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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | Synergistic improvement of perovskite film quality for efficient solar cells via multiple chloride salt additives显示文摘Perovskite crystal film quality is critical for obtaining efficient perovskite solar cells. Anti-solvent processing was used for fast crystallization of perovskite precursor film, which can form dense perovskite film.However, the crystals from this method are usually small due to the fast crystal growth process, which could lead to grain boundary recombination. Here, element chloride is introduced to enhance the perovskite layer crystallinity via slowing down the perovskite crystallization process by simultaneous introduction of methylammounium chloride(MACl) and cesium chloride(CsCl) into precursor solution.As a result, we achieve high quality of pin-hole free perovskite film with large crystal size. A power conversion efficiency of 21.55% with free of hysteresis of the device is obtained, which is among the highest efficiency of planar structure perovskite solar cells. | Pengyang Wang Qi Jiang Yang Zhao Yong Chen Zema Chu Xingwang Zhang Yuqin Zhou Jingbi You | 2018 | Science Bulletin2018，63，11： | 6 |
| 3 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 4 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 5 | Research progress in large-area perovskite solar cells显示文摘The record power conversion efficiency of small-area perovskite solar cells has impressively exceeded 25%.For commercial application,a large-area device is the necessary next step.Recently,significant progress has been achieved in fabricating efficient large-area perovskite solar cells.In this review,we will summarize recent achievements in large-area perovskite solar cells including the deposition methods as well as growth control of the large-area,high-quality perovskite layer and also the charge transport layer.Finally,we will give our insight into large-area perovskite solar cells. | Yang Zhao Fei Ma Feng Gao Zhigang Yin Xingwang Zhang Jingbi You | 2020 | Photonics Research2020，8，7： | 3 |
| 6 | Nickel oxide for inverted structure perovskite solar cells显示文摘The emergence of inverted perovskite solar cells(PSCs) has attached great attention derived from the potential in improving stability. Charge transporting layer, especially hole transporting layer is crucial for efficient inverted PSCs. Organic materials were used as hole transporting layer previously. Recently, more and more inorganic hole transporting materials have been deployed for further improving the device stability. Nickel oxide(NiOx) as p-type metal oxide, owning high charge mobility and intrinsic stability,has been widely adopted in inverted PSCs. High performance over 20% efficiency has been achieved on NiOx base inverted PSCs. Herein, we have summarized recent progresses and strategies on the NiOx based PSCs, including the synthesis or deposition methods of NiOx, doping and surface modification of NiOx for efficient and stable PSCs. Finally, we will discuss current challenges of utilizing NiOx HTLs in PSCs and attempt to give probable solutions to make further development in efficient as well as stable NiOx based PSCs. | Fei Ma Yang Zhao Jinhua Li Xingwang Zhang Haoshuang Gu Jingbi You | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 7 | 2020 Roadmap on two-dimensional nanomaterials for environmental catalysis显示文摘Environmental catalysis has drawn a great deal ofattention due to its clean ways to produce useful chemicals or carry out some chemical processes.Photocatalysis and electrocatalysis play important roles in these fields.They can decompose and remove organic pollutants from the aqueous environment,and prepare some fine chemicals.Moreover,they also can carry out some important reactions,such as 02 reduction reaction(ORR),O2 evolution reaction(OER),H2 evolution reaction(HER),CO2 reduction reaction(C02 RR),and N2 fixation(NRR).For catalytic reactions,it is the key to develop high-performance catalysts to meet the demand fortargeted reactions.In recentyears,two-dimensional(2 D) materials have attracted great interest in environmental catalysis due to their unique layered structures,which offer