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| 1 | Characterization of the Nanoscale Microstructure of an Immersion Silver on Sputtered Copper显示文摘Silver has grown its attraction of the scientists in microelectronic field recently. Electrochemical deposition of silver onto copper substrates by immersion method has been one of the keen topics. In this study, ethanol was used as the plating solution in which some chemicals were added. The silver deposits were characterized by a field emission scanning electron microscopy (FESEM), an atom force microscope (AFM), a transmission electron microscope (TEM) and a selected area electron diffraction (SAED). It was found that silver immersion using ethanol-based bath has good coverage feature. The highlands of the copper substrate are coated by silver particles whose sizes are around 12 nm, but those sizes at low-lying lands are a little smaller. | TANG Dian WEI Zhe-Liang SHAO Yan-Qun YOU Shao-Xin O'KEEFE Mathew O' KEEFE Thomas | 2005 | Chinese Journal of Structural Chemistry2005，24，8： | 6 |
| 2 | MiR-125a-5p Regulates Vitamin D Receptor Expression in a Mouse Model of Experimental Autoimmune Encephalomyelitis显示文摘Multiple sclerosis(MS)is a chronic and incurable autoimmune neurodegenerative disease of the central nervous system.Although the symptoms of MS can be managed by vitamin D3 treatment alone,this condition cannot be completely eradicated.Thus,there might be unknown factors capable of regulating the vitamin D receptor(VDR).Genome-wide analysis showed that miRNAs were associated with VDRs.We sought to determine the role and mechanism of action of miRNA-125a-5p and VDRs in a model of MS,mice with experimental autoimmune encephalomyelitis(EAE),which was induced by myelin oligodendrocyte glycoprotein 35–55 peptides.EAE mice showed decreased mean body weight but increased mean clinical scores compared with vehicle or control mice.And inflammatory infiltration was found in the lumbosacral spinal cord of EAE mice.In addition,VDR expression was significantly lower while the expression of miR-125a-5p was markedly higher in the spinal ventral horn of EAE mice than in vehicle or control mice.Importantly,activation of VDRs by paricalcitol or inhibition of miR-125a-5p by its antagomir markedly decreased the mean clinical scores in EAE mice.Interestingly,VDR and miR-125a-5p were co-localized in the same neurons of the ventral horn.More importantly,inhibition of miR-125a-5p remarkably blocked the decrease of VDRs in EAE mice.These results support a critical role for miR-125a-5p in modulating VDR activity in EAE and suggest potential novel therapeutic interventions. | Han-Chun Long Rui Wu Chun-Feng Liu Fei-Long Xiong Zu Xu Dian He Yi-Fan Zhang Bing Shao Ping-An Zhang Guang-Yin Xu Lan Chu | 2020 | Neuroscience Bulletin2020，36，2： | 6 |
| 3 | Pharmacokinetic and pharmacodynamic evidence for developing an oral formulation of octreotide against gastric mucosal injury显示文摘在 somatostatin 类似物之中, octreotide (10 月) 是通常经由静脉内或下的注射在诊所过去常治疗生长荷尔蒙, gastrin 或胰岛素的增加的分泌物引起的各种各样的疾病的大多数。以便 assesse 开发 10 月的口头的明确的表达的可行性,我们在几个动物模型进行了 10 月的系统的 pharmacokinetic 和 pharmacodynamic 分析。在老鼠的 pharmacokinetic 研究证明 10 月的 intragastric 管理有极其低的 bioavailability (<0.5%) ,但是它能明确地在老鼠胃由于 somatostatin 受体 2 的高表示(SSTR2 ) 散布到胃的 mucosa。pharmacodynamic 研究表明 10 月的 intragastric 管理 dose-dependently 带着胃的溃疡,它比得上那些由 10 月的静脉内的注射完成了的导致 WIRS 的老鼠在老鼠免于胃的 mucosal 损害(GMI ) ,并且这效果被 CYN-154806 的合作管理显著地稀释, SSTR2 的一个对手。在幽门的导致结扎的溃疡老鼠,我们进一步证明那个 10 月显著地减少了胃的酸的分泌物经由下面调整 gastrin 的水平,它为对 GMI 的 10 月的保护的效果负责。总的来说,我们为最重要地开发10月的口头的明确的表达的可行性提供了 pharmacokinetic 和 pharmacodynamic 证据,10月的 pharmacokinetics 和药效学上的 SSTR2 的影响建议10月的口头的明确的表达可能为另外的临床的指示是适用的,在这些肿瘤房间上由于 SSTR2 的 overexpression 包括 neuroendocrine 瘤和垂体腺瘤。 | Xi-nuo LI Tai RAO Yang-fan XU Kang-rui HU Zhang-pei ZHU Hao-feng LI Dian KANG Yu-hao SHAO Bo-yu SHEN Xiao-xi YIN Lin XIE Guang-ji WANG Yan LIANG | 2018 | Acta Pharmacologica Sinica2018，39，8： | 3 |
