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| 1 | A Data-Driven Clustering Recommendation Method for Single-Cell RNA-Sequencing Data显示文摘Recently,the emergence of single-cell RNA-sequencing(scRNA-seq)technology makes it possible to solve biological problems at the single-cell resolution.One of the critical steps in cellular heterogeneity analysis is the cell type identification.Diverse scRNA-seq clustering methods have been proposed to partition cells into clusters.Among all the methods,hierarchical clustering and spectral clustering are the most popular approaches in the downstream clustering analysis with different preprocessing strategies such as similarity learning,dropout imputation,and dimensionality reduction.In this study,we carry out a comprehensive analysis by combining different strategies with these two categories of clustering methods on scRNA-seq datasets under different biological conditions.The analysis results show that the methods with spectral clustering tend to perform better on datasets with continuous shapes in two-dimension,while those with hierarchical clustering achieve better results on datasets with obvious boundaries between clusters in two-dimension.Motivated by this finding,a new strategy,called QRS,is developed to quantitatively evaluate the latent representative shape of a dataset to distinguish whether it has clear boundaries or not.Finally,a data-driven clustering recommendation method,called DDCR,is proposed to recommend hierarchical clustering or spectral clustering for scRNA-seq data.We perform DDCR on two typical single cell clustering methods,SC3 and RAFSIL,and the results show that DDCR recommends a more suitable downstream clustering method for different scRNA-seq datasets and obtains more robust and accurate results. | Yu Tian Ruiqing Zheng Zhenlan Liang Suning Li Fang-Xiang Wu Min Li | 2021 | Tsinghua Science and Technology2021，26，5： | 3 |
| 2 | Recent Progress and Perspectives of Sodium Metal Anodes for Rechargeable Batteries显示文摘Sodium metal anodes have attracted significant attention due to their high specific capacity,low redox potential and abundant resources.However,the dendrites and unstable solid electrolyte interphase(SEI)of sodium anodes restrict the development of sodium metal batteries.This review includes the recent progress on the Na anode protection in sodium metal batteries.The strategies are summarized as modified three-dimensional current collectors,artificial solid electrolyte interphases,and electrolyte modifications.Conclusions and perspectives are envisaged for the further understanding and development of Na metal anodes. | FANG Hengyi GAO Suning ZHU Zhuo REN Meng WU Quan LI Haixia LI Fujun | 2021 | Chemical Research in Chinese Universities2021，37，2： | 3 |
| 3 | Effects of microlens array orientation errors on plenoptic imaging of flame radiative properties and uncertainty analysis显示文摘Plenoptic imaging(PI)systems can flexibly record both spatial and angular information on flame radiation,enabling volumetric reconstruction of complex flames.The accuracy and efficiency of the reconstruction are significantly affected by the orientation parameters of the microlens array(MLA)in the system.To investigate the influence of potential parameter errors on flame light fields,we establish a typical orientation error model and employ ray-splitting-based Monte Carlo method to simulate the entire and sectioned PI for the three-dimensional flame under four error conditions,in which different radiative properties of flame(extinction coefficient,scattering albedo,and scattering phase function)are considered.Through the proposed uncertainty evaluation scheme,the flame image characteristics,intensity,structure deviations,and their local distribution for four error types are analyzed.The results show that the extinction coefficient and the MLA error type determine the flame PI uncertainty features,while the scattering properties only change the deviation levels.The major impact of the extinction coefficient on the transfer and accumulation of uncertainty in flame-sectioned PI is also revealed. | LI SuNing YUAN Yuan TAN HePing | 2021 | Science China(Technological Sciences)2021，64，10： | 1 |
