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| 1 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 2 | BAFF, involved in B cell activation through the NF-κB pathway, is related to disease activity and bone destruction in rheumatoid arthritis显示文摘B cell activating factor of TNF family(BAFF)is a member of TNF ligand superfamily and plays a key role in B cell homeostasis,proliferation,maturation,and survival.In this study,we detected BAFF level,the expressions of BAFF receptors and important molecules in NF-κB pathway in rheumatoid arthritis(RA)patients and analyzed the correlation between BAFF level and clinical variables,laboratory parameters or X-ray scores in order to elucidate the roles of BAFF in RA.A total of 50 RA patients and 50 healthy controls(HCs)were enrolled.We showed that the serum BAFF level in RA patients was significantly higher than that of HCs,and the percentages of B cell subsets(CD19^(+)B cells,CD19^(+)CD27^(+)B cells,CD19^(+)CD20^(+)CD27^(+)B cells,and CD19^(+)CD20−CD27^(+)B cells)in the serum of RA patients were significantly increased compared with those of HCs.The percentages of CD19^(+)BAFFR^(+)B cells,CD19^(+)BCMA^(+)B cells,and CD19^(+)TACI^(+)B cells in RA patients were significantly increased compared with those in HCs.The expression of important molecules in the NF-κB pathway(MKK3,MKK6,p-P38,p-P65,TRAF2,and p52)was significantly higher in RA patients than in HCs,but p100 level in RA patients was lower than that in HCs.The serum BAFF level was positively correlated with C-reactive protein,rheumatoid factor,disease activity score(in 28 joints),swollen joint counts,tender joint counts,and X-ray scores.When normal B cells were treated with BAFF in vitro,the percentages of the B cell subset and the expression of BAFF receptors were significantly upregulated.BAFF also promoted the expression of MKK3,MKK6,p-P38,p-P65,TRAF2,and p52.In conclusion,this study demonstrates that BAFF level is correlated with the disease activity and bone destruction of RA.BAFF is involved in the differentiation,proliferation,and activation of B cells in RA through NF-κB signaling pathway,suggesting that BAFF might be an ideal therapeutic target for RA. | Ling-ling Zhang Hui Xiao Feng Zhang Yu-jing Wu Jin-ling Shu Ying Li Yu Tai Sheng-qian Xu Jian-hua Xu Wei Wei | 2021 | Acta Pharmacologica Sinica2021，42，10： | 9 |
| 3 | Corrosion behavior of aluminum alloys in Na_2SO_4 solution using the scanning electrochemical microscopy technique显示文摘The corrosion behavior of aluminum alloys 1060 and 2A12 in a 10 mM Na2SO4+5 mM KI solution was investigated by scanning electrochemical microscopy(SECM) and scanning electron microscopy(SEM) . The potential topography and corrosion morphology results show that the potential of the sample surface over the same area changes with the increase of immersion time. The corrosion area becomes large,and the potential becomes more negative. The corrosion potential of the 2A12 alloy surface is lower than that of 1060 aluminum,and 2A12 alloy becomes easily corrosive. This is the reason that preferential dissolution in the boundary region of some intermetallic particles(IMPs) occurs and different dissolution behaviors are associated with different types of IMPs because of different potentials. | He-rong Zhou Xiao-gang Li Chao-fang Dong Kui Xiao Tai Li | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，1： | 8 |
| 4 | Basaloid squamous carcinoma of esophagus:a clinicopathological,immunohistochemical and electron microscopic study of sixteen cases显示文摘INTRODUCTIONThetermbasaloidsquamouscarcinoma(BSC)wasfirstproposedbyWainetalin1986todescribearare,aggresiveneoplasmwithapredil... | ZHANG Xin Hua, SUN Gui Qin, ZHOU Xiao Jun, GUO Hui Fang and ZHANG Tai He | 1998 | World Journal of Gastroenterology1998，4，5： | 8 |
| 5 | Application of Contact Graph Routing in Satellite Delay Tolerant Networks显示文摘Satellite networks have many inherent advantages over terrestrial networks and have become an important part of the global network infrastructure.Routing aimed at satellite networks has become a hot and challenging research topic.Satellite networks,which are special kind of Delay Tolerant Networks(DTN),can also adopt the routing solutions of DTN.Among the many routing proposals,Contact Graph Routing(CGR) is an excellent candidate,since it is designed particularly for use in highly deterministic space networks.The applicability of CGR in satellite networks is evaluated by utilizing the space oriented DTN gateway model based on OPNET(Optimized Network Engineering Tool).Link failures are solved with neighbor discovery mechanism and route recomputation.Earth observation scenario is used in the simulations to investigate CGR's performance.The results show that the CGR performances are better in terms of effectively utilizing satellite networks resources to calculate continuous route path and alternative route can be successfully calculated under link failures by utilizing fault tolerance scheme. | ZHU Laitao LI Yong ZHANG Junxiang WU Jing TAI Xiao ZHOU Jianguo | 2015 | 空间科学学报2015，35，1： | 5 |
