|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bddsq6pxnp696cx66vb0.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 2 | Dual-wavelength in-line digital holography with untrained deep neural networks显示文摘Dual-wavelength in-line digital holography(DIDH)is one of the popular methods for quantitative phase imaging of objects with non-contact and high-accuracy features.Two technical challenges in the reconstruction of these objects include suppressing the amplified noise and the twin-image that respectively originate from the phase difference and the phase-conjugated wavefronts.In contrast to the conventional methods,the deep learning network has become a powerful tool for estimating phase information in DIDH with the assistance of noise suppressing or twin-image removing ability.However,most of the current deep learning-based methods rely on supervised learning and training instances,thereby resulting in weakness when it comes to applying this training to practical imaging settings.In this paper,a new DIDH network(DIDH-Net)is proposed,which encapsulates the prior image information and the physical imaging process in an untrained deep neural network.The DIDHNet can effectively suppress the amplified noise and the twin-image of the DIDH simultaneously by automatically adjusting the weights of the network.The obtained results demonstrate that the proposed method with robust phase reconstruction is well suited to improve the imaging performance of DIDH. | CHEN BAI TONG PENG JUNWEI MIN RUNZE LI YUAN ZHOU BAOLI YAO | 2021 | Photonics Research2021，9，12： | 3 |
| 3 | Digital holographic microscopy with phase-shift-free structured illumination显示文摘When structured illumination is used in digital holographic microscopy(DHM),each direction of the illumination fringe is required to be shifted at least three times to perform the phase-shifting reconstruction.In this paper,we propose a scheme for spatial resolution enhancement of DHM by using the structured illumination but without phase shifting.The structured illuminations of different directions,which are generated by a spatial light modulator,illuminate the sample sequentially in the object plane.The formed object waves interfere with a reference wave in an off-axis configuration,and a CCD camera records the generated hologram.After the object waves are reconstructed numerically,a synthetic aperture is performed by an iterative algorithm to enhance the spatial resolution.The resolution improvement of the proposed method is proved and demonstrated by both simulation and experiment. | Juanjuan Zheng Peng Gao Baoli Yao Tong Ye Ming Lei Junwei Min Dan Dan Yanlong Yang Shaohui Yan | 2014 | Photonics Research2014，2，3： | 2 |
| 4 | A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions显示文摘Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions(Ag^(+), Hg^(2+), Cu^(2+)). The probe shows divergent fluorescence(FL)/circular dichroism(CD) responses via divergent bond-cleavage cascade reactions(metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL “turn-off” and CD “turn-on” for Ag+(no hydrolysis), FL “turn-on” and CD “turn-off” for Hg^(+)(imine hydrolysis), and FL “self-threshold ratiometric” and CD “turn-off” for excess Cu^(2+)(lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments. | Junwei Chen Na Wang Hongjuan Tong Chao Song Huijuan Ma Yajun Zhang Feng Gao Huan Xu Wei Wang Kaiyan Lou | 2021 | Chinese Chemical Letters2021，32，12： | 2 |
| 5 | Resistive switching and artificial synaptic performances of memristor based on low-dimensional bismuth halide perovskites显示文摘Zero-dimensional(0D)-Cs_(3)Bi_(2)I_(9),two-dimensional(2D)-Cs_(3)Bi_(2)Br_(9),and one-dimensional(1D)-Cs3Bi2Cl9 perovskite films have been successfully grown on indium tin oxide(ITO)glass substrates,which were used to fabricate memristors with the structure of Al/Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)/ITO glass.The current three types of memristors exhibited bipolar resistive switching behaviors.Both the endurance and retention time tests clearly demonstrated the excellent stability of present devices.Especially,the ON/OFF ratio of the 0D-Cs_(3)Bi_(2)I_(9)device is close to 104 at the reading voltage of 0.1 V,which is nearly 100 and 1000 times larger than those of the 1D-Cs3Bi2Cl9 device and the 2D-Cs_(3)Bi_(2)Br_(9)device,respectively.The activation energy of halide vacancies in the Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)films was calculated using the density functional theory by considering a minimum migration path,demonstrating the dimensionality of the Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)film affected the formation and rupture of conductive filaments.Moreover,the short-term plasticity and long-term plasticity of biological synapse were simulated by evaluating the conductance responses of Al/Cs_(3)Bi_(2)X_(9)(X=I,Br,and Cl)/ITO devices under various voltage pulses in detail.The duration time of long-term plasticity in all the present devices can last for up to 250 s.The 0D-Cs_(3)Bi_(2)I_(9)device showed both the highest spikeduration-dependent plasticity and paired-pulse facilitation indexes compared to the other two devices.Additionally,the 0DCs_(3)Bi_(2)I_(9)device successfully established the associative learning behavior by simulating the Pavlov’s dog experiment. | Feifei Luo Yanzhao Wu Junwei Tong Fubo Tian Xianmin Zhang | 2023 | Nano Research2023，16，7： | 1 |
