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| 1 | Diagnostic criteria for autoimmune chronic pancreatitis revisited显示文摘自体免疫的慢性胰炎(AIP ) 逐渐地正在是广泛地认出了世界,,这个实体的知识积聚。首先, AIP 以它对与平常的慢性胰炎相对照的口头的类固醇治疗的戏剧的反应是到临床医生的很吸引人的疾病。尽管 AIP 的许多典型调查结果被描述了,明确的诊断标准充分没被建立。在一年 2002,日本胰社会在全世界出版了 AIP 和许多临床医生的诊断标准为 AIP 的诊断使用这些标准。然而,日本胰社会建议的诊断标准不是完全令人满意的,一些组在报导 AIP 使用他们的自己的标准。这评论为这个逐渐地公认的条件讨论当前的诊断标准的几潜在的限制。手稿被组织强调对召开一致发展的需要改进了诊断标准。 | Kyu-Pyo Kim Myung-Hwan Kim Jong Cheol Kim Sang Soo Lee Dong Wan Seo Sung Koo Lee | 2006 | World Journal of Gastroenterology2006，12，16： | 73 |
| 2 | Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer显示文摘AIM:To evaluate the depth of invasion of small,early colorectal cancers(ECCs)using conventional endoscopic features.METHODS:From January 2005 to September 2011,colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20mm underwent colonoscopy at the Yonsei University College of Medicine,Seoul,South Korea.Among them,8 patients were excluded due to incomplete medical records.Finally,a total of 64 ECCs with submucosa(SM)invasion and size less than 20 mm were included.One hundred fifty-two adenomas with size less than 20 mm were included as controls.Nine endoscopic features,including seven morphological findings(i.e.,loss of lobulation,excavation,demarcated and depressed areas,stalk swelling,fullness,fold convergence,and bleeding ulcers),pit patterns,and non-lifting signs,were evalu-ated retrospectively.All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology.RESULTS:Among the morphological findings,the size of deep submucosal cancers was bigger than that of superficial lesions(16.9 mm vs 12.3 mm,P<0.001).Also,demarcated depressed areas,stalk swelling,and fullness were more common in deep SM cancers than in superficial tumors(demarcated depressed areas:52.0%vs 15.7%,P<0.001;stalk swelling:100%vs4.2%,P<0.001;fullness:25.0%vs 0%,P=0.001).Among deep SM cancers,96%of polyps showed invasive pit patterns,whereas 19.4%of superficial tumors showed invasive pit patterns(P<0.001).A positive non-lifting sign was more common in deep SM cancers(85.0%vs 28.6%,P<0.001).Diagnostic accuracy of invasive morphology,invasive pit patterns,and nonlifting signs for deep SM cancers were 71%,82%,and75%,respectively.CONCLUSION:Conventional endoscopic findings were insufficient to discriminate small,deep SM cancers from superficial SM cancers by white light,standard colonoscopy. | Wan Park Bun Kim Soo Jung Park Jae Hee Cheon Tae Il Kim Won Ho Kim Sung Pil Hong | 2014 | World Journal of Gastroenterology2014，20，21： | 11 |
| 3 | Clinicopathologic factors influencing the accuracy of EUS for superficial esophageal carcinoma显示文摘AIM:To identify clinicopathologic factors influencing the accuracy of a high-frequency catheter probe endoscopic ultrasonography(EUS)for superficial esophageal carcinomas(SECs).METHODS:A total of 126 patients with endoscopically suspected SEC,who underwent EUS and curative treatment at Pusan National University Hospital during2005-2013,were enrolled.We reviewed the medical records of the 126 patients and compared EUS findings with histopathologic results according to clinicopathologic factors.RESULTS:A total of 114 lesions in 113 patients were included in the final analysis.The EUS assessment of tumor invasion depth was accurate in 78.9%(90/114)patients.Accuracy did not differ according to histologic type,tumor differentiation,tumor location,or macroscopic shape.However,accuracy significantly decreased for tumors≥3 cm in size(P=0.002).Overestimation and underestimation of the invasion depth occurred for 11(9.6%)and 13 lesions(11.4%),respectively.In multivariate analyses,tumor size≥3 cm was the only factor significantly associated with EUS accuracy(P=0.031),and was specifically associated with the underestimation of invasion depth.CONCLUSION:EUS using a high-frequency catheter probe generally provides highly accurate assessments of SEC invasion depth,but its accuracy decreases for tumors≥3 cm. | Jung Im Jung Gwang Ha Kim Hoseok I Do Youn Park Tae Kyun Kim Young Hwa Cho Yong Wan Sung Mun Ki Choi Bong Eun Lee Geun Am Song | 2014 | World Journal of Gastroenterology2014，20，20： | 9 |
