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| 1 | Applications of human hepatitis B virus preS domain in bio-and nanotechnology显示文摘Human hepatitis B virus(HBV) is a member of the family Hepadnaviridae, and causes acute and chronic infections of the liver. The hepatitis B surface antigen(HBs Ag) contains the large(L), middle(M), and small(S) surface proteins. The L protein consists of the S protein, pre S1, and pre S2. In HBs Ag, the pre S domain(pre S1 + pre S2) plays a key role in the infection of hepatocytic cells by HBV and has several immunogenic epitopes. Based on these characteristics of pre S, several pre S-based diagnostic and therapeutic materials and systems have been developed. Pre S1-specific monoclonal antibodies(e.g., MA18/7 and KR127) can be used to inhibit HBV infection. A myristoylated pre S1 peptide(amino acids 2-48) also inhibits the attachment of HBV to Hepa RG cells, primary human hepatocytes, and primary tupaia hepatocytes. Antibodies and antigens related to the components of HBs Ag, pre S(pre S1 + pre S2), or pre S1 can be available as diagnostic markers of acute and chronic HBV infections. Hepatocyte-targeting delivery systems for therapeutic molecules(drugs, genes, or proteins) are very important for increasing the clinical efficacy of these molecules and in reducing their adverse effects on other organs. The selective delivery of diagnosticmolecules to target hepatocytic cells can also improve the efficiency of diagnosis. In addition to the full-length HBV vector, pre S(pre S1 + pre S2), pre S1, and pre S1-derived fragments can be useful in hepatocyte-specific targeting. In this review, we discuss the literature concerning the applications of the HBV pre S domain in bio- and nanotechnology. | Riki Toita Takahito Kawano Jeong-Hun Kang Masaharu Murata | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Phase II Trial of Radiotherapy After Hyperbaric Oxygenation With Multiagent Chemotherapy (Procarbazine, Nimustine, and Vincristine) for High-Grade Gliomas: Long-Term Results显示文摘 | Kazuhiko Ogawa Shogo Ishiuchi Osamu Inoue Yoshihiko Yoshii Atsushi Saito Takashi Watanabe Shiro Iraha Takafumi Toita Yasumasa Kakinohana Takuro Ariga Goro Kasuya Sadayuki Murayama | 2012 | International Journal of Radiation Oncology Biology Physics2012，，2： | 2 |
| 3 | Amounts and composi-tional analysis of glycosaminoglycans in the tissue of fish显示文摘 | Arima K Fujita H Toita R | 2012 | Carbohyd Res2012，366，： | 1 |
| 4 | Current status and perspective of chemoradiotherapy for uterine cervical cancer 显示文摘 | Toita T Ariga T Kasuya G | 2015 | Gan To Ka- gaku Ryoho2015，42，10： | 1 |
| 5 | Postoperative radiotherapy for uterine cervical cancer:results of the 1995-1997 patterns of care process survey in Japan显示文摘 | Toita T Mitsuhashi N Teshima T | 2004 | Jpn J Clin Oncol2004，34，2： | 1 |
| 6 | A novel doublecoating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells显示文摘 | Tahara Y Kaneko T Toita R | 2012 | J Controlled Release2012，161，3： | 1 |
| 7 | Concurrent chemoradiotherapy with paclitaxel and cisplatin for adenocarcinoma of the cervix 显示文摘 | Nagai Y Toita T Wakayama A | 2012 | Anticancer Res2012，32，4： | 1 |
| 8 | Three-dimensional seeding of chondrocytes encapsulated in collagen gel into PLLA scaffolds显示文摘 | Ushida T Furukawa K Toita K | 2002 | Cell Transplant2002，11，5： | 1 |
| 9 | Radiotherapy for uterine cervical cancer:results of the 1995-1997 patterns of care process survey in Japan显示文摘 | Toita T Nakamura K Uno T | 2005 | Jpn J Clin Oncol2005，35，3： | 1 |
| 10 | Therapeutic value of neoadjuvant intra-arterial chemotherapy(cisplatin)and irradiation for locally advanced uterine cervical cancer显示文摘 | T Toita K Sakumoto M Higashi | 1997 | Gynecol Oncol1997，65，3： | 1 |
| 11 | Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors:a multiinstitutional retrospective analysis of 41 patients显示文摘 | Ogawa K Toita T Nakamura K | 2003 | Cancer2003，98，2： | 1 |
| 12 | Postoperative radiotherapy for uterine cervical cancer:results ofthe 1995-1997 patterns of care process surveyin Japan显示文摘 | Toita T Mitsuhashi N Teshima T | 2004 | Clin Oncol2004，34，2： | 1 |
| 13 | Hybrid of gel-cultured smooth muscle cells with PLLA sponge as a scaffold towards blood vessel regencration显示文摘 | Furukawa KS Ushida T Toita K | 2002 | Cell Transplant2002，11，5： | 1 |
| 14 | Comparison of prognostic value of MRI and FIGO stage among patients with cervical carcinoma treated with radiotherapy 显示文摘 | Kodaira T Fuwa N Toita T | 2003 | Int J Radiat Oncol Biol Phys2003，56，3： | 1 |
| 15 | Long-term results of radiotherapy for intracranial germinoma:a multi-institutronal retrospective review of 126 patients显示文摘 | OGAWA K SHIKAMA N TOITA T | 2004 | Int J Radiat Oncol Biol Phys2004，58，3： | 1 |
| 16 | Prospective multi- institutional study of definitive radiotherapy with high-dose-rate intracavitary brachytherapy in patients with nonbulky (<4 em) stage I and lI uterine cervical cancer (JAROG0401/ JROSG04-2)显示文摘 | Toita T Kato S Niibe Y | 2012 | Int J Radiat Oncol Biol Phys2012，82，1： | 1 |
| 17 | Long-term results of radiotherapy for intracranial germinoma: a multi-institutional retrospective review of 126 patients 显示文摘 | Ogawa K Toita T Kakinohana Y | 2004 | Int J Radiat Oncol Biol Phys J2004，58，： | 1 |
| 18 | Long-term results and prognostic factors in patients with stage 1 1V squamous cell carcinoma of the cervix treated with concurrent chemoradiotherapy from a single institution study 显示文摘 | Kudaka W Nagai Y Toita T | 2013 | Int J Clin Oncol2013，18，5： | 1 |
| 19 | Long-term results of radiotherapy for intracranial germinoma:a multi-institutional retrospective review of 126 patients显示文摘 | Ogawa K Shikama N Toita T | 2004 | Int J Radiat Oncol Biol Phys2004，58，3： | 1 |
| 20 | Postoperative radiotherapy for uterine cervical cancer; results of the 1995-1997 patterns of care process survey in Japan显示文摘 | Toita T Mitsuhashi N Teshima T | 2004 | Jpn J Clin Oncol2004，34，2： | 1 |
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