|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Holmium laser versus conventional transurethral resection of the bladder tumor显示文摘 | TENG Jing-fei WANG Kai YIN Lei QU Fa-jun ZHANG Dong-xu CUI Xin-gang XU Dan-feng | 2013 | Chinese Medical Journal2013，，9： | 32 |
| 2 | Component Analysis and Free Radicals Scavenging Activity of Physalis alkekengi L. Polysaccharide显示文摘A crude polysaccharide was extracted from Physalis alkekengi L. fruit. HPLC was used for the component analysis of the polysaccharide. The results indicate that Physalis alkekengi L. polysaccharide(PAP) was composed of rhamnose, xylose, arabinose, galactose, and glucose. Free radicals scavenging activity of PAP was studied through 3 free radicals scavenging tests. PAP exhibited high scavenging effects on OH and DPPH radicals, and both the scavenging rates were about 80%. The scavenging rate of O2 radical was about 22%. | CHENG Ying-kun LI Lei MENG Zhao-kun HOU A-li WU Yu-jie TENG Li-rong | 2008 | Chemical Research in Chinese Universities2008，24，2： | 18 |
| 3 | Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro显示文摘瞄准:为了构造 recombinant 侵入人体气管粘膜的病菌,那能同时表示两反感觉鸟氨酸脱羧酶(ODC ) 和 adenosylmethionine 脱羧酶(AdoMetDC ) 并且在细胞内部的聚胺水池上检测它的禁止的效果并且渲染表面的癌症房间生长。方法:AdoMetDC 的 A 205-bp cDNA 是插入颠倒的进 recombinant pAdTrack-ODCas 向量并且在 AdEasy-1 房间与 pAdEasy-1 向量重新结合。积极克隆被选择并且 transfected 进包装房间 HEK293 在以后他们被 PacI 线性化。格林荧光灯的蛋白质表示被用来监视包装的侵入人体气管粘膜的病菌的进程。ODC 和 AdoMetDC 蛋白质层次被西方的弄污识别,并且细胞内部的聚胺内容被反向阶段的高效液相色谱法检测。一个可行房间计数被用来决定 HT-29 房间的生长与或没有外长的聚胺。结果:定序证实 AdoMetDC cDNA 成功地被绑扎进 pAdTrack-ODCas 向量。在 293 个房间的 GFP 表示被萤光显微镜检查在病毒收拾行李和扩大期间观察。西方的弄污证明 ODC 和 AdoMetDC 低由 Ad-ODC-AdoMetDCas 调整了,并且因而, 3 种聚胺(腐胺,亚精胺和精胺) 被归结为很底层。当与控制条件,和生长相比拘捕没被外长的腐胺颠倒, HT-29 细胞生长显著地被禁止。结论:成功地构造的 recombinant 侵入人体气管粘膜的病菌, Ad-ODC-AdoMetDCas,堵住的聚胺合成并且为对待颜色有治疗学的潜力表面的癌症在试管内。 | Bing ZHANG Xian-xi LIU Yan ZHANG Chun-ying JIANG Qing-shan TENG Hai-yan HU Wei WANG Lei GONG | 2006 | Acta Pharmacologica Sinica2006，27，3： | 17 |
| 4 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 5 | Isolation and genetic charac-terization of a fragile plant mutant in rice (Oryza sativa L.)显示文摘The fragile rice mutant was isolated from an M2 population of indica variety Shuang Ke Zao (SKZ) treated with γ-rays, and designated as fp1 {fragile plant 1) because of its fragile leaves and culms. To map FP1 locus, an F2 mapping population was derived from a cross between the fp1 and C-bao, a polymorphic japonic variety. The primary mapping result places the FP1 locus in an interval between two molecular markers, microsatellite marker RM16 (3.1 cM proximal to FP1) and STS marker G144a (9.1 cM distal to FP1) in the centromere region of chromosome 3. A CAPS marker C524a was further developed between RM16 and G144a, with 0.4 cM genetic distances to the FP1 locus, providing a practical starting point for constructing a BAC con-tig spanning the FP1 locus and cloning the fp1 gene. Allelism test demonstrated that fpl is allelic to be 1, a fragile rice mutant reported previously. | QIAN Qian LI Yunhai ZENG Dali TENG Sheng WANG Zhengke LI Xueyong DONG Zhigang DAI Ning SUN Lei LI Jiayang | 2001 | Chinese Science Bulletin2001，46，24： | 12 |
| 6 | Effects of nano-HMX on the properties of RDX-CMDB propellant:Higher energy and lower sensitivity显示文摘Batch preparation of nano-HMX was achieved via a mechanical trituration method. The morphology and particle size of nano-HMX and raw RDX were characterized using SEM. Then nano-HMX was used in a formulation of composite modified double base propellant containing RDX. The method is to use nanoHMX to replace the RDX in the formulation by 10% gradually with the total mass content of RDX and HMX unchanged. The burning rate, mechanical sensitivity and mechanical property of propellant strands with different mass content of nano-HMX were tested. The results indicate that the 30% content of nanoHMX has the best comprehensive performance which can be used as an improvement of the existing formula. A possible mechanism of action was discussed. | Han GAO Xiao-ting HOU Xiang KE Jie LIU Gazi HAO Lei XIAO Teng CHEN Ying-ying ZUO Wei JIANG | 2017 | Defence Technology(防务技术)2017，13，5： | 10 |
