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		题名	作者	年代	出处	被引量
	1	Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.	Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero	2007	World Journal of Gastroenterology2007，13，44：	4
	2	Monitoring and toxicity of sulfonated derivatives of benzene and naphthalene in municipal sewage treatment plants 显示文摘	Alonso M C Tirapu L I Ginebreda A	2005	Environ Pollut2005，137，2：	1
	3	Wastewater toxicity screening of non-ionic surfactants by Toxalert and Microtox bioluminescence inhibition assays 显示文摘	Farre M Garcia M Tirapu L	2001	Anal Chim Acta2001，427，9：	1
	4	Wastewater toxicity screening of nonionic surfactants by Toxalert and Microtox bioluminescence inhibition assays显示文摘	LA FARRE M GARCA M J TIRAPU L		0，，：	1
	5	Wastewater tox- icity screening of non - ionic suffactants by Toxalert and Microtox bioluminescence inhibition assays 显示文摘	Farr6 M L Garcii M J Tirapu L	2001	Analyt Chem Acta2001，4272，：	1
	6	Wastewater toxicity screening of non-ionic surfactants by Toxalert (R)and Mierotox (R)biolu- minescence inhibit-tion assays 显示文摘	LA FARRE M GARCIA M J TIRAPU L	2001	Analytica Chimica Acta2001，427，2：	1

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