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| 1 | Towards a versatile point-of-care systemcombining femtosecond laser generatedmicrofluidic channels and direct laserwritten microneedle arrays显示文摘Microneedle-based microfluidic systems have a great potential to become well-accepted medical devices for simple,accurate,and painless drug delivery and lab-on-a-chip diagnostics.In this work,we report on a novel hybrid approach combining femtosecond direct laser written microneedles with femtosecond laser generated microfluidic channels providing an important step towards versatile medical point-of-care systems.Hollow microneedle arrays are fabricated by a laser system designed for two-photon polymerization applications.Compression tests of two different types of truncated cone-shaped microneedle arrays prepared from OrmoComp^(■)give information about the microneedle mechanical strength,and the results are compared to skin insertion forces.Three-dimensional microchannels are directly created inside PMMA bulk material by an ultrashort pulse laser system with vertical channels having adjustable cross-sectional areas,which allow attaching of microneedles to the microfluidic system.A comprehensive parameter study varying pulse duration and repetition rate is performed on two-photon polymerization to identify an optimal laser power range for fabricating microneedles using the same pulse duration and repetition rate as for microchannels.This addresses the advantage of a single laser system process that overcomes complex fabrication methods.A proof of concept flow test with a rhodamine B dye solution in distilled water demonstrates that the combination of microneedles and microchannels qualifies for microfluidic injection and extraction applications. | Anika Trautmann Gian-Luca Roth Benedikt Nujiqi Thomas Walther Ralf Hellmann | 2019 | Microsystems & Nanoengineering2019，5，1： | 3 |
| 2 | Who are the active investors?显示文摘 | Laura Bottazzi Marco Da Rin Thomas Hellmann | 2008 | Journal of Financial Economics2008，，3： | 2 |
| 3 | Who altethe active investors?Evidence from venture capital显示文摘 | Bottazzi Laura Marco Da Rin Thomas Hellmann | 2008 | Joumal of Financial Economics2008，89，3： | 1 |
| 4 | The Allocation of Control Rights in Venture Capital Contracts 显示文摘 | Hellmann Thomas | 1998 | Rand Journal of Economics1998，29，1： | 1 |
| 5 | IPOs,Acquisitions,and the Use of Convertible Securities in Venture Capital显示文摘 | Thomas Hellmann | 2006 | Journal of Financial Economics2006，，81： | 1 |
| 6 | Liberalization, Moral Hazard in Banking, and Prudential Regulation : Are Capital Requirements Enough ? 显示文摘 | HELLMANN THOMAS F KEV1N MURDOCK C JOSEPH STIGLITZ E | 2000 | The American Economic Review2000，90，1： | 1 |
| 7 | Venture Capital and the professionalization of Start-Up Firms:Empirical Evidence显示文摘 | Thomas Hellmann Manju Puri | 2002 | The Journal of Finance2002，，： | 1 |
| 8 | A theory of strategic venture investing显示文摘 | Thomas Hellmann | 2002 | Journal of Financial Economics2002，64，： | 1 |
| 9 | The Interaction between Product Market and Financing Strategy:The Role of Venture Capital 显示文摘 | Hellmann Thomas and Manju Puri | 2000 | Review of Financial Studies2000，13，4： | 1 |
| 10 | The Interaction between Product Market and Financing Strategy:The Role of Venture Captial 显示文摘 | Hellmann Thomas Manju Purl | | Review of Fiancial Studies0，13，4： | 1 |
| 11 | A theory of strategic venture investing显示文摘 | Thomas Hellmann | 2002 | Journal of Financial Economics2002，，2： | 1 |
| 12 | Venture Capital and the Profession- alization of Start-up Firms: Empirical Evidence 显示文摘 | Thomas Hellmann Manju Puri | 2002 | Journal of Fi- nance2002，，1： | 1 |
| 13 | Banks as catalysts for industrialization 显示文摘 | Marco Da Rin Thomas Hellmann | 2002 | Journal of Financial Intermediation2002，11，4： | 1 |
| 14 | Who are the Active Investors? Evidence from Venture Capita显示文摘 | LAURA Bottazzi MARCO Da Rin THOMAS Hellmann | 2008 | Journal of Finan- cial Economics2008，89，： | 1 |
| 15 | Venture Capital and the Professionalization of Start-up Firms: Empirical Evidence 显示文摘 | Hellmann Thomas and Manju Puri | 2002 | Journal of Finance2002，57，1： | 1 |
| 16 | Who are the Active Investors? Evidence from Venture Capital 显示文摘 | Bottazzi Laura Marco Da Rin Thomas Hellmann | 2008 | Journal of Fmanclal Economics2008，89，03： | 1 |
| 17 | IPOs, acquisitions, and the use of convertible securities in venture rapital显示文摘 | HELLMANN THOMAS | 2006 | Journal of Financial Economics2006，81，3： | 1 |
| 18 | Venture capital and the professionalization of start-up firms: empirical evi- dence显示文摘 | HELLMANN THOMAS PURI MANJU | 2002 | The Journal of Finance2002，57，1： | 1 |
| 19 | The Allocation of Control Rights in Venture Capital Contracts显示文摘 | | 1998 | Land Journal of Economics1998，，29： | 1 |
| 20 | IPOs, acquisitions, and the use of convertible securities in venture capital显示文摘 | Thomas Hellmann | 2006 | Journal of Financial Economics2006，，3： | 1 |
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