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| 1 | Texture control by {10-12} twinning to improve the formability of Mg alloys: A review显示文摘Texture control of wrought Mg alloys, particularly in rolled Mg alloy sheets, has been an important research topic for the past several decades because it has significant influence on stretch formability at room temperature. For Mg alloys, {10-12} twinning can be easily activated and causes a 86.3° lattice rotation. Thus, pre-twinning deformation is considered as an effective and low-cost method for texture control in wrought Mg and its alloys. Furthermore, it has been verified that texture control via pre-twinning deformation can remarkably improve stretch formability of rolled Mg alloy sheets. In this review, recent researches on texture control via twinning deformation and its influence on stretch formability will be critically reviewed. The main contents include the micro-mechanism and impact factors of control in twin-orientation, plastic processing techniques of pre-inducing twins and the application of pre-induced twins in improvement of stretch formability. Finally, further research directions on this field were proposed. | Bo Song Qingshan Yang Tao Zhou Linjiang Chai Ning Guo Tingting Liu Shengfeng Guo Renlong Xin | 2019 | Journal of Materials Science & Technology2019，35，10： | 8 |
| 2 | Constructing a high-density linkage map for Gossypium hirsutum × Gossypium barbadense and identifying QTLs for lint percentage显示文摘To introgress the good fiber quality and yield from Gossypium barbadense into a commercial Upland cotton variety, a high-density simple sequence repeat(SSR) genetic linkage map was developed from a BC1F1 population of Gossypium hirsutum×Gossypium barbadense. The map comprised 2,292 loci and covered 5115.16 centi Morgan(c M) of the cotton AD genome, with an average marker interval of 2.23 c M. Of the marker order for 1,577 common loci on this new map, 90.36% agrees well with the marker order on the D genome sequence genetic map. Compared with five published high-density SSR genetic maps, 53.14% of marker loci were newly discovered in this map. Twenty-six quantitative trait loci(QTLs) for lint percentage(LP) were identified on nine chromosomes. Nine stable or common QTLs could be used for marker-assisted selection. Fifty percent of the QTLs were from G. barbadense and increased LP by 1.07%–2.41%. These results indicated that the map could be used for screening chromosome substitution segments from G. barbadense in the Upland cotton background, identifying QTLs or genes from G. barbadense, and further developing the gene pyramiding effect for improving fiber yield and quality. | Yuzhen Shi Wentan Li Aiguo Li Ruihua Ge Baocai Zhang Junzhi Li Guangping Liu Junwen Li Aiying Liu Haihong Shang Juwu Gong Wankui Gong Zemao Yang Feiyü Tang Zhi Liu Weiping Zhu Jianxiong Jiang Xiaonan Yu Tao Wang Wei Wang Tingting Chen Kunbo Wang Zhengsheng Zhang Youlu Yuan | 2015 | Journal of Integrative Plant Biology2015，57，5： | 7 |
| 3 | Comparison of Modified Mohr-Coulomb Model and Bai-Wierzbicki Model for Constructing 3D Ductile Fracture Envelope of AA6063显示文摘Ductile fracture of metal often occurs in the plastic forming process of parts.The establishment of ductile fracture criterion can effectively guide the selection of process parameters and avoid ductile fracture of parts during machining.The 3D ductile fracture envelope of AA6063-T6 was developed to predict and prevent its fracture.Smooth round bar tension tests were performed to characterize the flow stress,and a series of experiments were conducted to characterize the ductile fracture firstly,such as notched round bar tension tests,compression tests and torsion tests.These tests cover a wide range of stress triaxiality(ST)and Lode parameter(LP)to calibrate the ductile fracture criterion.Plasticity modeling was performed,and the predicted results were compared with corresponding experimental data to verify the plasticity model after these experiments.Then the relationship between ductile fracture strain and ST with LP was constructed using the modified