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| 1 | Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes显示文摘The objective was to investigate the effect of kinsenoside(Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis(OA) progression.RAW264.7 macrophages were polarized to M1/M2 subtypes then administered with different concentrations of Kin. The polarization transitions were evaluated with quantitative real-time polymerase chain reaction(q RT-PCR), confocal observation and flow cytometry analysis. The mechanism of Kin repolarizing M1 macrophages was evaluated by Western blot. Further, macrophage conditioned medium(CM) and IL-1β were administered to chondrocytes. Micro-CT scanning and histological observations were conducted in vivo on anterior cruciate ligament transection(ACLT) mice with or without Kin treatment. We found that Kin repolarized M1 macrophages to the M2 phenotype. Mechanistically, Kin inhibited the phosphorylation of IκBα, which further reduced the downstream phosphorylation of P65 in nuclear factor-κB(NF-κB) signaling. Moreover, Kin inhibited mitogen-activated protein kinases(MAPK) signaling molecules p-JNK, p-ERK and p-P38. Additionally, Kin attenuated macrophage CM and IL-1β-induced chondrocyte damage. In vivo, Kin reduced the infiltration of M1 macrophages,promoted M2 macrophages in the synovium, inhibited subchondral bone destruction and reduced articular cartilage damage induced by ACLT. All the results indicated that Kin is an effective therapeutic candidate for OA treatment. | Feng Zhou Jingtian Mei Xiuguo Han Hanjun Li Shengbing Yang Minqi Wang Linyang Chu Han Qiao Tingting Tang | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 35 |
| 2 | NONLINEAR EFFECT OF THE DUALFREQUENCY IP SPECTRUM显示文摘NONLINEAREFFECTOFTHEDUALFREQUENCYIPSPECTRUMHeJishan;LiDaqing;TangJingtian(DepartmentofGeology,CentralSouthUniversityofTechnol... | He Jishan Li Daqing Tang Jingtian(Department of Geology,Central South University of Technology,Changsha 410083) | 1995 | 中国有色金属学会会刊:英文版1995，5，4： | 2 |
| 3 | Study of numerical simulation on dual-frequency IP method with FEM显示文摘Using the finite element method and Cole-Cole model for dual-frequency IP method to research numerical simulation, the authors introduced the fundamental principle of the dual-frequency IP method and the boundary value problem and variational equations, then replaced the complex resistivity of the model with the Cole-Cole model's parameters under ignoring the EM effect. Through solving the last linear equations, electric potentials of all the model's points were obtained. With changing model's parameters, the authors got different curves of the Fs and phases. According to the results of the simulation, the algorithm is proved to be correct and adaptable. | LIN Jiayong DIN Maobin TANG Jingtian YAN Hong | 2010 | Global Geology2010，13，2： | 2 |
| 4 | Tfibological behaviours of carbon fibre reinforced PEEK sliding on silicon nitride lubricated with water显示文摘 | TANG Qunguo CHEN Jingtian LIU Liping | 2010 | Wear2010，269，8： | 1 |
| 5 | Effect of local hyperthermia induced by nanometer magnetic fluid on the rabbit VX2 liver tumor model显示文摘磁性的 nanoparticles 导致的过高热是为过高热和 thermoablation 的本地指向的一条最近的治疗学的途径并且是恶意的肿瘤的有希望的治疗。这研究的目的是在兔子 VX2 肝肿瘤模型上评估磁性的液体过高热的潜在、治疗学的效果。兔子适用肝肿瘤在肿瘤培植以后的 14 天随机各被划分成五组 10 个盒子,包括三个控制组和二过高热组织。过高热在单个 intratumoral 注射以后立即被执行非常 ated 以水为基的 Fe 3 在一个轮流出现的磁场下面的磁性的液体仅仅曾经作为其它当作了在 5 天以后的一个过高热组和重复过高热的 O 4 组。磁性的液体的分发被扫描的 CT 评估。所有动物 4 个星期在肿瘤培植以后被牺牲。治疗学的效果被肿瘤尺寸和肝肿瘤的宏观、病理学的检查决定。磁性的液体与包围织物相比扔的 intratumoral 的本地更高的密度成像被扫描的 CT 清楚地观察。在肿瘤培植以后的 28 天,肿瘤二过高热的最大的直径和肿瘤体积显著地是控制组的不到那些(P <
0.05 ) 。由与三个控制组相比的单个或重复的过高热的肿瘤体积抑制是 71.93 79.91% 和 92.34 94.46%(P <
0.05 ) 分别地。在一台显微镜下面,凝结坏死在激烈的区域被观察,它与包围织物有一根清楚的边界线。特别在坏死的区域,磁性的 nanoparticles 的 intratumoral 分发显得比在未经治疗的更同质。这研究证明磁性的液体的直接 intratumoral 注射导致的过高热能安全地被使用,并且没有加热的高 intratumoral 温度的一致得好的分布邻近正常织物能被完成。 | Lehui Du Jumei Zhou Xiaowen Wang Lin Sheng Guihua Wang Xiaoxue Xie Guoquan Xu Lingyun Zhao Yuping Liao Jingtian Tang | 2009 | Progress in Natural Science:Materials International2009，19，12： | 1 |
| 6 | A new method for vehicle license plate character segmentation显示文摘 | Meisen Pan Jingtian Tang Qi Xiong | 2010 | ICIC Express Letters2010，4，3： | 1 |
| 7 | 3D direct current resistivity modeling with unstructured mesh by adaptive finite-element method显示文摘 | REN Zhengyong TANG Jingtian | 2010 | Geophysics2010，75，1： | 1 |