| 4 | Appropriate choice of collision-induced dissociation energy for qualitative analysis of notoginsenosides based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry显示文摘Liquid chromatography hybrid ion trap/time-of-flight mass spectrometry possesses both the MS^n ability of ion trap and the excellent resolution of a time-of-flight and has been widely used to identify drug metabolites and determine trace multi-components in natural products. Collision energy, one of the most important factors in acquiring MS^n information, could be set freely in the range of 10%–400%. Herein, notoginsenosides were chosen as model compounds to build a novel methodology for the collision energy optimization. Firstly, the fragmental patterns of the representatives for the authentic standards of protopanaxadiol-type and protopanaxatriol-type notoginsenosides were obtained based on accurate MS^2 and MS^3 measurements via liquid chromatography hybrid ion trap/time-of-flight mass spectrometry. The extracted ion chromatograms of characteristic product ions of notoginsenosides in Panax Notoginseng Extract were produced under a series of collision energies and compared to screen the optimum collision energies values for MS^2 and MS^3. The results demonstrated that the qualitative capability of liquid chromatography hybrid ion trap/time-of-flight mass spectrometry was greatly influenced by collision energies, and 50% of MS^2 collision energy was found to produce the highest collision-induced dissociation efficiency for notoginsenosides. Addtionally, the highest collision-induced dissociation efficiency appeared when the collision energy was set at 75% in the MS^3 stage. | WANG Guang-Ji FU Han-Xu XIAO Jing-Cheng YE Wei RAO Tai SHAO Yu-Hao KANG Dian XIE Lin LIANG Yan | 2016 | Chinese Journal of Natural Medicines2016，14，4： | 2 |
| 5 | Synthesis and characterization of nanoscale Ce(x) Ru(1 -x) O2 coatings with electrochemical activity 显示文摘 | Zhang Teng Tang Dian Shao Yanqun | 2007 | J Am Ceram Soc2007，90，3： | 1 |
| 6 | Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population显示文摘BACKGROUND Alcohol consumption is a known modifiable risk factor for atrial fibrillation.The association,however,might differ according to gender.We investigated gender-specific associations between alcohol consumption and incident atrial fibrillation in an elderly Chinese population.METHODS Our study participants were elderly residents(≥65 years)recruited from five community health centers in the urban area of Shanghai(n=6,618).Alcohol intake was classified as never drinkers and current light-to-moderate(<40 g/day)and heavy drinkers(≥40 g/day).Atrial fibrillation was detected by a 30-s single-lead electrocardiography(ECG,AliveCor®Heart Monitor)and further evaluated with a regular 12-lead ECG.RESULTS During a median of 2.1 years(interquartile range:2.0−2.2)follow-up,the incidence rate of atrial fibrillation was 1.10%in all study participants.It was slightly but non-significantly higher in men(n=2849)than