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1Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission.Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li 2021China CDC weekly2021,3,27:51
2Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal.Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang 2000World Journal of Gastroenterology2000,6,6:28
3TANDEM and GMAW Twin Wire Welding of Q690 Steel Used in Hydraulic Support显示文摘Compared with using semi-automatic gas shielded arc welding, using automatic TANDEM twin wire welding and twin wire gas metal arc welding (GMAW) to weld Q690 steel, a low-alloy high-strength structural steel used in the hydraulic support in the fully-mechanized mining face, the welding speed, deposition rate, production environment and welding quality can be obviously improved. Compared with GMAW twin wire welding, a refined microstructure in the weld and heat-affected zone (HAZ), narrow HAZ and improved joint strength were achieved with TANDEM on Q690. Also, due to the push-pull pulsed way in TANDEM welding, the droplet transfer, distribution on heat flow and interaction between two arcs were completely different from those in GMAW twin wire system. The heat input of TANDEM is only about 76.6% of GMAW, and correspondingly, the welding speed and welding seam can be obviously improved. The complete oscillation caused by TANDEM pulsed current occurred in the welding pool, which refined the grains in the microstructure. The results show that TANDEM twin wire welding is very suitable in the welding of Q690 used in the hydraulic support.FANG Chen-fu MENG Xiao-hui HU Qing-xian WANG Feng-jiang REN He WANG Hai-song GUO Yu MAO Ming 2012Journal of Iron and Steel Research(International)2012,19,5:22
4Deep carbon cycles constrained by a large-scale mantle Mg isotope anomaly in eastern China显示文摘Although deep carbon recycling plays an important role in the atmospheric CO_2 budget and climate changes through geological time,the precise mechanisms remain poorly understood.Since recycled sedimentary carbonate through plate subduction is the main light-δ^(26)Mg reservoir within deep-Earth,Mg isotope variation in mantle-derived melts provides a novel perspective when investigating deep carbon cycling.Here,we show that the Late Cretaceous and Cenozoic continental basalts from 13 regions covering the whole of eastern China have low δ^(26)Mg isotopic compositions,while the Early Cretaceous basalts from the same area and the island arc basalts from circum-Paciic subduction zones have mantle-like or heavy Mg isotopic characteristics.hus,a large-scale mantle low δ^(26)Mg anomaly in eastern China has been delineated,suggesting the contribution of sedimentary carbonates recycled into the upper mantle,but limited into the lower mantle.his large-scale spatial and temporal variation of Mg isotopes in the mantle places severe constraints on deep carbon recycling via oceanic subduction.Shu-Guang Li Wei Yang Shah Ke Xunan Meng Hengci Tian Lijuan Xu Yongsheng He Jian Huang Xuan-Ce Wang Qunke Xia Weidong Sun Xiaoyong Yang Zhong-Yuan Ren Haiquan Wei Yongsheng Liu Fancong Meng Jun Yan 2017National Science Review2017,4,1:23
5Tongguan Liqiao acupuncture therapy improves dysphagia after brainstem stroke显示文摘Tongguan Liqiao acupuncture therapy has been shown to effectively treat dysphagia after stroke-based pseudobulbar paralysis. We presumed that this therapy would be effective for dysphagia after bulbar paralysis in patients with brainstem infarction. Sixty-four patients with dysphagia following brainstem infarction were recruited and divided into a medulla oblongata infarction group(n = 22), a midbrain and pons infarction group(n = 16), and a multiple cerebral infarction group(n = 26) according to their magnetic resonance imaging results. All patients received Tongguan Liqiao acupuncture for 28 days. The main acupoints were Neiguan(PC6), Renzhong(DU26), Sanyinjiao(SP6), Fengchi(GB20), Wangu(GB12), and Yifeng(SJ17). Furthermore, the posterior pharyngeal wall was pricked. Before and after treatment, patient swallowing functions were evaluated with the Kubota Water Test, Fujishima Ichiro Rating Scale, and the Standard Swallowing Assessment. The Barthel Index was also used to evaluate their quality of life. Results showed that after 28 days of treatment, scores on the Kubota Water Test and Standard Swallowing Assessment had decreased, but scores on the Fujishima Ichiro Rating Scale and Barthel Index had increased in each group. The total efficacy rate was 92.2% after treatment, and was most obvious in patients with medulla oblongata infarction(95.9%). These findings suggest that Tongguan Liqiao acupuncture therapy can repair the connection of upper motor neurons to the medulla oblongata motor nucleus, promote the recovery of brainstem infarction, and improve patient's swallowing ability and quality of life.Chun-hong Zhang Jin-ling Bian Zhi-hong Meng Li-na Meng Xue-song Ren Zhi-lin Wang Xiao-yan Guo Xue-min Shi 2016Neural Regeneration Research2016,11,2:21
