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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 3 | Limita tion of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma 显示文摘 | WALDRON J TIN M M KELLER A | 2003 | Radiother Oncol2003，68，： | 1 |
| 4 | The effect of ruthenium on the intermediate to high temperature creep response of high refractory content single crystal suepralloy 显示文摘 | HOBBS R A ZHANG L RAE C M F TIN S | 2008 | Materials Science and Engineering A2008，489，： | 1 |
| 5 | Non-linear In-plane Buckling of Rationally Restrained Shallow Arches under a Central Con centrated Load显示文摘 | Pi Y L Bradford M A TIN L F | 2008 | International Journal of Non-Linear Me- chanics2008，43，1： | 1 |
| 6 | Directional solidification of large superalloy castings with radiation and liquid-metal cooling:a comparative assessment显示文摘 | Elliott A J Tin S Pollock T M | 2004 | Metallurgical and Materials Transactions A2004，35，： | 1 |
| 7 | Nonlinear Analysis and Buckling of Elastically Supported Circular Shallow Arches 显示文摘 | Pi Y L Bradford M A TIN L F | 2007 | International Journal of Solids andStructures2007，44，78： | 1 |
| 8 | A castability model based onelemental solid-liquid partitioning in advanced nickel-base single-crystal superalloys 显示文摘 | HOBBS R A TIN S RAE C M F | 2005 | Metallurgical and Materials Transactions A2005，36，27： | 1 |
| 9 | Determining factors in the success of R&D coopera- tive agreements between firms and research organizations显示文摘 | Mora - Valentin E M Montoro - Sanchez A Guerras - Mar- tin L A | 2004 | Research Policy2004，33，1： | 1 |
| 10 | Anterior Chamber Depth and the risk of Primary Angle Closure in 2 East Asian Populations 显示文摘 | Tin A Winifred P David M | 2005 | Arch Ophthalmol2005，123，4： | 1 |
| 11 | Effect of different vaccine formulations on the development of Glasser's disease induced in pigs by experimental Haemophilus parasuis infection显示文摘 | D L F A MAR TIN M C GUTIERREZ M C PEREZ | | 0，，2： | 1 |
| 12 | Transition metal complexes of guanidinate dianions:Reactions between gnanidines and M(NMe2)5 (M=Ta,Nb)显示文摘 | Tin M K T Yap G P A Richeson D S | 1998 | Inorg Chem1998，37，26： | 1 |
| 13 | Repeated laparoscopic ovarian diathermy is effective in women with anovulatory infertility due to polycytstic ovary syndrome显示文摘 | Saad A K S Tin C L Lan D C M | 2003 | Fertil Steril2003，79，： | 1 |
| 14 | Directional solidification oflarge superalloy castings with radiation and liquid-metal cooling: acomparative assessment 显示文摘 | Elliott A J Pollock T M Tin S | 2004 | Metallurgical and Materials TransactionsA2004，35，： | 1 |
| 15 | 7Cu lead-free solder with a rare earth (nd) addition显示文摘 | LIU M XIAN A E Tin whisker growth on the surface of Sn-0 | 2009 | Journal of Electronic Materials2009，38，11： | 1 |
| 16 | Possible effect of antibiotic-supplemented feed and environment on the oc- currence of multiple antibiotic resistant Escherichia coli in chickens显示文摘 | SALEHA A A TIN M KANNAN G | 2009 | Poultry Science2009，，8： | 1 |
| 17 | Directional Solidification of Large Superalloy Castings With Radiation and LiquidMetal Cooling: A Comparative Assessment 显示文摘 | Elliott A J Pollock T M Tin S | 2004 | Metallurgical and Materials Transactions2004，35，10： | 1 |
| 18 | HE4: a new po- tential early biomarker for the recurrence of ovarian cancer显示文摘 | Emanu ela A G iul ia G M V alen tin a V | 2010 | Tumor B iol2010，31，02： | 1 |
| 19 | Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides显示文摘 | BACH-MIZRACHI H UNDERWOOD M D TIN A | 2008 | Mol Psychiatry2008，13，5： | 1 |
| 20 | CD81T cells can mediate almost complete short-term and partial long-term inmunity to rotavirus in mice显示文摘 | Franco M A C Tin H B Greenberg | 1997 | J Virol1997，71，： | 1 |
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