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| 1 | Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker显示文摘AIM: To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1(MACC1) transcripts in plasma of gastric cancer patients.METHODS: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer MACC1 in a prospective study of gastric cancer patient plasma.MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers.We conducted a study to define the diagnostic and prognostic power of MACC1 transcripts using 76 plasma samples from gastric cancer patients,either newly diagnosed with gastric cancer,newly diagnosed with metachronous metastasis of gastric cancer,as well as follow-up patients.Findings were controlled by using plasma samples from 54 tumor-free volunteers.Plasma was separated,RNA was isolated,and levels of MACC1 as well as S100A4 transcripts were determined by quantitative RT-PCR.RESULTS: Based on the levels of circulating MACC1 transcripts in plasma we significantly discriminated tumorfree volunteers and gastric cancer patients(P < 0.001).Levels of circulating MACC1 transcripts were increased in gastric cancer patients of each disease stage,compared to tumor-free volunteers: patients with tumors without metastasis(P = 0.005),with synchronous metastasis(P = 0.002),with metachronous metastasis(P = 0.005),and patients during follow-up(P = 0.021).Sensitivity was 0.68(95%CI: 0.45-0.85) and specificity was 0.89(95%CI: 0.77-0.95),respectively.Importantly,gastric cancer patients with high circulating MACC1 transcript levels in plasma demonstrated significantly shorter survival whencompared with patients demonstrating low MACC1 levels(P = 0.0015).Furthermore,gastric cancer patients with high circulating transcript levels of MACC1 as well as of S100A4 in plasma demonstrated significantly shorter survival when compared with patients demonstrating low levels of both biomarkers or with only one biomarker elevated(P = 0.001).CONCLUSION: Levels of circulating MACC1 transcripts in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival in a prospective study. | Susen Burock Pia Herrmann Ina Wendler Markus Niederstrasser Klaus-Dieter Wernecke Ulrike Stein | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Quantificational indexes for design and evaluation of copper staves for blast furnaces显示文摘The quantificational and normative design is the precondition of improving the design of copper staves for blast furnaces. Based on a 3-dimensional temperature field calculation model,from the view point of heat transfer and long campaigns note with the core of forming accretion,the forming-accretion-ability(FAA)and the rib hot surface maximum temperature difference(ΔT_(max))as quantificational indexes to direct and evaluate the design of copper staves for blast furnaces were presented.The application of the two indexes in design essentially embodies the new long campaigns in the stage of design.With the application of the two indexes, good results can be obtained.Firstly,it was suggested that the rib height of a copper stave can be reduced to 15 mm,which is a new method and theory for the reduction of copper staves.Secondly,the influence of insert on FAA andΔT_(max)is decided by the volume of insert.According to this,the principle of design for the hot surface geometry of copper staves was put forward that the ratio of the rib hot surface to the copper stave hot surface(abbreviated as the ratio of rib to stave)must be maintained in the range of 45% to 55%; for the present copper stave with a 35-40 mm thick rib,the ratio of rib to stave in the range of 50% to 55% can optimize the design of copper staves;for the copper stave with a smaller rib thickness,for example 15 mm,the ratio of rib to stave in the range of 45% to 50% can optimize the design of copper staves.It can be summarized that the thicker the rib thickness,the larger is the ratio of rib to stave. | Liang Qian Susen Cheng Hongbo Zhao | 2008 | Journal of University of Science and Technology Beijing2008，15，1： | 6 |
| 3 | Designing for Long Campaign Life Blast Furnace (1)──The Mathematical Model of Temperature Field for Blast Furnace Lining and Cooling Apparatus and New Concept of Long Campaignship Blast Furnace Cooler Design显示文摘The physical and mathematical model of temperature field for blast furnace stave coolers was established. The computation results show that the heat resistance of 2-6 mm water scale within the cooling pipe is about 7%-20% of the total heat resistance of cooling stave body, as for drilling duct type, the heat resistance of 2-6 mm water scale is about 88%-98% of the total heat resistance. Using drilling duct or full cast pipe can eliminate gas clearance and coating layer between pipes and cast iron body and reduce the heat resistance of the cooler sharply and improve the coefficient of heat transfer to a great extent. The water velocity within coolers can be kept at the 1evel of 0.5- 1 .5 m/s, the higher water velocity can not decrease the hot surface temperature, but can increase energy consumption for cooling water. | Susen Cheng Qingguo Xue Weiguo Yang kaolin Wu Tianjun Yang(Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China)(Ironmaking Department, Bejing Central Engineering and Incoporation of Iron and Steel Industry, Bejing, 1000 | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，3： | 5 |