6APC and K-ras gene mutation in aberrant crypt foci of human colon显示文摘AIM To study the genetic alteration in ACF andto define the possibility that ACF may be a veryearly morphological lesion with molecularchanges, and to explore the relationshipbetween ACF and colorectal adenoma evencarcinoma.METHODS DNA from 35 CRC, 15 adenomas, 34ACF and 10 normal mucus was isolated by meansof microdissection. Direct gene sequencing of K-ras gene including codon 12, 13 and 61 as well asthe mutation cluster region (MCR) of APC genewas performed.RESULTS K-ras gene mutation frequency inACF, adenoma and carcinoma was 17.6% (6/34), 13.3% (2/ 15), and 14.3% (5/ 35)respectively, showing no difference ( P > 0.05)in K-fas gene mutation among three pathologicprocedures. The K-ras gene mutation inadenoma, carcinoma and 4 ACF restricted incodon 12 (GGT→GAT), but the other 2 mutationsfrom ACF located in codon 13 (GGC→GAC). K-res gene mutation was found more frequently inolder patients and patients with polypoidcancer. No mutation in codon 61 was found in thethree tissue types. Mutation rate of APO gene inadenoma and carcinoma was 22.9% (8/35) and26.7% (4/ 15), which was higher than ACF(2.9%) (P < 0.05). APC gene mutation incarcinoma was not correlated with age ofpatients, location, size and differentiation oftumor.CONCLUSION ACF might be a very earlymorphological lesion in the tumorogenesis ofcolorectal tumor. The morphological feature andgene mutation status was different in ACF andadenoma. ACF is possibly putative'microadenoma' that might be the precursor ofadenoma. In addition, the development of asubgroup of colorectal carcinomas mightundergo a way of 'normal epithelium→ ACF→carcinomas'.Ping Yuan~1 Meng Hong Sun~2 Jin Sheng Zhang~1 Xiong Zeng Zhu~2 Da Ren Shi~2 ~1Department of Pathology,Medical College of Fudan University,~2Department of Pathology,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,ChinaDr.Ping Yuan Studying Province.studying in Medical College of Fudan University,worked in Department of Pathology,Wannan Medical College,having eighteen papers published. 2001World Journal of Gastroenterology2001,7,3:20
7Excellent Structure-Based Multifunction of Morpho Butterfly Wings: A Review显示文摘Shichao Niu Bo Li Zhengzhi Mu Meng Yang Junqiu Zhang Zhiwu Han Luquan Ren 2015Journal of Bionic Engineering2015,12,2:19
8Interactive effects of wind speed,vegetation coverage and soil moisture in controlling wind erosion in a temperate desert steppe,Inner Mongolia of China显示文摘The rapid desertification of grasslands in Inner Mongolia of China poses a significant ecological threaten to northern China. The combined effects of anthropogenic disturbances(e.g., overgrazing) and biophysical processes(e.g., soil erosion) have led to vegetation degradation and the consequent acceleration of regional desertification. Thus, mitigating the accelerated wind erosion, a cause and effect of grassland desertification, is critical for the sustainable management of grasslands. Here, a combination of mobile wind tunnel experiments and wind erosion model was used to explore the effects of different levels of vegetation coverage, soil moisture and wind speed on wind erosion at different positions of a slope inside an enclosed desert steppe in the Xilamuren grassland of Inner Mongolia. The results indicated a significant spatial difference in wind erosion intensities depending on the vegetation coverage, with a strong decreasing trend from the top to the base of the slope. Increasing vegetation coverage resulted in a rapid decrease in wind erosion as explained by a power function correlation. Vegetation coverage was found to be a dominant control on wind erosion by increasing the surface roughness and by lowering the threshold wind velocity for erosion. The critical vegetation coverage required for effectively controlling wind erosion was found to be higher than 60%. Further, the wind erosion rates were negatively correlated with surface soil moisture and the mass flux in aeolian sand transport increased with increasing wind speed. We developed a mathematical model of wind erosion based on the results of an orthogonal array design. The results from the model simulation indicated that the standardized regression coefficients of the main effects of the three factors(vegetation coverage, soil moisture and wind speed) on the mass flux in aeolian sand transport were in the following order: wind speed>vegetation coverage>soil moisture. These three factors had different levels of interactive effects on the mass flux in aeolian sand transport. Our results will improve the understanding of the interactive effects of wind speed, vegetation coverage and soil moisture in controlling wind erosion in desert steppes, and will be helpful for the design of desertification control programs in future.MENG Zhongju DANG Xiaohong GAO Yong REN Xiaomeng DING Yanlong WANG Meng 2018Journal of Arid Land2018,10,4:19
