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| 1 | Comparative epidemiology of gastric cancer between Japan and China显示文摘AIM:To clarify the similarities and differences in gastric cancer epidemiology between Japan and China.METHODS:A comprehensive literature search of the PubMed database was performed.The relevant literature published in China was also been cited.Data on incidence and mortality rates in 2008 were obtained from the Cancer Mondial database,published by International Agency for Research on Cancer at http://gffzzdff0249c86de468fhn50unfbq0fuf65p9.ffgz.tsg.suse.edu.cn/.RESULTS:Gastric cancer remains a significant publichealth burden in both Japan and China.The prevalence of Helicobacter pylori(H.pylori)colonization is high in the adult populations of both countries.Accumulating evidence from intervention studies in both countries has shown the effectiveness of H.pylori eradication in reduc-ing gastric cancer incidence.There are differences,however,in many aspects of gastric cancer,including patterns of incidence and mortality,trends in the prevalence of H.pylori infection,H.pylori strains,the magnitude of risk of gastric cancer related to H.pylori infection,and associations with dietary habits.Compared with China,Japan has seen a more rapid decline in H.pylori infection among adolescents.While Japanese cohort studies have dominated the literature concerning the associations between gastric cancer and dietary habits,numerous case-control studies in China suggest a positive association between a high intake of preserved fish and vegetables and gastric cancer risk.There is a need for a multidisciplinary research approach to understand the interactions between various strains of H.pylori,host factors,and other lifestyle and environmental factors in gastric carcinogenesis in both countries.CONCLUSION:The shared high incidence of gastric cancer and high prevalence of H.pylori,as well as differences in many aspects of gastric cancer,provide an excellent opportunity to establish Sino-Japanese collaborations. | Yingsong Lin Junko Ueda Shogo Kikuchi Yukari Totsuka Wen-Qiang wei You-Lin Qiao Manami Inoue | 2011 | World Journal of Gastroenterology2011，17，39： | 64 |
| 2 | Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma显示文摘Although liver resection is considered the most effective treatment for hepatocellular carcinoma(HCC), treatment outcomes are unsatisfactory because of the high rate of HCC recurrence. Since we reported hepatitis B e-antigen positivity and high serum hepatitis B virus(HBV) DNA concentrations are strong risk factors for HCC recurrence after curative resection of HBV-related HCC in the early 2000 s, many investigators have demonstrated the effects of viral status on HCC recurrence and post-treatment outcomes. These findings suggest controlling viral status is important to prevent HCC recurrence and improve survival after curative treatment for HBV-related HCC. Antiviral therapy after curative treatment aims to improve prognosis by preventing HCC recurrence and maintaining liver function. Therapy with interferon and nucleos(t)ide analogs may be useful for preventing HCC recurrence and improving overall survival in patients who have undergone curative resection for HBV-related HCC. In addition, reactivation of viral replication can occur after liver resection for HBV-related HCC. Antiviral therapy can be recommended for patients to prevent HBV reactivation. Nevertheless, further studies are required to establish treatment guidelines for patients with HBVrelated HCC. | Shoji Kubo Shigekazu Takemura Shogo Tanaka Hiroji Shinkawa Takayoshi Nishioka Akinori Nozawa Masahiko Kinoshita Genya Hamano Tokuji Ito Yorihisa Urata | 2015 | World Journal of Gastroenterology2015，21，27： | 19 |
| 3 | Intracellular and extracellular TGF-β signaling in cancer: some recent topics显示文摘 | Kohei Miyazono Yoko Katsuno Daizo Koinuma Shogo Ehata Masato Morikawa | 2018 | Frontiers of Medicine2018，12，4： | 16 |