Mohr-Coulomb(MMC)model and Bai-Wierzbicki(BW)model to develop the 3D ductile fracture envelope.Finally,two ductile damage models were proposed based on the 3D fracture envelope of AA6063.Through the comparison of the two models,it was found that BW model had better fitting effect,and the sum of squares of residual error of BW model was 0.9901.The two models had relatively large errors in predicting the fracture strain of SRB tensile test and torsion test,but both of the predicting error of both two models were within the acceptable range of 15%.In the process of finite element simulation,the evolution process of ductile fracture can be well simulated by the two models.However,BW model can predict the location of fracture more accurately than MMC model. | Jianye Gao Tao He Yuanming Huo Miao Song Tingting Yao Wanbo Yang | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 6 |
| 4 | A novel approach to melt purification of magnesium alloys显示文摘A novel low-cost method for melt purification of magnesium alloys,the melt self-purifying technology(MSPT),has been developed successfully based on a low temperature melt treatment(LTMT)without adding any fluxes.The iron solubility in the molten liquid of magnesium and its alloys,and the settlement velocity of iron particles were calculated.It is shown that the low temperature melt treatment is an effective method to decrease the impurity Fe content in magnesium and its alloys.Without any additions,the Fe content in the AZ31 alloy was reduced to 15 ppm from the initial 65 ppm,and the Fe content in the AZ61 melt was decreased to 20 ppm from the initial 150 ppm after the low temperature melt treatment.The results also showed that the Fe content in AM60 and AM50 dropped to 15 and 18 ppm,respectively,from the initial 150 ppm after the low temperature melt treatment.For ZK 60,the Fe content in the melt down to less than 5 ppm was achieved.After the low temperature melt treatment,the Si content in the above alloys was also decreased obviously. | Fusheng Pan Xianhua Chen Tao Yan Tingting Liu Jianjun Mao Wei Luo Qin Wang Jian Peng Aitao Tang Bin Jiang | 2016 | Journal of Magnesium and Alloys2016，4，1： | 5 |
| 5 | mRNA enrichment protocols determine the quantification characteristics of external RNA spike-in controls in RNA-Seq studies显示文摘RNA-Seq promises to be used in clinical settings as a gene-expression profiling tool;however,questions about its variability and biases remain and need to be addressed.Thus,RNA controls with known concentrations and sequence identities originally developed by the External RNA Control Consortium(ERCC) for microarray and qPCR platforms have recently been proposed for RNA-Seq platforms,but only with a limited number of samples.In this study,we report our analysis of RNA-Seq data from 92 ERCC controls spiked in a diverse collection of 447 RNA samples from eight ongoing studies involving five species(human,rat,mouse,chicken,and Schistosoma japonicum) and two mRNA enrichment protocols,i.e.,poly(A) and RiboZero.The entire collection of datasets consisted of 15650143175 short sequence reads,131603796(i.e.,0.84%) of which were mapped to the 92 ERCC references.The overall ERCC mapping ratio of 0.84% is close to the expected value of 1.0% when assuming a 2.0% mRNA fraction in total RNA,but showed a difference of 2.8-fold across studies and 4.3-fold among samples from the same study with one tissue type.This level of fluctuation may prevent the ERCC controls from being used for cross-sample normalization in RNA-Seq.Furthermore,we observed striking biases of quantification between poly(A) and RiboZero which are transcript-specific.For example,ERCC-00116 showed a 7.3-fold under-enrichment in poly(A) compared to RiboZero.Extra care is needed in integrative analysis of multiple datasets and technical artifacts of protocol differences should not be taken as true biological findings. | QING Tao YU Ying DU TingTing SHI LeMing | 2013 | Science China(Life Sciences)2013，56，2： | 4 |