9From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed.Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou 2016Matter and Radiation at Extremes2016,1,1:19
10Curcumin inhibits hepatitis B virus infection by downregulating ccc DNA-bound histone acetylation显示文摘AIM To investigate the potential effect of curcumin on hepatitis B virus(HBV) covalently closed circular DNA(ccc DNA) and the underlying mechanism.METHODS A Hep G2.2.15 cell line stably transfected with HBV was treated with curcumin, and HBV surface antigen(HBs Ag) and e antigen(HBe Ag) expression levels were assessed by ELISA. Intracellular HBV DNA replication intermediates and ccc DNA were detected by Southern blot and real-time PCR, respectively. The acetylation levels of histones H3 and H4 were measured by Western blot. H3/H4-bound ccc DNA was detected by chromatin immunoprecipitation(Ch IP) assays. The deacetylase inhibitors trichostatin A and sodium butyrate were used to study the mechanism of action for curcumin. Additionally, short interfering RNAs(si RNAs) targeting HBV were tested along with curcumin.RESULTS Curcumin treatment led to time-and dose-dependent reductions in HBs Ag and HBe Ag expression and significant reductions in intracellular HBV DNA replication intermediates and HBV ccc DNA. After treatment with 20 μmol/L curcumin for 2 d, HBs Ag and ccc DNA levels in Hep G2.2.15 cells were reduced by up to 57.7%(P < 0.01) and 75.5%(P < 0.01), respectively, compared with levels in non-treated cells. Meanwhile, time-and dose-dependent reductions in the histone H3 acetylation levels were also detected upon treatment with curcumin, accompanied by reductions in H3-and H4-bound ccc DNA. Furthermore, the deacetylase inhibitors trichostatin A and sodium butyrate could block the effects of curcumin. Additionally, transfection of si RNAs targeting HBV enhanced the inhibitory effects of curcumin.CONCLUSION Curcumin inhibits HBV gene replication via downregulation of ccc DNA-bound histone acetylation and has the potential to be developed as a ccc DNA-targeting antiviral agent for hepatitis B.Zhi-Qiang Wei Yong-Hong Zhang Chang-Zheng Ke Hong-Xia Chen Pan Ren Yu-Lin He Pei Hu De-Qiang Ma Jie Luo Zhong-Ji Meng 2017World Journal of Gastroenterology2017,23,34:18
11COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented.Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu 2021China CDC weekly2021,3,21:16
12Coping as a Mechanism Linking Stressful Life Events and Mental Health Problems in Adolescents显示文摘Objective Although stressful life events represent an etiologic factor of mental health problems in adolescents,few studies have been conducted to address mechanisms linking the stress‐psychopathology relation.The present study was designed to examine coping as a mediate factor on the relationship between stressful life events and symptoms of anxiety and depression.Methods The participants were 13 512 students from eight cities of China,who participated in a school‐based survey.Data were collected by a questionnaire comprising coping,stressful life events,anxiety,and depressive symptoms.As a model,a series of regression equations were used to examine whether coping mediated the association between stressful life events and symptoms of anxiety and depression.Results Each dimension of stressful life events showed significant correlation with anxiety,depression and coping (all P<0.001).In the model to analyze mediate effects,all standardized coefficients (β) were significant (all P<0.01),indicating marked mediator effects.Furthermore,negative coping might account for more mediate effects than positive coping on this relationship.Conclusion Coping partially mediated the relationship between stressful life events and mental health during adolescence.This study highlighted an important public health priority for preventive interventions targeting stress‐related psychopathology,and for further promoting adolescents'mental health.MENG Xiu Hong TAO Fang Biao WAN Yu Hui HU Yan WANG Ren Xi 2011Biomedical and Environmental Sciences2011,24,6:16
