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| 1 | New aspects in the pathomechanism and diagnosis of the laryngopharyngeal reflux-clinical impact of laryngeal proton pumps and pharyngeal p H metry in extraesophageal gastroesophageal reflux disease显示文摘AIM:To determine the laryngeal H+K+-ATPase and pharyngeal p H in patients with laryngopharyngeal reflux(LPR)-symptoms as well as to assess the symptom scores during PPI therapy.METHODS:Endoscopy was performed to exclude neoplasia and to collect biopsies from the posterior cricoid area(immunohistochemistry and PCR analysis).Immunohistochemical staining was performed with monoclonal mouse antibodies against human H+K+-ATPase.Quantitative real-time RT-PCR for each of the H+K+-ATPase subunits was performed.The p H values were assessed in the aerosolized environment of the oropharynx(Dxp H Catheter) and compared to a subsequently applied combined p H/MII measurement.RESULTS:Twenty patients with LPR symptoms were included.In only one patient,the laryngeal H+K+-ATPase was verified by immunohistochemical staining.In another patient,real-time RT-PCR for each H+K+-ATPase subunit was positive.Fourteen out of twenty patients had pathological results in Dxp H,and 6/20 patients had pathological results in p H/MII.Four patients had pathological results in both functional tests.Nine out of twenty patients responded to PPIs.CONCLUSION:The laryngeal H+K+-ATPase can only be sporadically detected in patients with LPR symptoms and is unlikely to cause the LPR symptoms.Alternative hypotheses for the pathomechanism are needed.The role of pharyngeal p H-metry remains unclearand its use can only be recommended for patients in a research study setting. | Valentin Becker Romina Drabner Simone Graf Christoph Schlag Simon Nennstiel Anna Maria Buchberger Roland M Schmid Dieter Saur Monther Bajbouj | 2015 | World Journal of Gastroenterology2015，21，3： | 14 |
| 2 | 直肠癌术前热疗、放疗及化疗的临床病理意义显示文摘目的 探讨直肠癌手术前热疗、放疗及化疗后临床病理特征。方法 38例局部进展期直肠癌病例进行了手术前热疗、放疗及化疗。局部热疗采用SIGMA60热疗机 (BSD - 2 0 0 0 ) ,放疗总剂量为 45Gy。四氢叶酸 +5 -FU全身化疗共 2个疗程。辅助治疗完成后 4~ 6周手术。结果 经过术前辅助治疗 ,肿瘤的直径平均缩小 35 .5 %。 4例 (1 0 .5 % )达到病理完全缓解 ,另外 2 7例 (71 .0 % )达到PR(癌细胞坏死率≥ 50 % ) ,总有效率达 81 .6 %。辅助治疗后淋巴结阳性率由 68.4 %降至 44 .7%。病理检查所有肿瘤均有不同程度的癌细胞变性、细胞结构破坏、肿瘤血管破坏、出血及大片凝固性坏死。瘢痕区域可见灶性钙化、再生上皮。结论 术前热疗、放疗及化疗可以使部分肿瘤获得病理完全缓解、缩小原发瘤。 | 梁寒 郝希山 战中利 Haensch W Schlag PM | 2002 | 肿瘤2002，22，1： | 6 |
| 3 | 乳腺癌淋巴结微小转移状态下前哨与非前哨淋巴结免疫细胞的改变显示文摘目的观察乳腺癌淋巴结微小转移状态下前哨淋巴结(SLN)与非前哨淋巴结(Non-SLN)免疫细胞密度的改变。方法53例符合研究标准的女性乳腺癌患者按SLN不同转移状态分为阴性、游离肿瘤细胞及微转移3组。从各组随机选择6对SLN和Non—SLN与DC-LAMP,CD68,CD123,Foxp3抗体行免疫组织化学染色,半定量评估染色细胞密度改变;所有SLN和Non-SLN蜡块切片均行与DC-LAMP抗体免疫反应的免疫组织学检查以确认成熟树突状细胞(DC)。蔡司图像分析系统定量分析每个淋巴结DC-LAMP阳性细胞的相对密度(DC—LAMP阳性细胞面积/淋巴结面积)。Wicoxon检验和Mann-Whimey检验分别用于DC-LAMP阳性细胞的相对密度的组内和组间比较。结果DC—LAMP阳性细胞密度改变显著。组内比较显示阴性组和微转移组SLN内DC-LAMP阳性细胞平均密度较Non-SLN高(P〈0.05);组间比较显示微转移组SLN和Non-SLN内DC-LAMP阳性细胞密度较阴性组显著升高(P〈0.05)。结论SLN和Non-SLN内DC-LAMP+细胞平均密度在淋巴结肿瘤转移形成早期发生改变,揭示SLN在肿瘤与引流淋巴结免疫相互作用中起重要作用。 | 黎剑 詹文华 蔡世荣 Bembenek A Schlag PM | 2007 | 中华实验外科杂志2007，24，1： | 4 |