| 6 | A thermostability perspective on enhancing physicochemical and cytological characteristics of octacalcium phosphate by doping iron and strontium显示文摘Investigation of thermostability will lead the groundbreaking of unraveling the mechanism of influence of ion-doping on the properties of calcium phosphates.In this work,octacalcium phosphate(OCP),a metastable precursor of biological apatite,was used as a stability model for doping ions(Fe^(3+)and Sr^(2+))with different ionic charges and radii.After treated under hot air at different temperatures(110-200◦C),the phase,morphology,structure,physicochemical properties,protein affinity,ions release,and cytological responses of the ion-doped OCPs were investigated comparatively.The results showed that the collapse of OCP crystals gradually occurred,accompanying with the dehydration of hydrated layers and the disintegration of plate-like crystals as the temperature increased.The collapsed crystals still retained the typical properties of OCP and the potential of conversion into hydroxyapatite.Compared to the undoped OCP,Fe-OCP,and Sr-OCP had lower and higher thermostability respectively,leading to different material surface properties and ions release.The adjusted thermostability of Fe-OCP and Sr-OCP significantly enhanced the adsorption of proteins(BSA and LSZ)and the cytological behavior(adhesion,spreading,proliferation,and osteogenic differentiation)of bone marrow mesenchymal stem cells to a varying extent under the synergistic effects of corresponding surface characteristics and early active ions release.This work paves the way for understanding the modification mechanism of calcium phosphates utilizing ion doping strategy and developing bioactive OCP-based materials for tissue repair. | Haishan Shi Xiaoling Ye Jing Zhang Tingting Wu Tao Yu Changren Zhou Jiandong Ye | 2021 | Bioactive Materials2021，6，5： | 3 |
| 7 | Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration显示文摘Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes(CMs).However,the signaling mechanisms by which injury induces CM renewal remain incompletely understood.Here,we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors,including Dickkopf 1(Dkkl),Dkk3,secreted Frizzled-related protein 1(sFrpl),and sFrp2,in cardiac tissue adjacent to injury sites.Experimental blocking of Wnt activity via Dkkl overexpression enhances CM proliferation and heart regeneration,whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and proliferation.Although Wnt signaling is dampened upon injury,the cytoplasmic β-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound edges.Our analyses indicated that p21-activated kinase 2(Pak2)is induced at regenerating CMs,where it phosphorylates cytoplasmic β-catenin at Ser 675 and increases its stability at disassembled sarcomeres.Myocardial-specific induction of the phospho-mimeticβ-catenin(S675E)enhances CM dedifferentiation and sarcomere disassembly in response to injury.Conversely,inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylatedβ-catenin(pS675-β-catenin)and attenuates CM sarcomere disorganization and dedifferentiation・Taken together,these findings demonstrate that coordination of Wnt signaling inhibition and Pak2/pS675-βYatenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation. | Xiangwen Peng Kaa Seng Lai Peilu She Junsu Kang Tingting Wang Guobao Li Yating Zhou jianjian Sun Daqing Jin Xiaolei Xu Lujian Liao Jiandong Liu Ethan Lee Kenneth D.Poss Tao P.Zhong | 2021 | Journal of Molecular Cell Biology2021，13，1： | 3 |
| 8 | Grazing alters environmental control mechanisms of evapotranspiration in an alpine meadow of the tibetan Plateau显示文摘Aims Evapotranspiration(Et)is an important component of the terrestrial water cycle and is easily affected by external disturbances,such as climate change and grazing.Identifying Et responses to grazing is instructive for determining grazing activity and informative for understanding the water cycle.Methods this study utilized 2 years(2014 and 2017)of eddy covariance data to test how grazing regulated Et for an alpine meadow ecosystem on the tibetan Plateau(tP)by path analysis.Important Findings Radiation dominated Et with a decision coefficient of 64-74%.the soil water