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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | Day-ahead Optimization Schedule for Gas-electric Integrated Energy System Based on Second-order Cone Programming显示文摘This paper proposes an optimal day-ahead opti-mization schedule for gas-electric integrated energy system(IES)considering the bi-directional energy flow.The hourly topology of electric power system(EPS),natural gas system(NGS),energy hubs(EH)integrated power to gas(P2G)unit,are modeled to minimize the day-ahead operation cost of IES.Then,a second-order cone programming(SOCP)method is utilized to solve the optimization problem,which is actually a mixed integer nonconvex and nonlinear programming issue.Besides,cutting planes are added to ensure the exactness of the global optimal solution.Finally,simulation results demonstrate that the proposed optimization schedule can provide a safe,effective and economical day-ahead scheduling scheme for gas-electric IES. | Yonghui Sun Bowen Zhang Leijiao Ge Denis Sidorov Jianxi Wang Zhou Xu | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 14 |
| 3 | Mass elevation effect and its forcing on timberline altitude显示文摘集体举起效果的概念(massenerhebungseffect, MEE ) 被 A 介绍。de Quervain 大约 100 年以前排队为象树那样的温度相关的参数说明观察趋势并且比在他们的外部边缘上在中央阿尔卑斯山脉发生在更高的举起的 snowline。它广泛地也在世界的另外的区域被观察了,但是没有重要,更不用说量,关于这现象的研究。特别,它完全通常在开发树带界线举起的恰当的模型被忽视了,与仅仅看作影响因素的经度或纬度。这篇论文试着确定到树带界线的 MEE 的贡献举起。认为更多广泛陆地团并且特别越高在陆地质量的内部的山底,越 greater 集体举起效果,这篇论文作为 MEE 的大小拿山底举起(MBE ) 。我们收集树带界线举起的 157 个数据点,并且把他们的纬度,经度和 MBE 用作独立变量在东南的欧亚的大陆为树带界线举起造一个多重线性回归方程。结果生产到树带界线高度活动范围 25.11% , 29.43% ,和 45.46% 的纬度,经度和 MBE 的贡献分别地。北纬度的诺思 | HAN Fang YAO Yonghui DAI Shibao WANG Chun SUN Ranhao XU Juan ZHANG Baiping | 2012 | Journal of Geographical Sciences2012，22，4： | 12 |
| 4 | V4C3Tx MXene:A promising active substrate for reactive surface modification and the enhanced electrocatalytic oxygen evolution activity显示文摘Presented are the synthesis,characterizations,and reactive surface modification(RSM)of a novel nine atomic layered V4C3Tx MXene.With the advantages of the multilayered V4C3Tx MXene that can simultaneously support the RSM reaction and keep the inner skeleton stable,a series of amorphous Ni/Fe/Vternary oxide hydroxides thin layer can be successfully modified on the surface of the V4C3Tx MXene(denoted as MOOH@V4C3Tx,M=Ni,Fe,and V)without disrupting its original structure.Attributed to the in situ reconstruction of highly active oxide hydroxide layer,the nanohybrids exhibited an enhanced oxygen evolution reaction(OER)activity and excellent long-time stability over 70 hours.In particular,a current density of 10 mA cm−2 can be reached by the nanohybrid with the optimized Ni/Fe ratio at an overpotential(η)as low as 275.2 mV,which is comparable to most of the state-of-the-art OER catalysts and better than other MXene-based derivatives.Demonstrated by the tunable physicochemical properties and excellent structural stability of these nanohybrids,we may envision the promising role of the M4X3-based MXenes as substrates for a wide range of energy conversion and storage materials. | Cheng-Feng Du Xiaoli Sun Hong Yu Wei Fang Yao Jing Yonghui Wang Shuiqing Li Xianhu Liu Qingyu Yan | 2020 | InfoMat2020，2，5： | 8 |
| 5 | FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice显示文摘Dear Editor,Animal models,most commonly mice,that lack a protein of interest play an important role in phenotypic and functional studies of a target gene,allowing researchers to answer various biological questions(Chaible et al,2010).At pre-sent,a variety of tools act at the DNA or RNA level to enable researchers to model gene function(and thus protein)deficiency,including nucleic acid based RNA interference(EI-bashir et al.,2001),antisense oligonucleotides(Schoch and Miller,2017),and genome editing-based CRISPR-Cas9(Doudna and Charpentier,2014)strategies.However,challenges remain. | Hongying Gao Chunwei Zheng Jian Du Yue Wu Yonghui Sun Chunsheng Han Kehkooi Kee Yu Rao | 2020 | Protein & Cell2020，11，7： | 5 |
