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| 1 | Neoadjuvant therapy for pancreas cancer: Past lessons and future therapies显示文摘Pancreatic adenocarcinoma remains a most deadly malignancy, with an overall 5-year survival of 5%. A subset of patients will be diagnosed with potentially resectable disease, and while complete surgical resection provides the only chance at cure, data from trials of postoperative chemoradiation and/or chemotherapy demonstrate a modest survival advantage over those patients who undergo resection alone. As such, most practitioners believe that completion of multimodality therapy is the optimal treatment. However, the sequence of surgery, chemotherapy and radiation therapy is frequently debated, as patients may benefit from a neoadjuvant approach by initiating chemotherapy and/or chemoradiation prior to resection. Here we review the rationale for neoadjuvant therapy, which includes a higher rate of completion of multimodality therapy, minimizing the risk of unnecessary surgical resection for patients who develop early metastatic disease, improved surgical outcomes and the potential for longer overall survival. However, there are no prospective, randomized studies of the neoadjuvant approach compared to a surgeryfirst strategy; the established and ongoing investigations of neoadjuvant therapy for pancreatic cancer are discussed in detail. Lastly, as the future of therapeutic regimens is likely to entail patient-specific genetic and molecular analyses, and the treatment that is best applied based on those data, a review of clinically relevant biomarkers in pancreatic cancer is also presented. | Jeffrey M Sutton Daniel E Abbott | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | Etiology of apple sooty blotch disease in North Carolina显示文摘 | Johnson E M Sutton T B Hodges C S | 1997 | Phytopathology1997，87，： | 1 |
| 3 | 查看详情显示文摘 | Haynam C A Wegner P J Auerbach J M Bowers M W Dixit S N Erbert G V Heestand G M Henesian M A Hermann M R Jancaitis K S Manes K R Marshall C D Mehta N C Menapace J Moses E Murray J R Nostrand M C Orth C D Patterson R SacksR A Shaw M J Spaeth M Sutton S B W | | 0，，： | 1 |
| 4 | Impact of Field Release of Genetically Modified Pseudomonas Fluoreseens on Indigenous Microbial Populations of Wheat显示文摘 | DE L F SUTTON E J WHIPPS J M | 1995 | Appl Environ Micrnbiol1995，61，： | 1 |
| 5 | Peltaster fructicola:A new species in the complex of fungi causing apple sooty blotch显示文摘 | Johnson E M Sutton T B Hodges C S | 1996 | Mycologia1996，88，： | 1 |
| 6 | The relationship of dys- pnoea to function and quality of life in systemic sclerosis显示文摘 | Baron M Sutton E Hudson M | 2008 | Ann Rheum Dis2008，67，5： | 1 |
| 7 | The drug efflux protein, P-glycoprotein, additionally protects drug- resistant tumor cells from multiple forms of caspase-de- pendent apoptosis显示文摘 | Smyth M J Krasovskis E Sutton V R | 1998 | Proc Natl Acad Sci U S A1998，95，： | 1 |
| 8 | HIV,but not routine leukemia virus, vectors mediate high efficiency gene transfer in- to freshly isolated G0/G1 human hematopoietic stem cells 显示文摘 | Uchida N Sutton R E Friera A M | 1998 | Proc Natl Acad Sci USA1998，95，11： | 1 |
| 9 | Sources and sinks of ammonia within an oilseed rape canopy 显示文摘 | Nemitz E Sutton M A Gut A | 2000 | Agricultural and Forest Meteorology2000，105，： | 1 |
| 10 | Sources and Sinks of Ammonia within an Oilseed Rape Canopy显示文摘 | NEMITZ E SUTTON M A | 2000 | Agricultural and Forest Meteorology2000，105，4： | 1 |
| 11 | Initiation of apoptosis by granzyme B requires direct cleavage of bid,but not direct granzyme B-mediated easpase activation显示文摘 | Sutton V R Davis J E Caneilla M | 2000 | J Exp Med2000，192，10： | 1 |
| 12 | Powdery mil- dew infection of wheat leaves ehanges host solute transport and invertase activity 显示文摘 | Sutton P N Gilbert M J Williams L E | 2007 | Physiologia Plantarum2007，129，4： | 1 |
| 13 | A mesoscale phytoplankton bloom in the polar Southern Ocean stimulated by iron fertilization 显示文摘 | Boyd P W Watson A J Law C S Abraham E R Trull T Murdoeh R Bakker D C E Bowie A R Buesseler K O Chang H Charette M Croot P Downing K Frew R Gall M Hadfield M Hall J Harvey M Jameson G LaRoche J Liddicoat M Ling R Maldonado M T McKay R M Nodder S Pickmere S Pridmore R Rintoul S Sail K Sutton P Strzepek R Tanneberger K Turner S Waite A Zeldis J | 2000 | Nature2000，407，6805： | 1 |
| 14 | Ventricular disfunction and the risk of stroke after myocardial infarction显示文摘 | LOH E SUTTON M S WUN C C | 1997 | N Engl J Med1997，336，： | 1 |
| 15 | The crystal structure of C3stau2 from Staphylococcus aureus and its complex with NAD显示文摘 | SUTTON J M HOLLOWAY D E | 2003 | J Biol Chem2003，278，45： | 1 |
| 16 | Free oscillations of the earth observed on strain and pendulum seismographs 显示文摘 | Alsop L E Sutton G H and Ewing M | 1961 | Journal of Geophysical Research1961，66，2： | 1 |
| 17 | Insomnia and health problems in Canadians显示文摘 | Sutton D A Moldofsky H Badley E M | 2001 | Sleep2001，24，6： | 1 |
| 18 | 115 W Tm:YAG diode-pumped solid-state laser显示文摘 | Honea E C Beach R J Sutton S B Speth J A Mitchell S C Skidmore J A Emanuel M A Payne S A | 1997 | IEEE Journal of Quantum Electronics1997，33，9： | 1 |
| 19 | Biosphere-atmosphere interactions of ammonia with grasslands:Experimental strategy and results from a new European initiative显示文摘 | SUTTON M A MIFORD C NEMITZ E THEOBALD M R HILL P W FOWLER D | 2001 | Plant and Soil2001，228，1： | 1 |
| 20 | Projections of When Temperature Change will Exceed 2 ℃ above Pre-industrial Levels显示文摘 | Joshi M Hawkins E Sutton R | | 0，，01： | 1 |
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