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| 1 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 2 | 外刊拾贝显示文摘1.根据2018年美国糖尿病学会标准诊断中国糖尿病患病率:全国横断面研究目的:评估糖尿病患病率及其危险因素。设计:基于人群的横断面研究。背景:2015-2017年中国大陆31省份全国横断面数据。调查对象:75880名18周岁及以上代表中国大陆人口的成年人样本。主要观察指标:根据2018年美国糖尿病学会和世界卫生组织标准诊断中国成人不同性别、区域和种族的糖尿病患病率。通过问卷的方式记录调查对象的社会人口学信息、生活方式和疾病史。 | 单忠艳 Li Y Teng D Shi X Ba J 王看然 李启富 Wang K Hu J Yang J | 2020 | 国际内分泌代谢杂志2020，40，5： | 42 |
| 3 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells显示文摘尽管发信号的 Activin/Nodal 调整人的胚胎的茎(ES ) 的 pluripotency 细胞,这个发信号怎么在老鼠 ES 细胞行动,仍然保持大部分不清楚。调查这,我们证实了房间拥有活跃调停 Smad2 的 Activin/Nodal 发信号的那老鼠 ES 并且发现调停 Smad2 的 Activin/Nodal 发信号为自强维护是非必需的,但是向 mesendoderm 系为合适的区别被要求。到进内在的机制的获得卓见,联系 Smad2 的基因被染色体宽的染色质 immunoprecipitation 薄片分析识别。结果证明在 Smad2 绑定和 Activin/Nodal 发信号调整之间有 transcriptional 关联,并且发展相关的基因在 Smad2 固定的目标之中被充实。我们进一步在 Activin/Nodal-Smad2 小径下游地行动的老鼠 ES 房间的 mesendoderm 区别作为一个关键播放器识别了 Tapbp。一起拿,我们的调查结果建议发信号的调停 Smad2 的 Activin/Nodal 通过相应发展管理者表示的直接调整安排鼠标 ES 房间的 mesendoderm 系承诺。 | Teng Fei Shanshan Zhu Kai Xia Jianping Zhang Zhongwei Li Jing-Dong J Han Ye-Guang Chen | 2010 | Cell Research2010，20，12： | 4 |
| 6 | FRP-Strengthened RC beams( I ):Review of debonding strength models 显示文摘 | Smith S T Teng J G | 2002 | Engineering Structures2002，，24： | 2 |
| 7 | Pandrug-resistant Acinetobacter baumannii causing nosocomial infections in a university hospital, Taiwan显示文摘 | Hsueh P R Teng L J Chen C Y | 2002 | Emerg Infect Dis2002，8，8： | 1 |
| 8 | Focused on beam fabrication of thermally actuated bimorph cantilever 显示文摘 | TENG J PREWETT P D | 2005 | Sensors Actuators: A2005，，： | 1 |
| 9 | A labview based virtual instrument for power analyzers显示文摘 | Teng J H Chan S Y | 2000 | IEEE Trans on Power System Technology2000，51，1： | 1 |
| 10 | Broad-band excited quantum cutting in Eu^2+-Yb^3+ co-doped aluminosilicate glasses 显示文摘 | ZHOU J TENG Y LIN G | 2010 | J Electrochem Soc2010，157，8： | 1 |
| 11 | Hybrid FRP-concrete-steel tubular col- umns:concept and behavior 显示文摘 | Teng J G Yu T Wong Y L | 2007 | Construction and Building Mate- rials2007，21，4： | 1 |
| 12 | Member IEEE A Direct Approach for Distribution System Load Flow Solutions 显示文摘 | Teng J H | | IEEE Trans on Power Delivery0，，： | 1 |
| 13 | Optimal pricing and ordering policy under permissible delay in payments显示文摘 | Teng J T Chang C T Goyal S K | 2005 | International Journal of Production Economics2005，97，： | 1 |
| 14 | Purification, crystallization and preliminary crystallographic analysis of AHP IX-bp, a zinc ion and pH-dependent coagulation factor IX binding protein from Agkistrodon halys Pallas venom 显示文摘 | Zang J Teng M Niu L | 2003 | Acta Crystallogr D Biol Crystallogr2003，59，4： | 1 |
| 15 | Extraordinary transmission in planar waveguide loaded with anisotrop- ic metamaterials 显示文摘 | Feng Y J Teng X H Wang Z B | 2009 | J Appl Phys2009，105，03： | 1 |
| 16 | Stress-strain behavior of concrete in hybrid FRP-concrete-steel double-skin tu- bular columns 显示文摘 | YU T TENG J G WONG Y L | 2010 | Journal of Structural Engineering2010，136，4： | 1 |
| 17 | Transferring R&D knowledge: the key factors affecting knowledge transfer success 显示文摘 | Cummings J L Teng B S | 2003 | Journal of Engineering and Technology Management2003，20，2： | 1 |
| 18 | Biodiesel from palm oil via loading KF/Ca-A1 hydrotalcite catalyst显示文摘 | Gao L J Teng G Y Xiao G M | 2010 | Biomass and Bioenergy2010，34，： | 1 |
| 19 | Intelligent controlled- wind-turbine emulator and induction-generator system using RBFN显示文摘 | Lin F J Teng L T Shieh P H | 2006 | IEEE Proceedings of Electric Power Applications2006，153，4： | 1 |
| 20 | Numerical Investigation of Oxygen Impurity Distribution during Multicrystalline Silicon Crystal Growth Usinga Gas Flow Guidance Device显示文摘 | Teng Y Y Chen J C Lu C W | 2011 | Journal of Crystal Growth2011，360，： | 1 |
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