women(n=3769,1.30%vs.0.96%,P=0.19)and in current drinkers(n=793)than never drinkers(n=5825,1.64%vs.1.03%,P=0.12).In both unadjusted and adjusted analyses,there was interaction between sex and current alcohol intake in relation to the incidence of atrial fibrillation(P<0.0001).After adjustment for confounding factors,current drinkers had a significantly higher incidence rate of atrial fibrillation than never drinkers in women(12.96%[7/54]vs.0.78%[29/3715],adjusted odds ratio[OR]=10.25,95%confidence interval[CI]:3.54−29.67,P<0.0001),but not in men(0.81%[6/739]vs.1.47%[31/2110],OR=0.62,95%CI:0.25−1.51,P=0.29).CONCLUSIONS Our study showed a significant association between alcohol intake and the incidence of atrial fibrillation in elderly Chinese women,but not men. | Xiao-Fei YE Wei ZHANG Yi CHEN Chao-Ying MIAO Qi-Fang HUANG Chang-Sheng SHENG Shuai SHAO Dian WANG Shao-Kun XU Lei LEI Di ZHANG Yi-Lin CHEN Lei-Xiao HU Jia-Hui XIA Yi-Bang CHENG Ying WANG Qian-Hui GUO Yan LI Nicole Lowres Ben Freedman Ji-Guang WANG | 2022 | Journal of Geriatric Cardiology2022，19，1： | 1 |
| 7 | Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatinⅥ显示文摘New D-seco-taxoids were synthesized from 1-deoxybaccatinⅥand their structures were confirmed by ~1H NMR,^(13)C NMR, ESIMS and X-ray crystallography.The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance(MDR) reversal agents and new synthetic precursors of paclitaxel analogues. | Jun Chao Shao Zhi Hua Ye Hai Xia Lin Dian Long Wang Na Han | 2010 | Chinese Chemical Letters2010，21，11： | 1 |
| 8 | Synthesis and characterization of nanoscale CexRu(1-x)O2 coatings with electrochemical activity显示文摘 | ZHANG Teng TANG Dian SHAO Yan-qun KE Xue-biao YOU Shao-xin | 2007 | J Am Ceram Soc2007，90，3： | 1 |
| 9 | HIV Populations Are Large and Accumulate High Genetic Diversity in a Nonlinear Fashion显示文摘 | Frank Maldarelli Mary Kearney Sarah Palmer Robert Stephens JoAnn Mican Michael A. Polis Richard T. Davey Joseph Kovacs Wei Shao Diane Rock-Kress Julia A. Metcalf Catherine Rehm Sarah E. Greer Daniel L. Lucey Kristen Danley Harvey Alter John W. Mellors Joh | 2013 | Journal of Virology2013，，18： | 1 |
| 10 | Synthesis of highly ordered the mally stable cubic mesostructured zirconium oxophosphate templated by tri-headgroup quaternary ammonium surfactants 显示文摘 | SHEN SHAO DIAN TIAN BO ZHI YU CHENG ZHONG | 2003 | Chem Mater2003，15，： | 1 |
| 11 | Synthesis and characterization of nanoscale Ce(,) Ru(l -x) 02 coatings with electrochemical activity 显示文摘 | Zhang Teng Tang Dian Shao Yanqun | 2007 | J Am Ceram Soc2007，90，3： | 1 |
| 12 | Is the combinational administration of doxorubicin and glutathione a reasonable proposal?显示文摘The combinational administration of antioxidants and chemotherapeutic agents during conventional cancer treatment is among one of the most controversial areas in oncology. Although the data on the combinational usage of doxorubicin (DOX) and glutathione (GSH) agents have been explored for over 20 years, the duration, administration route, and authentic rationality have not yet been fully understood yet. In the current study, we systematically investigated the pharmacokinetics (PK) and pharmacodynamics (PD) with both in vivo and in vitro models to elucidate the infiuence of GSH on the toxicity and efficacy of DOX. We first studied the cardioprotective and hepatoprotective effects of GSH in Balb/c mice, H9c2, and HL7702 cells. We showed that coadministration of exogenous GSH (5, 