| 4 | Endoscopic ultrasound-guided choledochoduodenostomies with fully covered self-expandable metallic stents显示文摘AIM:To investigate the long-term outcomes of endoscopic ultrasound-guided choledochoduodenostomy(EUS-CDS) with a fully covered self-expandable metallic stent(FCSEMS).METHODS:From April 2009 to August 2010,15 patients with distal malignant biliary obstructions who were candidates for alternative techniques for biliary decompression due to a failed endoscopic retrograde cholangiopancreatography(ERCP) were included.These 15 patients consisted of 8 men and 7 women and had a median age of 61 years(range:30-91 years).The underlying causes of the distal malignant biliary obstruction were pancreatic cancer(n = 9),ampulla of Vater cancer(n = 2),renal cell carcinoma(n = 1),advanced gastric cancer(n = 1),lymphoma(n = 1),and duodenal cancer(n = 1).RESULTS:The technical success rate of EUS-CDS with an FCSEMS was 86.7%(13/15),and functional success was achieved in 100%(13/13) of those cases.In two patients,the EUS-CDS failed because an FCSEMS with a delivery device could not be passed into the common bile duct.The mean duration of stent patency was 264 d.Early adverse events developed in three patients(3/13,23.1%),including self-limited pneumoperitoneum in two patients and cholangitis requiring stent reposition in one patient.During the follow-up period(median:186 d,range:52-388 d),distal stent migration occurred in four patients(4/13,30.8%).In 3 patients,the FCSEMS could be reinserted through the existing choledochoduodenal fistula tract.CONCLUSION:EUS-CDS with an FCSEMS is technically feasible and can lead to effective palliation of distal malignant biliary obstructions after failed ERCP. | Tae Jun Song Yil Sik Hyun Sang Soo Lee Do Hyun Park Dong Wan Seo Sung Koo Lee Myung-Hwan Kim | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 5 | Absolute monocyte and lymphocyte count prognostic score for patients with gastric cancer显示文摘AIM:To measure the prognostic significance of absolute monocyte count/absolute lymphocyte count prognostic score(AMLPS) in patients with gastric cancer.METHODS:We retrospectively examined the combination of absolute monocyte count(AMC) and absolute lymphocyte count(ALC) as prognostic variables in a cohort of 299 gastric cancer patients who underwent surgical resection between 2006 and 2013 and were followed at a single institution.Both AMC and ALC were dichotomized into two groups using cut-off points determined by receiving operator characteristic curve analysis.An AMLPS was generated,which stratified patients into three risk groups:low risk(both low AMC and high ALC),intermediate risk(either high AMC or low ALC),and high risk(both high AMC and low ALC).The primary objective of the study was to validate the impact of AMLPS on both disease-free survival(DFS) and overall survival(OS),and the second objective was to assess the AMLPS as an independent prognostic factor for survival in comparison with known prognostic factors.RESULTS:Using data from the entire cohort,the most discriminative cut-off values of AMC and ALC selected on the receiver operating characteristic curve were 672.4/μL and 1734/μL for DFS and OS.AMLPS risk groups included 158(52.8%) patients in the lowrisk,128(42.8%) in the