| 4 | Hyperthermia in combined treatment of cancer显示文摘 | P Wust B Hildebrandt G Sreenivasa B Rau J Gellermann H Riess R Felix PM Schlag | 2002 | Lancet Oncology2002，，8： | 2 |
| 5 | EndoResect study: endoscopic full-thickness resection of gastric subepithelial tumors显示文摘 | C. Schlag D. Wilhelm S. von Delius H. Feussner A. Meining | 2013 | Endoscopy2013，，01： | 2 |
| 6 | Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma显示文摘 | Roumen RMH Redl H Schlag G | 1995 | Crit Care Med1995，23，3： | 1 |
| 7 | Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma显示文摘 | San Miguel JF Schlag R Khuageva NE | 2008 | N Engl J Med2008，359，9： | 1 |
| 8 | Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma显示文摘 | San Miguel JF Schlag R Khuageva NK | 2008 | N Engl J Med2008，359，9： | 1 |
| 9 | Sentinel lymph node biopsy for gastrointestinal cancers显示文摘 | Bembenek A Gretsehel S Schlag PM | 2007 | J Surg Oncol2007，96，4： | 1 |
| 10 | Gastric Cancer Surgery in Elderly Patients显示文摘 | Stephen Gretschel MD Lope Estevez-Schwarz MD Michael Hünerbein MD Ulrike Schneider MD Peter M. Schlag MD PhD | 2006 | World Journal of Surgery2006，，8： | 1 |
| 11 | Reconstruction after gastrectomy and quality of life显示文摘 | Buhl K Lehnert T Schlag P | 1995 | World J Surg1995，19，4： | 1 |
| 12 | Fracture Initiation and Progress in Wood Specimens Stressed in Tension显示文摘 | Josef Bodner Michael Grorg Schlag Gerhard Grull | 1997 | Holzforschung1997，51，： | 1 |
| 13 | Bortezomib plus melphalan and prednisone for initial treatment of mul-tiple myeloma显示文摘 | San Miguel JF Schlag R Khuageva NK | | 0，，09： | 1 |
| 14 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 15 | The long-term effects of pretreatment with activated protein C in a rat model of compressioninduced spinal cord injury显示文摘 | Schlag MG Hopf R | 2000 | Spinal Cord2000，38，12： | 1 |
| 16 | Visual and presaccadic neuronal act ivity in thalamic internal medullary lamina of cat: a study of targeting显示文摘 | | 1977 | J Neurophysiol1977，40，： | 1 |
| 17 | Outcome after emergency surgery for cancer of the large intestine显示文摘 | Runkel NS Schlag P Schwarz V | 1991 | Br J Surg1991，78，1： | 1 |
| 18 | Immunodetection of epithelial mucin (MUC1, MUC3) and mucin-associated glycotopes (TF, Tn, and sialosyl-Tn) in benign and malignant lesions of colonic epithelium: apolar localization corresponds to malignant transformation显示文摘 | Cao Y Schlag PM Karsten U | 1997 | Virchows Arch1997，431，： | 1 |
| 19 | Epidermal growth fac-tor receptor agonists increase expression of glutamate transporterGLT-1 in astrocytes through pathways dependent on phosphatidyli-nositol 3-kinase and transcription factor NF-kappaB显示文摘 | Zelenaia O Schlag BD Gochenauer GE | 2000 | Mol Phar-macol2000，57，4： | 1 |
| 20 | Inflammatory mediators in relation to the development of multiple organ failure in patients after sever blunt traurna显示文摘 | ROUMEN R M REDL H SCHLAG G | 1995 | Crit Care Med1995，23，： | 1 |
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