us to make use of their electronic and structural characteristics.Great progress has been made so far,including graphene,black phosphorus,oxides,layered double hydroxides(LDHs),chalcogenides,bismuth-based layered compounds,MXenes,metal organic frameworks(MOFs),covalent organic frameworks(COFs),and others.This content drives us to invite many famous groups in these fields to write the roadmap on two-dimensional nanomaterials for environmental catalysis.We hope that this roadmap can give the useful guidance to researchers in future researches,and provide the research directions. | Yulu Yang Mingguang Wu Xingwang Zhu Hui Xu Si Ma Yongfeng Zhi Hong Xia Xiaoming Liu Jun Pan Jie-Yinn Tang Siang-Piao Chai Leonardo Palmisano Francesco Parrino Junli Liu Jianzhong Ma Ze-Lin Wang Ling Tan Yu-Fei Zhao Yu-Fei Song Pardeep Singh Pankaj Raizada Deli Jiang Di Li R.A.Geioushy Jizhen Ma Jintao Zhang Song Hu Rongjuan Feng Gang Liu Minghua Liu Zhenhua Li Mingfei Shao Neng Li Jiahe Peng Wee-Jun Ong Nikolay Kornienko Zhenyu Xing Xiujun Fan Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 2 |
| 8 | RiceENCODE:A comprehensive epigenomicdatabase as a rice Encyclopedia of DNA Elements显示文摘Dear Editor,Rice(Oryza sativa)is one of the most important crops in the worldand a common model plant for genomic research.The genomesofXian/IndicaandGeng/Japonicahave been completelysequenced and annotated with accurate genome information.Over the past few years,epigenomic information,including DNAmethylation,histone modification,and chromatin accessibility,has been characterized in theXian/IndicaandGeng/Japonicage-nomes(Zhao et al.,2020).Quite a few rice three-dimensionalgenome studies have been published in the meantime(Zhaoet al.,2019).However,it is still a big challenge for many groupsthat lack dedicated bioinformatic personnel or sufficientcomputational resources to utilize such epigenetic data. | Liang Xie Minghao Liu Lun Zhao Kai Cao Peng Wang Wenhao Xu Wing-Kin Sung Xingwang Li Guoliang Li | 2021 | Molecular Plant2021，14，10： | 2 |
| 9 | Stabilizing the black phase of cesium lead halide inorganic perovskite for efficient solar cells显示文摘Inorganic perovskite cesium lead halide is extensively studied because of its potential in improving the thermal stability of perovskite materials. However, the tolerance factor of this type of perovskite is near the critical value, which leads to phase instability. The optoelectronic active black phases(α,β, and γ phases of CsPbI3) are metastable at room temperature, which can be easily transferred into an optoelectronic inactive yellow phase(δ-CsPbI3). This review highlights recent progress in stabilizing the black phase for efficient and stable perovskite solar cells. | Qiufeng Ye Yang Zhao Shaiqiang Mu Pingqi Gao Xingwang Zhang Jingbi You | 2019 | Science China Chemistry2019，62，7： | 2 |
| 10 | Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies:a phase I clinical study显示文摘Chimeric antigen receptor(CAR)-T cell therapy against T cell malignancies faces major challenges including fratricide between CAR-T cells and product contamination from the blasts.Allogeneic CAR-T cells,generated from healthy donor T cells,can provide ready-to-use,blast-free therapeutic products,but their application could be complicated by graft-versus-host disease(GvHD)and host rejection.Here we developed healthy donor-derived,CD7-targeting CAR-T cells(RD13-01)with genetic modifications to resist fratricide,GvHD and allogeneic rejection,as well as to potentiate antitumor function.A phase I clinical trial(NCT04538599)was conducted with twelve patients recruited(eleven with T cell leukemia/lymphoma,and one with CD7-expressing acute myeloid leukemia).All patients achieved pre-set end points and eleven proceeded to efficacy evaluation.No dose-limiting toxicity,GvHD,immune effector cell-associated neurotoxicity or severe cytokine release syndrome(grade≥3)were observed.28 days post infusion,81.8%of patients(9/11)showed objective responses and the complete response rate was 63.6%(7/11,including the patient with AML).3 of the responding patients were bridged to allogeneic hematopoietic stem cell transplantation.With a median follow-up of 10.5 months,4 patients remained in complete