intermediate-risk,and 13(4.3%) in the high-risk group.With a median followup of 37.2 mo(range:1.7-91.4 mo),five-year DFS rates in the low-,intermediate-,and high-risk groups were 83.4%,78.7%,and 19.8%,respectively.And fiveyear OS rates in the low-,intermediate-,and high-risk groups were 89.3%,81.1%,and 14.4%,respectively.On multivariate analysis performed with patient- and tumor-related factors,we identified AMLPS,age,and pathologic tumor-node-metastasis stage as the most valuable prognostic factors impacting DFS and OS.CONCLUSION:AMLPS identified patients with a poor DFS and OS,and it was independent of age,pathologic stage,and various inflammatory markers. | Wan Kyu Eo Da Wun Jeong Hye Jung Chang Kyu Yeoun Won Sung Il Choi Se Hyun Kim Sung Wook Chun Young Lim Oh Tae Hwa Lee Young Ok Kim Ki Hyung Kim Yong Il Ji Ari Kim Heung Yeol Kim | 2015 | World Journal of Gastroenterology2015，21，9： | 6 |
| 6 | Preliminary report on a new hybrid metal stent for EUS-guided biliary drainage (with videos)显示文摘 | Tae Jun Song Sang Soo Lee Do Hyun Park Dong Wan Seo Sung Koo Lee Myung-Hwan Kim | 2014 | Gastrointestinal Endoscopy2014，，： | 4 |
| 7 | Simplified fistula dilation technique and modified stent deployment maneuver for EUS-guided hepaticogastrostomy显示文摘AIM:To evaluate the success rates,procedural time and adverse event rates of the modified methods in endoscopic ultrasonography-guided hepaticogastrostomy(EUS-HGS).METHODS:Twenty-eight patients in a prospective case series who underwent EUS-HGS(phaseⅠ).Fortysix patients in a matched case-control study(phaseⅡ).The simplified technique for fistula dilation was the primary use of a 4 mm balloon catheter with a stainless steel stylet.The stent deployment was modified by deploying the metal stent inside a bile duct(half of the stent)under EUS and fluoroscopic guidance and gently pulling the echoendoscope after full deployment of the stent inside the echoendoscope channel(remaining portion of the stent)under fluoroscopic guidance.This cohort was compared with a matched historical cohort.RESULTS:In phaseⅠ,the technical and clinical success with the modified method was 96%(27/28)and89%(24/27 as per-protocol analysis).The overall adverse event rate was 7%.In phaseⅡ,there was no difference in technical and clinical success,stent patency and overall adverse events in each group.However,the procedural time(15.3±5.2 min vs 22.3±6.0 min,P<0.001)and early adverse events(0%vs 26%,P=0.02)were statistically improved in case cohort compared with control cohort.CONCLUSION:Compared with the conventional EUSHGS technique,the procedural time was shorter and early adverse events were less frequent with our simplified and modified technique. | Woo Hyun Paik Do Hyun Park Jun-Ho Choi Joon Hyuk Choi Sang Soo Lee Dong Wan Seo Sung Koo Lee Myung-Hwan Kim Jung Bok Lee | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 8 | Colonic Mucosal Immune Activity in Irritable Bowel Syndrome: Comparison with Healthy Controls and Patients with Ulcerative Colitis显示文摘 | Ji Yong Ahn Kyung Hun Lee Chang Hwan Choi Ju Wan Kim Hyun Woong Lee Jeong Wook Kim Mi Kyung Kim Gui Young Kwon Seungbong Han Seong-Eun Kim Sung Min Kim Sae Kyung Chang | 2014 | Digestive Diseases and Sciences2014，，5： | 3 |
| 9 | A novel device for endoscopic submucosal dissection,the Fork knife显示文摘瞄准:用一台新奇设备介绍并且评估功效和内视镜的粘膜下层解剖(ESD ) 的技术方面,叉刀。方法:从 2004 年 3 月到 2008 年 4 月, ESD 在一个单个第三级的工作分派中心用 Flexknife (组 B ) 在使用一把叉刀(Endo FSregister )( 组 A ) 的 265 胃的损害上并且在 72 胃的损害上被执行。我们回顾地比较了 resected 标本的肿瘤,病理检查所见,和尺寸的内视镜的特征。我们也比较了在二个组之间的整块切除术率,完全的切除术率,复杂并发症,和过程时间。结果:resected 标本的吝啬的尺寸是 4.27 +/- 在组 A 和 4.29 +/- 的 1.26 厘米在组 B 的 1.48 厘米。整块切除术率是 95.8%(254/265 损害) 在组 A 并且 93.1%(67/72 ) 在组 B。没有 resected 边缘的肿瘤房间侵略的完全的 ESD 在 81.1% 被获得(215/265 ) 组 A 并且在 73.6%(53/72 ) 组 B。穿孔率是 0.8%(2/265 ) 在组 A 并且 1.4%(1/72 ) 在组 B。吝啬的过程时间是 59.63 +/- 在组 A 和 76.65 +/- 的 56.12 min 在组 B 的 70.75 min (P <