| 8 | 3D finite-element modeling of Earth induced electromagnetic field and its potential applications for geomagnetic satellites显示文摘The accumulated large amount of satellite magnetic data strengthens our capability of resolving the electrical conductivity of Earth’s mantle.To invert these satellite magnetic data,accurate and efficient forward modeling solvers are needed.In this study,a new finite-element based forward modeling solver is developed to accurately and efficiently compute the induced electromagnetic field for a realistic 3D Earth.Firstly,the nodal-based finite element method with linear shape function on tetrahedral grid is used to assemble the final system of linear equations for the magnetic vector potential and electric scalar potential.The FGMRES solver with algebraic multigrid(AMG)preconditioner is used to quickly solve the final system of linear equations.The weighted moving least-square method is employed to accurately recover the electromagnetic field from the numerical solutions of magnetic vector and electric scalar potentials.Furthermore,a local mesh refinement technique is employed to improve the accuracy of the estimated electromagnetic field.At the end,two synthetic models are used to verify the accuracy and efficiency of our newly developed forward modeling solver.A realistic 3D Earth model is used to simulate the induced magnetic field at 450 and 200 km altitudes which are the planned flying altitudes of Macao’s geomagnetic satellites.The simulation indicates that(1)the amplitude of the mantle-induced magnetic field can reach 10–30 nT at 450 km altitude,which is 10–30%of the primary magnetic field.The induced magnetic field at 200 km altitude has larger amplitudes.These mantleinduced magnetic fields can be measured by Macao geomagnetic satellites;(2)the amplitude of the ocean-induced magnetic field can reach 5–30 nT at satellite altitudes,which needs to be carefully considered in the interpretation of satellite magnetic data.We are confident that our newly developed forward modeling solver will become a key tool for interpreting satellite magnetic data. | Hongbo YAO Zhengyong REN Jingtian TANG Yufeng LIN Changchun YIN Xiangyun HU Qinghua HUANG Keke ZHANG | 2021 | Science China Earth Sciences2021，64，10： | 1 |
| 9 | An Analysis Method for Magnetotelluric Data Based on the Hilbert-Huang Transform显示文摘 | Cai Jianhua Tang Jingtian | | 0，，2： | 1 |
| 10 | De-Noising Algo-rithm for Magnetotelluric Signal Based on Mathema-tical Morphology Filtering显示文摘 | Li Jin Tang Jingtian Xiao Xiao | | 0，，11： | 1 |
| 11 | 3D direct current resistivity forward modeling by adaptive multigrid finite element method显示文摘 | TANG Jingtian WANG Feiyan REN Zhengyong | 2010 | J Cent South Univ Technol2010，17，3： | 1 |
| 12 | 3D direct current resistivity modeling with unstructured mesh by adaptive finite-element method显示文摘 | REN Zhengyong TANG Jingtian | 2010 | Geophysics2010，75，： | 1 |
| 13 | An analysis method for magnetotelluric data based on the Hilbert-Huang Transtbrm 显示文摘 | CAI Jianhua TANG Jingtian HUA Xirui | 2009 | Exploration Geophysics2009，40，： | 1 |
| 14 | Tfibological behaviours of carbon fibre reinforced PEEK sliding on silicon nitride lubricated with water显示文摘 | TANG Qunguo CHEN Jingtian LIU Liping | 2010 | Wear2010，269，7： | 1 |
| 15 | Application of integrated geophysical interpretation on accumulation body显示文摘Integrated geophysical interpretation is a method of combinating different geophysics prospecting methods based on different physical properties of accumulation. As different geophysical methods own different interpretations and varying detection accuracies, the key issue becomes how to integrate the results of several geophysical methods to corrently carry out a comprehensive explanation. Based on different geophysical results, the authors proposed an integrated geophysical explanation method and successfully applied it in practical engineering problems. | Caikun GAO Huakun DU Jingtian TANG Kangxiu WU Chang'an XIAO Shiping WANG | 2008 | Global Geology2008，11，3： | 0 |
| 16 | EQUIVALENT CIRCUIT OF NONLINEAR EFFECT OF SPECTRAL IP显示文摘EQUIVALENTCIRCUITOFNONLINEAREFFECTOFSPECTRALIP￥He,Jishan;Li,Daqing;Tang,Jingtian(DepartmentofGeology,CentralSouthUniversityof... | He, Jishan Li, Daqing Tang, Jingtian(Department of Geology, Central South University of Technology, Changsha 410083) | 1995 | 中国有色金属学会会刊:英文版1995，5，3： | 0 |
| 17 | SQUARE WAVE COHERENT METHOD FOR EXTRACTING IP EFFECT显示文摘SQUAREWAVECOHERENTMETHODFOREXTRACTINGIPEFFECT￥He,Jishan;Wang,Shaowu;TangJingtian(CentralSouthUnivercityofTechnology,Changsha,... | He, Jishan Wang, Shaowu Tang Jingtian(Central South Univercity of Technology, Changsha, 410083) | 1995 | 中国有色金属学会会刊:英文版1995，5，2： | 0 |
