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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D显示文摘AIM: To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. METHODS: A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV geno-type was determined by using quantitative real-time polymerase chain reaction and sequence analysis, and tyrosine-methionine-aspartate-aspartate (YMDD) motif mutations were determined using the reverse transcriptase hybridization method. RESULTS: Lamivudine resistance was determined in a total of 25 (10.7%) chronic hepatitis B patients. Eight subjects (4%) had primary resistance to lamivudine, and 17 (53.1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey. CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside nave. | Orhan Yιldιz Bilgehan Aygen Nese Demirtürk Tuna Demirdal Dilara Inan Taner Yιldιrmak Arzu Kantürk Ediz Tütüncü Hepatitis B Study Group | 2011 | World Journal of Gastroenterology2011，17，45： | 3 |
| 3 | Increased secretion of insulin during oral glucose tolerance test can be a predictor of stent restenosis in nondiabetic patients显示文摘 | Babalik E Gurmen T Orhan L | 2003 | Catheter Cardiovasc Interv2003，58，3： | 1 |
| 4 | Malignant tumors metastatic to the ovarics显示文摘 | Ali A Selcuk T Orhan B | 1995 | J Surg Oncol1995，60，： | 1 |
| 5 | Anaerobic treatment of dairy wastewaters显示文摘 | Burak Demirel Orhan Yenigun Turgut T | 2005 | A review Process Biochemistry2005，40，： | 1 |
| 6 | Revisiting the PredictiveFactors for Intra-Operative Complications of Rigid Ureteroscopy显示文摘 | Orhan T Mesrur SS Mustafa K | 2012 | Urol J2012，9，2： | 1 |
| 7 | Assessment of shoulder impairment after functional neck dissection:long term results显示文摘 | Guldiken Y Orhan KS Demirel T | 2005 | Attris Nasus Larynx2005，32，4： | 1 |
| 8 | Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial 显示文摘 | Orhan T Bundy B Becker DJ | 2011 | Lancet2011，378，9789： | 1 |
| 9 | Determination of bismuth, indium and lead in geological samples by electrothermal AAS Part 2. Comparative study of palladium and molybdenum containing chemical modifiers*显示文摘 | Orhan Acar A. Rehber Türker Ziya K?l?? | 1998 | Fresenius’ Journal of Analytical Chemistry1998，，6： | 1 |
| 10 | Hemodynamic response to intravitreal triamcinolone in eyes with macular edema显示文摘 | Osman ?eki? Yavuz Bardak ?ahin U. T?? Aykut Demirkol Mustafa M. Ekim ?nem Alt?nta? Ahmet Ye?ilda? Orhan Oyar | 2007 | International Ophthalmology2007，，5： | 1 |
| 11 | Dentin hypersensi- tivity: a randomized clinical comparison of three different a- gents in a short-term treatment period 显示文摘 | Ozen T Orhan K Avsever H | 2009 | Operative den- tistry2009，34，4： | 1 |
| 12 | Calcifying fibrous pseudotumor of lung:a previously unreported entity显示文摘 | Soyer T Ciftei A O Gücer S Orhan D Senocak M E | | 0，，： | 1 |
| 13 | Anaerobic treatment of dairy wastewaters:a review 显示文摘 | Burak Demirel Orhan Yenigtm Turgut T Onay | 2005 | Process Biochemistry2005，，40： | 1 |
| 14 | Thermal degradation mechanisms of aluminium phosphinate,melamine polyphosphate and zinc borate in poly(methyl methacrylate)显示文摘 | Orhan T Isitman N A Haealoglu J | 2011 | Polymer Deg- radation and Stability2011，96，10： | 1 |
| 15 | Treatment of textile wastewaters by electrocoagulation using iron and aluminum electrodes显示文摘 | MEHMET K ORHAN T C MAHMUT B | 2003 | Journal of Hazardous Materials2003，100，123： | 1 |
| 16 | The electrical conductivity properties of polythiophene/TiO2 nanocomposites prepared in the presence of surfactants 显示文摘 | Aysegul U T Orhan S Songul | 2009 | Current Applied Phys- ics2009，，9： | 1 |
| 17 | Diffusion bonding of a microduplex stainless steel to Ti-6Al-4V显示文摘 | Orhan N Khan T I Eroglu M | 2001 | Scripta Materialia2001，45，4： | 1 |
| 18 | Thermal degradation mechanisms of aluminium phosphinate,melamine polyphosphate and zinc borate in poly(methyl methacrylate)显示文摘 | Orhan T Isitman N A Hacaloglu J | 2011 | Polymer Degradation and Stability2011，96，10： | 1 |
| 19 | Diffusion Bonding Between Ti-6Al-4V Alloy and Microduplex Stainless Steel with Copper Interlayer显示文摘 | EROGLU M KHAN T I ORHAN N | 2002 | Materials Science and Technology2002，18，： | 1 |
| 20 | Diffusion Bonding of a Microduplex Stainless Steel to Ti-6Al-4V 显示文摘 | Orhan N Khan T I Eroglu M | 2001 | Scripta Materialia2001，45，： | 1 |
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