content(SWc)worked as the limiting factor in the fenced site.However,in the grazing site,the limiting factor was the vapor pressure deficit(VPD).Grazing had large effects on Et because it greatly affected the water conditions.the SWc and VPD were enhanced by 14.63%and 4.36%in the grazing site,respectively.therefore,sufficient water was supplied to Et,especially during drought,and strengthened the transpiration pull.As a result,a favorable micrometeorological environment was created for Et.Grazing shifted the limiting factor of Et from the SWc to VPD,which weakened the limiting effect of the water conditions on Et and advanced the Et peak time.In addition,grazing altered the compositions of Et by changing the community structure,which directly resulted in an increased Et.In summary,grazing enhanced Et through altering the community structure and micrometeorological environments.the findings of this study further improve our understanding of the driving mechanisms of grazing on Et and will improve our predictions for the global water cycle. | Tingting An Mingjie Xu Tao Zhang Chengqun Yu Yingge Li Ning Chen Jiaxing Zu Junxiang Li Juntao Zhu Yi Sun Tingting Zhao Guirui Yu | 2019 | Journal of Plant Ecology2019，12，5： | 3 |
| 9 | Herbal formula of Bushen Jianpi(补肾健脾方)combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle显示文摘OBJECTIVE:To investigate the efficacy of an herbal formula of Bushen Jianpi(补肾健脾方,BSJP)combined with sorafenib on hepatocellular carcinoma(HCC)in vitro and in vivo,and to study the underlying mechanisms of action.METHODS:BSJP,a mixture of 12 raw herbs,was extracted in 70%alcohol/30%water and freeze-dried into a powder.The in vitro effects of BSJP alone,sorafenib alone,and their combination on cell survival,apoptosis,and cell cycle distribution were evaluated in HCC cell lines HCCLM3,HepG2,and SMMC-7721.The expression of B-cell lymphoma-2(Bcl-2),caspase-3,and caspase-9 in HCCLM3 cells was measured using Western blots after drug administration.The in vivo effects of BSJP and sorafenib were evaluated in a tumor surgical resection model using 4-week old male athymic BALB/c nude mice injected with HCCLM3 cells.Immunohistochemical analysis of tumor tissues was performed to evaluate the effects of BSJP alone,sorafenib alone,and their combination on the expression of caspase-3,caspase-9,and Bcl-2.RESULTS:BSJP decreased the survival rate of HCC cell lines,and the combination of BSJP and sorafenib further decreased the survival rate.BSJP significantly promoted cell apoptosis and blocked cell-cycle progression in HCCLM3,HepG2,and SMMC-7721 cells in a dose-dependent manner.Furthermore,the administration of BSJP and sorafenib inhibited the growth of HCCLM3 cell xenografts in nude mice,with no reduction in body weight.In vivo and in vitro experiments showed that BSJP combined with sorafenib could significantly decrease the expression of Bcl-2.CONCLUSION:Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent. | ZHOU Zhangjie LIU Xinhua WU Tingting QUE Zujue WU Zhonghua WU Weizhong FU Shujuan ZHANG Shiqiang YANG Yun JIANG Haiyan XIA Xiaoting LV Junqiang DU Boqian LI Yun LU Tao ZHANG Zhihui ZHONG Yi | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 3 |
| 10 | Estimating the macrobenthic species richness with an optimized sampling design in the intertidal zone of Changjiang Estuary显示文摘It is a challenge in the field sampling to face conflict between the statistical requirements and the logistical constraints when explicitly estimating the macrobenthos species richness in the heterogeneous intertidal wetlands. To solve this problem, this study tried to design an optimal, efficient and practical sampling strategy by comprehensively focusing on the three main parts of the entire process(to optimize the sampling method, to determine the minimum sampling effort and to explore the proper sampling interval) in a typical intertidal wetland of the Changjiang(Yangtze) Estuary, China. Transect sampling was selected and optimized by stratification based on pronounced habitat types(tidal flat, tidal creek, salt marsh vegetation). This type of sampling