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| 1 | European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants - 2013 Update显示文摘 | Sweet David G Carnielli Virgilio Greisen Gorm Hallman Mikko Ozek Eren Plavka Richard Saugstad Ola D Simeoni Umberto Speer Christian P Vento Maximo Halliday Henry L | 2013 | Neonatology2013，，4： | 3 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | BIL- SAT,l: A low-cost, agile, earth observation microsatel- lite for turkey显示文摘 | BRADFORD A GOMES L M SWEETING M | 2003 | Acta astronautica2003，，53： | 1 |
| 4 | Atmospheric deposition of PAHs,PCBs, and organochlorine pesticides to Corpus Christi Bay, Texas显示文摘 | Park J S Terry L W Sweet S | 2002 | Atmospheric Environment2002，36，： | 1 |
| 5 | Tributyltin in environmental samples from the Former Derecktor Shipyard, Coddington Cove, Newport RI显示文摘 | Wade T L Sweet S T Quinn J G Cairns R W King J W | 2004 | Environmental Pollution2004，129，2： | 1 |
| 6 | Genesis field, gulf of Mexico:recognizing reservoir compartments on geologic and production time scales in deep-water reservoirs显示文摘 | Sweet M L Sumpter L T | 2007 | AAPG Bulletin2007，91，12： | 1 |
| 7 | Glycopeptidolipids from mycobacteri-um avium promote macrophage activation in a TLR2- andMyD88-dependent manner 显示文摘 | Sweet L Schorey JS | 2006 | J Leukoc Biol2006，80，： | 1 |
| 8 | Atmospheric distribution of polyeyclic aromatic hydrocarbons and deposition to Galveston Bay, Texas, USA显示文摘 | Park J S Wade T L Sweet S T | 2001 | Atmospheric Environment2001，35，： | 1 |
| 9 | Modeling heterogeneity in a low-permeability gas reservoir using geostatistical techniques, Hyde field, Southern North Sea显示文摘 | SWEET M L BLEWDEN C J CARTER A M | 1996 | AAPG Bulletin1996，80，11： | 1 |
| 10 | Fathers and breast feeding very-low- birthweight preterm babies显示文摘 | Sweet L Darbyshire P | 2009 | Midwifery2009，25，： | 1 |
| 11 | The essential elements ofteam-based learning 显示文摘 | Michaelsen L K Sweet M | 2008 | New Dir Teach Learn2008，，116： | 1 |
| 12 | Flame-excited luminescence in the oxides Ta2OsNb2Os, TiO2, ZnO, and SnO2显示文摘 | PROVENZANO P L JINDAL G R SWEET J a | 2001 | J Lumin2001，92，4： | 1 |
| 13 | An empirical model eolian dune leeface flow显示文摘 | Sweet M L Kocurek G | 1990 | Sedimentology1990，37，： | 1 |
| 14 | Neuroanatomical correlates of malingered memory impairment,event-related fMRI of deception on a reognition memory task显示文摘 | BROWNDYLY J N PASKAVITZ J SWEET L H | 2008 | Brain Inj2008，22，6： | 1 |
| 15 | Assessment of sediment contamination in Casco Bay, Maine, USA 显示文摘 | WADE T L SWEET S T KLEIN A G | 2008 | Environmental Pollution2008，152，： | 1 |
| 16 | NCT with boron in the treatment of GBM显示文摘 | FARR L E SWEET W H ROBERTSON J S | 1954 | Am J Roentgenol1954，71，： | 1 |
| 17 | The surgical management of carcinoma of the lung:A study of the cases treated at the Massachusetts General Hospital from 1930 to 1950显示文摘 | Churchill ED Sweet RH Soutter L | | 0，，03： | 1 |
| 18 | Pathological study of eight patients with GBM treated by NCTusing boron 10显示文摘 | GODWIN J T FARR L E SWEET W H | 1955 | Cancer1955，8，： | 1 |
| 19 | Wheelset Mechanics During Wheel Climb Derailment显示文摘 | KALMEL A SWEET L M | 1984 | Transactions of ASME1984，51，5： | 1 |
| 20 | Developmental expression of Wnt signaling factors in mouse brain显示文摘 | Coyle-Rink J Del Valle L Sweet T Khalili K.Amini S | | 0，，06： | 1 |
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