| 6 | Non-small molecule PROTACs(NSM-PROTACs):Protein degradation kaleidoscope显示文摘The proteolysis targeting chimeras(PROTACs)technology has been rapidly developed since its birth in 2001,attracting rapidly growing attention of scientific institutes and pharmaceutical companies.At present,a variety of small molecule PROTACs have entered the clinical trial.However,as small molecule PROTACs flourish,non-small molecule PROTACs(NSM-PROTACs)such as peptide PROTACs,nucleic acid PROTACs and antibody PROTACs have also advanced considerably over recent years,exhibiting the unique characters beyond the small molecule PROTACs.Here,we briefly introduce the types of NSM-PROTACs,describe the advantages of NSM-PROTACs,and summarize the development of NSM-PROTACs so far in detail.We hope this article could not only provide useful insights into NSM-PROTACs,but also expand the research interest of NSM-PROTACs. | Sinan Ma Jianai Ji Yuanyuan Tong Yuxuan Zhu Junwei Dou Xian Zhang Shicheng Xu Tianbao Zhu Xiaoli Xu Qidong You Zhengyu Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 1 |
| 7 | Electrically manipulating magnetization reversal via energy band engineering显示文摘Realization of a magnetization reversal by an external electric field is vital for developing ultra-low-power spintronic devices.In this report,starting from energy band engineering,a general design principle is proposed for achieving electrical manipulation of a nonvolatile 180°magnetization reversal.A half semiconductor(HSC)and a bipolar magnetic semiconductor(BMS)are selected as the model of magnetic layers,whose conduction-band minimum and valence-band maximum are in the same and opposite spin states,respectively.Based on the analysis of virtual hopping and tight-binding models,the interlayer coupling of HSC/insulator/BMS devices is successfully tuned between ferromagnetic and antiferromagnetic interactions by varying electric field directions.Moreover,the interlayer coupling nearly disappears after removing the electric field,proving the nonvolatile magnetization reversal.Using first-principles calculations,the feasibility of present design strategy is further confirmed by a representative device with the structure of CrBr3/h-BN/2H-VSe_(2).This design guideline and physical phenomena may open an avenue to explore magnetoelectric coupling mechanisms and develop next-generation spintronic devices. | Junwei Tong Yanzhao Wu Feifei Luo Fubo Tian Xianmin Zhang | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，5： | 0 |
| 8 | High-efficiency resistive switch and artificial synaptic simulation in antimony-based perovskite devices显示文摘Three kinds of Cs_(3)Sb_(2)X_(9)(X=I,Br,Cl)perovskite films have been prepared to fabricate the resistive memory devices with the structure of Al/Cs_(3)Sb_(2)X_(9)(X=I,Br,Cl)/indium tin oxide(ITO)glass.All devices exhibited a bipolar resistive switching behavior at room temperature by applying scanning voltage of 0→1→0→-1.8→0 V.The switching voltages in the Al/Cs_(3)Sb_(2)X_(9)(X=I,Br,Cl)/ITO devices gradually decreased with the X from I,Br to Cl due to the different migration rates of halide vacancy in perovskite films,which is confirmed by the first-principles calculations of activation energy.The ON/OFF ratio under the reading voltage of 0.1 V significantly increased up to 100 in the Al/Cs_(3)Sb_(2)Cl_(9)/ITO device,which is nearly 10 and 3 times larger than that of the Al/Cs3Sb2I9/ITO device and the Al/Cs_(3)Sb_(2)Br_(9)/ITO device,respectively.The endurance cycles and retention time of current devices were evaluated,showing the excellent electrical stability.Importantly,the three kinds of Al/Cs_(3)Sb_(2)X_(9)(X=I,Br,Cl)/ITO device can successfully simulate the short-term plasticity of biological synapse.The Al/Cs_(3)Sb_(2)Cl_(9)/ITO device showed the highest paired-pulsed facilitation index compared with that of other two devices,which was explored for the longterm plasticity and learning experience processes of synapse.In addition,the Al/Cs_(3)Sb_(2)Cl_(9)/ITO device established associative learning behavior by simulating the Pavlov’s dog experiment. | LUO FeiFei WU YanZhao TONG JunWei XU DaKe QIN GaoWu TIAN FuBo ZHANG XianMin | 2023 | Science China(Technological Sciences)2023，66，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员