondria drives mitochondrial network formation显示文摘Chong Wang Wanqing Du Qian Peter Su Mingli Zhu Peiyuan Feng Ying Li Yichen Zhou Na Mi Yueyao Zhu Dong Jiang Senyan Zhang Zerui Zhang Yujie Sun Li Yu 2015Cell Research2015,25,10:8
2Study on the tourism contracts显示文摘Sun SenYan 1999Dong-wu Law lournal1999,,1:1
3驱动蛋白介导自噬性溶酶体出管显示文摘本研究通过在体外重构自噬性溶酶体出管的单分子研究体系,详细解析了驱动蛋白KIF5B介导自噬性溶酶体出管再生的分子机制。Wanqing Du Qian Peter Su Yang Chen Yueyao Zhu Dong Jiang Yueguang Rong Senyan Zhang Yixiao Zhang He Ren Chuanmao Zhang Xinquan Wang Ning Gao Yanfeng Wang Lingfei Sun 孙育杰 俞立 2017科学新闻2017,19,4:0
4Thiol-mediated transportation pathway:an approach for improving tumor penetration of nanomedicines in vivo显示文摘Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective anti-tumor.Herein,we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation pathway.To achieve active tumor accumulation in vivo,disulfide-based nanoparticles are modified with folic acid units(FA-DBNPs).It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway,which facilitates transcellular transportation and tumor penetration both in vitro and in vivo.Besides,FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization,indicating that the GSH level in tumor tissues regulates the penetration depth of FA-DBNPs.Benefiting from these advantages,FA-DBNPs showed potent anti-tumor activity in mouse models,leading to the significant regression of tumors.The current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy.Junjie Zhang Weican Sun Xing Wang Senyan Chen Jingying Li Huanghao Yang 2024Science China Chemistry2024,67,1:0
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