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| 1 | 基于一个大型随机试验预测稳定性心绞痛队列患者死亡、心肌梗死和卒中的危险评分显示文摘目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专科门诊患者。入选者7311例具有全部需要资料的患者被入选。主要结局的测量指标平均随访4.9年时间内所有原因的死亡、心肌梗死或者致残性卒中。结果1063例患者发生任何原因死亡或者持久性心肌梗死或者致残性卒中。这些复合终点的5年危险性在危险性最低的十分位患者为4%,而在危险性最高的十分位患者为35%。危险评分结合16项临床常规变量的降序排序是:年龄、左心室射血分数、吸烟、白细胞计数、糖尿病、随机血糖浓度、肌酐浓度、既往卒中病史、1周至少1次心绞痛发作、冠状动脉造影发现(如果能够获得)、降脂治疗、QT间期、收缩期血压≥150mmHg、抗心绞痛药物数量、陈旧性心肌梗死以及性别。把这个模型分别应用于任何原因所致的死亡、心肌梗死和卒中进行预测评估,所得的结果相似。危险评分似乎不能预测事件性质(39%的死亡、46%心肌梗死以及15%致残性卒中)或者冠状动脉造影或血管重建率(占29%的患者)。结论该危险评分对客观地决定稳定性心绞痛患者进一步治疗措施以减少重要预后事件发生是有帮助的。该危险评分同样可以用于将来的计划性试验。 | Tim C Clayton Stuart J Pocock Jacobus Lubsen Zoltán Vokó Bridget-Anne Kirwan Keith A A Fox Philip A Poole-Wilson | 2006 | 英国医学杂志中文版2006，9，1： | 2 |
| 2 | Fuel Consumption Minimization of a Microgrid 显示文摘 | Carlos A Hernandez-Arambur Tim C Green Nicolas Mugniot | 2005 | IEEE Transactions on Industry Applications2005，41，3： | 1 |
| 3 | Label-free imaging of trabecular meshwork cells using Coherent Anti-Stokes Raman Scattering (CARS) microscopy显示文摘 | Tim C L David A A Omid M | 2011 | Mol Vis2011，17，： | 1 |
| 4 | Organic compounds trapped in aqueous fluid inclusions 显示文摘 | Tim E R Simon C G Mark L Robinson A Q | 1998 | Organic Geochemistry1998，29，13： | 1 |
| 5 | Defining Spinal Mobility in Ankylosing Spondylitis (AS):The Bath AS Metrology Index显示文摘 | TIM R JENKINSON PATRICIA A MALLORIE HELEN C WHITELOCK | 1994 | Journal of Rheumatology1994，21，9： | 1 |
| 6 | Fuel consumption minimization of a microgrid显示文摘 | Hernandez-Aramburo C A Tim C Green Nicolas Mugniot | | 0，，03： | 1 |
| 7 | Influence of moisture con- tent and temperature on methane adsorption isotherm analy- sis for coals from a low-rank,biogenically sourced gas reser- voir显示文摘 | Peter J C Tim A M Tennille E M | 2008 | International Journal of Coal Geology2008，76，1： | 1 |
| 8 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 9 | Bioanalytics and Biolabeling with Semiconductor Nanoparticles(Quantum Dots)显示文摘 | Lin C J Tim L Ralph A S | 2007 | Journal of Matery Chemistry2007，17，： | 1 |
| 10 | Discovery of genes associated with fruit ripening in Carica popaya using expreased sequence tags显示文摘 | Devitt L C Tim S Timothy A H | 2006 | Plant Science2006，170，： | 1 |
| 11 | Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy显示文摘 | Hongxiang Liu Agnes Ruskon-Fourmestraux Anne Lavergne-Slove Hongtao Ye Thierry Molina Yoram Bouhnik Rifat A Hamoudi Tim C Diss Ahmet Dogan Francis Megraud Jean Claude Rambaud Ming-Qing Du Peter G Isaacson | 2001 | The Lancet . 2001 (9249)2001，，： | 1 |
| 12 | Discovery of genes associated with fruit ripening in Carica papaya using expressed sequence tags 显示文摘 | Devitt L C Tim S Timothy A H | 2006 | Plant Sci2006，170，： | 1 |
| 13 | Microbial production and modification of gases in , sedimentary basins : A geochemical case study from a Devonian shale gas play, Michiganbasin 显示文摘 | Martini A M Walter L Y Tim C W Ku | 2003 | AAPGBulletin2003，87，8： | 1 |
| 14 | A simple and robust adaptive controller for detuning correction in field-oriented induction machines 显示文摘 | Julio C Moreira Hung Kam Tim Lipo T A | 1992 | IEEE Trans on Ind App1992，，： | 1 |
| 15 | Estimating rotational iron losses in an induction machine显示文摘 | Carlos A Hernandez-Aramburo Tim C Green Alexander C Smith | 2003 | IEEE Transactions on Magnetics2003，39，6： | 1 |
| 16 | Microbial production and modification of gases in sedimentary basins:a geochemical case study from a Devonian shale gas play, Michigan Basin显示文摘 | MARTINI A M LYNN M WALTER TIM C W KI | 2003 | AAPG2003，87，8： | 1 |
| 17 | Evaluation of antidotes for poisoning by organophosphorus pesticides显示文摘 | Dag Jacobsen Tim J Meredith Peter Eyer Andrew J Heath David A Ligtenstein Tim C Marrs Ladislaus Szinicz J Allister Vale and John A Haines | 2000 | Emergency Medicine2000，，12： | 1 |
| 18 | Treatment by in vitro fertilisation with surrogacy: experience of one British Centre显示文摘 | BRINSDEN P R TIM C A ELIZABETH M | 2000 | British Medical Journal2000，320，7239： | 1 |
| 19 | Measuring marketing productivity: current knowledge and future directions显示文摘 | Roland T R Tim A Gregory S C | 2004 | Journal of Marketing2004，68，4： | 1 |
| 20 | Feasibility of extacting lead from lead battery recycling dite soil using high-concentration chloride solutions显示文摘 | Dennis A C | 2000 | Environmental Progress2000，19，3： | 1 |
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