50, and 500 mg/kg per day, intragastric) significantly attenuated DOX-induced cardiotoxicity and hepatotoxicity by increasing intracellular GSH levels, whereas the elevated GSH concentrations did not affect the exposure of DOX in mouse heart and liver. From PK and PD perspectives, then the infiuences of GSH on the chemotherapeutic efficacy of DOX were investigated in xenografted nude mice and cancer cell models, including MCF-7, HepG2, and Caco-2 cells, which revealed that administration of exogenous GSH dose-dependently attenuated the anticancer efficacy of DOX in vivo and in vitro, although the elevated GSH levels neither infiuenced the concentration of DOX in tumors in vivo, nor the uptake of DOX in MCF-7 tumor cells in vitro. Based on the results we suggest that the combined administration of GSH and DOX should be contraindicated during chemotherapy unless DOX has caused serious hepatotoxicity and cardiotoxicity. | Bo-yu Shen Chong Chen Yang-fan Xu Jia-jia Shen Hui-min Guo Hao-feng Li Xi-nuo Li Dian Kang Yu-hao Shao Zhang-pei Zhu Xiao-xi Yin Lin Xie Guang-ji Wang Yan Liang | 2019 | Acta Pharmacologica Sinica2019，40，5： | 0 |
| 13 | Smart epidermal electrophysiological electrodes:Materials,structures,and algorithms显示文摘Epidermal electrophysiological monitoring has garnered significant attention for its potential in medical diagnosis and healthcare,particularly in continuous signal recording.However,simultaneously satisfying skin compliance,mechanical properties,environmental adaptation,and biocompatibility to avoid signal attenuation and motion artifacts is challenging,and accurate physiological feature extraction necessitates effective signal-processing algorithms.This review presents the latest advancements in smart electrodes for epidermal electrophysiological monitoring,focusing on materials,structures,and algorithms.First,smart materials incorporating self-adhesion,self-healing,and self-sensing functions offer promising solutions for long-term monitoring.Second,smart meso-structures,together with micro/nanostructures endowed the electrodes with self-adaption and multifunctionality.Third,intelligent algorithms give smart electrodes a“soul,”facilitating faster and more-accurate identification of required information via automatic processing of collected electrical signals.Finally,the existing challenges and future opportunities for developing smart electrodes are discussed.Recognized as a crucial direction for next-generation epidermal electrodes,intelligence holds the potential for extensive,effective,and transformative applications in the future. | Yuanming Ye Haochao Wang Yanqiu Tian Kunpeng Gao Minghao Wang Xuanqi Wang Zekai Liang Xiaoli You Shan Gao Dian Shao Bowen Ji | 2023 | Nanotechnology and Precision Engineering2023，6，4： | 0 |
| 14 | 敲开机会之门显示文摘我的研究生涯始于15岁,当时我在大学实验室里找工作。当我把这个故事告诉自己的另一半(另一位学者)时,我们对一个连高中都没毕业的孩子要砸开未来实验室大门的想法哄然大笑。这听起来毫无头绪,毕竟科学界的许多人都认为,“才能”本身是成功的科学事业最重要的因素。对于有这种心态的人来说,那些积极推销自己或为自己的职业生涯奋斗的人肯定不那么聪明或并不值得。但在反思自己的人生轨迹时,我很高兴自己足够大胆——或者说足够无知——在自己职业生涯早期主动提出自己的所需。 | Diane Shao 倪伟波(译) | 2018 | 科学新闻2018，0，11： | 0 |
| 15 | Treatment of 56 Cases with Acute Lumbar Sprain by Acupuncturing Xia Shan DianPoint.显示文摘Treatmentof56CaseswithAcuteLumbarSprainbyAcupuncturingXiaShanDianPoint.￥ShaoShuqin(hospitalofdongdianNo.4Co,LiaoYangCity,Liao... | Shao Shuqin(hospital of dong dian No.4 Co, Liao Yang City,Liaoning Province) | 1995 | 中国针灸1995，15，S2： | 0 |
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