13Paleogene Tectonic Evolution Controls on Sequence Stratigraphic Patterns in the Central Part of Deepwater Area of Qiongdongnan Basin, Northern South China Sea显示文摘In active rift basins, tectonism is extremely important for sequence stratigraphic patterns, affecting both the sequence architecture and internal makeup. Sequence stratigraphic framework of a Paleogene rift succession in Qiongdongnan Basin, northern South China Sea, was built using seismic profiles, complemented by well logs and cores. One first-order and three second-order sequences were identified on the basis of basin-scale unconformities, and seven third-order sequences are defined by unconformities along the basin margins and correlative conformities within the central basin. Through unconformity analysis and backstripping procedure, the Paleogene synrift tectonic evolution of deepwater area of Qiongdongnan Basin was proved to be episodic, which can be divided into rifting stage-I, rifting stage-II and rifting stage-III. Episodic rifting resulted in the formation of various types of structural slope break belts, which controlled different architectures and internal makeup of sequences. This study enhances the understanding of the control of tectonic evolution on sequence stratigraphic patterns and establishes relevant patterns in a typical rift basin, and further proposes the favorable sandstone reservoirs developing in different sequence stratigraphic patterns, which will be pretty helpful for subtle pool exploration in deepwater area of petroliferous basins.Guangzeng Song Hua Wang Huajun Gan Zhipeng Sun Xiaolong Liu Meng Xu Jinfeng Ren Ming Sun Di Sun 2014Journal of Earth Science2014,25,2:16
14Effect of Saccharomyces cerevisiae on alfalfa nutrient degradation characteristics and rumen microbial populations of steers fed diets with different concentrate-to-forage ratios显示文摘Live yeast(Saccharomyces cerevisiae) constitutes an effective additive for animal production;its probiotic effect may be related to the concentrate-to-forage ratio(CTFR).The objective of this study was to assess the effects of S.cerevisiae(SC) on fiber degradation and rumen microbial populations in steers fed diets with different levels of dietary concentrate.Ten Simmental × Local crossbred steers(450 ± 50 kg BW) were assigned to a control group or an SC group.Both groups were fed the same basal diet but the SC group received SC supplementation(8 × 10~9 cfu/h/d through the ruminal fistula)following a two-period crossover design.Each period consisted of four phases,each of which lasted 17 d:10 d for dietary adaptation,6 d for degradation study,and 1 d for rumen sample collection.From the 1^(st) to the 4^(th) phase,steers were fed in a stepwise fashion with increasing CTFRs,i.e.,30:70,50:50,70:30,and 90:10.The kinetics of dry matter and fiber degradation of alfalfa pellets were evaluated;the rumen microbial populations were detected using real-time PCR.The results revealed no significant(P> 0.05) interactions between dietary CTFR and SC for most parameters.Dietary CTFR had a significant effect(P< 0.01) on degradation characteristics of alfalfa pellets and the copies of rumen microorganism;the increasing concentrate level resulted in linear,quadratic or cubic variation trend for these parameters.SC supplementation significantly(P< 0.05) affected dry matter(DM) and neutral detergent fiber(NDF)degradation rates(c_(DM),c_(NDF)) and NDF effective degradability(ED_(NDF)).Compared with the control group,there was an increasing trend of rumen fungi and protozoa in SC group(P < 0.1);copies of total bacteria in SC group were significantly higher(P< 0.05).Additionally,percentage of Ruminobacter amylophilus was significantly lower(P< 0.05)but percentage of Selenomonas ruminantium was significantly higher(P< 0.05) in the SC group.In a word,dietary CTFR had a significant effect on degradation characteristics of forage and rumen microbial population.S.cerevisiae had positive effects on DM and NDF degradation rate or effective degradability of forage;S.cerevisiae increased rumen total bacteria,fungi,protozoa,and lactate-utilizing bacteria but reduced starch-degrading and lactate-producing bacteria.Gengzhi Ding Ying Chang Liping Zhao Zhenming Zhou Liping Ren Qingxiang Meng 2014Journal of Animal Science and Biotechnology2014,5,4:15
15COL4A3 mutations cause focal segmenta glomerulosclerosis显示文摘Jingyuan Xie Xiaoxi Wu Hong Ren Weiming Wang Zhaohui Wang Xiaoxia Pan Xu Hao Jun Tong Jun Ma Zhibin Ye Guoyu Meng Yufei Zhu Krzysztof Kiryluk Xiangyin Kong Landian Hu Nan Chen 2014Journal of Molecular Cell Biology2014,8,6:15