| 6 | Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin显示文摘Isolation rearing(IR) enhances aggressive behavior, and the central serotonin(5-hydroxytryptamine,5-HT) system has been linked to IR-induced aggression.However, whether the alteration of central serotonin is the cause or consequence of enhanced aggression is still unknown. In the present study, using mice deficient in central serotonin Tph2-/-and Lmx1 b-/-, we examined the association between central serotonin and aggression with or without social isolation. We demonstrated that central serotonergic neurons are critical for the enhanced aggression after IR. 5-HT depletion in wild-type mice increased aggression. On the other hand, application of 5-HT in Lmx1 b-/-mice inhibited the enhancement of aggression under social isolation conditions. Dopamine was downregulated in Lmx1 b-/-mice. Similar to 5-HT, L-DOPA decreased aggression in Lmx1 b-/-mice. Our results linkthe serotoninergic system directly to aggression and this may have clinical implications for aggression-related human conditions. | Yiqiong Liu Yunong Sun Xiaoyan Zhao Ji-Young Kim Lu Luo Qian Wang Xiaolu Meng Yonghui Li Nan Sui Zhou-Feng Chen Chuxiong Pan Liang Li Yan Zhang | 2019 | Neuroscience Bulletin2019，35，5： | 5 |
| 7 | Robust H_∞ Load Frequency Control of Multi-area Power System With Time Delay:A Sliding Mode Control Approach显示文摘This paper is devoted to investigate the robust H∞sliding mode load frequency control(SMLFC) of multi-area power system with time delay. By taking into account stochastic disturbances induced by the integration of renewable energies,a new sliding surface function is constructed to guarantee the fast response and robust performance, then the sliding mode control law is designed to guarantee the reach ability of the sliding surface in a finite-time interval. The sufficient robust frequency stabilization result for multi-area power system with time delay is presented in terms of linear matrix inequalities(LMIs). Finally,a two-area power system is provided to illustrate the usefulness and effectiveness of the obtained results. | Yonghui Sun Yingxuan Wang Zhinong Wei Guoqiang Sun Xiaopeng Wu | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，2： | 4 |
| 8 | Acute carbon monoxide poisoning in Shandong, China: an observational study显示文摘Background: Carbon monoxide (CO) poisoning remains a major cause of accidental injuries and multiple studies have indicated that CO is also associated with significantly severe or long-term toxicity to the central nervous system. Given that CO poisoning causes serious morbidity and mortality, a better understanding of epidemiological features and clinical characteristics of acute CO poisoning in China is crucial.Methods: We collected the clinical data of acute CO poisoning in patients between November 2019 and April 2020 across Shandong province, China and analyzed its characteristics focusing on the weekly amount and the severity of the confirmed cases.Results: A total number of 21,088 acute CO poisoning cases were diagnosed. The overall incidence of acute CO poisoning was approximately 0.021%. On severity rankings, 63% of confirmed cases (n=13,378) were mild, 27%(n=5635) were moderate, and 10% (n=2075) were severe. Interestingly, the coastal cities had more confirmed cases than the inland/suburban areas in Shandong. Meanwhile, the number of confirmed cases was negatively correlated with the local mean daily temperature (P=0.0167).Conclusions: Mild acute CO poisoning cases accounted for the majority of all confirmed cases during the winter of 2019. In Shandong province, which is located in east China, residents of the coastal cities are more susceptible to CO poisoning than residents of inland cities. | Lina Zhang Di Wu Mingyue Xu Yonghui Bian Youcun Wang Guangkai Gao Qing Sun | 2022 | Chinese Medical Journal2022，，13： | 4 |
