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| 1 | Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer显示文摘AIM:To evaluate the depth of invasion of small,early colorectal cancers(ECCs)using conventional endoscopic features.METHODS:From January 2005 to September 2011,colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20mm underwent colonoscopy at the Yonsei University College of Medicine,Seoul,South Korea.Among them,8 patients were excluded due to incomplete medical records.Finally,a total of 64 ECCs with submucosa(SM)invasion and size less than 20 mm were included.One hundred fifty-two adenomas with size less than 20 mm were included as controls.Nine endoscopic features,including seven morphological findings(i.e.,loss of lobulation,excavation,demarcated and depressed areas,stalk swelling,fullness,fold convergence,and bleeding ulcers),pit patterns,and non-lifting signs,were evalu-ated retrospectively.All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology.RESULTS:Among the morphological findings,the size of deep submucosal cancers was bigger than that of superficial lesions(16.9 mm vs 12.3 mm,P<0.001).Also,demarcated depressed areas,stalk swelling,and fullness were more common in deep SM cancers than in superficial tumors(demarcated depressed areas:52.0%vs 15.7%,P<0.001;stalk swelling:100%vs4.2%,P<0.001;fullness:25.0%vs 0%,P=0.001).Among deep SM cancers,96%of polyps showed invasive pit patterns,whereas 19.4%of superficial tumors showed invasive pit patterns(P<0.001).A positive non-lifting sign was more common in deep SM cancers(85.0%vs 28.6%,P<0.001).Diagnostic accuracy of invasive morphology,invasive pit patterns,and nonlifting signs for deep SM cancers were 71%,82%,and75%,respectively.CONCLUSION:Conventional endoscopic findings were insufficient to discriminate small,deep SM cancers from superficial SM cancers by white light,standard colonoscopy. | Wan Park Bun Kim Soo Jung Park Jae Hee Cheon Tae Il Kim Won Ho Kim Sung Pil Hong | 2014 | World Journal of Gastroenterology2014，20，21： | 11 |
| 2 | Predictors for difficult cecal insertion in colonoscopy: The impact of obesity indices显示文摘AIM To identify the factors influencing cecal insertion time(CIT) and to evaluate the effect of obesity indices on CIT. METHODS We retrospectively reviewed the data for participants who received both colonoscopy and abdominal computed tomography(CT) from February 2008 to May 2008 as part of a comprehensive health screening program. Age, gender, obesity indices [body mass index(BMI), waist-to-hip circumference ratio(WHR), waist circumference(WC), visceral adipose tissue(VAT)volume and subcutaneous adipose tissue(SAT) volume on abdominal CT], history of prior abdominal surgery, constipation, experience of the colonoscopist, quality of bowel preparation, diverticulosis and time required to reach the cecum were analyzed. CIT was categorized as longer than 10 min(prolonged CIT) and shorter than or equal to 10 min, and then the factors that required a CIT longer than 10 min were examined.RESULTS A total of 1678 participants were enrolled. The mean age was 50.42 ± 9.931 years and 60.3% were men. The mean BMI, WHR, WC, VAT volume and SAT volume were 23.92 ± 2.964 kg/m2, 0.90 ± 0.076, 86.95 ± 8.030 cm, 905.29 ± 475.220 cm3 and 1707.72 ± 576.550 cm3, respectively. The number of patients who underwent abdominal surgery was 