| 7 | A high-fat diet reverses improvement in glucose tolerance induced by duodenal-jejunal bypass in type 2 diabetic rats显示文摘背景 Bariatric 外科为类型 2 糖尿病 mellitus ( T2DM )的成功的分辨率提供 .However , T2DM 的复发在学习试图在 duodenal-jejunal 以后在 T2DM 老鼠导致糖尿病的改进的颠倒的 bariatric surgery.This 以后与起始的分辨率在很多个病人被观察了绕过( DJB ),并且识别可能是 involved.Methods DJB 外科的重量变化和内脏荷尔蒙的效果在二个 T2DM 老鼠模型(为每个组的 n=20 )被执行:非肥胖的 Goto-Kakizaki 然而,他们不在 HFD 颠倒的喂 HFD 、喂 LFD 的 rats.Conclusion 之间是显著地不同的在葡萄糖忍耐的改进在 T2DM 老鼠由 DJB 外科导致了,首先归功于到胰岛素敏感的重新缺陷,但是不改变身体重量, GLP-1 和 PYY 层次。 | LIU Shao-zhuang SUN Dong ZHANG Guang-yong WANG Lei LIU Teng SUN Yu LI Ming-xia HU San-yuan | 2012 | Chinese Medical Journal2012，，5： | 10 |
| 8 | Re-evaluating Transarterial Chemoembolization Failure/Refractoriness:A Survey by Chinese College of Interventionalists显示文摘Background and Aims:The recognition of transarterial chemoembolization(TACE)failure/refractoriness among Chinese clinicians remains unclear.Using an online survey conducted by the Chinese College of Interventionalists(CCI),the aim of this study was to explore the recognition of TACE failure/refractoriness and review TACE application for hepatocellular carcinoma(HCC)treatment in clinical practice.Methods:From 27 August 2020 to 30 August 2020 during the CCI 2020 annual meeting,a survey with 34 questions was sent by email to 264 CCI clinicians in China with more than 10 years of experience using TACE for HCC treatment.Results:A total of 257 clinicians participated and responded to the survey.Most participants agreed that the concept of“TACE failure/refractoriness”has scientific and clinical significance(n=191,74.3%).Nearly half of these participants chose TACE-based combination treatment as subsequent therapy after so-called TACE failure/refractoriness(n=88,46.1%).None of the existing TACE failure/refractoriness definitions were widely accepted by the participants;thus,it is necessary to re-define this concept for the treatment of HCC in China(n=235,91.4%).Most participants agreed that continuing TACE should be performed for patients with preserved liver function,presenting portal vein tumor thrombosis(n=242,94.2%)or extrahepatic spread(n=253,98.4%),after the previous TACE treatment to control intrahepatic lesion(s).Conclusions:There is an obvious difference in the recognition of TACE failure/refractoriness among Chinese clinicians based on existing definitions.Further work should be carried out to re-define TACE failure/refractoriness. | Bin-Yan Zhong Wan-Sheng Wang Shen Zhang Hai-Dong Zhu Lei Zhang Jian Shen Xiao-Li Zhu Gao-Jun Teng Cai-Fang Ni | 2021 | Journal of Clinical and Translational Hepatology2021，9，4： | 9 |
| 9 | Design and application of structural health monitoring system in long-span cable-membrane structure显示文摘Cable-membrane structures have small rigidity and are highly sensitive to wind. Structural health monitoring is necessary to ensure the serviceability and safety of the structure. In this research, the design method of a structural health monitoring system is using the characteristics of a cable-membrane structure. Taking the Yueyang Sanhe Airport Terminal as an example, a finite element model is established to determine the critical structural components. Next, the engineering requirements and the framework of the monitoring system are studied based on the results of numerical analysis. The specific implementation of the structural health monitoring is then carried out, which includes sensor selection, installation and wiring. The proposed framework is successfully applied to the monitoring system for the Yueyang Airport terminal building, and the synchronous acquisition of fiber Bragg grating and acceleration sensor signals is implemented in an innovative way. The successful implementation and operation of structural health monitoring will help to guarantee the safety of the cablemembrane structure during its service life. | Tang Teng Yang Dong-Hui Wang Lei Zhang Jian-Ren Yi Ting-Hua | 2019 | Earthquake Engineering and Engineering Vibration2019，18，2： | 8 |