0.05 ) 。结论:叉刀(Endo FSregister ) 为临床的实践是有用的并且有的优点减少过程时间。 | Hyun Gun Kim Joo Young Cho Gene Hyun Bok Won Young Cho Wan Jung Kim Bong Min Ko Jin Oh Kim Joon Seong Lee Moon Sung Lee Chan Sup Shim | 2008 | World Journal of Gastroenterology2008，14，43： | 3 |
| 10 | Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery显示文摘AIM To investigate the factors affecting diagnostic delay and outcomes of diagnostic delay in inflammatory bowel disease(IBD) METHODS We retrospectively studied 165 patients with Crohn's disease(CD) and 130 patients with ulcerative colitis(UC) who were diagnosed and had follow up durations > 6 mo at Korea University Ansan Hospital from January 2000 to December 2015. A diagnostic delay was defined as the time interval between the first symptom onset and IBD diagnosis in which the 76^(th) to 100^(th) percentiles of patients were diagnosed.RESULTS The median diagnostic time interval was 6.2 and 2.4 mo in the patients with CD and UC, respectively. Among the initial symptoms, perianal discomfort before diagnosis(OR = 10.2, 95%CI: 1.93-54.3, P = 0.006) was associated with diagnostic delays in patients with CD; however, no clinical factor was associated with diagnostic delays in patients with UC. Diagnostic delays, stricturing type, and penetrating type were associated with increased intestinal surgery risks in CD(OR = 2.54, 95%CI: 1.06-6.09; OR = 4.44, 95%CI: 1.67-11.8; OR = 3.79, 95%CI: 1.14-12.6, respectively). In UC, a diagnostic delay was the only factor associated increased intestinal surgery risks(OR = 6.81, 95%CI: 1.12-41.4).CONCLUSION A diagnostic delay was associated with poor outcomes, such as increased intestinal surgery risks in patients with CD and UC. | Dong-won Lee Ja Seol Koo Jung Wan Choe Sang Jun Suh Seung Young Kim Jong Jin Hyun Sung Woo Jung Young Kul Jung Hyung Joon Yim Sang Woo Lee | 2017 | World Journal of Gastroenterology2017，23，35： | 3 |
| 11 | Detection of Helicobacter pylori DNA in Human Biliary Tree and Its Association with Hepatolithiasis显示文摘 | Seung-Jae Myung Myung-Hwan Kim Ki Nam Shim Yeon-Suk Kim Eun Ok Kim Hong-Ja Kim Eun-Taek Park Kyo-Sang Yoo Byeung-Cheol Lim Dong Wan Seo Sung Koo Lee Young Il Min Ji Yeon Kim | 2000 | Digestive Diseases and Sciences2000，，7： | 2 |
| 12 | Clinical features of strabismus and nystagmus in bilateral congenital cataracts显示文摘AIM:To evaluate the prevalence,clinical features,and the factors affecting onset of strabismus and nystagmus in patients with bilateral congenital cataracts.METHODS:This study evaluated 116 eyes of 58 patients who underwent lens removal for the treatment of bilateral congenital cataracts between January 1999 and January 2011.The presence and type of strabismus and nystagmus were determined before and after surgery.Type of strabismus and final visual acuity were compared in patients with and without nystagmus.Patients were divided into three groups(orthotropia/orthotropia,orthotropia/strabismus,and strabismus/strabismus) according to their preoperative and postoperative ocular alignment.Age at cataract surgery and associations of nystagmus and primary intraocular lens(IOL) implantation with strabismus were analyzed.RESULTS:Six patients(10.3%) had strabismus preoperatively and an additional 11(19.0%) developed postoperative strabismus.Exotropia was more common than esotropia both preoperatively and postoperatively.Eighteen patients(31.0%) had postoperative nystagmus,with sensory nystagmus being the most common type.Of the 18 patients with nystagmus,10 had strabismus,with exotropia being more common than