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| 1 | Endoplasmic reticulum oxidoreductin 1α mediates hepatic endoplasmic reticulum stress in homocysteine-induced atherosclerosis显示文摘Endoplasmic 蜂窝胃(嗯) 应力作为不同病理学的过程的一个重要调节的人并且作为贡献导致的 homocysteine (Hcy ) 的机制正在出现 hepar 损害。然而,分子的事件导致 Hcy 嗯在在动脉粥样硬化背景下面的 hepar 的应力当前是未知的。Endoplasmic 蜂窝胃 oxidoreductin (ERO1 ) 1 在维持起一个关键作用嗯压力功能。在这研究,我们在 hepacytes 在 hyperhomocysteinemia 和 ERO1 的效果在 hepar 决定了 ERO1 的表示嗯应力面对 Hcy。HHcy 模型被在 apolipoprotein-E-deficient (ApoE-/-) 喂蛋氨酸食谱建立老鼠,和 hepatocytes 与 Hcy 的叶酸、不同的集中被孵化。我们的结果证明 Hcy 被触发嗯应力描绘了由一调整葡萄糖的蛋白质的增加的内容 78 (GRP78 ) ,蛋白质 kinase 象 RNA 一样嗯 kinase (津贴) ,激活抄写因素(ATF ) 6 并且 X 盒子有约束力的 protein-1 (XBP-1 ) 。在 HHcy 老鼠和对待 Hcy 的 hepatocytes 的 ERO1 表情在 ApoE-/- 组和控制 hepacytes 与那些相比被减少(P < 0.05 ) 分别地。有小介入的 RNA 的 ERO1 的表示显著地扩充了的敲门下面导致 Hcy 嗯应力。同时,表情嗯压力相关的因素包括 GRP78,津贴, ATF6 和 XBP-1,当 ERO1 基因在 hepacytes 是过去表示的时,显著地被减少。我们的结果建议 ERO1 可以涉及导致 Hcy 的 hepar 嗯 ERO1 表示的应力,和抑制能加速这进程。 | Xiaoling Yang Hua Xu Yinju Hao Li Zhao Xin Cai Jue Tian Minghao Zhang Xuebo Han Shengchao Ma Jun Cao Yideng Jiang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 14 |
| 2 | Scalable microfabrication of three-dimensional porous interconnected graphene scaffolds with carbon spheres for high-performance all carbon-based micro-supercapacitors显示文摘As one of the most important micro energy storage devices(MESDs),graphene-based micro-supercapacitors(G-MSCs)possess the advantages of excellent flexibility,long cycle life,affordability and high reliability.In most cases,constructing three-dimensional(3D)graphene networks is widely utilized to promote the permeation of electrolyte and enhance the utilization of active materials.In this work,conventional freeze-drying process is utilized in the fabrication of G-MSCs to constitute 3D interconnected networks micro-electrodes,and further by regulating the composition of inks,carbon spheres(CSs)at different mass loadings are introduced into the graphene scaffolds to further increase the active sites of the micro-electrodes.The fabricated all carbon-based MSC with the optimal mass loading of CSs(0.406 mg cm^(-2))exhibits a high specific areal capacitance of 17.01mF cm^(-2)at the scan rate of 10mV s^(-1)and a capacitance retention of 93.14%after 10000 cycles at the scan rate of 500 mV s^(-1).The proposed microfabrication process is facile and fully compatible with modern microtechnologies and will be highly suitable for large-scale production and integration. | Yiming Chen Minghao Guo Liang He Wei Yang Lin Xu Jiashen Meng Xiaocong Tian Xinyu Ma Qiang Yu Kaichun Yang Xufeng Hong Liqiang Mai | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 3 | The Research and Realization of UDDI in Service-Oriented Architecture显示文摘It is a trend that SOA is becoming the future enterprise software architecture world widely.The key point is howto describe and discover services,thus these mainly rely on UDDI.Firstly,the current situation of SOA and UDDI are introduced,and then UDDI V3and related technical specifications are analyzed.Secondly,UDDI models,working principle,the mapping of WSDL and UDDI,and its implementation technologies are delved into.On this basis,the overall framework of UDDI is built and the service publishing and inquiring process are analyzed.Finally,a registry based on the latest standard of UDDI is achieved. | ZANG Tianxiang TIAN Minghao ZHANG Liyuan FENG Yongxin | 2014 | 沈阳理工大学学报2014，33，6： | 1 |
| 4 | MHC-mismatched mice liver transplantation promotes tumor growth in liver graft显示文摘 | Sheng Yan Yuan Ding Yang Tian Zhongjie Lu Yan Wang Qiyi Zhang Yufu Ye Lin Zhou Haiyang Xie Hui Chen Minghao Zheng Shusen Zheng | 2014 | Cancer Letters2014，，： | 1 |
| 5 | Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia显示文摘Dear Editor,Since last December,the outbreak of 2019-nCoV in Wuhan has caused ever-increasing attention and public panic all over the world.Up to February 9,2020,40,171 patients had been diagnosed with 2019-nCoV infection,including 6484(16.14%)severe cases and 908 deaths(2.27%).Compared to SARS and MERS,2019-nCoV appears to be much more contagious but less lethal,as most patients have mild symptoms and good prognosis1,2.However,according to the Chinese government’s daily report,13.2–21.3%of patients with 2019-nCoV infection developed into severe or fatal illness(Fig.S1a),which is characterized by the rapid development to acute respiratory distress syndrome(ARDS)or septic shock.Along with an increasing number of confirmed cases,the cumulative total of severe patients with 2019-nCoV is growing(Fig.S1b).Treatment of these critically ill patients is becoming one of the major challenges we are facing. | Wei Zhou Yisi Liu Dongdong Tian Cheng Wang Sa Wang Jing Cheng Ming Hu Minghao Fang Yue Gao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 6 | In-situ selective surface engineering of graphene micro-supercapacitor chips显示文摘Surface modification of