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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Travel to high altitude with pre-existing lung disease显示文摘 | Luks A M Swenson E R | 2007 | Eur Respir J2007，29，： | 1 |
| 3 | Effects of acute and chronic acetazolamide on resting ventilation and ventilatory responses in men显示文摘 | Swenson E R Hughes J M | 1993 | J Appl Physiol1993，74，1： | 1 |
| 4 | Assessment of the ^137Cs method for estimating sediment accumulation rates:Louisiana salt marshes显示文摘 | Milan C S Swenson E M Turner R E | 1995 | Journal of Coastal Research1995，11，2： | 1 |
| 5 | Pathogenesis of high - altitude pulmonary edema :inflammation is not an etiologic factor显示文摘 | Swenson E R Maggiorini M Mongovin S | 2002 | JAMA2002，287，17： | 1 |
| 6 | Synthesis and Structures of Mono-and Bis(amidinate)Complexes of Aluminum显示文摘 | Coles M P Swenson D C Jordan R F | 1997 | Organometallics1997，16，： | 1 |
| 7 | H, t3C, and 15N backbone, side-chain, and heme chemical shift assign- ments for oxidized and reduced forms of the monoheme c-type cytochrome ApcA isolated from the acidophilic metal-reducing bacterium Acidiphilium cryptum显示文摘 | CORT J R SWENSON M W MAGNUSON T S | 2011 | Biomolecular NMR Assign- ments2011，5，1： | 1 |
| 8 | Summer hypoxia in the northern Gulf of Mexico and its pre -diction from 1978 to 1995 显示文摘 | TURNER R E RABALAIS N N SWENSON E M | 2005 | Marine Environmental Re - search2005，59，1： | 1 |
| 9 | Assessment of the ^137 Cs method for estimating sediment accumulation rates: Louisiana salt marshes显示文摘 | Milan C S Swenson E M Turner R E | 1995 | Journal of Coastal Research1995，11，2： | 1 |
| 10 | Fixation of phosphate by iron and aluminum and replacement by organic and inorganic ions 显示文摘 | Swenson R M Cole C V Sieling D H | 1949 | Soil Sci1949，67，： | 1 |
| 11 | Medication and dosage consid- erations in the prophylaxis and treatment of high-altitude illness显示文摘 | Luks A M Swenson E R | 2008 | Chest2008，133，3： | 1 |
| 12 | Assessment of the 137Cs method for estimating sediment accumulation rates: Louisiana salt marshes显示文摘 | MILAN C S SWENSON E M TURNER R E | 1995 | Journal of Coastal Research1995，11，2： | 1 |
| 13 | Performance of eight methods, including two new rapid methods, for detection of oxacillin resistance in a challenge set of Staphylococcus aureus organisms 显示文摘 | Swenson J M Portia P Williams R | 2001 | J Clin Microbiol2001，39，10： | 1 |
| 14 | Assessment of the ^137Cs method for estimating sediment accumulation rates : Louisiana salt marshes显示文摘 | Milan C S Swenson E M Turner R E | 1995 | Journal of Coastal Research1995，11，： | 1 |
| 15 | An-timicrobial Susceptibility of Vancomycin Resistant Leuconostoc,Pediococ-cus and Lactobacillus Species显示文摘 | SWENSON J M FACKLAM R R and THORNSBERRY C | 1990 | Antimicrobial Agents and Chemothera-py1990，34，54： | 1 |
| 16 | Antimicrobial susceptibility of vancomycin resistant Leuconostoc,Pediococcus and Lactobacillus species显示文摘 | Swenson J M Facklam R R Thornsberry C | 1990 | Antimierobial Agents and Chemotherapy1990，34，： | 1 |
| 17 | Summer hypoxia in the northern Gulf of Mexico and its prediction from 1978 to 1995显示文摘 | TURNER R E RABALAIS N N SWENSON E M | 2005 | Marine Environmental Research2005，59，1： | 1 |
| 18 | A change in perspective: results for ischemic mitral valve repair are similar to mitral valve repair for degenerative disease显示文摘 | Gazoni L M Kern J A Swenson B R Dent J M | 2007 | Ann Thorac Surg2007，84，： | 1 |
| 19 | Thermodynamic reasons for per- ception-action cycles显示文摘 | SWENSON R TURVEY M | 1991 | Ecological Psy1991，，4： | 1 |
| 20 | Pulse oximetry at high altitude 显示文摘 | LUKS A M SWENSON E R | 2011 | High Alt Med Biol2011，12，2： | 1 |
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