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| 1 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 2 | In planta functions of the Arabidopsis cytokinin receplor family显示文摘 | Higuchi M Pischke M.S M(a) h(o)nen A.P Miyawaki K Hashimoto Y Seki M Kobayashi M Shinozaki K Kato T Tabata S Helarintta Y Sussman M.R Kalimoto T | | 0，，： | 1 |
| 3 | Gibberellins Promote Flowering of Arabidopsis by Activating the LEAFY Promoter显示文摘 | BLAZQUES M A GREEN R NILSSON O SUSSMAN M R WEIGEL D | 1998 | Plant Cell1998，10，： | 1 |
| 4 | The heart : mostly postmitotic or mostly premitotic? Myocyte cell cycle, senescence ,and quies- cence 显示文摘 | SIDDIQI S SUSSMAN M A | 2014 | Can J Cardiol2014，30，11： | 1 |
| 5 | The Arabidopsis CDPK-SnRK superfamily of protein kinases显示文摘 | Hrabak E M Chan C W Gribskov M Harper J F Choi J H Halford N KUdla J Luan S Nimmo H G Sussman M R Thomas M Walker-simmons K Zhu J K Harmon A C | 2003 | Plant Physiology2003，132，： | 1 |
| 6 | Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis显示文摘 | ULLAH H CHEN J G YOUNG J C IM K H SUSSMAN M R JONES A M | 2001 | Science2001，292，： | 1 |
| 7 | Major sperm protein and actin genes in free-living and parasitic nematodes显示文摘 | Scott A L Dinman J Sussman D J | 1989 | Parasitology1989，98，： | 1 |
| 8 | Mass Spectrometric Resolution of Reversible Protein Phosphorylation in Photosynthetic Membranes of Arabidopsis Thaliana显示文摘 | Vener AV Harms A Sussman MR | 2001 | J Biol Chem2001，276，： | 1 |
| 9 | Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium显示文摘 | Harkness K A Adamson P Sussman J D | 2000 | Brain2000，123，： | 1 |
| 10 | Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1 显示文摘 | Sussman MA Welch S Walker A | 2000 | J Clin Invest2000，105，7： | 1 |
| 11 | How do serine proteases really work? 显示文摘 | Warshel A Naray-Szabo G Sussman F | 1989 | Biochemistry1989，28，9： | 1 |
| 12 | Myocardial AKT:the omnipresent nexus显示文摘 | Sussman M A Vlkers M Fischer K | 2011 | Physiol Rev2011，91，： | 1 |
| 13 | Pinl : a molecu- lar orchestrator in the heat显示文摘 | HARIHARAN N SUSSMAN M A | 2014 | Trends Cardiovas Med2014，24，6： | 1 |
| 14 | Dance band on the titanic:biomechanical signaling in cardiac hypertrophy显示文摘 | Sussman A Mcculloch A Borg TK | 2002 | Circ Res2002，91，10： | 1 |
| 15 | Low-power, fast, selec- tive nanoparticle-based hydrogen sulfide gas sensor 显示文摘 | Mickelson W Sussman A Zettl A | 2012 | Applied Physics Letters2012，100，17： | 1 |
| 16 | The Rac and Rho hall of fame:a decade of hypertrophic signaling hits显示文摘 | Brown J H Del Re D P Sussman M A | 2006 | Circ Res2006，98，6： | 1 |
| 17 | Recent development in latency and recombination of PRV显示文摘 | MAES R K SUSSMAN M D VILNS A | 1997 | Vet Microbiol1997，5，： | 1 |
| 18 | Recent development s in latency and recombination of pseudorabies virus 显示文摘 | Maes R K Sussman M D Vilnis A | 1997 | Vet Microbiol1997，55，： | 1 |
| 19 | Mass spectrometric resolution of reversible protein phosphorylation in photosynthetic membranes of Arabidopsis thaliana 显示文摘 | Harms A Sussman MR | 2001 | J Biol Chem2001，276，： | 1 |
| 20 | Recent developments in latency and recombination of PRV显示文摘 | Maes R K Sussman M D Vilnis A | 1997 | Vet Microbiol1997，55，： | 1 |
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