|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 中国糖尿病防治研究的现状和挑战显示文摘糖尿病,特别是2型糖尿病,已成为一个全球性的健康威胁。随着国内人民生活水平的提高,膳食结构和生活方式的改变导致了与糖脂代谢紊乱相关疾病的迅猛增加。其中,糖尿病人群已接近1亿,糖尿病前期人群大约2亿。糖尿病相关的合并症,如大血管病变、微血管病变和肿瘤已成为国内人群主要的致死和致残原因。我国糖尿病患者人数急剧增多的原因可能是遗传和环境因素综合作用的结果,涉及易感基因、表观遗传作用、糖脂代谢紊乱等众多因素。近年来,我国在糖尿病流行病学调查、遗传易感基因确定、膳食营养因子作用、胰岛素分泌调节、胰岛素敏感性调控、糖脂代谢紊乱机制、合并症发生机制和防治策略制定方面取得了长足进步。然而,糖尿病危害的消除还有赖于政府、社会、医药界及患者的共同努力。 | 康继宏 Tiao Guan 宁光 吴家睿 管又飞 | 2012 | 转化医学研究(电子版)2012，2，3： | 83 |
| 2 | Molecular cloning and expression profile of an abiotic stress and hormone responsive MYB transcription factor gene from Panax ginseng显示文摘v-myb 鸟的 myeloblastosis 病毒的 oncogene 相当或相同的事物 MYB 家庭组成抄写因素的最丰富的组之一并且在植物在发展过程和防卫回答起重要作用。人参人参属人参 C ·迈耶·米布基因被克隆并且指定了为 PgMYB1。PgMYB1 的 cDNA 长是 762 基础对并且编码在于的 R2R3 类型蛋白质 238 氨基酸。Subcellular 本地化证明那 PgMYB1-mGFP5 熔化蛋白质在原子核是明确地局部性的。理解 PgMYB1 的功能的角色,我们在不同纸巾并且在各种各样的条件下面调查了 PgMYB1 的表示模式。量的即时聚合酶链反应和西方的污点分析证明 PgMYB1 比在茎和种子在根,叶子,和侧面的根在高水平被表示。PgMYB1 的表示由 abscisic 酸,水杨酸酸, NaCl,和寒冷是起来调整的由甲基寒心、下面调整的 jasmonate。这些结果建议 PgMYB1 可能涉及对环境压力和荷尔蒙作出回应。 | Sadia Afrin Jie Zhu Hongzhe Cao Jingjia Huang Hao Xiu Tiao Luo Zhiyong Luo | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 15 |
| 3 | Transcriptomics-based identification of WRKY genes and characterization of a salt and hormone-responsive PgWRKY1 gene in Panax ginseng显示文摘WRKY 蛋白质属于一个抄写因素(TF ) 家庭和戏在许多植物过程,对不能生活、关於生命的压力的包括的植物回答,以及第二等的新陈代谢的动态角色。然而,在人参属人参 C ·迈耶的 WRKY 基因都没迄今为止被报导。在这研究,从甲基 jasmonate (MeJA ) 的很多 WRKY unigenes 对待偶然这种的根 transcriptome 用下一代的定序被识别技术。编码 WRKY 蛋白质的 48 有希望的 WRKY unigenes 的一个总数被消除冤屈和不完全的开的读物框架(ORF ) 获得。种系发生的分析揭示 48 WRKY TF,包括 11 组我, 36 组 II,和 1 组 III。而且,指定为 PgWRKY1 的一 MeJA 应答的 unigene 被克隆并且描绘。它包含 1077 bp 的全部 ORF 并且编码 358 氨基酸残余的多肽。PgWRKY1 蛋白质包含由保存氨基酸顺序主题 WRKYGQK 和 C 2 H 2-type 锌手指主题属于 WRKY 亚群 II-d。在洋葱和烟草外皮房间的 PgWRKY1-GFP 熔化蛋白质的 Subcellular 本地化表明 PgWRKY1 在原子核是只在场的。量的即时聚合酶链反应分析证明 PgWRKY1 的表示与叶子,茎,和种子相比在根和侧面的根是相对更高的。重要地, PgWRKY1 表示被水杨酸显著地导致酸, abscisic 酸,和 NaCl,而是由 MeJA 处理的 downregulated。这些结果建议 PgWRKY1 可能是对荷尔蒙和盐压力作出回应的多重压力可诱导的基因。 | Mohammed Nuruzzaman Hongzhe Cao Hao Xiu Tiao Luo Jijia Li Xianghui Chen Junli Luo Zhiyong Luo | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 12 |
| 4 | Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-~ signaling pathway显示文摘人参皂甙 Rh2,从人参属人参提取的 triterpene saponin,对多重癌症的展览药理学活动。然而,人参皂甙 Rh2 的 anticancer 机制是不清楚的。在这研究,我们发现人参皂甙 Rh2 有效地禁止生长并且导致 HL-60 房间的 apoptosis。用 microarray 技术,我们发现了那个肿瘤坏死因素 --(TNF-) 清楚地是起来调整的。而且, anti-TNF- 抗体经由 caspase-8, caspase-9,和 caspase-3 激活的抑制减轻了导致 Rh2 的 HL-60 房间 apoptosis。另外, TNF- 起来规定也在另外的对待 Rh2 的癌症房间线被观察。这些结果证明 TNF- 在人参皂甙起一个关键作用导致 Rh2 的房间 apoptosis。 | Jingjia Huang Kunjian Peng Linghao Wang Bin Wen Lin Zhou Tiao Luo Min Su Jijia Li Zhiyong Luo | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 11 |
| 5 | The Synthesis of a Stewart Platform for a Specific Workspace with a Genetic Algorithm显示文摘The synthesis problem of a 6-SPS Stewart platform with semi-regular hexagons is studied in this paper. We present a genetic algorithm approach to synthesize a Stewart platform whose workspace must include a desired workspace with orienting capabilities in a given 3D region. Based on the observation that the constant orientation workspace gets smaller as the given orientations increase, a simple method is presented to describe the workspace with orienting capabilities, which need only search the constant orientation workspaces with the eight sets of extremal orientations of given 3D region and use their common part.To verify the method, a numerical example is given. The GA is used to optimize architectural parameters and obtain a compact manipulator. The method is applied to synthesize a Stewart platform whose workspace must include a prescribed cylinder with orienting capabilities. | 陈学生 Chen Zaili Xie Tiao | 2004 | High Technology Letters2004，10，1： | 11 |
