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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan显示文摘 | Hsueh P R Teng L J Chen C Y | 2002 | Emerg Infect Dis2002，8，8： | 1 |
| 3 | Background air levels of polychlorinated biphenyls in China 显示文摘 | Wu J J Teng M Gao L R | 2011 | Science of the Total Environment2011，409，10： | 1 |
| 4 | Liver ab- scess due to Neisseria sieea after repeated transcathe- ter arterial embolization显示文摘 | CHUNG H C TENG L J HSUEH P R | 2007 | J Med Microbiol2007，56，： | 1 |
| 5 | Proliposomes containing a bile salt for oral delivery Of Ginkgo biloba extract: Formulation optimization, characterization, oral bioavailability and tissue distribution in rats 显示文摘 | Zheng B Teng L R Xing G Y | 2015 | Eur J Pharm Sci2015，77，： | 1 |
| 6 | Relationship between satellite microwave radiometric data, antecedent precipitation index, and regional soil moisture显示文摘 | Teng W L Wang J R Doraiswmay P C | 1993 | International Journal of Remote Sensing1993，14，13： | 1 |
| 7 | Analytic expression of the diffraction of a circular aperture 显示文摘 | Teng S Y Liu L R Liu D A | 2005 | Optik2005，116，12： | 1 |
| 8 | Pan-drug-resistant Pseudomonas aeruginosa causing nosocomial infection at a university hospital in Taiwan显示文摘 | Hsueh P R Tseng S P Teng L J | 2005 | Clin Microbiol Infect2005，11，8： | 1 |
| 9 | Valproie acid enhances Oct4 promoter activity in myogenic显示文摘 | Teng H F Kuo Y L Loo M R Li C L Cbu T W Suo H Liu H S Lin K H and Chen S L | | 0，，： | 1 |
| 10 | Ciprofloxacin-resistant Salmonella enterica typhimurium and choleraesuis from pigs to humans, Taiwan显示文摘 | Hsueh P R Teng L J Tseng S P | 2004 | Emerg Infect Dis2004，10，1： | 1 |
| 11 | Outbreak of Pseudomonas fluorescens bacteremia amongoncology patients 显示文摘 | Hsueh P R Teng L J Pan H J | 1998 | J Clin Microbiol1998，36，10： | 1 |
| 12 | Genetic diversity and disease control in rice 显示文摘 | Zhu Y Y Chen H R Fan J H Wang Y Y Li Y Chert J B Fan J X Yang S S Hu L P Leung H Mew T W Teng P S Wang Z H Mundt C C | 2000 | Nature2000，406，： | 1 |
| 13 | An enzyme from a thermophilic bacteria and the identification of the strain显示文摘 | TENG L R GAO C H WANG J P | 2006 | Journal of Jilin University (Science Edition)2006，44，5： | 1 |
| 14 | Lithium isotopic composition and concentration of the upper continen- tal crust显示文摘 | Teng F Z McDonough W F Rudnick R L | 2004 | Geochimica et Cosmochimica Acta2004，68，20： | 1 |
| 15 | In vitro activites of antimicrobial combinations against clinical isolates of Stenotrophomonas maltophilia显示文摘 | Liaw S J Teng L J Hsueh P R | 2002 | Formos Med Assoc2002，101，7： | 1 |
| 16 | An alternative interacting boson model description of the n=90nuclei显示文摘 | DAI L R TENG W X PAN F | 2011 | Chin PhysLett2011，28，05： | 1 |
| 17 | Lithium isotopic composition and concentration of the upper conti- nental crust显示文摘 | Teng F Z MeDonough W F Rudnick R L | 2004 | Geochimica et Cosmochimica Acta2004，68，： | 1 |
| 18 | Lack of medication dose uniformity in commonly split tablets 显示文摘 | TENG J SONG C K WILLIAMS R L | 2002 | J Am Pharm Assoc2002，42，2： | 1 |
| 19 | Pandrug-resistant Acinetobacter baumannii causing nosocomial infection in an university hospital,Taiwan显示文摘 | HSUEH P R TENG L J ChEU C Y | 2002 | Emerg Infect Dis2002，8，8： | 1 |
| 20 | Multi-antenna based spectrum sensing for cognitive radios:a GLRT approach显示文摘 | ZHANG R TENG J L LIANG Y C e al | 2010 | IEEE Transactions on Communications2010，58，1： | 1 |
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