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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 3 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 2 |
| 4 | Exercise Training in Patients With Severe Congestive Heart Failure: Enhancing Peak Aerobic Capacity While Minimizing the Increase in Ventricular Wall Stress显示文摘 | Laura Demopoulos Rachel Bijou Icilma Fergus Margaret Jones Joel Strom Thierry H LeJemtel | 1997 | Journal of the American College of Cardiology1997，，3： | 1 |
| 5 | Reduced PWM harmonic distortion for multilevel inverters operating over a wide modulation range显示文摘 | Brendan P M Donald G H Thierry M | 2006 | IEEE Transactions on Power Electronics2006，21，4： | 1 |
| 6 | Use and abuse of flexible intramedullary nailing in children and adolescents显示文摘 | PIERRE L THIERRY H PIERRE J | 2006 | Pediatr Orthop2006，26，6： | 1 |
| 7 | Reinforcement of the cube texture during recrystallization of a 1050 aluminum alloy partially recrystallized and 10% cold-rolled显示文摘 | Wei W Anne-Laure H Thierry B | 2012 | Materials Characterization2012，64，： | 1 |
| 8 | Evidence of diversity and recombination in Arsenophonus symbionts of the Bemisia tabaci spe- cies complex显示文摘 | Mouton L Thierry M Henri H | 2012 | Microbiology2012，12，1： | 1 |
| 9 | Molecular mechanisms of the cardiovascular protective effects of polyphenols显示文摘 | Andriantsitohaina R Auger C Thierry Chataigneau T ltienne-Selloum N Huige Li H Marttnez MC Schini-Kerth VB Laher I | | 0，，： | 1 |
| 10 | Bilateral Trade of Cultural Goods, ECPII显示文摘 | Silvio H T Tal Thierry Mayer | 2007 | Working Paper2007，，20： | 1 |
| 11 | 显示文摘 | Thierry van Dessel H J Lee PD Faessen G | 1999 | J Clin Endocrinol Metab1999，84，9： | 1 |
| 12 | Localized Electrochemical Impedance Spectroscopy for Studying Pitting Corrosion on Stainless Steels 显示文摘 | ZOU F THIERRY D ISAACS H S | 1997 | J Electrochem Soc1997，144，： | 1 |
| 13 | Cooperative subcontracting relationship within a project supply chain: a simulation approach显示文摘 | PARROD N THIERRY C FANRGIER H | 2007 | Simulation Modelling Practice and Theory2007，15，1： | 1 |
| 14 | Stern cell factor in combination with filgrastim after chemotherapy improves peripheral blood progenitor cell yield and reduces apheresis requirements in multiple myelama patients:a randomized,controlled trial 显示文摘 | Thierry F Jean-Luc H Frederic M et al | 1999 | Blood1999，94，4： | 1 |
| 15 | Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 PI05 promoters显示文摘 | Romanczuk H Thierry F Howley PM | 1990 | J V irol1990，64，6： | 1 |
| 16 | Comparative HPLC enantioseparation of new chiral hydantoin derivatives on three different polysaccharide type chiral stationary phases显示文摘 | IRMA K MARTIAL K THIERRY H | 2002 | J Pharm Biomed Anal2002，27，3： | 1 |
| 17 | Bilateral trade of cultural goods显示文摘 | Anne-Ce'lia Disdier Silvio H T.Tai Lionel Fontagne' Thierry Mayer | | 0，，145： | 1 |
| 18 | The Influence of a Muscle Relaxant Bolus on Bispectral and Datex-Ohmeda Entropy Values During Propofol-Remifentanil Induced Loss of Consciousness 显示文摘 | Ngai Liu Thierry C Isabelle H | 2005 | Anesth Analg2005，101，6： | 1 |
| 19 | An Additive Factor Analysis of the Effect of Depression on the Reaction Time of Old Patients 显示文摘 | Sylvie B G Olivier B Thierry H | 2004 | Acta Psychologica2004，117，： | 1 |
| 20 | Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – NCT01514890<!-- Doctopic: VH -->显示文摘 | Christophe Hézode Hélène Fontaine Céline Dorival Dominique Larrey Fabien Zoulim Valérie Canva Victor de Ledinghen Thierry Poynard Didier Samuel Marc Bourlière Jean-Pierre Zarski Jean-Jacques Raabe Laurent Alric Patrick Marcellin Ghassan Riachi Pierre-Henr | 2013 | Journal of Hepatology2013，，： | 1 |
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