16Experimental investigation of shale imbibition capacity and the factors influencing loss of hydraulic fracturing fluids显示文摘Spontaneous imbibition of water-based fracturing fluids into the shale matrix is considered to be the main mechanism responsible for the high volume of water loss during the flowback period. Understanding the matrix imbibition capacity and rate helps to determine the fracturing fluid volume, optimize the flowback design, and to analyze the influences on the production of shale gas.Imbibition experiments were conducted on shale samples from the Sichuan Basin, and some tight sandstone samples from the Ordos Basin. Tight volcanic samples from the Songliao Basin were also investigated for comparison. The effects of porosity, clay minerals, surfactants, and KCl solutions on the matrix imbibition capacity and rate were systematically investigated. The results show that the imbibition characteristic of tight rocks can be characterized by the imbibition curve shape, the imbibition capacity, the imbibition rate, and the diffusion rate. The driving forces of water imbibition are the capillary pressure and the clay absorption force. For the tight rocks with low clay contents,the imbibition capacity and rate are positively correlated with the porosity. For tight rocks with high clay content,the type and content of clay minerals are the most important factors affecting the imbibition capacity. The imbibed water volume normalized by the porosity increases with an increasing total clay content. Smectite and illite/smectite tend to greatly enhance the water imbibition capacity.Furthermore, clay-rich tight rocks can imbibe a volume ofwater greater than their measured pore volume. The average ratio of the imbibed water volume to the pore volume is approximately 1.1 in the Niutitang shale, 1.9 in the Lujiaping shale, 2.8 in the Longmaxi shale, and 4.0 in the Yingcheng volcanic rock, and this ratio can be regarded as a parameter that indicates the influence of clay. In addition,surfactants can change the imbibition capacity due to alteration of the capillary pressure and wettability. A 10wt% KCl solution can inhibit clay absorption to reduce the imbibition capacity.Hong-Kui Ge Liu Yang Ying-Hao Shen Kai Ren Fan-Bao Meng Wen-Ming Ji Shan Wu 2015Petroleum Science2015,12,4:13
17A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice.Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan 2019Cell Research2019,29,10:13
18Vagus Nerve Stimulation for Pediatric and Adult Patients with Pharmaco-resistant Epilepsy显示文摘Fan-Gang Meng Fu-Min Jia Xiao-Hui Ren Yan Ge Kai-Liang Wang Yan-Shan Ma Ming Ge Kai Zhang Wen-Han HU Xin Zhang Wei Hu Jian-Guo Zhang 2015Chinese Medical Journal2015,,19:13
19A unifying approach in simulating the shot peening process using a 3D random representative volume finite element model显示文摘Using a modified 3D random representative volume(RV)finite element model,the effects of model dimensions(impact region and interval between impact and representative regions),model shapes(rectangular,square,and circular),and peening-induced thermal softening on resultant critical quantities(residual stress,Almen intensity,coverage,and arc height)after shot peening are systematically examined.A new quantity,i.e.,the interval between impact and representative regions,is introduced and its optimal value is first determined to eliminate any boundary effect on shot peening results.Then,model dimensions are respectively assessed for all model shapes to reflect the actual shot peening process,based on which shape-independent critical shot peening quantities are obtained.Further,it is found that thermal softening of the target material due to shot peening leads to variances of the surface residual stress and arc height,demonstrating the necessity of considering the thermal effect in a constitutive material model of shot peeing.Our study clarifies some of the finite element modeling aspects and lays the ground for accurate modeling of the SP process.Dianyin HU Ye GAO Fanchao MENG Jun SONG Yanfei WANG Mengxi REN Rongqiao WANG 2017Chinese Journal of Aeronautics2017,30,4:13
20The next-generation sequencing technology and application显示文摘As one of the key technologies in biomedical research,DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few years.This is largely due to the advent of newer generations of sequencing platforms,offering ever-faster and cheaper ways to analyze sequences.In our previous review,we looked into technical characteristics of the nextgeneration sequencers and provided prospective insights into their future development.In this article,we present a brief overview of the advantages and shortcomings of key commercially available platforms with a focus on their suitability for a broad range of applications.Xiaoguang Zhou Lufeng Ren Qingshu Meng Yuntao Li Yude Yu Jun Yu 2010Protein & Cell2010,1,6:13
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