| 6 | Keggin type heteropolyacids-catalyzed synthesis of quinoxaline derivatives in water显示文摘Keggin 类型 heteropolyacids 被发现是为从有在水里的优秀收益的 1,2-dicarbonyl 混合物的 1,2 肼的冷凝作用的生物学上活跃的 quinoxaline 衍生物的合成的有效、可重用的催化剂。这个方法以催化剂,底层的一个宽范围,和简单病情的检查过程的小数量提供一个新、有效的协议。 | Tai Kun Huang Lin Shi Rui Wang Xing Zhou Guo Xiao Xia Lu | 2009 | Chinese Chemical Letters2009，20，2： | 4 |
| 7 | ISORHYNCHOPHYLLIC ACID,A NEW AIKALOID FROM UNCARIA SINENSIS显示文摘From the hook of Uncaria sinensis, a new alkaloid, isorhynchophyllicacid was isolated and its structure was elucidated by spectral data and chemicalreaction. | Hong Mei LIU Xiao Zhang FENG Yang LU Qi Tai ZHENG Institetu of Materia Medica, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050 | 1992 | Chinese Chemical Letters1992，3，6： | 4 |
| 8 | Development and application of a throughflow method for high-loaded axial flow compressors显示文摘In this paper, a novel engineering platform for throughflow analysis based on streamline curvature approach is developed for the research of a 5-stage compressor. The method includes several types of improved loss and deviation angle models, which are combined with the authors' adjustments for the purpose of reflecting the influences of three-dimensional internal flow in high-loaded multistage compressors with higher accuracy. In order to validate the reliability and robustness of the method, a series of test cases, including a subsonic compressor P&W 3S1, a transonic rotor NASA Rotor 1B and especially an advanced high pressure core compressor GE E^3 HPC, are conducted. Then the computation procedure is applied to the research of a 5-stage compressor which is designed for developing an industrial gas turbine. The overall performance and aerodynamic configuration predicted by the procedure, both at design- and part-speed conditions, are analyzed and compared with experimental results, which show a good agreement. Further discussion regarding the universality of the method compared with CFD is made afterwards. The throughflow method is verified as a reliable and convenient tool for aerodynamic design and performance prediction of modern high-loaded compressors. This method is also qualified for use in the further optimization of the 5-stage compressor. | LI Bo GU Chun Wei LI Xiao Tang LIU Tai Qiu XIAO Yao Bing | 2016 | Science China(Technological Sciences)2016，59，1： | 3 |
| 9 | Ideal Cardiovascular Health Metrics and Coronary Artery Calcification in Northern Chinese Population:A Cross-sectional Study显示文摘Objective Coronary artery calcification(CAC) is a well-established risk predictor of coronary heart disease events and is recognized as an indicator of subclinical atherosclerosis.Methods A cross-sectional study consisting of 2999 participants aged ≥40 years from the Jidong community of Tangshan City,an industrial and modern city of China,was conducted between 2013 and 2014 to examine the association between the ideal cardiovascular health(CVH) metrics and CAC.The ideal CVH metrics were determined based on the definition of the American Heart Association(AHA).The participants were then grouped into 4 categories according to the quartiles of their CVH metric scores as follows:first quartile(0-2),second quartile(3),third quartile(4),and fourth quartile(5-7).CAC was assessed by using high-pitch dual-source CT,and patients were identified based on thresholds of 0,10,100,or 400 Agatston units,as per common practice.Results The prevalence of subclinical atherosclerosis was 15.92%,13.85%,6.76%,and 1.93%,determined by using the CAC scores at thresholds of 0,10,100,and 400 Agatston units,respectively.Compared with the group in the first quartile,the other three CVH groups had a lower odds ratio of CAC >0 after adjusting for age,sex,income level,education level,and alcohol use in the logistic regression analysis.The odds ratios in these groups were 0.86 [95% confidence interval(CI),0.63-1.17;P<0.05],0.75(95% CI,0.55-1.02;P<0.05),and 0.49(95% CI,0.35-0.69;P<0.05),respectively.These associations of CAC with the CVH metrics were consistent when different CAC cutoff scores were used(0,10,100,or 400).Conclusion The participants with more-ideal cardiovascular metrics had a lower prevalence of subclinical atherosclerosis determined according to CAC score.Maintaining an ideal cardiovascular health may be valuable in the prevention of atherosclerosis in the general population. | LUO Tai Yang LIU Xiao Hui DAI Tian Yi LIU Xin Min ZHANG Qian DONG Jian Zeng | 2016 | Biomedical and Environmental Sciences2016，29，7： | 2 |