| 4 | Advantage of autologous blood transfusion in surgery for hepatocellular carcinoma显示文摘AIM: To evaluate the significance of autologous blood transfusion (AT) in reducing homologous blood transfusion (HT) in surgery for hepatocellular carcinoma (HCC). METHODS: The proportion of patients who received HT was compared between two groups determined by the time of AT introduction; period A (1991-1994, n = 93) and period B (1995-2000, n = 201). Multivariate logistic regression analysis was performed in order to identify independent significant predictors of the need for HT. We also investigated the impact of AT and HT on long-term postoperative outcome after curative surgery for HCC. RESULTS: The proportion of patients with HT was significantly lower in period B than period A (18.9% vs 60.2%, P < 0.0001). Multivariate logistic regression analysis identified AT administration as a significant independent predictor of the need for HT (P < 0.0001). Disease-free survival in patients with AT was comparable to that without any transfusion. Multivariate analysis identified HT administration as an independent significant factor for poorer disease-free survival (P = 0.0380). CONCLUSION: AT administration significantly decreased the need for HT. Considering the postoperative survival disadvantage of HT, AT administration could improve the long-term outcome of HCC patients. | Yoshito Tomimaru Hidetoshi Eguchi Shigeru Marubashi Hiroshi Wada Shogo Kobayashi Masahiro Tanemura Koji Umeshita Yuichiro Doki Masaki Mori Hiroaki Nagano | 2011 | World Journal of Gastroenterology2011，17，32： | 8 |
| 5 | Natural regression of fibrosis in chronic hepatitis B显示文摘The fibrosis of liver cirrhosis was considered to be irreversible before the anti-viral drugs showed that it is reversible when they lead to continuous suppression of viral replication and inflammation. However, several reports previously showed that fibrosis of type B liver cirrhosis was almost completely absorbed after the natural remission of chronic inflammation. This phenomenon might not be limited to exceptional patients, but rather occur commonly, considering the dynamic clinical features of chronic hepatitis B(CHB), where inactive carrier stage normally follows aggravation of hepatitis and progression of fibrosis at the time of HBe Ag seroconversion. Thus, fibrosis levels of CHB as a hepatocellular carcinoma(HCC)-surveillance marker, particularly those of the inactive stage, could be underestimated, because some of them might have been(pre)cirrhotic in the past and recovered with the natural regression of fibrosis. We argue that cirrhosisinduced HCC mechanisms, rather than direct action of viral genome, may be more common than generally considered in CHB patients. This may have some impact on reconsidering the surveillance rationale for HCC in CHB, from where advanced HCCs tended to be missed. In addition, a molecular marker to assess the cancer-prone characteristics of the liver will definitely be needed to resolve the issue. | Shogo Ohkoshi Haruka Hirono Kazuhiko Watanabe Katsuhiko Hasegawa Kenya Kamimura Masahiko Yano | 2016 | World Journal of Gastroenterology2016，22，24： | 8 |
| 6 | LOV Domain-Containing Light-Dependent Protein in Arabidopsis F-Box Proteins: Degradation Modules显示文摘植物常常用光敏电阻器的几个集合调查包围环境。他们能在数量(=intensity ) 和光的质量(=wavelength ) 察觉到变化并且使用这个信息调整他们的生理的回答,生长,和发展模式。除了古典光敏电阻器,例如 phytochromes , cryptochromes ,和 phototropins , ZEITLUPE ( ZTL ),黄素绑定, KELCH 重复,F盒子 1 ( FKF1 ),并且 LOV KELCH 蛋白质 2 ( LKP2 )蛋白质最近作为蓝光的光敏电阻器被识别了为生理节奏的钟和 photoperiodic flowering 的规定是重要的。ZTL/FKF1/LKP2 蛋白质家庭拥有领域的唯一的联合:与领域一起的领域在蛋白质降级包含了的 blue-light-absorbing LOV (光,氧,或电压) 。这里,我们在我们 Arabidopsis ZTL/FKF1/LKP2 蛋白质的功能的理解总结最近的进展。我们总结他们的 LOV 领域的不同光化学的性质并且讨论 ZTL/FKF1/LKP2 蛋白质由控制 blue-light-dependent 蛋白质降级由调整生理节奏的钟和 photoperiodic flowering 的分子的机制。 | Shogo Ito Young Hun Song Takato Imaizumi | 2012 | Molecular Plant2012，5，3： | 8 |
