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| 1 | Significance of hepatitis virus infection in the oncogenicinitiation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common causes of cancer-related death worldwide. Chronic infection of hepatitis B virus(HBV) and/or hepatitis C virus(HCV) is a major risk factor in the development of the HCC, independently from excessive alcohol abuse and metabolic disease. Since the biology of HBV and HCV is different, their oncogenic effect may go through different mechanisms, direct and/or indirect. Viral hepatitis infection is associated with cellular inflammation, oxidative stress, DNA damage, that may lead to subsequent hepatic injuries such as chronic hepatitis, fibrosis, cirrhosis, and finally HCC. Direct oncogenic properties of these viruses are related with their genotypic characteristics and the ability of viral proteins to interact with host proteins, thus altering the molecular pathways balance of the cells. In addition, the integration of HBV DNA, especially the gene S and X, in a particular site of the host genome can disrupt chromosomal stability and may activate various oncogenic mechanisms, including those in hematopoietic cells. Recently, several studies also had demonstrated that viral hepatitis could trigger the population of hepatic cancer stem cells. This review summarize available pre-clinical and clinical data in literature regarding oncogenic properties of HBV and HCV in the early initiation of HCC. | Caecilia HC Sukowati Korri E El-Khobar Susan I Ie Beatrice Anfuso David H Muljono Claudio Tiribelli | 2016 | World Journal of Gastroenterology2016，22，4： | 18 |
| 2 | Shoot and root traits in drought tolerant maize(Zea mays L.) hybrids显示文摘This study aimed to investigate the differences in shoot and root traits, and water use and water use efficiency(WUE) in drought tolerant(DT) maize(Zea mays L.) hybrids under full and deficit irrigated conditions. A two-year greenhouse study was conducted with four hybrids(one conventional hybrid, 33D53AM, two commercial DT hybrids, P1151 AM, N75H, and an experimental hybrid, Exp HB) grown under two water regimes(I_(100) and I_(50), referring to 100 and 50% of evapotranspiration requirements). Under water stress, the hybids P1151 AM, N75, and Exp HB showed more drought tolerance and had either greater shoot dry weight or less dry weight reduction than the conventional hybrid(33 D53 AM). However, these three hybrids responded to water stress using different mechanisms. Compared with the conventional hybrid, the two commercial DT hybrids(P1151 AM and N75H) had a smaller leaf area, shoot dry weight, and root system per plant. As a result, these hybrids used less water but had a higher WUE compared with the conventional hybrid. In contrast, the experimental hybrid(ExpHB) produced more shoot biomass by silking stage at both irrigation levels than all other hybrids, but it had relatively lower WUE. The hybrids demonstrated different drought response mechanisms that may require different irrigation management strategies. More investigation and validation are needed under field conditions and in different soil types. | ZHAO Jin XUE Qing-wu Kirk E Jessup HOU Xiao-bo HAO Bao-zhen Thomas H Marek XU Wen-wei Steven R Evett Susan A O'Shaughnessy David K Brauer | 2018 | Journal of Integrative Agriculture2018，17，5： | 3 |
| 3 | Perception of fruity and vegetative aromas in red wine显示文摘 | KAREN H SUSAN E E HILDEGARDE H | 2009 | Journal of Sensory Studies2009，24，： | 1 |
| 4 | Bioinformatics and management sci- ence: Some common tools and techniques显示文摘 | All E A Susan P H | 2004 | Operations Research2004，52，2： | 1 |
| 5 | A short scale for measuring safety climate 显示文摘 | SUSAN E H LAWRENCE R M | 2008 | Safety Science2008，4，46： | 1 |
| 6 | Telomerase activity and differential expression of telomerase genes and c-myc in chicken cells in vitro显示文摘 | SUSAN E SEANBERG WILLIAM S P H D | 2004 | Development Dynamics2004，231，： | 1 |
| 7 | Identification of Severe Acute Respiratory Syndrome in Canada显示文摘 | M Donald E and Bonie H | 2003 | N Eng1 J Med2003，348，： | 1 |
| 8 | Simultaneous determi- nation of fluoroquinolones and tetracyelines in chicken muscle using HPLC with fluorescence detection 显示文摘 | MaIilyn J S Susan E B Ixchel R H | 2007 | J Chromatogr B2007，846，1： | 1 |
| 9 | Heartbeat awareness and heart rate reactivity in anxiety sensitivity: A further investigation显示文摘 | Sherry H Stewart Susan E Buffett-Jerrott Racqel Kokaram | 2001 | Journal of Anxiety Disorders2001，，： | 1 |
| 10 | Studies on mass summer mortality of cultured zhikong scallops(Chlamys Jhrreri Jones et Preston) in China 显示文摘 | Jie X Susan E F Yang H S | 2005 | Aquaculture2005，250，34： | 1 |
| 11 | Nutrition knowledge, attitude and practices of older and younger elderly in rural alias 显示文摘 | Coleen A F Susan J C Karen E H | 1991 | J Am Diet Assoc1991，91，11： | 1 |
| 12 | Visual-acuity Development in Healthy Preterm Infants:Effect of Marine-oil Supplementatetion显示文摘 | CARLSON S E SUSAN H Werkman Philip G Rhodes | 1993 | The American Journal of Clinical Nutririon1993，，58： | 1 |
| 13 | Functions of Tat:the versatile protein of human immunodeficiency virus type 1显示文摘 | BIZHAN R SUSAN E RICHARD H | 2010 | J Gen Virol2010，91，： | 1 |
| 14 | Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy显示文摘 | Alexander H Hoon Patricia O Freese Elsie M Reinhardt Mary Ann Wilson William T Lawrie Susan E Harryman Frank S Pidcock Michael V Johnston | 2001 | Pediatric Neurology2001，，1： | 1 |
| 15 | A New Dietary Inflammatory Index Predicts Interval Changes in Serum High-Sensitivity C-Reactive Protein1-3显示文摘 | Cavicchia Philip P Steck Susan E Hurley Thomas G Hussey James R Ma Yunsheng Ockene Ira S Hébert James R | 2009 | The Journal of Nutrition2009，，12： | 1 |
| 16 | Bootstrap confidence levels for phylogenetic trees显示文摘 | Bradley E Elizabeth H Susan H | 2003 | Nat Rev Genet2003，4，4： | 1 |
| 17 | Putting evidence into practice: evidence-based intervention for fatigue during and following cancer and its treatment显示文摘 | Sandra A M Susan L B Linda E H | 2007 | Clinical Journal of Oncology Nursing2007，11，1： | 1 |
| 18 | Putting evidence into practice:Evidence-based intervention for fatigue during and following cancer and its treatment显示文摘 | Sandra A M Susan L B Linda E H | | 0，，01： | 1 |
| 19 | Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee显示文摘 | David W Dempster Juliet E Compston Marc K Drezner Francis H Glorieux John A Kanis Hartmut Malluche Pierre J Meunier Susan M Ott Robert R Recker A Michael Parfitt | 2012 | J Bone Miner Res2012，，1： | 1 |
| 20 | Optimising cryopreservation protocols for haematopoietic progenitor cells: a methodological approach for umbilical cord blood 显示文摘 | CHARLES J H DAVID E P SUSAN E A | 2006 | Cryo-Letters2006，27，2： | 1 |
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