| 6 | Low-intensity pulsed ultrasound therapy: a potential strategy to stimulate tendon-bone junction healing显示文摘Incorporation of a tendon graft within the bone tunnel represents a challenging clinical problem. Successfulanterior cruciate ligament (ACL) reconstruction requires solid healing of the tendon graft in the bone tunnel. En-hancement of graft healing to bone is important to facilitate early aggressive rehabilitation and a rapid return topre-injury activity levels. No convenient, effective or inexpensive procedures exist to enhance tendon-bone (T-B)healing after surgery. Low-intensity pulsed ultrasound (LIPUS) improves local blood perfusion and angiogenesis,stimulates cartilage maturation, enhances differentiation and proliferation of osteoblasts, and motivates osteogenic differentiation of mesenchymal stem cells (MSCs), and therefore, appears to be a potential non-invasive tool for T-Bhealing in early stage of rehabilitation of ACL reconstruction. It is conceivable that LIPUS could be used to stimulateT-B tunnel healing in the home, with the aim of accelerating rehabilitation and an earlier return to normal activities inthe near future. The purpose of this review is to demonstrate how LIPUS stimulates T-B healing at the cellular andmolecular levels, describe studies in animal models, and provide a future direction for research. | Zhi-min YING Tiao LIN Shi-gui YAN | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，12： | 7 |
| 7 | Diagnosis and treatment of labral tear显示文摘Objective:To review the literature regarding diagnosis and treatment of labral tear.Data sources:A systematic search was performed in PubMed using various search terms and their combinations including hip, labrum, acetabular labral tear, arthroscopy, diagnosis, and anatomy.Study selection:For each included study, information regarding anatomy, function, etiology, diagnosis, and management of acetabular labral tear was extracted.Results:Five hundred and sixty abstracts about anatomy, function, etiology, diagnosis, and management of acetabular labral tear were reviewed and 66 selected for full-text review.The mechanism of labral tear has been well explained while the long-term outcomes of various treatment remains unknown.Conclusions:Labral tear is generally secondary to femoroacetabular impingement, trauma, dysplasia, capsular laxity, and degeneration.Patients with labral tear complain about anterior hip or groin pain most commonly with a most consistent physical examination called positive anterior hip impingement test.Magnetic resonance arthrography is a reliable radiographic examination with arthroscopy being the gold standard.Conservative treatment consists of rest, non-steroidal anti-inflammatory medication, pain medications, modification of activities, physical therapy, and intra-articular injection.When fail to respond to conservative treatment, surgical treatment including labral debridement, labral repair, and labral reconstruction is often indicated. | Tiao Su Guang-Xing Chen Liu Yang | 2019 | Chinese Medical Journal2019，，2： | 6 |
| 8 | Photosynthesis and Dry Matter Accumulation in Different Chlorophyll-Deficient Rice Lines显示文摘Three different chlorophyll-deficient rice isogenic lines chl,fgl and pgl,and their recurrent parent zhefu802 (zf802) were used to study effects of leaf color on photosynthesis,dry matter accumulation,yield,and quality in early season indica rice.Analysis showed that the chlorophyll (Chl.) a/b ratio of isogenic lines chl-8,pgl and fgl was 5.35,10.00 and 15.46,respectively,among them,line fgl had higher leaf area index (LAI),higher net photosynthetic rate and higher grain-filling rate than its recurrent parent zf802 at the later period of grain filling stage;while LAI,net photosynthetic rate and dry matter accumulated in lines chl-8 and pgl were lower than in zf802.Differences were found in the grain yield and quality among chlorophyll deficient isogenic lines,lines fgl,chl-8 and zf802 had similar grain yield,which was significantly higher than that of pgl;the highest milling quality was observed in isogenic line fgl,with relatively high protein content.This study showed that isogenic line fgl would become a unique material for the development of high yield rice with high grain quality because of its slow aging process and relative steady grain-filling rate. | WANG Dan-ying XU Chun-mei CHEN Song TIAO Long-xing ZHANG Xiu-fu | 2012 | Journal of Integrative Agriculture2012，11，3： | 4 |