| 10 | Accurate and generalizable quantitative scoring of liver steatosis from ultrasound images via scalable deep learning显示文摘BACKGROUND Hepatic steatosis is a major cause of chronic liver disease.Two-dimensional(2D)ultrasound is the most widely used non-invasive tool for screening and monitoring,but associated diagnoses are highly subjective.AIM To develop a scalable deep learning(DL)algorithm for quantitative scoring of liver steatosis from 2D ultrasound images.METHODS Using multi-view ultrasound data from 3310 patients,19513 studies,and 228075 images from a retrospective cohort of patients received elastography,we trained a DL algorithm to diagnose steatosis stages(healthy,mild,moderate,or severe)from clinical ultrasound diagnoses.Performance was validated on two multiscanner unblinded and blinded(initially to DL developer)histology-proven cohorts(147 and 112 patients)with histopathology fatty cell percentage diagnoses and a subset with FibroScan diagnoses.We also quantified reliability across scanners and viewpoints.Results were evaluated using Bland-Altman and receiver operating characteristic(ROC)analysis.RESULTS The DL algorithm demonstrated repeatable measurements with a moderate number of images(three for each viewpoint)and high agreement across three premium ultrasound scanners.High diagnostic performance was observed across all viewpoints:Areas under the curve of the ROC to classify mild,moderate,and severe steatosis grades were 0.85,0.91,and 0.93,respectively.The DL algorithm outperformed or performed at least comparably to FibroScan control attenuation parameter(CAP)with statistically significant improvements for all levels on the unblinded histology-proven cohort and for“=severe”steatosis on the blinded histology-proven cohort.CONCLUSION The DL algorithm provides a reliable quantitative steatosis assessment across view and scanners on two multi-scanner cohorts.Diagnostic performance was high with comparable or better performance than the CAP. | Bowen Li Dar-In Tai Ke Yan Yi-Cheng Chen Cheng-Jen Chen Shiu-Feng Huang Tse-Hwa Hsu Wan-Ting Yu Jing Xiao Lu Le Adam P Harrison | 2022 | World Journal of Gastroenterology2022，28，22： | 2 |
| 11 | Consumption of Large Amounts of Allium Vegetables Reduces Risk for Gastric Cancer in a Meta-analysis显示文摘 | Yong Zhou Wen Zhuang Wen Hu Guan–Jian Liu Tai–Xiang Wu Xiao–Ting Wu | 2011 | Gastroenterology2011，，1： | 2 |
| 12 | Appropriate choice of collision-induced dissociation energy for qualitative analysis of notoginsenosides based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry显示文摘Liquid chromatography hybrid ion trap/time-of-flight mass spectrometry possesses both the MS^n ability of ion trap and the excellent resolution of a time-of-flight and has been widely used to identify drug metabolites and determine trace multi-components in natural products. Collision energy, one of the most important factors in acquiring MS^n information, could be set freely in the range of 10%–400%. Herein, notoginsenosides were chosen as model compounds to build a novel methodology for the collision energy optimization. Firstly, the fragmental patterns of the representatives for the authentic standards of protopanaxadiol-type and protopanaxatriol-type notoginsenosides were obtained based on accurate MS^2 and MS^3 measurements via liquid chromatography hybrid ion trap/time-of-flight mass spectrometry. The extracted ion chromatograms of characteristic product ions of notoginsenosides in Panax Notoginseng Extract were produced under a series of collision energies and compared to screen the optimum collision energies values for MS^2 and MS^3. The results demonstrated that the qualitative capability of liquid chromatography hybrid ion trap/time-of-flight mass spectrometry was greatly influenced by collision energies, and 50% of MS^2 collision energy was found to produce the highest collision-induced dissociation efficiency for notoginsenosides. Addtionally, the highest collision-induced dissociation efficiency appeared when the collision energy was set at 75% in the MS^3 stage. | WANG Guang-Ji FU Han-Xu XIAO Jing-Cheng YE Wei RAO Tai SHAO Yu-Hao KANG Dian XIE Lin LIANG Yan | 2016 | Chinese Journal of Natural Medicines2016，14，4： | 2 |