| 9 | A Hybrid Dynamic Demand Control Strategy for Power System Frequency Regulation显示文摘The rapid increase in renewable energy integration brings with it a series of uncertainty to the transmission and distribution systems.In general,large-scale wind and solar power integration always cause short-term mismatch between generation and load demand because of their intermittent nature.The traditional way of dealing with this problem is to increase the spinning reserve,which is quite costly.In recent years,it has been proposed that part of the load can be controlled dynamically for frequency regulation with little impact on customers’living comfort.This paper proposes a hybrid dynamic demand control(DDC)strategy for the primary and secondary frequency regulation.In particular,the loads can not only arrest the sudden frequency drop,but also bring the frequency closer to the nominal value.With the proposed control strategy,the demand side can provide a fast and smooth frequency regulation service,thereby replacing some generation reserve to achieve a lower expense. | Qingxin Shi Hantao Cui Fangxing Li Yilu Liu Wenyun Ju Yonghui Sun | 2017 | CSEE Journal of Power and Energy Systems2017，3，2： | 3 |
| 10 | Ginsenoside Rb1 prevents high glucose-induced Schwann cell injury through the mitochondrial apoptosis pathway显示文摘OBJECTIVE: To investigate the effects of ginsenoside Rb1 on high glucose-induced neurotoxicity and the underlying molecular mechanism in primary cultured Schwann cells(SCs).METHODS: Cultured SCs were divided into six groups that received(a) normal glucose,(b) osmotic control,(c) high glucose,(d) high glucose plus 1μM ginsenoside Rb1,(e) high glucose plus 10 μM ginsenoside Rb1, or(f) high glucose plus 100 μM alpha lipoic acid(ALA). Intracellular reactive oxygen species(ROS) generation and mitochondrial transmembrane potential(ΔΨm) were detected by flow cytometric analyses. Apoptosis was confirmed by the annexin V-FITC/propidium iodide(PI) method,and the concentration of 8-hydroxy-2-deoxy guanosine(8-OHd G) was detected by an enzyme-linked immunosorbent assay. Western blotting was performed to analyze the expression levels of important transcription factors such as cytochrome c, bcl-2, bax, activated caspase-3, and activated poly(ADP-ribose) polymerase(PARP).RESULTS: Ginsenoside Rb1 inhibited high glucose-induced oxidative stress by decreasing ROS and 8-OHd G levels as well as mitochondrial depolarization in SCs. 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide and annexin V-FITC/PI assays showed that incubating SCs with high glucose decreased cell viability and increased the number of apoptotic cells, whereas treatment with ginsenoside Rb1 protected SCs against high glucose-induced cell damage. Furthermore, ginsenoside Rb1 down-regulated the expression of high glucose-induced bax and cytochrome c release but up-regulated bcl-2 expression. In addition, ginsenoside Rb1 attenuated high glucose-induced activation of caspase-3 and minimized cleavage of PARP in SCs.CONCLUSION: These results suggest that ginsenoside Rb1 antagonizes high glucose-induced oxidative stress and activation of the mitochondrial apoptosis pathway in SCs. | Li Xiaogang Zhang Zhe Wang Rui Xia Xinxin Liu Yonghui Sun Lianqing | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 11 | Crystal structure determination of nanolaminated Ti_(5)Al_(2)C_(3) by combined techniques of XRPD,TEM and ab initio calculations显示文摘Crystal structure of Ti_(5)Al_(2)C_(3)was determined by means of X-ray powder diffraction(XRPD),transmission electron microscopy(TEM)and ab initio calculations.In contrast to the already known P63/mmc space group that the MAX phases crystallize,it was demonstrated that the R3_m space group could better satisfy the experimental data.The lattice parameters are a=0.30564 nm,c=4.81846 nm in a hexagonal unit cell. | Hui ZHANG Xiaohui WANG Yonghui MA Luchao SUN Liya ZHENG Yanchun ZHOU | 2012 | Journal of Advanced Ceramics2012，1，4： | 3 |
| 12 | Synthetical Numerical Model for Evaluating Blade Fatigue Life of Liquid Corrosion in Steam Turbine显示文摘 | Yonghui Xie Di Zhang Zhenping Feng Bi Sun | 2006 | Key Engineering Materials2006，324，： | 1 |