268(16.0%). Colonoscopy was performed by an attending physician alone in 61.9% of cases and with the involvement of a fellow in 38.1% of cases. The median CIT was 7 min(range 2-56 min, IQR 5-10 min), and mean CIT was 8.58 ± 5.291 min. Being female, BMI, VAT volume and involvement of fellow were significantly associated with a prolonged CIT in univariable analysis. In multivariable analysis, being female(OR = 1.29, P = 0.047), lower BMI(< 23 kg/m2)(OR = 1.62, P = 0.004) or higher BMI(≥ 25 kg/m2)(OR = 1.80, P < 0.001), low VAT volume(< 500 cm3)(OR = 1.50, P = 0.013) and fellow involvement(OR = 1.73, P < 0.001) were significant predictors of prolonged CIT. In subgroup analyses for gender, lower BMI or higher BMI and fellow involvement were predictors for prolonged CIT in both genders. However, low VAT volume was associated with prolonged CIT in only women(OR = 1.54, P = 0.034).CONCLUSION Being female, having a lower or higher BMI than the normal range, a low VAT volume, and fellow involvement were predictors of a longer CIT. | Soo Yun Moon Byung Chang Kim Dae Kyung Sohn Kyung Su Han Bun Kim Chang Won Hong Bum Joon Park Kum Hei Ryu Ji Hyung Nam | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 3 | Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours显示文摘 | Jaihwan Kim Woo Jin Lee Sang Hyub Lee Kyoung Bun Lee Ji Kon Ryu Yong-Tae Kim Sun-Whe Kim Yong Bum Yoon Jin Hyeok Hwang Ho-Seong Han Sang Myung Woo Sang Jae Park | 2011 | Digestive and Liver Disease2011，，12： | 3 |
| 4 | Risk Factors and Prognosis of Pulmonary Complications After Endoscopic Submucosal Dissection for Gastric Neoplasia显示文摘 | Chan Hyuk Park Hyunzu Kim Young Ae Kang In Rae Cho Bun Kim Su Jin Heo Suji Shin Hyuk Lee Jun Chul Park Sung Kwan Shin Yong Chan Lee Sang Kil Lee | 2013 | Digestive Diseases and Sciences2013，，2： | 2 |
| 5 | Photochromic liquid crystalline cyclic siloxanes containing spiropyran groups显示文摘 | Natarajan L V Bunning T J Kim S Y | 1994 | Macromolecules1994，27，： | 1 |
| 6 | Proximal disease extension and related predicting factors in ulcerative proctitis显示文摘 | Bun Kim Soo Jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Jae Hee Cheon | 2014 | Scandinavian Journal of Gastroenterology2014，，： | 1 |
| 7 | Photochromic liquidcrystalline cylic sioxanes containing spiropyran groups显示文摘 | Natarajan L V Bunning T J Kim S Y | 1994 | Macromolecules1994，27，： | 1 |
| 8 | Early versus delayed laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage显示文摘 | In Woong Han Jin-Young Jang Mee Joo Kang Kyoung Bun Lee Seung Eun Lee Sun-Whe Kim | 2012 | Journal of Hepato - Biliary - Pancreatic Sciences2012，，2： | 1 |
| 9 | Evaluation of the hepatic artery in potential donors for living donor liver transplantation by computed tomography angiography using multidetector row computed tomography:comparison of volume rendering and maximum intensity projection techniques显示文摘 | Bun JH Kim TK Lee SS | 2003 | J Comput Assist Tomogr2003，27，2： | 1 |
| 10 | Photochromic liquidcrystalline cylic sioxanes containing spiropyran groups显示文摘 | Natarajan L V Bunning T J Kim S Y | 1994 | Macromolecules1994，27，： | 1 |
| 11 | Photochromic liquid crystalline cylic sioxanes containing spiropyran groups显示文摘 | Natarajan L V Bunning T J Kim S Y | 1994 | Macromolecules1994，27，： | 1 |