| 10 | Identification and characterization of Argonaute gene family and meiosis-enriched Argonaute during sporogenesis in maize显示文摘Argonaute(AGO) proteins play a key role in regulation of gene expression through small RNA‐directed RNA cleavage and translational repression, and are essential for multiple developmental processes. In the present study, 17 AGO genes of maize(Zea mays L., ZmAGOs) were identified using a Hidden Markov Model and validated by rapid amplification of cDNA ends assay. Subsequently, quantitative PCR revealed that expressions of these genes were higher in reproductive than in vegetative tissues. AGOs presented five temporal and spatial expression patterns, which were likely modulated by DNA methylation, 50‐untranslated exons and microRNA‐mediated feedback loops. Intriguingly, ZmAGO18 b was highly expressed in tassels during meiosis. Furthermore, in situ hybridization and immunofluorescence showed that ZmAResearchGO18b was enriched in the tapetum and germ cells in meiotic anthers. We hypothesized that ZmAGOs are highly expressed in reproductive tissues, and that ZmAGO18 b is a tapetum and germ cell‐specific member of the AGO family in maize. | Lihong Zhai Wei Sun Ke Zhang Haitao Jia Lei Liu Zhijie Liu Feng Teng Zuxin Zhang | 2014 | Journal of Integrative Plant Biology2014，56，11： | 8 |
| 11 | A novel phenylpropanoid glycoside from Callicarpa kwangtungensis Chun显示文摘新奇 phenylpropanoid glycoside, Callicarposide A 从 Callicarpa kwangtungensis Chun 的天线部分被孤立。化学结构被阐明根据光谱分析。 | Er Lei Xie Guo Ping Zhou Teng Fei Ji Jun Wu Gui Ping Yuan | 2009 | Chinese Chemical Letters2009，20，7： | 8 |
| 12 | Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose显示文摘This study was conducted to examine the association of perfluoroalkyl substance(PFAS)exposure with gestational diabetes mellitus(GDM) risk and postpartum fasting blood glucose.We used a 1:2 matched case–control study with 84 GDM subjects and 168 healthy pregnant women from Beijing, China. The maternal blood was collected at 1–2 days before delivery, and eight linear isomers and fourteen branched isomers were determined in maternal serum.Logistic regression analyses were performed to evaluate the associations after adjusting for potential confounders. The median of the sum of levels of total PFASs was 4.24 ng/m L with a interquartile range(IQR) of 2.82–6.54 ng/m L. Although maternal PFAS exposure was not associated with risk of GDM, significant positive associations were observed between evaluated exposure to specific PFAS congeners and increasing blood glucose. The odds ratio(ORs) of the highest category of postpartum fasting blood glucose for perfluoro-1-metylheptylsulfonat(1 m-PFOS), perfluoro-3/4-metylheptylsulfonat(3 m+4 m-PFOS), perfluoro-5-metylheptylsulfonat(5 m-PFOS), and perfluorohexane sulfonate(PFHx S) were 2.03(95% CI: 1.09–3.77), 1.93(95% CI:1.04–3.58), 2.48(95% CI: 1.33–4.65), and 2.26(95% CI: 1.21–4.21), respectively, suggesting negative effects of maternal exposure to specific PFAS compounds on glucose metabolism. | Yuxin Wang Lei Zhang Yue Teng Jiayu Zhang Lin Yang Jingguang Li Jianqiang Lai Yunfeng Zhao Yongning Wu | 2018 | Journal of Environmental Sciences2018，30，7： | 8 |