remission.Cytomegalovirus(CMV)and/or Epstein-Barr virus(EBV)reactivation was observed in several patients,and one died from EBV-associated diffuse large B-cell lymphoma(DLBCL).Expansion of CD7-negative normal T cells was detected post infusion.In summary,we present the first report of a Phase I clinical trial using healthy donor-derived CD7-targeting allogeneic CAR-T cells to treat CD7^(+)hematological malignancies.Our results demonstrated the encouraging safety and efficacy profiles of the RD13-01 allogeneic CAR-T cells for CD7^(+)tumors. | Yongxian Hu Yali Zhou Mingming Zhang Houli Zhao Guoqing Wei Wengang Ge Qu Cui Qitian Mu Gong Chen Lu Han Tingting Guo Jiazhen Cui Xiaoyan Jiang Xiujun Zheng Shuhui Yu Xiaolong Li Xingwang Zhang Mingxi Chen Xiuju Li Ming Gao Kang Wang Cheng Zu Hao Zhang Xiaohong He Yanbin Wang Dongrui Wang Jiangtao Ren He Huang | 2022 | Cell Research2022，32，11： | 2 |
| 11 | Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population显示文摘 | Jixia Liu Yongyong Shi Wei Tang Tingwei Guo Dawei Li Yifeng Yang Xinzhi Zhao Hongsheng Wang Xingwang Li Guoyin Feng Niufan Gu Shaomin Zhu Huijun Liu Yangling Guo Jianguo Shi Hong Sang Lijuan Yan Lin He | 2005 | Biochemical and Biophysical Research Communications2005，，3： | 1 |
| 12 | Recent progress in synthesis of two-dimensional hexagonal boron nitride显示文摘Two-dimensional(2D) materials have recently received a great deal of attention due to their unique structures and fascinating properties,as well as their potential applications.2D hexagonal boron nitride(2D hBN),an insulator with excellent thermal stability,chemical inertness,and unique electronic and optical properties,and a band gap of 5.97 e V,is considered to be an ideal candidate for integration with other 2D materials.Nevertheless,the controllable growth of high-quality 2D h-BN is still a great challenge.A comprehensive overview of the progress that has been made in the synthesis of 2D h-BN is presented,highlighting the advantages and disadvantages of various synthesis approaches.In addition,the electronic,optical,thermal,and mechanical properties,heterostructures,and related applications of 2D h-BN are discussed. | Haolin Wang Yajuan Zhao Yong Xie Xiaohua Ma Xingwang Zhang | 2017 | Journal of Semiconductors2017，38，3： | 1 |
| 13 | Elevated Plasma Ferritin Is Associated with Increased Incidence of Type 2 Diabetes in Middle-Aged and Elderly Chinese Adults123显示文摘 | Liang Sun Geng Zong An Pan Xingwang Ye Huaixing Li Zhijie Yu Yao Zhao Shurong Zou Danxia Yu Qianlu Jin Frank B. Hu Xu Lin | 2013 | Journal of Nutrition2013，，9： | 1 |
| 14 | Asymmetric epigenome maps of subgenomes reveal imbalanced transcription and distinct evolutionary trends in Brassica napus显示文摘The complexity of the epigenome landscape and transcriptional regulation is significantly increased during plant polyploidization,which drives genome evolution and contributes to the increased adaptability to diverse environments.However,a comprehensive epigenome map of Brassica napus is still unavailable.In this study,we performed integrative analysis of five histone modifications,RNA polymerase Ⅱ CCU-pancy,DNA methylation,and transcriptomes in two B.napus lines(2063A and B409),and established global maps of regulatory elements,chromatin states,and their dynamics for the whole genome(including the An and Cn subgenomes)in four tissue types(young leaf,flower bud,silique,and root)of these two lines.Approximately 65.8% of the genome was annotated with different epigenomic signals.Compared with the Cn subgenome,the An subgenome possesses a higher level of active epigenetic marks and lower level of repressive epigenetic marks.Genes from subgenome-unique regions contribute to the major differences between the An and Cn subgenomes.Asymmetric histone modifications between homeologous gene pairs reflect their biased expression patterns.We identified a novel bivalent chromatin state(with H3K4me1 and H3K27me3)in B.napus that is associated with tissue-specific gene expression.Furthermore,we observed that different types of duplicated genes have discrepant patterns of histone modification and DNA methylation levels.Collectively,our findings provide a valuable epigenetic resource for allopolyploid plants. | Qing Zhang Pengpeng Guan Lun Zhao Meng Ma Liang Xie Yue Li Ruiqin Zheng Weizhi Ouyang Shunyao Wang Hongmeijuan Li Ying Zhang Yong Peng Zhilin Cao Wei Zhang Qin Xiao Yuanling Xiao Tingdong Fu Guoliang Li Xingwang Li Jinxiong Shen | 2021 | Molecular Plant2021，14，4： | 1 |
