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| 1 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 2 | ALK,the Key Gene for Gelatinization Temperature,is a Modifier Gene for Gel Consistency in Rice显示文摘Gelatinization temperature(GT) is an important parameter in evaluating the cooking and eating quality of rice.Indeed,the phenotype,biochemistry and inheritance of GT have been widely studied in recent times.Previous map-based cloning revealed that GT was controlled by ALK gene,which encodes a putative soluble starch synthase II-3.Complementation vector and RNAi vector were constructed and transformed into Nipponbare mediated by Agrobacterium.Phenotypic and molecular analyses of transgenic lines provided direct evidence for ALK as a key gene for GT.Meanwhile,amylose content,gel consistency and pasting properties were also affected in transgenic lines.Two of four nonsynonymous single nucleotide polymorphisms in coding sequence of ALK were identified as essential for GT.Based on the single nucleotide polymorphisms(SNPs),two new sets of SNP markers combined with one cleaved amplified polymorphic sequence marker were developed for application in rice quality breeding. | Zhenyu Gao Dali Zeng Fangmin Cheng Zhixi Tian Longbiao Guo Yan Su Meixian Yan Hua Jiang Guojun Dong Yuchen Huang Bin Han Jiayang Li Qian Qian | 2011 | Journal of Integrative Plant Biology2011，53，9： | 13 |
| 3 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 4 | Methane dehydroaromatization with periodic CH_4-H_2 switch:A promising process for aromatics and hydrogen显示文摘Long-term stability test of Mo/HZSM-5-N catalysts(HZSM-5-N stands for nano-sized HZSM-5) in methane dehydroaromatization(MDA)reaction has been performed with periodic CH4-H2 switch at 1033-1073 K for more than 1000 h.During this test,methane conversion ranges from 13% to 16%,and mean yield to aromatics(i.e.benzene and naphthalene) exceeds 10%.N2-physisorption,XRD,NMR and TPO measurements were performed for the used Mo/HZSM-5 catalysts and coke deposition,and the results revealed that the periodic hydrogenation can effectively suppress coke deposition by removing the inert aromatic-type coke,thus ensuring Mo/HZSM-5 partly maintained its activity even in the presence of large amount of coke deposition.The effect of zeolite particle size on the catalytic activity was also explored,and the results showed that the nano-sized zeolite with low diffusion resistance performed better.It is recognized that the size effect was enhanced by reaction time,and it became more remarkable in a long-term MDA reaction even at a low space velocity. | Changyong Sun Guangzong Fang Xiaoguang Guo Yuanli Hu Shuqi Ma Tianhua Yang Jie Han Hao Ma Dali Tan Xinhe Bao | 2015 | Journal of Energy Chemistry2015，24，3： | 6 |
| 5 | Polyoxometalates-engineered hydrogen generation rate and durability of Pt/CNT catalysts from ammonia borane显示文摘Heterogeneously catalyzed hydrolytic dehydrogenation of ammonia borane is a remarkable structure sensitive reaction. In this work, a strategy by using polyoxometalates(POMs) as the ligands is proposed to engineer the surface and electronic properties of Pt/CNT catalysts toward the enhanced hydrogen generation rate and durability. Three kinds of POMs, i.e., silicotungstic acid(STA), phosphotungstic acid(PTA)and molybdophosphoric acid(PMA), are comparatively studied, among which the STA shows positive effects on the catalytic activity and durability. A catalyst structure-performance relationship is established by a combination of kinetic and isotopic analyses with multiple characterization techniques, such as HAADF-STEM, EDS, Raman spectroscopy and XPS. It is shown that the STA compared to the other two POMs can increase the Pt binding energy and thus promote the reaction. The insights demonstrated here could open a new avenue for boosting the reaction by employing the POMs as the ligands to engineer the catalyst electronic properties. | Wenzhao Fu Chen Han Dali Li Wenyao Chen Jian Ji Gang Qian Weikang Yuan Xuezhi Duan Xinggui Zhou | 2020 | Journal of Energy Chemistry2020，29，2： | 5 |
| 6 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bdds55vxfwww9voc6nox.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 7 | Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics显示文摘 | Xingyu Lu Dali Han Boxuan Simen Zhao Chun-Xiao Song Li-Sheng Zhang Louis C Dore Chuan He | 2015 | Cell Research2015，25，3： | 4 |
