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您的检索式：作者名="TANG Meili"
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| 1 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 2 | An Efficent and Scalable Density-based Clustering Algorithm显示文摘 | LüYinghua Ma Tinghuai Tang Meili | 2015 | Neurocomputing2015，171，1： | 1 |
| 3 | A survey of privacy preserving data publishing using generalization and suppression显示文摘 | XU Yang MA Tinghuai TANG Meili | 2014 | Applied Mathematics & Information Sciences2014，8，3： | 1 |
| 4 | Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice显示文摘Dysbiosis of gut microbiota and its derived metabolites has been linked to the occurrence and development of nonalcoholic fatty liver disease.Our previous study has demonstrated that mung bean coat(MBC)might be mainly responsible for the beneficial effects of whole mung bean on high fat diet(HFD)-induced metabolic disorders.To investigate whether MBC,which is rich in dietary fiber and phytochemicals,can protect against HFD-induced hepatic steatosis in mice via targeting gut microbiota and its metabolites,we conducted this study.Results showed that MBC could effectively alleviative the obese phenotype,reduce the lipid accumulation and insulin resistance,and improve the hepatic oxidative stress and inflammatory response.Furthermore,MBC significantly prevented the HFD-induced changes in the structure and composition of gut microbiota,characterized by promoting the bloom of Akkermansia,Lachnospiraceae_NK4 A136_group,and norank_f_Muribaculaceae,and along with the elevated short-chain fatty acids concentrations.Non-targeted metabolomic analysis indicated a metabolism disorder that was obviously improved by MBC via regulating sphingolipid metabolism andα-linolenic acid metabolism.These findings suggested that MBC could improve hepatic steatosis through manipulating the crosstalk between gut microbiota and its metabolites. | Dianzhi Hou Jian Tang Meili Huan Fang Liu Sumei Zhou Qun Shen | 2022 | Food Science and Human Wellness2022，11，5： | 1 |
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