| 15 | Guidelines for the Diagnosis and Treatment of Dengue in China显示文摘Dengue is the most prevalent and rapidly spreading mosquito-borne viral disease.As a dengue non-endemic country,China has experienced several dengue outbreaks in recent years.However,dengue patients in China display clinical characteristics that are distinct from those of patients in dengue-endemic countries.To standardize the diagnosis and treatment of dengue fever,the experts at the Society of Infectious Diseases,Society of Tropical Medicine and Parasitology of the Chinese Medical Association,and the Society of Emergency Medicine of China Association of Chinese Medicine have developed a guideline after reviewing the following guidelines and data:guidelines for diagnosis,treatment,prevention,and control of dengue(World Health Organization,2009);the guidelines for diagnosis and treatment of dengue(National Health and Family Planning Commission of the People’s Republic of China,2014,Edition 2);health industry standard of the People’s Republic of China“diagnosis for dengue fever(WS216-2018)”;and systemic reports on dengue.The new guideline includes eight aspects:introduction,terminology,epidemiology and prevention,etiology and pathogenesis,clinical features,diagnosis,treatment,and problems to be solved. | Fuchun Zhang Jianfeng He Jie Peng Xiaoping Tang Chengfeng Qin Hongzhou Lu Xingwang Li Qingquan Liu Hong Zhao Jifang Sheng Guiqiang Wang Society of Infectious Diseases,Society of Tropical Medicine and Parasitology,Chinese Medical Association Society of Emergency Medicine,China Association of Chinese Medicine | 2021 | Infectious Diseases & Immunity2021，1，3： | 1 |
| 16 | Mapping Multi-factor-mediated Chromatin Interactions to Assess Dysregulation of Lung Cancer-related Genes显示文摘Studies on the lung cancer genome are indispensable for developing a cure for lung cancer.Whole-genome resequencing,genome-wide association studies,and transcriptome sequencing have greatly improved our understanding of the cancer genome.However,dysregulation of longrange chromatin interactions in lung cancer remains poorly described.To better understand the three-dimensional(3D)genomic interaction features of the lung cancer genome,we used the A549 cell line as a model system and generated high-resolution chromatin interactions associated with RNA polymerase II(RNAPII),CCCTC-binding factor(CTCF),enhancer of zeste homolog 2(EZH2),and histone 3 lysine 27 trimethylation(H3K27me3)using long-read chromatin interaction analysis by paired-end tag sequencing(ChIA-PET).Analysis showed that EZH2/H3K27me3-mediated interactions further repressed target genes,either through loops or domains,and their distributions along the genome were distinct from and complementary to those associated with RNAPII.Cancer-related genes were highly enriched with chromatin interactions,and chromatin interactions specific to the A549 cell line were associated with oncogenes and tumor suppressor genes,such as additional repressive interactions on FOXO4 and promoter–promoter interactions between NF1 and RNF135.Knockout of an anchor associated with chromatin interactions reversed the dysregulation of cancer-related genes,suggesting that chromatin interactions are essential for proper expression of lung cancer-related genes.These findings demonstrate the 3D landscape and gene regulatory relationships of the lung cancer genome. | Yan Zhang Jingwen Zhang Wei Zhang Mohan Wang Shuangqi Wang Yao Xu Lun Zhao Xingwang Li Guoliang Li | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 17 | Enantioselective Synthesis of Optically Active Bis(β-hydroxy) Sulfones through Asymmetric Hydrogenation of Corresponding Ketones Catalyzed by a Chiral Cationic Ruthenium Diamine Catalyst显示文摘Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β-hydroxy)sulfones catalyzed by a chiral cationic ruthenium diamine catalyst.A series of bis(β-hydroxy)sulfones have been obtained in excellent yields(up to 99%)with excellent enantioselectivities(up to 99%)as well as good diastereoselectivities(up to 99∶1). | Xiaofei Huang Min Zhao Naikai Li Haiyan Li Jie Li Xingwang Wang | 2014 | Chinese Journal of Chemistry2014，32，8： | 0 |