| 8 | Chronobiologic Approach to Beat-To-Beat Variations of Cultrued Murine Myocardial Cells显示文摘 | Huiwan Han Dali Shao Jinyi Wu | 1991 | Cell Biophysics1991，18，： | 1 |
| 9 | Applications of human amniotic fluid stem cells in wound healing显示文摘Complete wound regeneration preserves skin structure and physiological functions,including sensation and perception of stimuli,whereas incomplete wound regeneration results in fibrosis and scarring.Amniotic fluid stem cells(AFSCs)would be a kind of cell population with self-renewing and non-immunogenic ability that have a considerable role in wound generation.They are easy to harvest,culture,and store;moreover,they are non-tumorigenic and not subject to ethical restrictions.They can differentiate into different kinds of cells that replenish the skin,subcutaneous tissues,and accessory organs.Additionally,AFSCs independently produce paracrine effectors and secrete them in exosomes,thereby modulating local immune cell activity.They demonstrate anti-inflammatory and immunomodulatory properties,regulate the physicochemical microenvironment of the wound,and promote full wound regeneration.Thus,AFSCs are potential resources in stem cell therapy,especially in scar-free wound healing.This review describes the biological characteristics and clinical applications of AFSCs in treating wounds and provide new ideas for the treatment of wound healing. | Han Luo Zhen Wang Fang Qi Dali Wang | 2022 | Chinese Medical Journal2022，135，19： | 1 |
| 10 | Phylogenetic relationships among five species of Armeniaca Scop. (Rosaceae) using microsatellites (SSRs) and capillary electrophoresis显示文摘The genus Armeniaca Scop.is well known for its popular cultivated edible fruit trees such as Armeniaca vulgaris Lam.and ornamental flowers such as A.mume Sieb.Another species,A.cathayana Fu et al.,one of six important dry fruits(kernel-using apricot),is cultivated for its edible seeds in North China.In the present study,DNA from 70 individuals of Armeniaca,including 38 of A.cathayana,18 of A.vulgaris,12 of A.sibirica,1 of A.dasycarpa and 1 of A.mume,was extracted and analyzed using microsatellites and capillary electrophoresis.For 20 polymorphic loci selected,339 alleles and 140.7 effective alleles were detected.The number of alleles per locus ranged from 8 to 28,with an average of 16.95 alleles per locus.The observed heterozygosity(Ho) and the expected heterozygosity(He) ranged from 0.427 to 0.971 and from 0.737 to 0.912,respectively.The polymorphism information content varied from 0.708 to0.905,with an average of 0.827.Based on the genetic similarity among 70 individuals,a UPGMA was used to establish the phylogenetic relationships.The taxonomic positions among five species were clearly revealed,and A.cathayana was more closely related to A.vulgaris than to A.sibirica.The results will provide a scientific basis for research on the taxonomy,germplasm resources and breeding of Armeniaca,especially for A.cathayana. | Dali Fu Lüyi Ma Yue Qin Mengpei Liu Han Zhao Gaopu Zhu Hao Fu | 2016 | Journal of Forestry Research2016，27，5： | 1 |
| 11 | Leaf nitrogen and phosphorus stoiehiometry across 753 terrestrial plant spe- cies in China显示文摘 | Han Wenxuan Fang Jingyun Guo Dali | 2005 | New Phytologist2005，168，2： | 1 |
| 12 | Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a highly infectious respiratory disease that continues to pose a serious global public health emergency.The disease shows a high infection rate,long incubation period,and rapidly emerging variants,which have led to its rapid spread worldwide(Krammer 2020).Many vaccines have been developed for the control of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for COVID-19,including vaccines based on messenger RNA(mRNA)(Polack et al.2020),viral vectors(Zhu et al.2020),recombinant proteins(Yang et al.2020),and inactivated SARS-CoV-2(Zhang et al.2021). | Dali Tong Mei Zhang Yunru Yang Han Xia Haiyang Tong Huajun Zhang Weihong Zeng Muziying Liu Yan Wu Huan Ma Xue Hu Weiyong Liu Yuan Cai Yanfeng Yao Yichuan Yao Kunpeng Liu Shifang Shan Yajuan Li Ge Gao Weiwei Guo Yun Peng Shaohong Chen Juhong Rao Jiaxuan Zhao Juan Min Qingjun Zhu Yanmin Zheng Lianxin Liu Chao Shan Kai Zhong Zilong Qiu Tengchuan Jin Sandra Chiu Zhiming Yuan Tian Xue | 2023 | Protein & Cell2023，14，1： | 0 |
| 13 | 影响免疫疗法通路的蛋白质显示文摘或成解锁癌症疫苗的钥匙创新点癌症免疫疗法作为人类治愈癌症的希望之一,于2018年获得了诺贝尔生理学或医学奖,其原理是通过移除障碍,使人体自身的免疫系统得以发挥功能,清除体内的肿瘤细胞。目前研究显示,有40%的黑色素瘤患者对免疫疗法有反应,通过免疫疗法能使他们的免疫系统T细胞攻击癌细胞,进而控制病情。 | HAN Dali LIU Jun CHEN Chuanyuan | 2019 | 张江科技评论2019，0，2： | 0 |