| 9 | Parity-decomposition and moment analysis for stationary Wigner equation with inflow boundary conditions显示文摘我们由使用 L 的同等值分解与流入边界条件在一个围住的、一个维的空间领域上学习静止 Wigner 方程。Barletti 和 P. F。Zweifel [运输理论统计员。Phys, 2001, 30 (4-6 ) :507-520 ] 。分解减少一半范围,二点的边界价值问题进二 decoupled 平部分的起始的价值问题和奇怪的部分。没有在零速度附近使用截止近似,我们证明为平部分的起始的价值问题是提出得好的。为奇怪的部分,我们由分析片刻系统在奇怪的 L 2-space 证明解决方案的唯一。一个例子被提供看那怎么使用分析与流入边界条件获得静止 Wigner 方程的答案。 | Ruo LI Tiao LU Zhangpeng SUN | 2017 | Frontiers of Mathematics in China2017，12，4： | 4 |
| 10 | Potential dual expansion of domesticated donkeys revealed by worldwide analysis on mitochondrial sequences显示文摘Molecular studies on donkey mitochondrial sequences have clearly defined two distinct maternal lineages involved in domestication.However,domestication histories of these two lineages remain enigmatic.We therefore compared several population characteristics between these two lineages based on global sampling,which included 171 sequences obtained in this study(including Middle Asian,East Asian,and African samples)plus 536 published sequences(including European,Asian,and African samples).The two lineages were clearly separated from each other based on whole mitochondrial genomes and partial non-coding displacement loop(D-loop)sequences,respectively.The Clade I lineage experienced an increase in population size more than 8000 years ago and shows a complex haplotype network.In contrast,the population size of the Clade II lineage has remained relatively constant,with a simpler haplotype network.Although the distribution of the two lineages was almost equal across the Eurasian mainland,they still presented discernible but complex geographic bias in most parts of Africa,which are known as their domestication sites.Donkeys from sub-Saharan Africa tended to descend from the Clade I lineage,whereas the Clade II lineage was dominant along the East and North coasts of Africa.Furthermore,the migration routes inferred from diversity decay suggested different expansion across China between the two lineages.Altogether,these differences indicated non-simultaneous domestication of the two lineages,which was possibly influenced by the response of pastoralists to the desertification of the Sahara and by the social expansion and trade of ancient humans in Northeast Africa,respectively. | Xi-Yao Ma Tiao Ning Adeniyi CAdeola Jie Li Ali Esmailizadeh Jacqueline KLichoti Bernard RAgwanda Jainagul Isakova Almaz AAldashev Shi-Fang Wu He-Qun Liu Najmudinov Tojiddin Abdulloevich Manilova Elena Afanasevna Khudoidodov Behruz Ibrohimovich Rahamon Akinyele Moshood Adedokun Sunday Charles Olaogun Oscar JSanke Godwin FMangbon Xi Chen Wei-Kang Yang Zhe Wang Min-Sheng Peng Sheila COmmeh Yan Li Ya-Ping Zhang | 2020 | Zoological Research2020，41，1： | 3 |
| 11 | Comparison of minimally invasive surgery and mini-incision technique for total hip arthroplasty: a sub-group meta-analysis显示文摘背景为全部的新潮的关节造形术( THA )的最低限度地侵略的外科( MIS )应该与更少或没有肌肉损坏结合并且与微型切口技术不同,这很好被接受, MIS 应该比当前的分析的微型切口 surgery.The 目的是把明确地定义的亚群分析用于的有更好的结果证实这个假设是否是 true.Methods 计算机化的文学搜索被使用有关 MIS 或微型切口 THAs.A | ZHAO Xiang LIN Tiao CAI Xun-zi YAN Shi-gui | 2011 | Chinese Medical Journal2011，，24： | 3 |
| 12 | Transcriptomics-based identification and characterization of 11 CYP450 genes of Panax ginseng responsive to MeJA显示文摘Cytochromes P450 (CYP450s),a superfamily of mono-oxygenases,are essential to generate highly functionalized secondary metabolites in plants and contribute to the diversification of specialized triterpenoid biosynthesis in eudicots.However,screening and identifying the exact CYP450 genes in ginsenoside biosynthesis is extremely challenging due to existence of large quantities of members in CYP450 superfamily.Therefore,to screen the CYP450 genes involved in ginsenoside bio- synthesis,transcriptome dataset of Panax ginseng was created in our previous work using the technique of the next-generation sequencing.On the basis of bioinformatics analysis,16 putative CYP450 genes with significant differential expression were screened from the dataset and submit- ted to GenBank,in which 11 of them have been cloned.Methyl jasmonate (MeJA)was used as