| 18 | Machine learning-enabled MIMO-FBMC communication channel parameter estimation in IIoT: A distributed CS approach显示文摘Compressed Sensing(CS)is a Machine Learning(ML)method,which can be regarded as a single-layer unsupervised learning method.It mainly emphasizes the sparsity of the model.In this paper,we study an ML-based CS Channel Estimation(CE)method for wireless communications,which plays an important role in Industrial Internet of Things(IIoT)applications.For the sparse correlation between channels in Multiple Input Multiple Output Filter Bank MultiCarrier with Offset Quadrature Amplitude Modulation(MIMO-FBMC/OQAM)systems,a Distributed Compressed Sensing(DCS)-based CE approach is studied.A distributed sparse adaptive weak selection threshold method is proposed for CE.Firstly,the correlation between MIMO channels is utilized to represent a joint sparse model,and CE is transformed into a joint sparse signal reconstruction problem.Then,the number of correlation atoms for inner product operation is optimized by weak selection threshold,and sparse signal reconstruction is realized by sparse adaptation.The experiment results show that the proposed DCS-based method not only estimates the multipath channel components accurately but also achieves higher CE performance than classical Orthogonal Matching Pursuit(OMP)method and other traditional DCS methods in the time-frequency dual selective channels. | Han Wang Fida Hussain Memon Xianpeng Wang Xingwang Li Ning Zhao Kapal Dev | 2023 | Digital Communications and Networks2023，9，2： | 0 |
| 19 | Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review显示文摘Plant growth and development are controlled by a complex gene regulatory network,which is currently a focal point of research.It has been established that epigenetic factors play a crucial role in plant growth.Trichomes,specialized appendages that arise from epidermal cells,are of great significance in plant growth and development.As a model system for studying plant development,trichomes possess both commercial and research value.Epigenetic regulation has only recently been implicated in the development of trichomes in a limited number of studies,and microRNA-mediated post-transcriptional regulation appears to dominate in this context.In light of this,we have conducted a review that explores the interplay between epigenetic regulations and the formation of plant trichomes,building upon existing knowledge of hormones and transcription factors in trichome development.Through this review,we aim to deepen our understanding of the regulatory mechanisms underlying trichome formation and shed light on future avenues of research in the field of epigenetics as it pertains to epidermal hair growth. | Yuming Dong Sen Li Haoying Wu Yiming Gao Zhongxuan Feng Xi Zhao Li Shan Zhongren Zhang Huazhong Ren Xingwang Liu | 2023 | Horticulture Research2023，10，9： | 0 |
| 20 | A Bayesian matrix factorization model for dynamic user embedding in recommender system显示文摘1 Introduction The main idea of recommender system is how to learn accurate users’embeddings from behavior data[1].Each dimension of users’embeddings can reflect the interests of users in different potential aspects.In real-world scenarios,users’interests are drifting over time,which brings a challenge to learn accurate dynamic users’embeddings.Recently,various time-aware recommendation methods have been proposed to tackle this problem by modeling the evolution process of users’interests[2−4].However,they usually assume that users’embeddings drift with the same range on all dimensions.In practice,users’embeddings should change diversely on different dimensions over time.Specifically,for the rapidly changing interests of the users,the corresponding dimensions should change significantly.On the contrary,the dimensions representing stable interests may change slightly. | Kaihan ZHANG Zhiqiang WANG Jiye LIANG Xingwang ZHAO | 2022 | Frontiers of Computer Science2022，16，5： | 0 |
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