| 13 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 14 | Effects of recrystallization on the low cycle fatigue behavior of directionally solidified superalloy DZ40M显示文摘The effects of recrystallization on low cycle fatigue behavior were investigated on directionally solidified Co-base superalloy DZ40M. Opti-cal microscopy and SEM were used to examine the microstructure and fracture surface of the specimens. The mechanical testing results demonstrated that the low cycle fatigue property of DZ40M significantly decreased with the partial recrystallization. Fatigue cracks initiate near the carbides and the grain boundaries with slip-bands. Both the fatigue crack initiation and propagation can be accelerated with the oc-currences of recrystallized grain boundaries. | ZHAO Yang WANG Lei LI Hongyun YU Teng LIU Yang | 2008 | Rare Metals2008，27，4： | 8 |
| 15 | Effects of water regime, crop residues, and application rates on control of Fusarium oxysporum f.sp.cubense显示文摘Biological soil disinfestation is an effective method to control soil-borne disease by flooding and incorporating with organic amendments, but field conditions and resources sometimes limited its practical application. A laboratory experiment was conducted to develop practice guidelines on controlling Fusarium wilt, a widespread banana disease caused by Fusarium oxysporum f. sp. cubense(FOC). FOC infested soil incorporated with rice or maize straw at rates of 1.5 tons/ha and 3.0 tons/ha was incubated under flooded or water-saturated(100% water holding capacity) conditions at 30℃ for 30 days. Results showed that FOC populations in the soils incorporated with either rice or maize straw rapidly reduced more than 90% in the first 15 days and then fluctuated till the end of incubation, while flooding alone without organic amendment reduced FOC populations slightly. The rapid and dramatic decrease of redox potential(down to- 350 m V) in straw-amended treatments implied that both anaerobic condition and strongly reductive soil condition would contribute to pathogen inactivation. Water-saturation combined with straw amendments had the comparable effects on reduction of FOC, indicating that flooding was not indispensable for inactivating FOC. There was no significant difference in the reduction of FOC observed in the straw amendments at between 1.5 and 3 tons/ha. Therefore,incorporating soil with straw(rice or maize straw) at a rate of 3.0 tons/ha under 100%water holding capacity or 1.5 tons/ha under flooding, would effectively alleviate banana Fusarium wilt caused by FOC after 15-day treating under 30℃. | Teng Wen Xinqi Huang Jinbo Zhang Tongbin Zhu Lei Meng Zucong Cai | 2015 | Journal of Environmental Sciences2015，27，5： | 8 |
| 16 | Allelochemical p-hydroxybenzoic acid inhibits root growth via regulating ROS accumulation in cucumber(Cucumis sativus L.)显示文摘Allelopathy is prevalent in agricultural ecosystems and mediated by plant-derived secondary metabolites(allelochemicals).Allelochemicals are released by donor plants and affect the root growth and development of receptor plants.Allelopathy is responsible for the continuous cropping obstacles in cucumber(Cucumis sativus L.).p-Hydroxybenzoic acid(pHBA),an autotoxin from root exudates of cucumber,has been proposed to be an important allelopathic chemical.However,the molecular mechanism by which pHBA affect root growth and development in cucumber is unknown.Here,we found that pHBA treatment suppressed root growth of cucumber by reducing the meristem activity and cell length.This root growth defect is caused by reduced reactive oxygen species(ROS)accumulation in root tips.After pHBA treatment,the expression levels of several ROS-scavenging-related genes were increased,including peroxidase(POD),catalase(CAT)and metallothionein(MT).Moreover,exogenously application of salicylhydroxamate(SHAM),a peroxidase inhibitor,can partially restore the pHBA treatment induced root growth inhibition.Furthermore,we found that there is natural variation for the inhibitory effect of pHBA on root growth.We also showed that pHBA treatment could maintain higher level of ROS accumulated in the pHBA less sensitive cucumber than that in the pHBA-sensitive cucumber.These results suggest that pHBA inhibits root growth by reducing root tip ROS level in cucumber. | HUANG Cheng-zhen XU Lei Sun Jin-jing ZHANG Zhong-hua FU Mei-lan TENG Hui-ying YI Ke-ke | 2020 | Journal of Integrative Agriculture2020，19，2： | 8 |