| 18 | CHOPPING WAVE METHOD FOR REMOVING ELECTROMAGNETIC INDUCTION COUPLING显示文摘CHOPPINGWAVEMETHODFORREMOVINGELECTROMAGNETICINDUCTIONCOUPLINGHe;JishanWang;ShaowuTang;Jingtian(CentralSouthUniversityoftechno... | He Jishan Wang Shaowu Tang Jingtian(Central South University of technology , Changsha 410083) | 1995 | 中国有色金属学会会刊:英文版1995，5，1： | 0 |
| 19 | Through-Wall Tracking of Human Movers Using Continuous-Wave Radar显示文摘An intelligent frequency fitting algorithm is presented for continuous-wave radar to track human movers through walls. With the proper fitting dimension,which is usually determined by the practical detection requirements, this technique can improve the localization accuracy and the tracking performance without introducing too much calculation burden, and more precisely identify different targets even in the frequency ambiguous areas.This technology can also help to match the estimation results to their corresponding targets automatically, which is of great importance to certain urban sensing applications,such as specific target surveillance and tracking. To further improve the detection performance and better identify the weak targets in the presence of strong noise, CLEAN algorithm and adaptive filter technology are also involved.Experimental results are provided to illustrate the algorithm performance. | DING Yipeng TANG Jingtian Cheng Dong Fang Guangyou | 2014 | Chinese Journal of Electronics2014，23，2： | 0 |
| 20 | High-precision modeling of tide-induced 3-D magnetic field and analysis of geomagnetic satellite orbit requirements显示文摘Ground-based magnetic observatories and geomagnetic satellites can observe the induced magnetic field generated by the motion of seawater containing sodium and chlorine ions.Calculating the three-dimensional(3-D)spatial distribution of tide-induced magnetic fields(TIMF)is crucial for inverting the electrical conductivity structure of the oceanic lithosphere.It also serves as an essential basis for designing optimal geomagnetic observatories and satellite orbits.However,existing methods for simulating TIMF suffer from limitations in inaccurately modeling realistic coastlines,heterogeneous land and sea surface properties,and complex deep Earth structures,thereby the interpretational level of TIMF data is reduced.To overcome this issue,we developed a tetrahedral-based finite element method for simulating TIMF,which can efficiently approximate realistic coastlines,heterogeneous land and sea surface properties,and complex deep Earth structures.Firstly,we derived the boundary value problem for the seawater motion-induced electromagnetic field,which was solved using the vector finite element method based on tetrahedral elements.Secondly,using the latest ocean depth and seafloor sediment layer models,we constructed a 3-D conductivity model of the Earth,which includes realistic coastlines,heterogeneous land and sea conductivity distributions.We then computed the TIMF using the M_(2)tidal source as an example and validated our method by comparing it with results obtained from spherical harmonic finite element and integral equation methods.Finally,utilizing the computed high-precision M_(2),N_(2),and O1 TIMF signals,we marked global observatories capable of observing strong M_(2),N_(2),and O1 TIMF signals and predicted alternative stations suitable for tide signal observations.Additionally,we calculated TIMF at heights of 450 and 200 km for the Macao Science Satellite 1 and its subsequent satellites.The results indicate that the amplitude of the tidal-induced magnetic field at 200 km is approximately twice that at 450 km.The maximum amplitudes of M_(2),N_(2),and O1 TIMF at 200 km are eight,two,and three times the measurement accuracy of the magnetic sensing payload(0.5 nT),respectively.The 200 km orbit has great potential for detecting high-resolution electrical structures of the seafloor lithosphere and asthenosphere in regions such as New Zealand,southern Iceland,the southern Indian Ocean,the Ross Sea region of Antarctica,and the Sea of Okhotsk.It also holds the potential for studying large-scale oceanic dynamic processes and properties. | Zhengyong REN Cong YANG Hongbo YAO Xu TANG Jingtian TANG Keke ZHANG | 2024 | Science China Earth Sciences2024，67，1： | 0 |
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