an elicitor to analyze the expression profiles of candidate CYP450 genes by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR).The results of qRT-PCR analysis revealed that the expression of some CYP450 genes were strongly induced by MeJA and showed different transcription levels at different treatment time points.Homology analysis indicated that each putative CYP450 protein of P.ginseng has a conserved domain consisting of E-E-R-F-P-R-G. The CYP450 genes were screened and cloned here to enrich the resources of CYP450 genes,and the results of bioinformatics analysis provided a foundation to further identify the function of CYP450s involved in ginsenoside biosynthesis.Furthermore,this study facilitated the construction of microbial cell factories for increasing the production of ginsenosides by means of metabolic engineering. | Xu Zeng Tiao Luo Jijia Li Gui Li Donghua Zhou Tuo Liu Xian Zou Aparna Pandey Zhiyong Luo | 2018 | Acta Biochimica et Biophysica Sinica2018，50，11： | 2 |
| 13 | The sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors显示文摘 | Hobler S C Tiao G Fischer J E | 1998 | Am J Physiol1998，274，： | 2 |
| 14 | Sepsis stimulates nonlysosomal,energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle显示文摘 | Tiao G Fagan J M Samuels N | 1994 | J Clin Invest1994，94，： | 2 |
| 15 | A curve-based material recognition method in MeV dual-energy X-ray imaging system显示文摘High-energy dual-energy X-ray digital radiography imaging is mainly used in the material recognition of cargo inspection. We introduce the development history and principle of the technology and describe the data process flow of our system. The system corrects original data to get a dual-energy transparence image. Material categories of all points in the image are identified by the classification curve,which is related to the X-ray energy spectrum. For the calibration of classification curve, our strategy involves a basic curve calibration and a real-time correction devoted to enhancing the classification accuracy. Image segmentation and denoising methods are applied to smooth the image. The image contains more information after colorization. Some results show that our methods achieve the desired effect. | Zhi-Qiang Chen Tiao Zhao Liang Li | 2016 | Nuclear Science and Techniques2016，27，1： | 2 |
| 16 | Adaptive Conservative Cell Average Spectral Element Methods for Transient Wigner Equation in Quantum Transport显示文摘A new adaptive cell average spectral element method(SEM)is proposed to solve the time-dependent Wigner equation for transport in quantum devices.The proposed cell average SEM allows adaptive non-uniform meshes in phase spaces to reduce the high-dimensional computational cost of Wigner functions while preserving exactly the mass conservation for the numerical solutions.The key feature of the proposed method is an analytical relation between the cell averages of the Wigner function in the k-space(local electron density for finite range velocity)and the point values of the distribution,resulting in fast transforms between the local electron density and local fluxes of the discretized Wigner equation via the fast sine and cosine transforms.Numerical results with the proposed method are provided to demonstrate its high accuracy,conservation,convergence and a reduction of the cost using adaptive meshes. | Sihong Shao Tiao Lu Wei Cai | 2011 | Communications in Computational Physics2011，9，3： | 2 |
| 17 | House of quality:a fuzzy logic-based requirements analysis显示文摘 | TEMPONI C YEN J TIAO W A | 1999 | European Journal of Operational Research1999，117，2： | 1 |
| 18 | Intervention Analysis with Applications to Eco- nomic and Environmental Problems显示文摘 | Box G E P Tiao G C | 1975 | Journal of American Statistical Association1975，70，349： | 1 |
| 19 | Detecting the recovery of total column ozone显示文摘 | Weatherhead E C Reinsel G C Tiao G C | 2000 | Journal of Geophysical Research2000，105，22： | 1 |
| 20 | Kurtosis of GARCH and Stochastic Volatility Models with Nonnormal Innovations显示文摘 | BAI RUSSELL TIAO | 2003 | Journal of Econometrics2003，，114： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员