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| 1 | Immunization against Egyptian Schistosoma mansoni infection by multivalent DNA vaccine显示文摘由几抗原组成的多价的疫苗的发展是对不同寄生虫紧张和寄生虫生命周期阶段创造宽广范围的保护的一条新奇途径。我们以前证实了血吸虫 Sm21.7 和 Sm Fimbrin (SmFim ) 蛋白质能在老鼠导致保护。因此,这研究试图构造多价的 DNA 疫苗的 Sm21.7-SmFim/pBudCE4.1 并且评估它的有免疫力的功效。二血吸虫 mansoni 基因, Sm21.7 和 SmFim 的开的读物框架,被插入到为独立人士设计的真核细胞的表示原生质标志 pBudCE4.1 在哺乳动物的房间的二基因的表示。评估在里面在老鼠的多价的 Sm21.7-SmFim/pBudCE4.1 DNA 疫苗和它的免疫学的效果的 vitro 表示, recombinant 原生质标志 Sm21.7-SmFim/pBudCE4.1 习惯于 mRNA 的 transfect 293T 房间,和表示,蛋白质用反向的抄写聚合酶链反应和蛋白质印迹分析被检验。然后 Sm21.7-SmFim/pBudCE4.1 到的能力免于 S。mansoni 挑战感染在老鼠的种痘以后根据蠕虫负担和鸡蛋减小率被分析。种牛痘的老鼠出现了保护(56%) 的重要水平,和在数字和尺寸的减少,和在细胞的侧面的变化, granulomas。分别地,在肝和肠的鸡蛋减小是 41.53% 和 55.63% 相对仅仅收到了空向量的老鼠同样坚定。除了在蠕虫生存能力的减小,蠕虫肥沃和鸡蛋孵化能力被观察在使免疫的组跟随挑战感染。结果证明 Sm21.7-SmFim/pBudCE4.1 能表示 Sm2 1.7 和 SmFim mRNA 和蛋白质。连接酶的免疫吸着剂试金和蛋白质印迹分析显示使免疫的老鼠对 Sm21.7-SmFim/pBudCE4.1 产生了特定的免疫球蛋白 G。这些结果与多价的 S 建议那种痘。mansoni DNA 疫苗(SmFim-Sm21.7/pBudCE4.1 ) 不仅在蠕虫和卵负担导致重要减小,而且显著地减少卵 granulomas 的尺寸。在摘要,多价的疫苗与保护的重要水平刺激了特定的免疫并且反病理学的效果。 | Mahmoud H Romeih Hanem M Hassan Tarek S Abou Shousha Mohamed A Saber | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 3 |
| 2 | A SiC14-ZnC12 induced general, mild and efficient one-pot, three- component synthesis of fl-amido ketone libraries 显示文摘 | Tarek A Salama Saad S Elmorsy Abdel-Galel M Khalil | 2007 | Tetrahedmn Letters2007，48，： | 1 |
| 3 | Safety e-valuation of right-turn smart channels using auto-mated traffic conflict analysis显示文摘 | JARVIS A TAREK S MoHAMED H | 2011 | Accident AnalysisPrevention2011，45，11： | 1 |
| 4 | Preoperative risk factors for intraabdominal adhesions should not contraindicate surgical laparoscopy for infertility显示文摘 | Tarek S Ahmed B Hatem AH | 2008 | Journal of the Society of Laparoendoscopic Surgeons2008，21，3： | 1 |
| 5 | A carbon sensitive supply chain network problem with green procure- ment显示文摘 | TAREK A ALI D DAVID S L | 2010 | IPCC2010，，3： | 1 |
| 6 | Investigations of factors that influence the acrylamide content of heated foodstuffs显示文摘 | RYDBERG P ERIKSSON S TAREKE E | 2003 | Jour-nal of Agricultural and Food Chemistry2003，51，： | 1 |
| 7 | Treatment of Highly Polluted Paper Mill Wwastewater by Solar Photocatalytic Oxidation with Synthesized Nano TiO2 显示文摘 | Ghaly Montaser Y Jamila Tarek S E1-Seesy Ibrahim E | 2011 | Chemical Engineering Journal2011，168，1： | 1 |
| 8 | Induction of apoptosis in human lung cancer cells by curcumin显示文摘 | G Radhakrishna Pillai Anand S Srivastava Tarek I Hassanein Dharam P Chauhan Ewa Carrier | 2004 | Cancer Letters2004，，2： | 1 |
| 9 | Ischemic toler-ance following low dose NMDA involves modulation of cellularstress proteins显示文摘 | MONIQUE C S BARRY J C TAREK M S | 2009 | Brain Research2009，1247，2： | 1 |
| 10 | Mucins and inflammatory bowel disease显示文摘 | Tarek S Robert JL Anthony PC | 2000 | Postgrad Med J2000，76，： | 1 |
| 11 | Acrylamide: a cooking carcinogent 显示文摘 | TAREKE E RYDBERG P KARLSSON S | 2002 | Chem Res Toxicol2002，13，： | 1 |
| 12 | Development of a dynamic transit signal priority strategy显示文摘 | WAEL E TAREK S MOHAMED E | 2009 | Journal of the Transportation Research Board2009，2111，： | 1 |
| 13 | Contrast enhancedspiral computerized tomography in patients with chronic obstructive uropathy and normal serum creatinine: a single session for anatomical and functional assessment显示文摘 | Mohamed E A Ahmed A S Tarek A E | 2004 | The Journal of Urology2004，172，3： | 1 |
| 14 | Assessing large scale emergency rescue plans: an agent based approach 显示文摘 | Narjes B S Tarek B M Julie D Bernard P Mohamed B A | 2006 | International Journal of Intelligent Control and Systems2006，11，4： | 1 |
| 15 | Can repetitive magnetic stimulation improve cognition in schizophrenia?Pilot data from a randomized controlled trial显示文摘 | Mera S Faranak F Tarek K | 2013 | Biological Psychiatry2013，73，： | 1 |
| 16 | Leisure Time Physical Activity in Saudi Arabia: Prevalence, Pattern and Determining Factors 显示文摘 | TAREK T A Ali S A K MOHAMMAD A A H | 2012 | Asian Pacific Journal of Cancer Prevention2012，13，： | 1 |
| 17 | Effect of driver and road characteristics on required preview sight distance 显示文摘 | Yasser H Tarek S | 2002 | Canadian Journal of Civil Engineering2002，29，2： | 1 |
| 18 | Automatic reduction of hyperspectral imagery using wavelet spectral analysis 显示文摘 | KAEWOUHUT S LE J M TAREK E G | 2003 | IEEE Transactions on Geosciences and Remote Sensing2003，41，4： | 1 |
| 19 | Investigations of factors that influence the acrylamide content of heated foodstuffs显示文摘 | Rydberg P Eriksson S Tareke E | 2003 | Agric Food Chem2003，，51： | 1 |
| 20 | Acrylamide; A cooking carcinogent显示文摘 | Tareke E Rudberg P Karlsson S | 2002 | Chem Res Toxiclo2002，13，： | 1 |
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