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| 1 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 2 | Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study显示文摘AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer(CRC) at multiple Japanese institutions.METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group's department of gastroenterological surgery. Among them, 234 patients with stage Ⅱ/Ⅲ disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASAPS(HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/d L(HR = 2.96, P = 0.007), T4 tumor(HR = 2.73, P = 0.002) and R1 resection(HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers(HR = 6.28, P = 0.009), a T4 tumor(HR = 3.46, P = 0.011) and R1 resection(HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. | Ishibe Atsushi Ota Mitsuyoshi Yamaguchi Kazuya Kaida Syuhei Kamiya Noriyuki Momiyama Masashi Watanabe Akira Sekizawa Kentaro Kamimukai Nobuyuki Sugimasa Natsuko Watanabe Jun Ichikawa Yasushi Kunisaki Chikara Endo Itaru | 2016 | World Journal of Gastroenterology2016，22，22： | 9 |
| 3 | A high quality surface finish grinding process to produce total reflection mirror for x-ray fluorescence analysis显示文摘Total reflection x-ray fluorescence analysis is applied to trace element detection in liquid for effective environmental monitoring.This analytical approach requires x-ray total reflection mirrors.In order to achieve high sensitivity element detection,the mirrors require high surface quality for high x-ray reflectivity.Surface finishing for x-ray mirrors is typically conducted through a series of abrasive processes,such as grinding and polishing,and is thus time consuming.The purpose of this study is to streamline and enhance the surface finishing process based on unique high quality grinding techniques for the production of x-ray total reflection mirrors. | Hitoshi Ohmori Shinjiro Umezu Yunji Kim Yoshihiro Uehara Hiroshi Kasuga Teruko Kato Nobuhide Itoh Syuhei Kurokawa Takayuki Kusumi Yugo Sugawara Shinsuke Kunimura | 2020 | International Journal of Extreme Manufacturing2020，2，1： | 2 |
| 4 | IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a β <sub>2</sub>‐adrenergic agonist显示文摘 | Tokuhisa Abo Ryo‐hei Iida Syuhei Kaneko Takeo Suga Hiroyuki Yamada Yoshiki Hamada Akira Yamane | 2012 | Cell Biochem Funct2012，，8： | 1 |
| 5 | IGF and myo- statin pathways are respectively induced during the earlierand the later stages of skeletal muscle hypertrophy induced by clenbuter- ol, a β-adrenergic agonist显示文摘 | Tokuhisa Abo Ryo-hei Iida Syuhei Kaneko | 2012 | Cell Biochem Funct2012，30，： | 1 |
| 6 | Glucose-responsive polymer bearing a novel phenylborate derivative as a glucose-sensing moiety operating at physiological pH conditions显示文摘 | Akira M Syuhei I Atsushi H | 2003 | Biomacromolecules2003，4，： | 1 |
| 7 | Effect of crowding on growth and reproduction of Simocephalus vetuls O F Müller显示文摘 | Syuhei Ban | 1999 | Hydrobiologia1999，391，： | 1 |
| 8 | Seasonal changes in nano/micro-zooplankton herbivory and heterotrophic nano-flagellates bacterivory off Cape Esan,Southwestern Hokkaido,Japan显示文摘 | Akiyoshi Shinada Syuhei Ban Tsutomu Ikeda | 2003 | Journal of Oceanography2003，59，： | 1 |
| 9 | Transmission error analysis of involute cylindrical gears with consideration of gear eccentricity显示文摘 | SYUHEI K ARIURAY NAKANISHI T | 2007 | Transactions of the Japan Society of Mechanical Engineers Part C2007，73，8： | 1 |
| 10 | IGF and myo-statin pathways are respectively induced during the earlierand the lat-er stages of skeletal muscle hypertrophy induced by clenbuterol,aβ2-adrenergic agonist显示文摘 | Tokuhisa Abo Ryo-hei Iida Syuhei Kaneko | 2012 | Cell Biochem Funct2012，30，67： | 1 |
| 11 | Transmission error analysis of involute cylindrical gears with consideration of gear eccentricity 显示文摘 | Syuhei Kurokawa Ariura Yasutsune Nakanishi Takuya | 2007 | Transactions of the Japan Society of Mechanical Engineers: Part C2007，73，8： | 1 |
| 12 | Expressions of urokinase-type plasminogen activator, its receptor and plasminogen activator inhibitor-1 in gastric cancer cells and effects of Helicobacter pylori显示文摘 | Junichi Iwamoto Yuji Mizokami Kimiko Takahashi Kazuhiko Nakajima Toshiya Ohtsubo Syuhei Miura Toshiaki Narasaka Hiroki Takeyama Takayuki Omata Koichi Shimokobe Masanori Ito Hisashi Takehara Takeshi Matsuoka | 2005 | Scandinavian Journal of Gastroenterology2005，，7： | 1 |
| 13 | High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report显示文摘BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination modalities.However,it can be diagnosed by pancreatic juice cytology from indirect findings.Most previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic cysts.MRCP revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD dilatation.Thus,course observation was performed.After 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic cyst.We performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology examination.We performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade PanIN.Pancreatic parenchyma invasion was not observed,and curative resection was achieved.CONCLUSION High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation. | Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka | 2024 | World Journal of Clinical Cases2024，12，8： | 0 |
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