graphene oxide(GO)is a powerful strategy to develop its energy density for electrochemical energy storage.However,pre-modified GO always exhibits unsatisfactory hydrophilia and its ink-relevant utilization is extremely limited.Although GO ink is widely utilized in fabricating micro energy storage devices via extrusion-based 3D-printing,simultaneously obtaining satisfactory hydrophilia and high energy density still remains a challenge.In this work,an in-situ surface engineering strategy was employed to enhance the performance of GO micro-supercapacitor chips.Three dimensionally printed GO micro-supercapacitor chips were treated with pyrrole monomer to achieve selective and spontaneous anchoring of polypyrrole on the microelectrodes without affecting interspaces between the finger electrodes.The interface-reinforced graphene scaffolds were edge-welded and exhibited a considerably improved specific capacitance,from 13.6 to 128.4 mF·cm^(-2).These results are expected to provide a new method for improving the performance of micro-supercapacitors derived from GO inks and further strengthen the practicability of 3D printing techniques in fabricating energy storage devices. | Yiming Chen Minghao Guo Lin Xu Yuyang Cai Xiaocong Tian Xiaobin Liao Zhaoyang Wang Jiashen Meng Xufeng Hong Liqiang Mai | 2022 | Nano Research2022，15，2： | 0 |
| 7 | Improvement of Update Mechanism for Object Management in High Level Architecture显示文摘As the distributed interactive simulation technology,the High Level Architecture(HLA)with the common Runtime Infrastructure(RTI)services has been applied to all kinds of simulation and computation areas,w hich has more interoperability and interactivity.Especially,w ith the development of hierarchical RTI softw are technology,the efficiency,flexibility,and levels of resolution etc.can be improved.How ever,updating mechanism for object management in hierarchical RTI can't supply the dynamic object subscription to the simulation operation,specially updating limitation in consistence and synchronization.Therefore,the improvement of update mechanism for object management has been proposed,and the process of w hich has been described.The results of simulation show that the improvement mechanism can achieve better updating rates and latency than traditional mechanism,considering the consistence need. | FENG Yongxin FEI Shunchao TIAN Minghao QIAN Bo | 2014 | 沈阳理工大学学报2014，33，2： | 0 |
| 8 | Smart epidermal electrophysiological electrodes:Materials,structures,and algorithms显示文摘Epidermal electrophysiological monitoring has garnered significant attention for its potential in medical diagnosis and healthcare,particularly in continuous signal recording.However,simultaneously satisfying skin compliance,mechanical properties,environmental adaptation,and biocompatibility to avoid signal attenuation and motion artifacts is challenging,and accurate physiological feature extraction necessitates effective signal-processing algorithms.This review presents the latest advancements in smart electrodes for epidermal electrophysiological monitoring,focusing on materials,structures,and algorithms.First,smart materials incorporating self-adhesion,self-healing,and self-sensing functions offer promising solutions for long-term monitoring.Second,smart meso-structures,together with micro/nanostructures endowed the electrodes with self-adaption and multifunctionality.Third,intelligent algorithms give smart electrodes a“soul,”facilitating faster and more-accurate identification of required information via automatic processing of collected electrical signals.Finally,the existing challenges and future opportunities for developing smart electrodes are discussed.Recognized as a crucial direction for next-generation epidermal electrodes,intelligence holds the potential for extensive,effective,and transformative applications in the future. | Yuanming Ye Haochao Wang Yanqiu Tian Kunpeng Gao Minghao Wang Xuanqi Wang Zekai Liang Xiaoli You Shan Gao Dian Shao Bowen Ji | 2023 | Nanotechnology and Precision Engineering2023，6，4： | 0 |
| 9 | When liver disease diagnosis encounters deep learning:Analysis,challenges,and prospects显示文摘The liver is the second-largest organ in the human body and is essential for digesting food and removing toxic substances.Viruses,obesity,alcohol use,and other factors can damage the liver and cause liver disease.The diagnosis of liver disease used to depend on the clinical experience of doctors,which made it subjective,difficult,and time-consuming.Deep learning has made breakthroughs in various fields;thus,there is a growing interest in using deep learning methods to solve problems in liver research to assist doctors in diagnosis and treatment.In this paper,we provide an overview of deep learning in liver research using 139 papers from the last 5 years.We also show the relationship between data modalities,liver topics,and applications in liver research using Sankey diagrams and summarize the deep learning methods used for each liver topic,in addition to the relations and trends between these methods.Finally,we discuss the challenges of and expectations for deep learning in liver research. | Yingjie Tian Minghao Liu Yu Sun Saiji Fu | 2023 | iLIVER2023，2，1： | 0 |