| 14 | Correction to: Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://gffzzeb6f7f563f66445dh55vxfwww9voc6nox.ffgz.tsg.suse.edu.cn/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2019 | Protein & Cell2019，10，9： | 0 |
| 15 | New Mechanism Revealed for Tumor-associated Macrophages to Regulate the Fate of CD8^(+)T Cells显示文摘Immune checkpoint blockade therapy is an efficient way to reinvigorate CD8+T cells,which has demonstrated clinical benefits in multiple types of cancer.However,many patients do not respond to immunotherapies effectively due to the irreversibly dysfunctional state of tumor-infiltrating T cells. | HAN Dali | 2021 | Bulletin of the Chinese Academy of Sciences2021，35，2： | 0 |
| 16 | Two New Diterpenoids from Isodon Lungshengensis显示文摘Two new diterpenoids, lungshengenin B and C (1-2), were isolated from Isodon lungshengensis. The structures were determined as 1α-2β,3β,11β,15β-tetraacetoxy ent-kaur-16-en-6-one, 11α-hydroxy-2β, 3β, 6α-triacetoxy-ent-kaur-16-en-15-one by 1 D and 2D N-MR techniques (COSY, HETCOR, COLOC) | Bei JIANG Xing Rong CHEN Ze Qin LU Zhong Wen LIN and Han Dong SUN(Laboratory of Pbytochemistry, Kunming Institute of Botany, Academia Sinica Kunming 650204)( W of Pharmacy Dali Medical College, Dali, Yunnan 671000)(Department of Chemistry and Chemical I | 1997 | Chinese Chemical Letters1997，8，12： | 0 |
| 17 | A Knowledge Survey on Health Education of Echinococcosis Among Students — Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China, 2020显示文摘Summary What is already known about this topic?Previous surveys have mainly focused on how well residents and primary school students have understood the core knowledge of echinococcosis control and are limited in terms of the comprehensiveness of the knowledge category and respondents.What is added by this report?There were some shortcomings in related knowledge of echinococcosis among students,which showed a tendency to know methods but not the rationale.The differences among regions indicated a lack of a unified system for training educators and allocating comprehensive educational material.What are the implications for public health practices?The results of this study provide evidence to potentially help improve health education programs in the new phase of echinococcosis prevention and control in China. | Xu Wang Meihua Fu Qian Wang Wei Li Zeli Danba Shuai Han Xiaozhou He Jianfeng Ba Chumu Luorong Quzhen Jiangyang Yixi Luorong Dali Chunyang Li Dandan Shi Yayi Guan Weiping Wu Ning Xiao | 2022 | China CDC weekly2022，4，8： | 0 |
| 18 | Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor显示文摘Genome editing through adeno-associated viral(AAV) vectors is a promising gene therapy strategy for various diseases,especially genetic disorders. However, homologous recombination(HR) efficiency is extremely low in adult animal models. We assumed that increasing AAV transduction efficiency could increase genome editing activity, especially HR efficiency, for in vivo gene therapy. Firstly, a mouse phenylketonuria(PKU) model carrying a pathogenic R408W mutation in phenylalanine hydroxylase(Pah) was generated. Through co-delivery of the general AAV receptor(AAVR), we found that AAVR could dramatically increase AAV transduction efficiency in vitro and in vivo. Furthermore, co-delivery of SaCas9/sgRNA/donor templates with AAVR via AAV8 vectors increased indel rate over 2-fold and HR rate over 15-fold for the correction of the single mutation in Pah;mice. Moreover, AAVR co-injection successfully increased the site-specific insertion rate of a 1.4 kb Pah cDNA by 11-fold, bringing the HR rate up to 7.3% without detectable global off-target effects. Insertion of Pah cDNA significantly decreased the Phe level and ameliorated PKU symptoms. This study demonstrates a novel strategy to dramatically increase AAV transduction which substantially enhanced in vivo genome editing efficiency in adult animal models, showing clinical potential for both conventional and genome editing-based gene therapy. | Shuming Yin Lie Ma Tingting Shao Mei Zhang Yuting Guan Liren Wang Yaqiang Hu Xi Chen Honghui Han Nan Shen Wenjuan Qiu Hongquan Geng Yongguo Yu Shichang Li Weishi Yu Mingyao Liu Dali Li | 2022 | Science China(Life Sciences)2022，65，4： | 0 |
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