| 4 | RecCac:Recommendation-Empowered Cooperative Edge Caching for Internet of Things显示文摘Edge caching is an emerging technology for supporting massive content access in mobile edge networks to address rapidly growing Internet of Things(IoT)services and content applications.However,the edge server is limited with the computation/storage capacity,which causes a low cache hit.Cooperative edge caching jointing neighbor edge servers is regarded as a promising technique to improve cache hit and reduce congestion of the networks.Further,recommender systems can provide personalized content services to meet user’s requirements in the entertainment-oriented mobile networks.Therefore,we investigate the issue of joint cooperative edge caching and recommender systems to achieve additional cache gains by the soft caching framework.To measure the cache profits,the optimization problem is formulated as a 0-1 Integer Linear Programming(ILP),which is NP-hard.Specifically,the method of processing content requests is defined as server actions,we determine the server actions to maximize the quality of experience(QoE).We propose a cachefriendly heuristic algorithm to solve it.Simulation results demonstrate that the proposed framework has superior performance in improving the QoE. | HAN Suning LI Xiuhua SUN Chuan WANG Xiaofei Victor C.M.LEUNG | 2021 | ZTE Communications2021，19，2： | 1 |
| 5 | Computational and electrochemical studies on the inhibition of corrosion of mild steel by L-cysteine and its derivatives显示文摘 | Fu Jiajun Li Suning Wang Ying | 2011 | Journal of Materials Science2011，46，10： | 1 |
| 6 | Malignant versus benign nodules at CT screening for lung cancer: comparison of thin-section CT findings显示文摘 | Li F Sune S Abe H | 2004 | Radiology2004，233，： | 1 |
| 7 | Development and formation of wing cuticle based on transcriptomic analysis in Locusta migratoria during metamorphosis显示文摘Wings are an important flight organ of insects.Wing development is a complex process controlled by a series of genes.The flightless wing pad transforms into a mature wing with the function of migratory flight during the nymphto-adult metamorphosis.However,the mechanism of wing morphogenesis in locusts is still unclear.This study analyzed the microstructures of the locust wing pads at pre-eclosion and the wings after eclosion and performed the comparative transcriptome analysis.RNA-seq identified 25,334 unigenesand 3,430 differentially expressed genes(DEGs)(1,907 up-regulated and 1,523 down-regulated).The DEGs mainly included cuticle development(LmACPs),chitin metabolism(Lm Idgf4),lipid metabolism-related genes,cell adhesion(Integrin),zinc finger transcription factors(LmSalm,LmZF593 andLmZF521),and others.Functional analysis based on RNA interference and hematoxylin and eosin(H&E)staining showed that the three genes encoded zinc finger transcription factors are essential for forming wing cuticle and maintaining morphology in Locusta migratoria.Finally,the study found that the LmSalm regulates the expression of LmACPs in the wing pads at pre-eclosion,and LmZF593 and LmZF521 regulate the expression of LmIntegrin/LmIdgf4/LmHMT420 in the wings after eclosion.This study revealed that the molecular regulatory axis controls wing morphology in nymphal and adult stages of locusts,offering a theoretical basis for the study of wing development mechanisms in hemimetabolous insects. | Jing Zhang Zhaochen Wu Shuo Li He Huang Suning Liu Weimin Liu Xiaoming Zhao Jianzhen Zhang | 2024 | Journal of Integrative Agriculture2024，23，4： | 0 |
| 8 | Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)显示文摘Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma(BCL)due to their reliable efficacy,manageable safety,high accessibility,and convenience for use.Still,no guidelines or consensus focusing on oral drug therapies for BCL is available.To provide a reference of oral agent-based treatment for mature BCL,a panel of experts from the Lymphocyte Disease Group,Chinese Society of Hematology,Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugs for Chinese BCL patients on the basis of the current application status of oral drugs in China,combined with the latest authoritative guidelines in the world and current research reports.This consensus reviewed the application of oral drugs in the treatment of BCL and the latest research and provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients.With the deepening of research and the development of standardized clinical applications,oral medications will bring better treatment to BCL patients,enabling more patients to benefit from them. | Suning Chen Weili Zhao Jianyong Li Depei Wu on behalf of Lymphoid Disease Group,Chinese Society of Hematology,Chinese Medical Association | 2022 | Frontiers of Medicine2022，16，5： | 0 |
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