esotropia.Postoperative visual acuity was poor in patients with nystagmus.Age at cataract surgery and rate of primary IOL implantation were significantly lower,and postoperative nystagmus was more common,in the orthotropia/strabismus group than in the other two groups.CONCLUSION:Exotropia and sensory nystagmus are common in patients with bilateral congenital cataracts.Age at cataract surgery and rate of IOL implantation are lowerand nystagmus more common in patients with postoperative onset of strabismus.Nystagmus is associated with poor visual prognosis. | Sung Soo Hwang Wan Soo Kim Soo Jung Lee | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 2 |
| 13 | <ce:link locator='fx1'/> Substitution of Aspartic Acid at Position 57 of the DQβ1 Affects Relapse of Autoimmune Pancreatitis显示文摘 | Do Hyun Park Myung–Hwan Kim Heung Bum Oh Oh–Joong Kwon Young–Jin Choi Sang–Soo Lee Tae Yoon Lee Dong–Wan Seo Sung–Koo Lee | 2008 | Gastroenterology2008，，2： | 2 |
| 14 | Covered Versus Uncovered Wallstent for Malignant Extrahepatic Biliary Obstruction: A Cohort Comparative Analysis显示文摘 | Do Hyun Park Myung–Hwan Kim Jung Sik Choi Sang Soo Lee Dong Wan Seo Ji Hye Kim Jimin Han Jong Cheol Kim Eun Kwang Choi Sung Koo Lee | 2006 | Clinical Gastroenterology and Hepatology2006，，： | 2 |
| 15 | Efficacy of endoscopic and percutaneous treatments for biliary complications after cadaveric and living donor liver transplantation显示文摘 | Ju Sang Park Myung-Hwan Kim Sung Koo Lee Dong Wan Seo Sang Soo Lee Jimin Han Young Il Min Shin Hwang Kwang Min Park Young Joo Lee Seung Gyu Lee Kyu Bo Sung | 2003 | Gastrointestinal Endoscopy2003，，1： | 2 |
| 16 | Expression of survivin and clinical correlation in patients with breast cancer显示文摘 | Doo Min Sohn Sung Yong Kim Moo Jun Baek Cheol Wan Lim Min Hyuk Lee Moo Sik Cho Tae Yoon Kim | 2006 | Biomedicine & Pharmacotherapy2006，，6： | 2 |
| 17 | 每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性比较显示文摘通过一项为期12周的多中心、随机、开放、平行组试验,比较每日一次与按需使用乌地那非对治疗2型糖尿病患者勃起功能障碍的有效性和安全性。按需服用乌地那非200mg能够改善勃起功能障碍的161名患者,被随机分为200mg按需治疗组(n=80)和50mg每日一次组仰=81),两组分别接受相应治疗8周,8周后停药并随访4周,这些患者均通过性活动日志中Q2(插入成功率)和Q3(性交中保持勃起至完成性交的成功率)进行评估。主要的疗效指标是国际勃起功能问卷.勃起功能分级(IIEF.EFD)评分的变化。次要的疗效指标包括性活动日志02、Q3,国际勃起功能问卷的Q3、Q4及其他部分,全球评估问卷,以及正常率(EFD_〉26)的变化。我们也对血管内皮细胞标志物进行了检测。经过8周的治疗,两组的IIEF.EFD评分都得到改善fP〈O.0001),且两组之间没有显著的统计学差异。但这种改善并没有维持到无治疗随访期之后。次要的疗效指标也有类似的结果。在血管内皮标志物方面,两组之间无显著差异。患者对每日一次乌地那非具有更好的耐受性,且两组之间药物不良反应以及不良事件方面无显著性差异。其中脸红和头痛是最常见的不良反应。这两种方案都能改善糖尿病患者的勃起功能障碍,且均有良好的患者耐受性。乌地那非每日给药对糖尿病患者勃起功能障碍的治疗作用值得进一步研究。 | Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon Ah Sung Tae Hwa Kim Jae Min Lee Kang Seo Park | 2015 | Asian Journal of Andrology2015，17，1： | 2 |
| 18 | MSC-based VEGF gene therapy in rat myocardial infarction model using facial amphipathic bile acid-conjugated polyethyleneimine显示文摘 | Hyung-Ho Moon Min Kyung Joo Hyejung Mok Minhyung Lee Ki-Chul Hwang Sung Wan Kim Ji Hoon Jeong Donghoon Choi Sun Hwa Kim | 2014 | Biomaterials2014，，5： | 2 |
| 19 | Prospective efficacy and safety study of neoadjuvant gemcitabine with capecitabine combination chemotherapy for borderline-resectable or unresectable locally advanced pancreatic adenocarcinoma显示文摘 | Jae-Lyun Lee Song Cheol Kim Ji-Hoon Kim Sang Soo Lee Tae-Won Kim Do Hyun Park Dong Wan Seo Sung Koo Lee Myung-Hwan Kim Jong Hoon Kim Jin-Hong Park Sang Hyun Shin Duck Jong Han | 2012 | Surgery2012，，5： | 2 |
| 20 | Can MRCP replace the diagnostic role of ERCP for patients with choledochal cysts? <ce:link locator='fx1'/>显示文摘 | Do Hyun Park Myung-Hwan Kim Sung Koo Lee Sang Soo Lee Jung Sik Choi Yoon Seon Lee Dong Wan Seo Hyung Jin Won Min-Young Kim | 2005 | Gastrointestinal Endoscopy2005，，3： | 2 |
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