| 12 | Eow - temperature sintering of MnO2-doped PZT-PZN Piezoelectric ceramics 显示文摘 | Sung - Mi Lee Seung- Ho Lee Chang- Bun Yoon Hyoun - Ee Kim Kyung - Woo Lee | 2007 | J Electroceram2007，18，： | 1 |
| 13 | 17β-Estradiol attenuates vascular contraction through inhibition of RhoA/Rho kinase pathway显示文摘 | Enyue Yang Su Bun Jeon Inji Baek Zheng-ai Chen Zheng Jin In Kyeom Kim | 2009 | Naunyn-Schmiedeberg’s Archives of Pharmacology2009，，1： | 1 |
| 14 | Photochromic liquid crystalline cyclic siloxanes containing spiropyran groups 显示文摘 | Natarajan L V Bunning T J Kim S Y | 1994 | Macromolecules1994，27，25： | 1 |
| 15 | Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells显示文摘 | Dong Joon Kim Young Soo Park Min Gu Kang Yeon-Mi You Yuri Jung Han Koo Jung-Ae Kim Mi-Ju Kim Seung-Mo Hong Kyong Bun Lee Ja-June Jang Kyung Chan Park Young Il Yeom | 2015 | Experimental Cell Research2015，，1： | 1 |
| 16 | Heparin resitance during cardiopulmonary bypass 显示文摘 | Hyun Ju Jung Jong Bun Kim Kyong Shil lm | 2009 | Journal of Cardiovascular Medicine2009，10，： | 1 |
| 17 | Clinical meaning of BRAF mutation in Korean patients with advanced colorectal cancer显示文摘AIM:To evaluate the clinicopathological features ofcolorectal cancer(CRC)with a v-Raf murine sarcomaviral oncogene homolog B1(BRAF)mutation and itsmolecular interaction with microsatellite instability(MSI)and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)in patients with advanced CRCs.METHODS:From October 2009 to December 2011,141 patients with stageⅢ(n=51)orⅣ(n=90)CRCs who were tested for the BRAF mutation at Severance Hospital were included.Among 141 patients,fivewere excluded due to follow-up loss.Therefore,136patients were included in the study.The clinicopathological data,MSI status,and KRAS/BRAF mutation status were reviewed retrospectively.In addition,to evaluating the value of BRAF mutation status,progressionfree survival and overall survival in all patients werecollected and compared between the BRAF wild-typegroup and BRAF mutation group.RESULTS:Of 136 patients,80(58.8%)were male and the mean age was 59 years.BRAF and KRAS mutations were detected in 9.6%and 35.3%of patients,respectively.Only 4.3%of patients had MSIhigh tumors and there were no MSI-high in tumors with a BRAF mutation.BRAF mutations tended to be more frequent in stageⅣthan in stageⅢ(11.76%vs 5.88%,P=0.370).Patients with a BRAF mutation had a lower incidence of KRAS mutation than those without(7.69%vs 38.21%,P=0.033).Overall survival was significantly shorter in the BRAF mutation group than in the BRAF wild-type group both by univariate analysis(P=0.041)and multivariate analysis(HR=2.195;95%CI:1.039-4.640;P=0.039),while progression-free survival was not different according to BRAF mutation status.CONCLUSION:CRCs with a BRAF mutation have distinct molecular features and resulted in a poor prognosis in Korean patients with advanced CRC. | Bun Kim Soo Jung Park Jae Hee Cheon Tae Il Kim Won Ho Kim Sung Pil Hong | 2014 | World Journal of Gastroenterology2014，20，15： | 0 |
| 18 | 一生一歌乌镇木心美术馆显示文摘浙江乌镇东栅是著名旅美文学家、画家木心的故乡.为了纪念这位文化名人,在2014年时,当地就将乌镇的东栅财神湾168号“晚晴小筑”辟为的木心故居纪念馆;而此次位于西栅的木心美术馆,文化乌镇股份有限公司更是请到美国OLI建筑设计事务所设计督造,两位合伙人冈本博与林兵,历时4年,精心打造,美术馆于2015年11月正式开馆. | 时颜(整理) 冈本博 AIA 林兵 Fabian Servagnat Steve Hopkins AIA Po Chen Dongshin Lee Muzhi Chen Michael Zhao Grace Kim Michael Pryor S.J.Kwon Remi Bun Jerry Lu Shen Zhonghai(摄影) 无 | 2016 | 室内设计与装修2016，0，7： | 0 |
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