| 7 | Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis显示文摘Bone is one of the preferred sites for the metastasis of malignant tumours,such as breast cancer,lung cancer and malignant melanoma.Tumour cells colonizing bone have the capacity to induce the expression of receptor activator of nuclear factor-κB ligand(RANKL),which promotes osteoclast differentiation and activation.Tumour-induced osteoclastic bone resorption leads to a vicious cycle between tumours and bone cells that fuels osteolytic tumour growth,causing bone pain and hypercalcaemia.Furthermore,RANKL contributes to bone metastasis by acting as a chemoattractant to bone for tumour cells that express its receptor,RANK.Thus inhibition of the RANKL–RANK pathway is a promising treatment for bone metastasis,and a human monoclonal anti-RANKL antibody,denosumab,has been used in the clinic.However,orally available drugs targeting RANKL must be developed to increase the therapeutic benefits to patients.Here we report the efficacy of the small-molecule RANKL inhibitor AS2676293 in treating bone metastasis using mouse models.Oral administration of AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced osteolysis.AS2676293 suppressed RANKLmediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10,which is known not to trigger osteoclast activation.Based on the results from this study,RANKL inhibition with a small-molecule compound constitutes a promising therapeutic strategy for treating bone metastasis by inhibiting both osteoclastic bone resorption and tumour migration to bone. | Yuta Nakai Kazuo Okamoto Asuka Terashima Shogo Ehata Jun Nishida Takeshi Imamura Takashi Ono Hiroshi Takayanagi | 2019 | Bone Research2019，7，1： | 8 |
| 8 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet2008，，9636： | 7 |
| 9 | Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy显示文摘A well-known tumor suppressor, p21, acts parado-xically by promoting tumor growth in some cellular conditions. These conflicting functions have been demonstrated in association with the HBx gene and in hepatocarcinogenesis. The molecular behavior of p21 depends on its subcellular localization. Nuclear p21 may inhibit cell proliferation and be proapoptotic, while cytoplasmic p21 may have oncogenic and anti-apoptotic functions. Because most typical tumor suppressive proteins also have different effects according to subcellular localization, elucidating the regulatory mechanisms underlying nucleo-cytoplasmic transport of these proteins would be significant and may lead to a new strategy for anti-hepatocellular carcinoma(HCC) therapy. Chromosome region maintenance 1(CRM1) is a major nuclear export receptor involved in transport of tumor suppressors from nucleus to cytoplasm. Expression of CRM1 is enhanced in a variety of malignancies and in vitro studies have shown the efficacy of specific inhibition of CRM1 against cancer cell lines. Interestingly, interferon may keep p21 in the nucleus; this is one of the mechanisms of its anti-hepatocarcinogenic function. Here we review the oncogenic property of p21, which depends on its subcellular localization, and discuss the rationale underlying a new strategy for HCC treatment and prevention. | Shogo Ohkoshi Masahiko Yano Yasunobu Matsuda | 2015 | World Journal of Gastroenterology2015，21，42： | 6 |
| 10 | Direct cholangioscopy combined with doubleballoon enteroscope-assisted endoscopic retrograde cholangiopancreatography显示文摘Double-balloon enteroscope (DBE)-assisted endoscopic retrograde cholangiopancreatography (ERCP) is an effective endoscopic approach for pancreatobiliary disorders in patients with altered gastrointestinal anatomy. Endoscopic interventions via DBE in these postoperative settings remain difficult because of the lack of an elevator and the use of extra-long ERCP accessories. Here, we report the usefulness of direct cholangioscopy with an ultra-slim gastroscope during DBE-assisted ERCP. Three patients with choledocholithiasis in postoperative settings (two patients after Billroth Ⅱ gastrojejunostomy and one patient after Roux-en-Y gastrojejunostomy) were treated. DBE was used to gain access to the papilla under carbon dioxide insufflation, and endoscopic sphincterotomy was performed with a conventional sphincterotome. For direct cholangioscopy, the enteroscope was exchanged for an ultra-slim gastroscope through an incision in the overtube, which was inserted directly into the bile duct. Direct cholangioscopy was used to extract retained bile duct stones in two cases and to confirm the complete clearance of stones in one case. Bile duct stones were eliminated with a 5-Fr basket catheter under direct visual control. No adverse events were noted in any of the three cases. Direct cholangioscopy with an ultra-slim gastroscope facilitates subsequent treatment within the bile duct. This procedure represents another potential option during DBE-assisted ERCP. | Tatsuya Koshitani Shogo Matsuda Koji Takai Takayuki Motoyoshi Makoto Nishikata Yasuhide Yamashita Toshihiko Kirishima Naomi Yoshinami Hiroyuki Shintani Toshikazu Yoshikawa | 2012 | World Journal of Gastroenterology2012，18，28： | 6 |