is also termed within-transect stratification sampling. The optimal sampling intervals and the minimum sample effort were determined by two beneficial numerical methods: Monte Carlo simulations and accumulative species curves. The results show that the within-transect stratification sampling with typical habitat types was effective for encompassing 81% of the species, suggesting that this type of sampling design can largely reduce the sampling effort and labor. The optimal sampling intervals and minimum sampling efforts for three habitats were determined: sampling effort must exceed 1.8 m^2 by 10 m intervals in the salt marsh vegetation, 2 m^2 by 10 m intervals in the tidal flat, and 3 m^2 by 1 m intervals in the tidal creek habitat. It was suggested that the differences were influenced by the mobility range of the dominant species and the habitats' physical differences(e.g., tidal water, substrate, vegetation cover). The optimized sampling strategy could provide good precision in the richness estimation of macrobenthos and balance the sampling effort. Moreover, the conclusions presented here provide a reference for recommendations to consider before macrobenthic surveys take place in estuarine wetlands. The sampling strategy, focusing on the three key parts of the sampling design, had a good operational effect and could be used as a guide for field sampling for habitat management or ecosystem assessment. | Tingting Zhang Feng Zhao Sikai Wang Tao Zhang Jianyi Liu Yu Gao Ping Zhuang | 2019 | Acta Oceanologica Sinica2019，38，2： | 3 |
| 11 | Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma显示文摘Objective:Natural extracts,including nobiletin,have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs.However,whether and how nobiletin affects tumor growth and progression in renal cell carcinoma(RCC)are still unclear.Methods:Cell proliferation,cell cycle and apoptosis analyses,colony-formation assays,immunoblotting analysis,and q RT-PCR analysis were performed to investigate how nobiletin affected RCC cell proliferation in vitro.The nude mouse model was used to test the efficacy of nobiletin alone or in combination with palbociclib.Results:Nobiletin inhibited cell proliferation by inducing G1 cell cycle arrest and cell apoptosis in RCC cells.Mechanistically,nobiletin decreased SKP2 protein expression by reducing its transcriptional level.The downregulated SKP2 caused accumulation of its substrates,p27 and p21,which further inhibited the activity of the G1 phase-related protein,CDK2,leading to inhibition of cell proliferation and tumor formation.A higher SKP2 protein level indicated less sensitivity to the CDK4/6 inhibitor,palbociclib.A combination of nobiletin and palbociclib showed a synergistic tumor inhibition in vitro and in an in vivo model.Conclusions:Nobiletin downregulated the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and showed synergistic tumor inhibition effects with the CDK4/6 inhibitor,palbociclib,on RCC,which indicates a potential new therapeutic strategy. | Tingting Chen Liu Liu Yonghong Zou Xiaoyan Hu Wenfeng Zhang Tao Zhou Xi Luo Weihua Fu Jie Xu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 12 | Large-scale multiferroic complex oxide epitaxy with magnetically switched polarization enabled by solution processing显示文摘Complex oxides with tunable structures have many fascinating properties,though high-quality complex oxide epitaxy with precisely controlled composition is still out of reach.Here we have successfully developed solution-based single-crystalline epitaxy for multiferroic(1-x)BiTi(1-y)/2FeyMg(1-y)/2O3–(x)CaTiO3(BTFM–CTO)solid solution in large area,confirming its ferroelectricity at the atomic scale with strong spontaneous polarization.Careful compositional tuning leads to a bulk magnetization of 0.07±0.035μB/Fe at room temperature,enabling magnetically induced polarization switching exhibiting a large magnetoelectric coefficient of 2.7–3.0×10^-7 s/m.This work demonstrates the great potential of solution processing in large-scale complex oxide epitaxy and establishes novel room-temperature magnetoelectric coupling in epitaxial BTFM–CTO film,making it possible to explore a much wider space of composition,phase,and structure that can be easily scaled up for industrial applications. | Cong Liu Feng An Paria S.M.Gharavi Qinwen Lu Junkun Zha Chao Chen Liming Wang Xiaozhi Zhan Zedong Xu Yuan Zhang Ke Qu Junxiang Yao Yun Ou Zhiming Zhao Xiangli Zhong Dongwen Zhang Nagarajan Valanoor Lang Chen Tao Zhu Deyang Chen Xiaofang Zhai Peng Gao Tingting Jia Shuhong Xie Gaokuo Zhong Jiangyu Li | 2020 | National Science Review2020，7，1： | 2 |
