维普期刊资源整合服务平台（V6.5）

23篇 您的检索式：作者名="TIRAPU"

选中清除导出查看参考文献查看引证文献引用追踪共2页首页上一页第1页下一页末页 /2 跳转

	题名	作者	年代	出处	被引量
1	Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.	Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero	2007	World Journal of Gastroenterology2007，13，44：	4
2	Use of gene therapy in a subcutaneous murine model of lung cancer 显示文摘	Rodrigo Garzon M Tirapu Femondez de la Cuesta I Arina Iraeta A	2006	Arch Bronconeumol2006，42，10：	1
3	The immunotherapy potential of agonistic anti-CD137 (4-1BB) monoclonal antibodies for malignancies and chronic viral diseases显示文摘	Alfaro C Murillo O Tirapu I	2006	An Sist Sanit Navar2006，29，1：	1
4	Use of gcne therapy in subcutaneous murine model of lung cancer 显示文摘	Rodrigo Garzon M Tirapu Fernondez de la Cuesta 1 Arina Iraeta A	2006	Areh Bronconeumo12006，42，10：	1
5	Cytgokine gene transfer into dendritic cells for cancer treatment 显示文摘	Tirapu I Rodriguez-calvillo M Qiar C	2002	Curr Gene Ther2002，2，1：	1
6	Wastewater toxicity screening of non-ionic surfactants by toxalert and mierotox biolum inescenee inhibition assays显示文摘	Marinel la Farre Maria-Jesfis Garcfa Lluis Tirapu el al	2001	Analytiea chimica acta2001，70，2：	1
7	Cytokine gene transfer into dendritic cells for cancer treatment显示文摘	Rodriguez-Calvillo M Qian C	2002	Curr Gene Ther2002，2，1：	1
8	Monitoring and toxicity of sulfonated derivatives of benzene and naphthalene in municipal sewage treatment plants 显示文摘	Alonso M C Tirapu L I Ginebreda A	2005	Environ Pollut2005，137，2：	1
9	Study of the delay characteristics of 1-D photonic bandgap microstrip structure 显示文摘	Tirapu J Lopetegi T Laso M A G	1999	Microwave Optical Technol Lett1999，23，：	1
10	Wastewater toxicity screening of non-ionic surfactants by Toxalert and Microtox bioluminescence inhibition assays 显示文摘	Farre M Garcia M Tirapu L	2001	Anal Chim Acta2001，427，9：	1
11	Cytokine gene transfer into dendritic ceils for cancer treatment 显示文摘	Tirapu I Rodriguez - Calvillo M Qian C	2002	Curr Gene Ther2002，2，1：	1
12	Wastewater toxicity screening of nonionic surfactants by Toxalert and Microtox bioluminescence inhibition assays显示文摘	LA FARRE M GARCA M J TIRAPU L		0，，：	1
13	Cytgokine gene transfer into dendritic cells for cancer treatment显示文摘	Tirapu I Rodriguez-calvillo M Qiar C	2002	Curr Gene Ther2002，2，1：	1
14	Wastewater tox- icity screening of non - ionic suffactants by Toxalert and Microtox bioluminescence inhibition assays 显示文摘	Farr6 M L Garcii M J Tirapu L	2001	Analyt Chem Acta2001，4272，：	1
15	Low surface expression of B71 (CD80) is an immunoescape mechanism of colon carcinoma 显示文摘	Tirapu I Huarte E Guiducci C	2006	Cancer Res2006，66，4：	1
16	Evalua- tion of memory in acquired brain injury: A comparison between the Wechsler Memory Scale and the Rivermead Behaviour Memo- ry Test显示文摘	Guinea - Hidalgo A Luna - Lario P Tirapu - Ustarroz J	2009	Rev Neurot2009，49，5：	1
17	Low surface expression of B7-1 (CD80):is an immunoescape mechanism of colon carcinoma显示文摘	Tirapu I Huarte E Guiducci C	2006	Cancer Res2006，15，：	1
18	Wastewater toxicity screening of non-ionic surfactants by Toxalert (R)and Mierotox (R)biolu- minescence inhibit-tion assays 显示文摘	LA FARRE M GARCIA M J TIRAPU L	2001	Analytica Chimica Acta2001，427，2：	1
19	Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma显示文摘	Tirapu I Huarte E Guiduducci C	2006	Cancer Res2006，66，4：	1
20	Low surface expression of B7- 1 (CD80) is an immuno-escape mechanism of colon carcinoma 显示文摘	Tirapu I Huarte E Guiducci C	2006	Cancer Res2006，66，4：	1

返回顶部每页显示：

共2页首页上一页第1页下一页末页 /2 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示