| 11 | 中孔硫酸化氧化锆-氧化硅催化甘油转化制丙烯醛(英文)显示文摘一种中孔硫酸化的、只含Br?nsted酸位的氧化锆-氧化硅催化剂可将甘油转化为丙烯醛,其产率和选择性分别为81%和82%.即使在低温(523 K)下,产物时空收率可高达9.0 mmol h^(-1)g_(cat)^(-1).本催化剂的活性和选择性高于典型的硫酸化的ZrO_2催化剂.氧化硅稀释了锆物种而使得催化剂酸性更温和,较大的孔径使得传质更快,因此催化剂性能提高. | Hirokazu Kobayashi Shogo Ito Kenji Hara Atsushi Fukuoka | 2017 | Chinese Journal of Catalysis2017，38，3： | 5 |
| 12 | A novel use of TiO_2 fiber for photocatalytic ozonation of 2,4-dichlorophenoxyacetic acid in aqueous solution显示文摘More efficient oxidation methods are needed to degrade especially newly emerging recalcitrant organic contaminants at low concentrations in the water environment. Reduced photonic efficiency of immobilized TiO2 is a major challenge in TiO2-assisted advanced oxidation processes (AOP). Mineralization of 2,4-dichllorophenoxyacetic acid (2,4-D) in low aqueous solution by O3/UV/TiO2 using the world's first high-strength TiO2 fiber was investigated and compared with O3, UV/TiO2, and O3/TiO2 in laboratory batch experiments. The 2,4-D degradation and total organic carbon (TOC) removal followed pseudo first-order reaction kinetic, while their rates in O3/UV/TiO2 were respectively about 1.5 and 2.4 times larger than the summation of the values in O3 and UV/TiO2. The O3/UV/TiO2 was characterized by few aromatics with very low abundance, fast disappearance of aliphatics and more than 95% dechlorination. The discrepancies in organic carbon mass balance among the intermediates and 2,4-D were attributed mainly to few apparently major unidentified intermediates. The significantly enhanced 2,4-D mineralization in O3/UV/TiO2 was attributed to increased ozone dissolution followed by its decomposition, and reduced electron-hole recombination in presence of dissolved ozone resulting in a large number of hydroxyl radical (·OH) generation from more than one parallel path. The removal efficiencies of the systems can further be enhanced by optimizing design parameters, and O3/UV/TiO2 with the TiO2 fiber is promising to mineralize recalcitrant organic contaminants in water at low concentrations. | GIRI Rabindra Raj OZAKI Hiroaki TAKANAMI Ryohei TANIGUCHI Shogo | 2008 | Journal of Environmental Sciences2008，20，9： | 5 |
| 13 | Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava显示文摘Sclerosing epithelioid fibrosarcoma (SEF) is a rare and distinct variant of fibrosarcoma, composed of epithelioid tumor cells arranged in strands, nests, cords, or sheets embedded within a sclerotic collagenous matrix. We report a 39-year-old man with SEF of the liver, which infiltrated the inferior vena cava (IVC). The SEF of the liver was successfully resected, and the infiltrated IVC was also removed together with the liver tumor. Histopathological examination of the tumor showed typical histopathology of SEF. Immunohistochemically, the tumor was positive for vimentin. Recurrence was noted 7 mo after surgery. After chemotherapy, the recurrent tumor was resected surgically, and histopathological examination showed similar findingsto those of the primary tumor. To our knowledge, this is the first report of SEF of the liver with tumor invasion of the IVC. | Yoshito Tomimaru Hiroaki Nagano Shigeru Marubashi Shogo Kobayashi Hidetoshi Eguchi Yutaka Takeda Masahiro Tanemura Toru Kitagawa Koji Umeshita Nobuyuki Hashimoto Hideki Yoshikawa Kenichi Wakasa Yuichiro Doki Masaki Mori | 2009 | World Journal of Gastroenterology2009，15，33： | 5 |