| 4 | Designing for Long Campaign Life Blast Furnace (2)-The Simulation of Temperature Field of Lining and Cooling Apparatus显示文摘Through the numerical modeling of temperature field for Blast Furnace (BF) lining and stave coolers, it can tell designers how to design a cooler which the hot surface temperature is less than its critical temperature under very high heat flux. Applying low heat re- sistance lining and staves cooler to BF is good for a layer of slag skull frozen on the hot surface of cooling stave. As long as the slag skull can stand, the furnace wall is stable and the heat loss of furnace does not increase. This is the basic principle for designing long campa- ignship BF. | Qingguo Xue Weiguo Yang Susen Cheng Maolin Wu Tianjun Yang Metallurgy School, University of Science and Technology Beijing, Beijing 100083, China The Center of Engineering and Research for Iron and Steel, 100053, China | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，1： | 3 |
| 5 | Relevance of tissue factor in cardiovascular disease 显示文摘 | JUDE B ZAWADZKI C SUSEN S | 2005 | Arch Mal Coeur Vaiss2005，98，6： | 1 |
| 6 | Endothelial progenitor ceils are selectively mobilised immediately after coronary artery bypass grafting or valve surgery 显示文摘 | Smadja DM Godier A Susen S | 2009 | Thromb Haemost2009，101，5： | 1 |
| 7 | Metabolic syndrome and collateral vessd formation in patients with documented occluded coronary arteries: as- sociation with hyperglycaemla, insulin-resistance, adiponeetion and plas- minogen activator inhibitor-1 显示文摘 | Mouquet F Cuilleret F Susen S | 2009 | Eur Heart J2009，30，： | 1 |
| 8 | Metabolic syndrom and collateral vessel formation inpatients with documertted oceuluded coronary arteries: association with hyperglycaemia insulin resistence adiponectin and plasminogen activator inhibitor - 1 显示文摘 | Mouquet F Cuilleret E Susen S | 2009 | Eur Heart J2009，30，7： | 1 |
| 9 | Medical advances in the treatment of postpartum hemorrhage 显示文摘 | Ducloy-Bouthors AS Susen S Wong CA | 2014 | Anesth Analg2014，119，5： | 1 |
| 10 | Policy-based Softswitch System Management显示文摘This paper presents the design and implementation of the policy management layer of the softswitch system, which is currently under development in our lab. The distinguish key feature of our policy management subsystem is that the Parlay policy management architecture and the specific technical requirements of softswitch system management are closely incorporated. In this way, not only network providers but also authorized 3rd party application providers and application developers can develop services and applications to manage the access and use of network resources on a per user or application basis to best support established business objectives. The material presented in this document is heavily based on the work of Parlay policy management and IETF policy framework working group. | LIYa-bo SUSen CHENJun-liang | 2004 | The Journal of China Universities of Posts and Telecommunications2004，11，2： | 1 |
| 11 | Diagnostic and Prognostic Value of Metastasis Inducer S100A4 Transcripts in Plasma of Colon, Rectal, and Gastric Cancer Patients显示文摘 | Ulrike Stein Susen Burock Pia Herrmann Ina Wendler Markus Niederstrasser Klaus-Dieter Wernecke Peter M. Schlag | 2011 | The Journal of Molecular Diagnostics2011，，2： | 1 |
| 12 | Dyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques:evidence for a corrective effect of statins显示文摘 | Zawadzki C Susen S Richard F | 2007 | Atherosclerosis2007，195，2： | 1 |
| 13 | Dyslipidemia shifts the tissue factor/tissue factor pathway inhibitor balance toward increased thrombogenicity in atherosclerotic plaques : evidence for a corrective effect of statins 显示文摘 | Zawadzki C Susen S Richard F | 2007 | Atherosclerosis2007，195，2： | 1 |
| 14 | Medical advances in the treatment of postpartum hemorrhage显示文摘 | Ducloy-Bouthors AS Susen S Wong CA | 2014 | Anesth Analg2014，119，5： | 1 |
| 15 | Relevance of tissue factor in cardiovascular disease显示文摘 | Jude B Zawadzki C Susen S | 2005 | Arch Mal Coeur Vaiss2005，98，6： | 1 |
| 16 | Aldosterone, A major determinant of long term mortality in elective PCI显示文摘 | Eric Van Belle Sophie Susen Frederic Mouquet | 2007 | Circulation2007，116，5： | 1 |
| 17 | Trauma-induced coagulopathy显示文摘 | Godier A Susen S | 2013 | Ann Fr Anesth Reanim2013，32，78： | 1 |
| 18 | Serum hepatocyte growth factor levels predict long-term clinical outcome after percutaneous coronary revascularization 显示文摘 | Susen S Sautiere K Mouquet F | 2005 | Eur Heart J2005，26，22： | 1 |
| 19 | Obesity, inflammatory markers,and endometrial cancer risk:a prospective case- control study 显示文摘 | Laure D Sabina R Susen B | 2010 | Endocrine-Related Cancer2010，17，： | 1 |
| 20 | Homme replacement therapy and venous thronrboembolism显示文摘 | Trillot N Susen S Jude B | 2004 | Gynecal Obstet Fertil2004，32，9： | 1 |
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