| 17 | Confined van der Waals Epitaxial Growth of Two-Dimensional Large Single-Crystal In_(2)Se_(3) for Flexible Broadband Photodetectors显示文摘The controllable growth of two-dimensional(2D)semiconductors with large domain sizes and high quality is much needed in order to reduce the detrimental efect of grain boundaries on device performance but has proven to be challenging.Here,we analyze the precursor concentration on the substrate surface which signifcantly infuences nucleation density in a vapor deposition growth process and design a confned micro-reactor to grow 2D In_(2)Se_(3) with large domain sizes and high quality.Te uniqueness of this confned micro-reactor is that its size is∼102-103 times smaller than that of a conventional reactor.Such a remarkably small reactor causes a very low precursor concentration on the substrate surface,which reduces nucleation density and leads to the growth of 2D In_(2)Se_(3) grains with sizes larger than 200�m.Our experimental results show large domain sizes of the 2D In_(2)Se_(3) with high crystallinity.Te fexible broadband photodetectors based on the as-grown In_(2)Se_(3) show rise and decay times of 140 ms and 25 ms,efcient response(5.6 A/W),excellent detectivity(7×10^(10) Jones),high external quantum efciency(251%),good fexibility,and high stability.Tis study,in principle,provides an efective strategy for the controllable growth of high quality 2D materials with few grain boundaries. | Lei Tang Changjiu Teng Yuting Luo Usman Khan Haiyang Pan Zhengyang Cai Yue Zhao Bilu Liu Hui-Ming Cheng | 2019 | Research2019，，1： | 7 |
| 18 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 19 | Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats显示文摘Dihydromyricetin(DHM),as a bioactive flavanonol compound,is mainly found in“Tengcha”(Ampelopsis grossedentata)cultivated in south of China.This study aimed to investigate the anti-hyperglycemic and antidyslipidemic activities of DHM using type 2 diabetes mellitus(T2D)rats,which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin.Forty-eight freshlyweaned rats were randomly assigned into the negative control(Blank),low dose(100 mg/kg),medium dose(200 mg/kg),high dose(400 mg/kg),and positive(40 mg/kg,met)groups.Fasting blood glucose and body weight were measured at weekly interval.Oral glucose tolerance tests were performed on days 42.The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects.Moreover,after the DHM treatment,p-Akt and p-AMPK expression was upregulated,and glycogen synthase kinase-3β(GSK-3β)expression was downregulated,indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3βsignaling pathway. | Maojun Yao Hui Teng Qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei Chen | 2021 | Food Science and Human Wellness2021，10，2： | 6 |
| 20 | Verification of Numerical Modeling in 2-D Wave Propagation in Rock显示文摘Compressional harmonic wave propagation from a cylindrical tunnel or borehole in an intact rock is the basis for investigation of the practical explosion waves in a fractured rock mass. The amplitudes of the radial stress wave obtained from the universal distinct element code (UDEC) were compared with the analytical solutions for two cases with different conditions. Good agreements between the UDEC results and the analytical solutions have been achieved. It indicates that UDEC can model 2-D dynamic problems at a high degree of accuracy. | LEI Wei-dong HEFNY Ashraf TENG Jun ZHAO Jian SONG Hong-wei | 2005 | Journal of China University of Mining and Technology2005，15，4： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员