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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | In vitro anti-mycobacterial activities of a new quinolone,balofloxacin 显示文摘 | KAWAHARA S TADA A NAGARE H | 2001 | Kekkaku2001，76，1： | 1 |
| 3 | Sequence analysis and bioinformatics analysis of chromosome 17q25 in familial moyamoya disease显示文摘 | Nanba R Tada M Kuroda S | 2005 | Childs Nerv Syst2005，21，1： | 1 |
| 4 | Characterization and evaluation of miconazole salts and cocrystals for improved physicochemical properties显示文摘 | Tsutsumi S Iida M Tada N | 2011 | Int J Pharm2011，421，： | 1 |
| 5 | Inflammatory pseudotumor of the parapharyngeal space:a case report显示文摘 | Maruya S Miura K Tada Y | 2010 | Auris Nasus Larynx2010，37，3： | 1 |
| 6 | Successful catheter ablation of atrial tachycardia originating near the atrioventricular node fromthe noncoronary sinus of valsalva显示文摘 | Tada H Naito S Miyazaki A | 2004 | Pacing Clin Electrophysiol2004，27，10： | 1 |
| 7 | An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-beta and protein kinase C activity in cultured mesangial cells显示文摘 | Ishii H Tada H Isogai S | 1998 | Diabetologia1998，41，3： | 1 |
| 8 | Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma 显示文摘 | Ushio Y Tada K Shiraishi S | 2003 | Front Biosci2003，8，2： | 1 |
| 9 | Correlation between promoter hypermethylation of the O6-methylguanine-deoxyribonucleic acid methyltransferase gene and prognosis in patients with high-grade astrocytic tumors treated with surgery,radiotherapy,and 1-(4-amino-2-methyl-5 -pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitroso-urea-based chemotherapy显示文摘 | KAMIRYO T TADA K SHIRAISHI S | 2004 | Neurosurgery2004，54，2： | 1 |
| 10 | Reduction in non- fluorescence state of quantum dots on an immunofluorescence staining显示文摘 | Li-Shishido S Watanabe TM Tada H | 2006 | Biochem Biophys Res Commun2006，351，1： | 1 |
| 11 | The Nationwide GPS Array as an earth observation system 显示文摘 | Miyazaki S Hatanaka Y Sagiya T Tada T | 1998 | Bulletin of Geographical Survey Institute1998，44，： | 1 |
| 12 | Nanog expression in mouse germ cell development 显示文摘 | Yamaguchi S Kimura H Tada M | 2005 | Gene Expr Patterns2005，5，： | 1 |
| 13 | Influence of implant design and bone quality on stress/strain distribution in bone around implants: A 3-dimensional finite element analysis Int 显示文摘 | Tada S Stegaroiu R Kitamura E | 2003 | J Maxillofac Implants2003，18，3： | 1 |
| 14 | A free rodical scavenger,edaravone,attenuateds steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injnry显示文摘 | Nakamoto N Tada S Kameyama K | 2003 | Free Radic Kes2003，37，80： | 1 |
| 15 | Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats显示文摘 | Tada S Nakamuta M Enjoji M | 2001 | Clin Exp Pharmacol Physiol2001，28，： | 1 |
| 16 | Development and validation of an ECG algorithm for identifying the optimal ablation site for idiopathic ventricular outflow tract tachycardia显示文摘 | Ito S Tada H Naito S | 2003 | J Cardiovasc Electrophysiol2003，14，2： | 1 |
| 17 | Simultaneous de- termination of nitrate and nitrite ions in seawater by capillary zone electrophoresis using artificial seawater as the carrier solu- tion 显示文摘 | FUKUSHI K TADA K TAKEDA S | 1999 | J Chromatogr A1999，83，8： | 1 |
| 18 | Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme显示文摘 | Shinojima N Tada K Shiraishi S | 2003 | Cancer Res2003，63，： | 1 |
| 19 | Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis显示文摘 | Kitamura K Tada S Nakamoto N | 2007 | J Gastroenterol Hepatol2007，22，11： | 1 |
| 20 | Induction of communicating hydrocephalus in mice by intrathecal injection of human recombinant transforming growth factor-beta 1显示文摘 | Tada T Kanaji M Kobayashi S | 1994 | Journal of neuroimmunology1994，50，2： | 1 |
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