| 13 | Distortion Theorems for Normalized Biholomorphic Quasi-convex Mappings显示文摘In this paper, we will use the Schwarz lemma at the boundary to character the distortion theorems of determinant at the extreme points and distortion theorems of matrix on the complex tangent space at the extreme points for normalized locally biholomorphic quasi-convex mappings in the unit ball Bnrespectively. | Xiao Fei ZHANG Tai Shun LIU Yong Hong XIE | 2017 | Acta Mathematica Sinica,English Series2017，33，9： | 1 |
| 14 | Computed Tomography Angiography in Diagnosis and Treatment of Splenic Artery Aneurysm显示文摘Splenic artery aneurysm, without obvious symptoms, is a direct threat to the patient's life, once it ruptures as hemorrhagic shock.Imaging examinations have been the main diagnostic methods of splenic artery aneurysm, including ultrasound, computed tomography (CT), magnetic resonance imaging, and digital subtraction angiography (DSA).Although various inspective methods have their own advantages and disadvantages, abdominal CT examination is the most comprehensively applied method in clinical settings.The representative images of splenic artery aneurysm from a relatively large number of patients examined by CT are presented in this study. | Chun-Xi Wang Shu-Li GUO Li-Na Han Yang Jie Hai-Di Hu Jing-Ru Cheng Miao Yu Yue-Yong Xiao Tai Yin Fu-Tao Chu Fa-Qi Liang | 2016 | Chinese Medical Journal2016，，3： | 1 |
| 15 | Estimation of the number of sources based on hypothesis testing显示文摘 | Xiao Man-lin Wei Ping and Tai Heng-ming | 2012 | Journal of Communications and Networks2012，14，5： | 1 |
| 16 | Synthesis and phosphorescent properties of two novel iridium (Ⅲ) complexes bearing bulky tert-butyl substituents显示文摘The synthesis and phosphorescence properties of two novel Ir(Ⅲ)complexes bearing tert-butyl substituents,bis(4-tert-butyl-2- phenylbenzothiozolato-N,C2′)iridium(Ⅲ)(acetylacetonate)[(tbt)2Ir(acac)]and bis(4-tert-butyl-1-phenyl-1H-benzimidazolato- N,C2′)iridium(Ⅲ)(acetylacetonate)[(tpbi)2Ir(acac)],are reported,their molecular structures are confirmed by1H NMR,ESI-MS and elementary analysis.Photoluminescence(PL)studies revealed that they can emit strong green and orange phosphorescence in high quantum yields.Compared to their prototypes lacking of tert-butyl substituents,the two novel iridium(Ⅲ)complexes both have shorter lifetimes and improved or nearly similar PL quantum efficiencies,implying that the exciton quenching is inhibited effectively when molecular steric hindrance increases.The two chelates have great potential to be used as electrophosphorescent materials. | Rong Huang~a Xiao Qiang Wei~(a,b) Tai Ping Zhang~a Zhi Yun Lu~(a,*) Ming Gui Xie~a a College of Chemistry,Sichuan University,Chengdu 610064,China b School of Optic-electronic Information,University of Electronic Science and Technology of China,Chengdu 610054,China | 2007 | Chinese Chemical Letters2007，18，9： | 1 |
| 17 | Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells显示文摘 | GuoLi Xiao‐aiZhang Jin‐fangZhang Chu‐yanChan David Tai WaiYew Ming‐liangHe Marie Chia‐miLin Ping‐chungLeung Hsiang‐fuKung | 2010 | Phytother Res2010，，4： | 1 |
| 18 | Predictive chemotherapy of advanced breast cancer directed by MTT assay in vitro显示文摘 | Jian‐ming Xu San‐tai Song Zhong‐ming Tang Ze‐fei Jiang Xiao‐qing Liu Li Zhou Jing Zhang Xiu‐wen Liu | 1999 | Breast Cancer Research and Treatment1999，，1： | 1 |
| 19 | Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice显示文摘 | Xiaoyan Xiao Bin Ma Baojun Dong Peng Zhao Ningwen Tai Li Chen F. Susan Wong Li Wen | 2009 | Journal of Autoimmunity2009，，2： | 1 |
| 20 | SYNTHESIS OF 6-AMINO, 6-METHOXY AND 6-ETHOXY PURINENUCLEOSIDE DERIVATIVES显示文摘A convenient route for the conversion of inosine to the corresponding 6-amino, 6-methoxy and 6-ethoxy derivatives is reported. This conversion can be achieved by ammoniation or etherification of the 6-pyridinium intermediate(3) which can be readily produced under mild reaction conditions. The chemistry and characterization of these compounds are presented, A plausible mechanism of the reaction is proposed. | Li Ya ZHU~*, Xiao Tian LIANG Institute of Materia Medica, Chinese Academy of Medical Sciences Beijing 100050 Tai Shun LIN Department of Pharmacology, Yale University School of Medicine. New Haven, CT 06510 U. S. A. | 1991 | Chinese Chemical Letters1991，2，8： | 1 |
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