| 13 | Identification of two novel mutations in the GALNT3 gene in a Chinese family with hyperphosphatemic familial tumoral calcinosis显示文摘Hyperphosphatemic familial tumoral calcinosis(HFTC) is a rare, autosomal recessive genetic disease.This disease is characterized by the progressive calcification of soft tissues leading to symptoms of pressure and hyperphosphatemia but normal concentrations of serum calcium with or without an elevation of1,25-dihydroxyvitamin D3 levels.HFTC is caused by loss-of-function mutations in the GALNT3, FGF23 or KL genes. Here, we identified two novel mutations in the GALNT3 gene in a Chinese family with HFTC.Identification of a novel genotype in HFTC provides clues for understanding the phenotype–genotype relationships in HFTC and may assist not only in the clinical diagnosis of HFTC but also in the interpretation of the genetic information used for prenatal diagnosis and genetic counseling. | Lihao Sun Lin Zhao Lianiun Du Peipei Zhang Minjia Zhang Min Li Tingting Liu Lei Ye Bei Tao Hongyan Zhao Jianmin Liu Xiaoyi Ding | 2016 | Bone Research2016，4，4： | 2 |
| 14 | Activation of calcium-sensing receptors is associated with apoptosis in a model of simulated cardiomyocytes ischemia/reperfusion显示文摘Objective:Calcium-sensing receptors(CaSRs)are G-protein coupled receptors which maintain systemic calcium homeostasis and participate in hormone secretion,activation of ion channels,cell apoptosis,proliferation,and differentiation.Previous studies have shown that CaSRs induce apoptosis in isolated adult rat heart and in normal neonatal rat cardiomyocytes by G-protein-PLC-IP 3 signaling transduction.However,little knowledge is presently available concerning the role of CaSRs in the apoptosis induced by ischemia and reperfusion in neonatal cardiomyocytes.Methods:Primary neonatal rat ventricular cardiomyocytes were incubated in ischemiamimetic solution for 2 h,and then re-incubated in normal culture medium for 24 h to establish a model of simu- lated ischemia/reperfusion(I/R).Cardiomyocyte apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL).The expression of CaSRs mRNA was detected by real-time reverse transcription polymerase chain reaction(RT-PCR).In addition,the expressions of caspase-3 and Bcl-2 were analyzed by western blot.Results:The simulated I/R enhanced the expression of CaSRs and cardiomyocyte apopto- sis.GdCl 3 ,a specific activator of CaSRs,further increased the expression of CaSRs and cardiomyocyte apoptosis, along with up-regulation of caspase-3 and down-regulation of Bcl-2.Conclusion:CaSRs are associated with I/R injury and apoptosis in neonatal rat ventricular cardiomyocytes via suppressing Bcl-2 and promoting caspase-3 expression. | Ling Yan Tlebing Zhu Tingting Sun Liansheng Wang Shiyang Pan Zhengxlan Tao Zhijian Yang Kejiang Cao | 2010 | The Journal of Biomedical Research2010，24，4： | 2 |
| 15 | Research on LPI radar signal detection and parameter estimation technology显示文摘Modern radar signals mostly use low probability of intercept(LPI)waveforms,which have short pulses in the time domain,multicomponent properties,frequency hopping,combined modulation waveforms and other characteristics,making the detection and estimation of LPI radar signals extremely difficult,and leading to highly required significant research on perception technology in the battlefield environment.This paper proposes a visibility graphs(VG)-based multicomponent signals detection method and a modulation waveforms parameter estimation algorithm based on the time-frequency representation(TFR).On the one hand,the frequency