| 14 | Fresh frozen plasma transfusion does not affect outcomes following hepatic resection for hepatocellular carcinoma显示文摘AIM:To investigate whether fresh frozen plasma (FFP) transfusion affects outcomes following hepatic resection for hepatocellular carcinoma (HCC) in terms of liver function,postoperative complications and cancer prognosis.METHODS:We retrospectively compared the incidence of postoperative complications between 204 patients who underwent hepatectomy for HCC with routine FFP transfusion in an early period (1983-1993,Group A) and 293 with necessity for FFP transfusion during a later period (1998-2006,Group B),and also between two subgroups of Group B [22 patients with FFP transfusion (Group B1) and 275 patients without FFP transfusion (Group B2)].Additionally,only in limited patients in Group B1 and Group B2 with intraoperative blood loss≥ 2000 mL (Group B1 ≥ 2000 mL and Group B2 ≥ 2000 mL),postoperative complications,liver function tests,and cancer prognosis were compared.RESULTS:No mortality was registered in Group B,compared to 8 patients (3.9%) of Group A.The incidence of morbidity in Group B2 [23.2% (64/275)] was not significantly different from Group B1 [40.9% (9/22)] and Group A [27.0% (55/204)].The incidence of complications and postoperative liver function tests were comparable between Group B1 ≥ 2000 mL vs Group B2 ≥ 2000 mL.Postoperative prognosis did not correlate with administration of FFP,but with tumor-related factors.CONCLUSION:The outcome of hepatectomy for HCC is not influenced by FFP transfusion.We suggest FFP transfusion be abandoned in patients who undergo hepatectomy for HCC. | Yoshito Tomimaru Hiroshi Wada Shigeru Marubashi Shogo Kobayashi Hidetoshi Eguchi Yutaka Takeda Masahiro Tanemura Takehiro Noda Koji Umeshita Yuichiro Doki Masaki Mori Hiroak Nagano | 2010 | World Journal of Gastroenterology2010，16，44： | 5 |
| 15 | Facile and Scalable Synthesis of a Highly Hydroxylated Water-Soluble Fullerenol as a Single Nanoparticle显示文摘水溶性的 polyhydroxylated fullerene,即 fullerenol 与 44 个氢氧根组和 8 个第二等的界限水分子一起, C60 (哦) | Ken Kokubo Shogo Shirakawa Naoki Kobayashi Hisae Aoshima Takumi Oshima | 2011 | Nano Research2011，4，2： | 5 |
| 16 | Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity显示文摘 | F. Ann Ran Patrick D. Hsu Chie-Yu Lin Jonathan S. Gootenberg Silvana Konermann Alexandro E. Trevino David A. Scott Azusa Inoue Shogo Matoba Yi Zhang Feng Zhang | 2013 | Cell2013，，2： | 4 |
| 17 | Study on Blade Surface Flow around Wind Turbine by Using LDV Measurements显示文摘This paper has attempted to study a mechanism of three-dimensional flow around a horizontal axis wind turbine(HAWT) rotor blade. An experimental study of the flow phenomenon in the vicinity of the wind turbine blade is a challenging endeavor. In this research, the HAWT model with 2.4 m diameter was tested in the large wind tunnel. The flow around the rotating blade surface was measured simultaneously for three velocity components, and two probes were used for the synchronized measurement of three-dimensional flow components. The local velocity was detected for the single seeding particle measured in the point where three pairs of laser beams intersected. Blade sections of interest in this study are composed of radial positions r/R = 0.3, 0.5 and 0.7. Optimum and low tip speed ratio flow characteristics were also compared. The velocity flow vector, skin friction coefficient and bound circulation were calculated from LDV measurements, and the experimental research showed reasonably and clearly the experimental results. | Tinnapob Phengpom Yasunari Kamada Takao Maeda Junsuke Murata Shogo Nishimura Tasuku Matsuno | 2015 | Journal of Thermal Science2015，24，2： | 4 |
| 18 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet . 2008 (9636)2008，，： | 4 |
| 19 | Outcomes of hepatic resection for hepatolithiasis显示文摘 | Takahiro Uenishi Hiroyuki Hamba Shigekazu Takemura Kazuki Oba Masao Ogawa Takatsugu Yamamoto Shogo Tanaka Shoji Kubo | 2009 | The American Journal of Surgery2009，，2： | 3 |
| 20 | Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial显示文摘 | Kazutoshi Fukase Mototsugu Kato Shogo Kikuchi Kazuhiko Inoue Naomi Uemura Shiro Okamoto Shuichi Terao Kenji Amagai Shunji Hayashi Masahiro Asaka | 2008 | The Lancet2008，，9636： | 3 |
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