| 13 | Preparation and Charac- terization of Polymer-inorganic Nanocomposites by In Si- tu Melt Polycondensation of L-Lactic Acid and Surface- hydroxylated MgO显示文摘 | Yonghui Li Xiuzhi Susan Sun | 2010 | Biomacromolecules2010，11，7： | 1 |
| 14 | The Synthesis and Photoluminescent Properties of Calcium Tungstate Nanocrystals显示文摘 | Sun Lingna Cao Minhua Wang Yonghui | 2006 | Journal of Crystal Growth2006，289，： | 1 |
| 15 | The synthesis and photoluminescent properties of calcium tungstate nanocrystals显示文摘 | Lingna Sun Minhua Cao Yonghui Wang Genban Sun Changwen Hu | 2005 | Journal of Crystal Growth2005，，1： | 1 |
| 16 | Adaptive lag synchronization of unknown chaotic delayed neural networks with noise perturbation 显示文摘 | SUN Yonghui CAO Jinde | 2007 | Physics Letters A2007，364，34： | 1 |
| 17 | Anionic surfac-tantassisted hydrothermal synthesis of high-aspect-ratio ZnO nanowires and their photoluminescence property显示文摘 | Sun Genban Cao Minhua Wang Yonghui | 2006 | Materials Letters2006，60，21： | 1 |
| 18 | An approximate analytical propagation formula for Gaussian beams through a cateye optical lens under large incidence angle condition显示文摘 | Zhao Yanzhong Sun Huayan Zheng Yonghui | 2011 | Chin Phys Lett2011，28，07： | 1 |
| 19 | New cyclopiane diterpenes with anti-inflammatory activity from the sea sediment-derived fungus Penicillium sp.TJ403-2显示文摘Three new rare cyclopiane diterpenes(1-3),together with thirteen known compounds(4-16),were isolated and identified from a sea sediment-derived fungus Penicillium sp.TJ403-2.The planar and relative structures of compounds 1-3 were elucidated by HRESIMS,one-and two-dimensional NMR analyses,and their absolute configurations were further established by X-ray crystallography experiment.Compounds 1-3 were evaluated for the anti-inflammatory activity against LPS-induced NO production,and compound 1 showed notable inhibitory potency with an IC50 value of2.19±0.25μmol/L,which was three fold lower than the positive control indomethacin(IC50=8.76±0.92μmol/L).Further Western blot and immunofluorescence experiments demonstrated its mechanism of action to be that 1 inhibited the NF-κB-activated pathway,highlighting it as a promising starting point for the development of new anti-inflammatory agents. | Fengli Li Weiguang Sun Sitian Zhang Weixi Gao Shuang Lin Beiye Yang Chenwei Chai Huaqiang Li Jianping Wang Zhengxi Hu Yonghui Zhang | 2020 | Chinese Chemical Letters2020，31，1： | 1 |
| 20 | Ultra-thin CoAl layered double hydroxide nanosheets for the construction of highly sensitive and selective QCM humidity sensor显示文摘To achieve real-time monitoring of humidity in various applications,we prepared facile and ultra-thin CoAl layered double hydroxide(CoAl LDH)nanosheets to engineer quartz crystal microbalances(QCM).The characteristics of CoAl LDH were investigated by transmission electron microscopy(TEM),X-ray diffraction(XRD),X-ray photoelectric spectroscopy(XPS),Brunauer–Emmett–Telle(BET),atomic force microscopy(AFM)and zeta potential.Due to their large specific surface area and abundant hydroxyl groups,CoAl LDH nanosheets exhibit good humidity sensing performance.In a range of 11.3%and 97.6%relative humidity(RH),the sensor behaved an ultrahigh sensitivity(127.8 Hz/%RH),fast response(9.1 s)and recovery time(3.1 s),low hysteresis(3.1%RH),good linearity(R^(2)=0.9993),stability and selectivity.Besides,the sensor can recover the initial response frequency after being wetted by deionized water,revealing superior self-recovery ability under high humidity.Based on in-situ Fourier transform infrared spectroscopy(FT-IR),the adsorption mechanism of CoAl LDH toward water molecules was explored.The QCM sensor can distinguish different respiratory states of people and wetting degree of fingers,as well as monitor the humidity in vegetable packaging,suggesting excellent properties and a promising application in humidity sensing. | Yongheng Zhu Xuhua Dong Jinsheng Cheng Lumin Wang Cheng Zhao Yonghui Deng Siqi Xie Yingjie Pan Yong Zhao Gengzhi Sun Tianjun Ni | 2023 | Chinese Chemical Letters2023，34，8： | 1 |
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