domain VG is used to set the dynamic threshold for detecting the multicomponent LPI radar waveforms.On the other hand,the signal is projected into the time and frequency domains by the TFR method for estimating its symbol width and instantaneous frequency(IF).Simulation performance shows that,compared with the most advanced methods,the algorithm proposed in this paper has a valuable advantage.Meanwhile,the calculation cost of the algorithm is quite low,and it is achievable in the future battlefield. | WAN Tao JIANG Kaili LIAO Jingyi JIA Tingting TANG Bin | 2021 | Journal of Systems Engineering and Electronics2021，32，3： | 2 |
| 16 | Revisit the K-segment of the Southeast Indian Ridge for new evidence of hydrothermal plumes显示文摘在到在 2007 的东南印度理兹(SEIR ) 的中国研究巡航的第一条腿期间,我们重游 SEIR 的 K 片断并且在一个 CTD 演员组车站观察了一个水列混浊异例。这个车站被定位从一个羽毛异例上的一个捞网地点的 400 m 由美国科学家在 1996 检测了。在我们的调查检测的混浊异例的特征与那些不同以前观察了 11 年,暗示也,检测异例有不同、不同的羽毛来源或羽毛的坚韧性在干涉时间变化了。另外,混浊异例在深 tow-yo 侧面在 K 片断上在二个地区被观察。如果这二个异例没被连接,计算的羽毛发生将是大约 0.28,比为传播的 65 mm/a 的 0.25 的预言的价值大率。K 片断上的羽毛发生的这增加似乎与圣保拉姆斯特达姆热点的影响有关,定位了大约 300 km 到西北。 | WANG TingTing CHEN YongShun John TAO ChunHui | 2011 | Chinese Science Bulletin2011，56，33： | 2 |
| 17 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 18 | Surface characteristics, nano-indentation and corrosion behavior of Nb implanted NiTi alloy显示文摘 | Tingting Zhao Yan Li Yan Xiang Xinqing Zhao Tao Zhang | 2011 | Surface & Coatings Technology2011，，19： | 2 |
| 19 | Changes of DOM and its correlation with internal nutrient release during cyanobacterial growth and decline in Lake Chaohu, China显示文摘The seasonal changes in dissolved organic matter(DOM),and its correlation with the release of internal nutrients during the annual cycle of cyanobacteria in the eutrophic Lake Chaohu,China,were investigated from four sampling periods between November 2020 and July 2021.The DOM fluorescence components were identified as protein-like C1,microbial humic-like C2,and terrestrial humic-like C3.The highest total fluorescence intensity(FT)of DOM in sediments during the incubation stage is due to the decomposition and degradation of cyanobacteria remains.The lowest humification of DOM and the highest proportion of C1 in waters during the initial cyanobacterial growth indicate that fresh algae are the main source.The highest molecular weight of DOM and FT of the C2 in sediments during cyanobacterial outbreaks indicate the concurrent deposition of undegraded cyanobacterial remains and microbial degradation.The components of DOM are affected mainly by the dissolved total phosphorus in waters,while the temperature drives the annual cycle of cyanobacteria.The decreasing C1 in sediments and increasing nutrients in waters from the cyanobacterial incubation to outbreak indicate that mineralization of algal organic matter contributes importantly to the release of internal nutrients,with the strongest release of phosphorus observed during the early growth of cyanobacteria.The humic-like C2 and C3 components could also affect the dynamics of internal phosphorus through the formation of organic colloids and organic–inorganic ligands.The results show that the degradation of DOM leads to nutrients release and thus supports the continuous growth of cyanobacteria in eutrophic Lake Chaohu. | Yan Bao Tao Huang Chengwu Ning Tingting Sun Pengliang Tao Jie Wang Qingye Sun | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 20 | Corrigendum to“SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip”[Sci.Bull.(2021)66(8)783-793]显示文摘The authors would like to correct Fig.2g.An annotation error was introduced in the preparation of this figure for publication.The authors declare that this correction does not change the results or conclusions of this paper.The authors sincerely apologize for having this error in the article,and apologize for any inconvenience caused. | Yaqiong Guo Ronghua Luo Yaqing Wang Pengwei Deng Tianzhang Song Min Zhang Peng Wang Xu Zhang Kangli Cui Tingting Tao Zhongyu Li Wenwen Chen Yongtang Zheng Jianhua Qin | 2021 | Science Bulletin2021，66，20： | 2 |
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