| 10 | Structure and electrical properties of La_(2)O_(3)-doped(K,Na,Li)(Nb,Ta)O_(3)-(Bi,Na)TiO_(3) ceramics显示文摘In this paper,Lead-free based on 0.97(K_(0.48)Na_(0.48)Li_(0.04))(Nb_(0.8)Ta0.2)O_(3)-0.03Bi_(0.5)Na_(0.5)TiO_(3) with additives La_(2)O_(3)(1,2,3,4 wt.%)was prepared by the solid reaction method,and the effect of La dopant on the structural and electrical properties is investigated.The result indicates La dopant considerably decreases the optical band gap compared to the undoped composition.On the other hand,La doping leads to the higher dielectric property in a wider temperature,providing possibilities and directions for the subsequent development of ferroelectric photovoltaic materials with electrical properties and low optical band gap in a dramatical manner. | Bingsen Wang Junjun Wang Jiaqi Li Miao Yang Minghao Huang Tianyi Ma Yu Tian Fengmin Wu | 2023 | Journal of Advanced Dielectrics2023，13，2： | 0 |
| 11 | Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling显示文摘Light adaptation enables the vertebrate visual system to operate over a wide range of ambient illumination.Regulation of phototransduction in photoreceptors is considered a major mechanism underlying light adaptation.However,various types of neurons and glial cells exist in the retina,and whether and how all retinal cells interact to adapt to light/dark conditions at the cellular and molecular levels requires systematic investigation.Therefore,we utilized single-cell RNA sequencing to dissect retinal cell-type-specific transcriptomes during light/dark adaptation in mice.The results demonstrated that,in addition to photoreceptors,other retinal cell types also showed dynamic molecular changes and specifically enriched signaling pathways under light/dark adaptation.Importantly,Müller glial cells(MGs)were identified as hub cells for intercellular interactions,displaying complex cell‒cell communication with other retinal cells.Furthermore,light increased the transcription of the deiodinase Dio2 in MGs,which converted thyroxine(T4)to active triiodothyronine(T3).Subsequently,light increased T3 levels and regulated mitochondrial respiration in retinal cells in response to light conditions.As cones specifically express the thyroid hormone receptor Thrb,they responded to the increase in T3 by adjusting light responsiveness.Loss of the expression of Dio2 specifically in MGs decreased the light responsive ability of cones.These results suggest that retinal cells display global transcriptional changes under light/dark adaptation and that MGs coordinate intercellular communication during light/dark adaptation via thyroid hormone signaling. | Min Wei Yanping Sun Shouzhen Li Yunuo Chen Longfei Li Minghao Fang Ronghua Shi Dali Tong Jutao Chen Yuqian Ma Kun Qu Mei Zhang Tian Xue | 2023 | Protein & Cell2023，14，8： | 0 |
| 12 | The bright star survey telescope for the planetary transit survey in Antarctica显示文摘Transiting extrasolar planets(exoplanets),especially those orbiting bright stars, are desired for study of the diversity of planetary compositions, internal structures and atmospheres beyond our solar system. Dome A at Antarctica is a promising site for planetary transit surveys,where the continuous darkness and the large clear-sky fraction in the winter months greatly enhance the detection efficiency. The Chinese Small Telescope ARray and the Antarctic Survey Telescopes are the first facilities that have been operated at Dome A for use in exoplanet surveys. To increase the sky coverage, a low-temperature-resistant wide-field robotic telescope, named the bright star survey telescope(BSST), has been developed to join the ongoing planetary transit survey in Antarctica. The BSST has an aperture size of 300 mm and is equipped with a largeframe 4K×4K CCD camera to receive starlight from a 3.°4×3.°4 field of view. The BSST was operated at Lijiang observatory in April and May 2015 for a test run.Photometric precision of 3.5 mmag was achieved for stars with V~11 mag using 75 s exposures. The transiting events of two Jupiter-size exoplanets, HAT-P-3b and HATP-12 b, were observed on May 10 and May 20, 2015,respectively. | Qiguo Tian Peng Jiang Fujia Du Jian Wang Zhengyang Li Xiaoyan Li Zhiyong Zhang Haiping Lu Xiangyan Yuan Huigen Liu Hui Zhang Luming Sun Liang Chang Jianguo Wang Shaohua Zhang Tuo Ji Xiheng Shi Jie Chen Guangyu Zhang Minghao Jia Jiajing Liu Junyan Zhou Xiang Pan Shucheng Dong Fengxin Jiang Hongfei Zhang Jilin Zhou Lifan Wang Hongyan Zhou | 2016 | Science Bulletin2016，61，5： | 0 |
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